Articles tagged "Glomerular filtration rate (GFR)"

2021 American Transplant Congress
Early Reduction of Tacrolimus Trough Levels Improves Long-term Kidney Function without Increase in Incidence of Acr
M. Chen¹, B. Loza¹, A. Chang¹, R. Byfield², K. Olthoff¹, A. Shaked¹
¹Department of Surgery, University of Pennsylvania, Philadelphia, PA, ²Data Analytics Center, Penn Medicine Information Systems, University of Pennsylvania Health System, Philadelphia, PA
*Purpose: We examined the impact of clinical practice management of tacrolimus trough levels in liver transplant recipients on kidney function and incidence of rejection in…
2021 American Transplant Congress
High Levels of Donor-Derived Cell-Free DNA Predict EGFR Decline After Kidney Transplantation
T. Alhamad¹, V. Bowers², E. Stites³, S. Anand⁴, J. S. Bromberg⁵, H. Murad¹, G. Gupta⁶, I. Moinuddin⁶, L. Bu⁷, S. Ghosh⁸, J. Zeng⁸, A. Pai⁹
¹Washington University in St. Louis, St. Louis, MO, ²Tampa General Hospital, Tampa, FL, ³University of Colorado, Aurora, CO, ⁴Intermountain Medical Center, Murray, UT, ⁵University of Maryland School of Medicine, Baltimore, MD, ⁶Virginia Commonwealth University, Richmond, VA, ⁷University of Minnesota, Minneapolis, MN, ⁸CareDx, Brisbane, CA, ⁹University of Texas McGovern Medical School, Houston, TX
*Purpose: Persistent, low-grade inflammation is associated with decline in eGFR. Cross-sectional studies have demonstrated a consistent association between circulating inflammatory markers and kidney function. Our…
2021 American Transplant Congress
Removal of Race Factor in Egfr Decreases Disparities in Preemptive Listing for Kidney Transplantation
Y. Al-Salmay, N. Jandovitz, M. Abate, A. Baez, E. Molmenti, A. Fahmy, N. Breslin, L. Teperman, V. Nair
Organ Transplantation, Northwell Health, Manhasset, NY
*Purpose: GFR < 20 is required for kidney transplant listing. The Chronic Kidney Disease-Epidemiology Collaboration (CKD-EPI) and the Modification of Diet in Renal Disease (MDRD)…
2021 American Transplant Congress
Clinical Outcomes Associated with Induction Therapy Regimens for Kidney Transplantation in Children: A NAPRTCS and PHIS Collaborative Report
H. Pizzo¹, D. Levy Erez², N. M. Rodig³, T. Richardson⁴, M. Somers³
¹Pediatric Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Nephrology Institute, Schneider Children's Medical Center, Tel Aviv, Israel, ³Nephrology, Boston Children's Hospital, Boston, MA, ⁴Children's Hospital Association, Lenexa, KS
*Purpose: Choice of induction agent at the time of pediatric kidney transplant (KTx) is often based upon patient characteristics and center practice. There are limited…
2021 American Transplant Congress
Dynamic Forecasting of Patient-Specific Kidney Transplant Function with a Sequence-to-Sequence Deep-Learning Model
E. Van Loon¹, W. Zhang², A. Van Craenenbroeck¹, B. De Moor², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: Alike other clinical biomarkers, eGFR trajectories are characterized by intra-individual variability, related to biological fluctuations and analytical error. These fluctuations hamper the distinction between…
2021 American Transplant Congress
The Risk of Post-donation Kidney Function Impairment for Prospective Living Kidney Donors with Persistent Isolated Microscopic Hematuria
J. v. Weijden¹, M. van Londen¹, I. M. Nolte², M. H. De Borst¹, S. P. Berger¹
¹Nephrology, University Medical Center Groningen, Groningen, Netherlands, ²Epidemiology, University Medical Center Groningen, Groningen, Netherlands
*Purpose: According to current guidelines, a kidney biopsy is indicated in prospective living kidney donors who present with persistent isolated microscopic hematuria (PIMH) during evaluation,…
2021 American Transplant Congress
CT-measured Cortical Volume Ratio is an Alternative to Nuclear Medicine Split Scan Ratio Among Living Kidney Donors
J. Montgomery, C. Brown, A. Zondlak, K. Walsh, J. Kozlowski, A. Pinsky, E. Herriman, J. Sussman, Y. Lu, E. Stein, P. Shankar, R. Sung, K. Woodside
Michigan Medicine, Ann Arbor, MI
*Purpose: The 125I-iothalamate clearance and 99mTc-DTPA split scan nuclear medicine studies are used among living kidney donor candidates to determine mGFR and split-scan ratio (SSR).…
2021 American Transplant Congress
Impact of SARS-CoV 2 Infection on Graft Function in Kidney Transplant Recipients: An Academic Single Center Experience
S. Nahi, A. Shetty, S. Tanna, J. Leventhal
Northwestern University, Chicago, IL
*Purpose: Kidney transplant recipients are a unique cohort in regard to SARS-CoV 2 susceptibility and clinical course, owing to their immunosuppressed state and propensity for…
2021 American Transplant Congress
Estimated GFR by Serum Myo-inositol, Valine, Creatinine, and Cystatin-c Outperforms Current CKD-epi Equations in Renal Transplant Recipients
J. W. Meeusen¹, F. Stammler², J. Lieske³, M. Grassi², M. Shah⁴, E. Schiffer²
¹Cardiovascular Laboratory Medicine, Mayo Clinic, Rochester, MA, ²Research and Development, Numares, Boston, MA, ³Division of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, ⁴Clinical Research, Numares, Boston, MA
*Purpose: Current estimated GFR (eGFR) equations using creatinine and/or cystatin C do no perform well in kidney transplant (KTx) recipients. Therefore, some large transplant programs…
2021 American Transplant Congress
Association of Kidney Function with Patient Reported Outcomes After Kidney Transplantation
G. S. Kochar, S. A. Rega, I. D. Feurer, A. Dreher, H. Schaefer, D. Shaffer, R. C. Forbes, C. W. Pinson, B. P. Concepcion
Nephrology, Vanderbilt University Medical Center, Nashville, TN
*Purpose: Our study aimed to determine the association of posttransplant eGFR with patient reported outcomes (PROs) and, specifically, the risk of reduced health-related quality of…