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American Transplant Congress abstracts

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Articles tagged "Glomerular filtration rate (GFR)"

  • 2016 American Transplant Congress

    Age-Based High GFR Associates with Clinical Risk Among Potential Living Donors, but Only with Increased Nephron Number Among Approved Donors.

    H. Chakkera,1 E. Poggio,3 A. Denic,2 J. Mathew,2 W. Kremers,2 J. Larson,2 H. Amer,2 F. Cosio,2 M. Stegall,2 S. Taler,2 A. Rule.2

    1Mayo Clinic, Arizona; 2Mayo Clinic, Rochester; 3Cleveland Clinic, OH.

    Background:Association of high GFR with clinical and kidney structural characteristics among living donors has not been studied.Methods: Study cohort:potential kidney donors evaluated at Mayo Clinic…
  • 2016 American Transplant Congress

    Donor Interstitial Fibrosis and Tubular Atrophy (IFTA) Are Not Independent Risk Factors for a Lower GFR at One Year.

    R. Heilman, I. Qaqish, M. Smith, H. Khamash, B. Kaplan, K. Reddy.

    Mayo Clinic, Phoenix.

    BackgroundDonor age is a determinant of allograft outcome after deceased donor kidney transplant (DDTx). Our aim was to determine if chronic changes on a reperfusion…
  • 2016 American Transplant Congress

    5-Year Follow-Up After Live Donor Nephrectomy – A Prospective Cohort Study.

    S. Janki,1 E. Mulder,1 L. Dols,1 M. Betjes,2 I. Dooper,3 J. IJzermans.1

    1Department of Surgery, Division of HPB and Transplant Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; 2Department of Nephrology, Erasmus University Medical Center, Rotterdam, Netherlands; 3Department of Nephrology, Radboud University Medical Center, Nijmegen, Netherlands.

    BackgroundRecently some studies have reported less favorable results after live kidney donation. We investigated therefore which donors will possibly be at risk for chronic kidney…
  • 2016 American Transplant Congress

    Early Tacrolimus Exposure in Patients Treated De Novo with Once-Daily Tacrolimus After Liver Transplantation: Relationship with Acute Rejection and Long-Term Outcome.

    M. Gastaca, A. Valdivieso, J. Bustamante, P. Ruiz, J. Fernandez, A. Ventoso, M. Testillano, I. Palomares, M. Prieto, P. Salvador, A. Matarranz, M. Suarez, J. Ortiz de Urbina.

    Liver Transplantation Unit, Cruces University Hospital, Bilbao, Vizcaya, Spain.

    AIM: The aim of our study was to define the possible influence of early tacrolimus exposure on long-term outcomes in patients treated with de novo…
  • 2016 American Transplant Congress

    Metabolomic Profiling of Individuals with Failing Kidney Allograft.

    R. Bassi,1,2 M. Niewczas,3 L. Biancone,5 S. Bussolino,5 A. Lin,4 A. Chandraker,6 P. Fiorina.1,2

    1Nephrology, Boston Children's Hospital, Boston; 2Transplant Medicine, IRCCS San Raffaele Hospital, Milan, Italy; 3Genetics and Epidemiology, Joslin Diabetes Center, Boston; 4Radiology, Brigham and Women's Hospital, Boston; 5Nephrology and Transplantation, San Giovanni Battista Hospital, Turin, Italy; 6Transplantation Research Center, Brigham and Women's Hospital, Boston.

    Alteration of certain metabolites may play a role in the pathophysiology of renal allograft disease. To explore metabolome abnormalities in individuals with a failing kidney…
  • 2016 American Transplant Congress

    Angiotensin II Blockade and Fibroblast Growth Factor-23 in Stable Kidney Transplant Recipients.

    O. Sanchez, S. Reule, S. Li, D. Berglund, R. Spong, H. Ibrahim.

    U of MN, Mpls.

    Introduction: FGF-23 has been linked to allograft failure. However, careful serial profiling of FGF-23 has not been done. Therefore, we measured FGF-23 levels in recipients…
  • 2016 American Transplant Congress

    A 30% Decrease in Post-kidney Transplant Estimated Glomerular Filtration Rate (eGFR) from 6 Mo-2 Y Is a Surrogate for 5 Y eGFR: Results from Clinical Trials in Organ Transplantation-(CTOT)-17.

    G. Faddoul,1 G. Nadkarni,1 D. Hricik,2 P. Heeger,1 CTOT17 Investigators.

    1Medicine and Recanati Miller Transplant Institute, Icahn School of Medicine, NY, NY; 2Medicine, Case Medical Center, Cleveland, OH.

    Predicting long-term kidney allograft outcomes using early clinical/biomarker data could guide individualized therapy. Emerging evidence in progressive native kidney disease indicates >30% decrease in eGFR…
  • 2016 American Transplant Congress

    Surveillance Renal Allograft Biopsies Prognosticate Graft Function.

    J. Thompson, D. Taber, P. Baliga, K. Chavin, T. Srinivas.

    MUSC, Charleston, SC.

    Background: Surveillance biopsy of the renal allograft provides a window into the health of the allograft and could allow prognostication of function by affording better…
  • 2016 American Transplant Congress

    Fluctuation of Renal Function During the First Year Is Associated with Negative Impact on Long-Term Kidney Graft Survival: A Retrospective, Propensity Score-Matched Study.

    H. Choi,1 D. Joo,2,3 M. Song,4 M. Kim,2,3 Y. Kim,2,3 B. Kim.1,3

    1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; 2Department of Surgery, Yonsei University College of Medicine, Seoul, Korea; 3The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea; 4Department of Biostatistics Collaboration Unit, Yonsei University College of Medicine, Seoul, Korea.

    Background: Post-transplant renal function in the first year has been reported to predict long-term renal graft survival. The present study examined whether the fluctuation of…
  • 2016 American Transplant Congress

    Activated Cytoprotective Mechanisms in DBD Kidneys Correlate with Kidney Function in Transplant Recipients: A Study Using Clinical Samples from the UK QUOD Biobank.

    M. Kaisar,1 L. van Dullemen,2 Z. Akhtar,1 M. Lo Faro,1 H. Huang,1 H. Leuvenink,2 B. Kessler,1 R. Ploeg.1

    1Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; 2UMCG, UMCG, Groningen, Netherlands.

    The onset of abnormal pathophysiological changes following brain death adversely impact kidney function following transplantation. Understanding the biological mechanisms that affect kidney quality will allow…
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