Articles tagged "Genomics"

2018 American Transplant Congress
Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery
S. Bontha,¹ A. Fernandez,¹ E. Bardhi,¹ L. Gallon,² V. Mas,¹ D. Maluf.¹
¹Surgery, UVA, Charlottesville; ²NWU, Chicago.
Background: Ischemia reperfusion (I/R) is influenced by both donor and recipient characteristics and affects early graft function and the recovery process. To understand underlying mechanisms…
2018 American Transplant Congress
Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants
A. Haj,¹ J. Karl,¹ R. Wiseman,¹ D. O'Connor.^1,2
¹Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI; ²Wisconsin National Primate Research Center, Madison, WI.
Macaque monkeys are critical in transplantation studies, yet macaque genomics lags significantly behind human genomics. While reliable genotyping methods have been developed for some macaque…
2018 American Transplant Congress
Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study
S. Min,¹ T. Papaz,¹ T. Blydt-Hansen,³ O. Lee,¹ U. Allen,¹ P. Birk,² H. Grasemann,¹ L. Hamiwka,⁴ C. Litalien,⁵ V. Ng,¹ R. Parekh,¹ K. Tinckam,⁶ S. Urschel,⁷ B. Foster,⁸ S. Mital.¹
¹The Hospital for Sick Children, Toronto, Canada; ²Winnipeg Children's Hospital, Winnipeg, Canada; ³BC Children's Hospital, Vancouver, Canada; ⁴Alberta Children's Hospital, Calgary, Canada; ⁵CHU Ste-Justine, Montreal, Canada; ⁶University Health Network, Toronto, Canada; ⁷Stollery Children's Hospital, Edmonton, Canada; ⁸Montreal Children's Hospital, Montreal, Canada.
PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ S. Ganesh,¹ R. John,¹ P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,² A. Konvalinka,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹University Health Network, Toronto, ON, Canada; ²SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…
2018 American Transplant Congress
Shared Genetic Ancestry as a Predictor of Medium Term Renal Transplant Outcome in Deceased Donor Transplants
C. Stapleton,¹ On behalf of the UK and Ireland Renal Transplant Consortium, P. Conlon,² G. Cavalleri.¹
¹Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; ²Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
Sibling transplant pairs have better transplant outcomes than unrelated donor recipient (DR) pairs indicating that shared genetic ancestry between donors and recipients can aid in…
2018 American Transplant Congress
Identification of Novel Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients Using Next Generation Sequencing
C. Dorr,^1,2,3 B. Wu,² R. Remmel,² A. Muthusamy,¹ D. Schladt,¹ J. Abrahante,² W. Guan,² R. Mannon,⁴ A. Matas,² W. Oetting,² P. Jacobson,² A. Israni.^1,2,3
¹Minneapolis Medical Research Foundation, Minneapolis; ²Univ. of MN, Minneapolis; ³Hennepin County Medical Center, Minneapolis; ⁴Univ. of AL, Birmingham.
Tacrolimus (Tac) pharmacogenomics studies have identified common genetic variants that alter Tac troughs and developed specific dosing strategies for specific populations. Known common variants and…
2018 American Transplant Congress
Genomic Diversity of Epstein Barr Virus in Post-Transplant Lymphoproliferative Disorder
E. Maloney,¹ V. Busque,² S. Hui,² S. Krams,^1,2 C. Esquivel,^1,2 O. Martinez.^1,2
¹Stanford Immunology, Stanford University School of Medicine, Stanford, CA; ²Department of Surgery/Division of Abdominal Transplantation, Stanford University School of Medicine, Stanford, CA.
Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We utilized next-generation sequencing…
2017 American Transplant Congress
Identification of Kidney Transplant Patients at Risk for Skin Cancer by Differentially Methylated Regions in T Cells.
F. Peters,¹ A. Peeters,¹ P. Mandaviya,² J. van de Wetering,¹ M. Betjes,¹ C. Baan,¹ K. Boer.¹
¹Nephrology and Transplantation, Erasmus MC, University Medical Center, Rotterdam, Netherlands; ²Clinical Chemistry, Erasmus MC, University Medical Center, Rotterdam, Netherlands
Skin cancer, specifically cutaneous squamous cell carcinoma (cSCC), is the most often occurring malignancy in patients after organ transplantation, with an incidence of 100-200 times…
2017 American Transplant Congress
Plasma Extracellular Vesicles MicroRNA Signatures Associate with Graft Function Recovery Post-Acute Renal Allograft Injury.
V. Bontha, A. Fernandez-Pineros, D. Bagchi, D. Maluf, E. Rhone, V. Mas.
Surgery, UVA, Charlottesville
Background: Early host-allograft cell-to-cell communications have been reported to occur via extracellular vesicles (EVs)/protein-miRNA complexes that might determine early allograft outcomes like delayed graft function…
2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
B. Keating,¹ B.-L. Chang,¹ J. van Setten,² B. Cole,¹ L. Jennings,¹ G. Klintmalm,³ A. Shaked.¹
¹University of Pennsylvania, Philadelphia, PA; ²University Medical Center of Utrecht, UtrechT, Netherlands; ³Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…

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