Articles tagged "Genomics"

2018 American Transplant Congress
Identification of Anti-Inflammatory and Pro-Inflammatory Gut Microbiota That Determine Graft Survival
Y. Xiong, C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.
UMB, MD.
Introduction: The gut microbiota induce and train the host immune system. Whether microbiota from contrasting environments of colitic or pregnant mice are pro- or anti-inflammatory…
2018 American Transplant Congress
Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery
S. Bontha,¹ A. Fernandez,¹ E. Bardhi,¹ L. Gallon,² V. Mas,¹ D. Maluf.¹
¹Surgery, UVA, Charlottesville; ²NWU, Chicago.
Background: Ischemia reperfusion (I/R) is influenced by both donor and recipient characteristics and affects early graft function and the recovery process. To understand underlying mechanisms…
2018 American Transplant Congress
Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants
A. Haj,¹ J. Karl,¹ R. Wiseman,¹ D. O'Connor.^1,2
¹Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI; ²Wisconsin National Primate Research Center, Madison, WI.
Macaque monkeys are critical in transplantation studies, yet macaque genomics lags significantly behind human genomics. While reliable genotyping methods have been developed for some macaque…
2018 American Transplant Congress
Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study
S. Min,¹ T. Papaz,¹ T. Blydt-Hansen,³ O. Lee,¹ U. Allen,¹ P. Birk,² H. Grasemann,¹ L. Hamiwka,⁴ C. Litalien,⁵ V. Ng,¹ R. Parekh,¹ K. Tinckam,⁶ S. Urschel,⁷ B. Foster,⁸ S. Mital.¹
¹The Hospital for Sick Children, Toronto, Canada; ²Winnipeg Children's Hospital, Winnipeg, Canada; ³BC Children's Hospital, Vancouver, Canada; ⁴Alberta Children's Hospital, Calgary, Canada; ⁵CHU Ste-Justine, Montreal, Canada; ⁶University Health Network, Toronto, Canada; ⁷Stollery Children's Hospital, Edmonton, Canada; ⁸Montreal Children's Hospital, Montreal, Canada.
PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…
2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
P. Urbanellis,¹ M. Hamar,¹ I. Linares,¹ D. Kollmann,¹ S. Ganesh,¹ R. John,¹ P. Yip,¹ I. Mucsi,¹ A. Ghanekar,¹ D. Bagli,² A. Konvalinka,¹ D. Grant,¹ L. Robinson,² M. Selzner.¹
¹University Health Network, Toronto, ON, Canada; ²SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…
2018 American Transplant Congress
Shared Genetic Ancestry as a Predictor of Medium Term Renal Transplant Outcome in Deceased Donor Transplants
C. Stapleton,¹ On behalf of the UK and Ireland Renal Transplant Consortium, P. Conlon,² G. Cavalleri.¹
¹Department of Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland; ²Department of Nephrology, Beaumont Hospital, Dublin, Ireland.
Sibling transplant pairs have better transplant outcomes than unrelated donor recipient (DR) pairs indicating that shared genetic ancestry between donors and recipients can aid in…
2018 American Transplant Congress
Identification of Novel Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients Using Next Generation Sequencing
C. Dorr,^1,2,3 B. Wu,² R. Remmel,² A. Muthusamy,¹ D. Schladt,¹ J. Abrahante,² W. Guan,² R. Mannon,⁴ A. Matas,² W. Oetting,² P. Jacobson,² A. Israni.^1,2,3
¹Minneapolis Medical Research Foundation, Minneapolis; ²Univ. of MN, Minneapolis; ³Hennepin County Medical Center, Minneapolis; ⁴Univ. of AL, Birmingham.
Tacrolimus (Tac) pharmacogenomics studies have identified common genetic variants that alter Tac troughs and developed specific dosing strategies for specific populations. Known common variants and…
2017 American Transplant Congress
Changes in Peripheral Blood Gene Expression Profile After Calcineurin Inhibitor (CNI) Withdrawal in Kidney Transplant Recipients.
P. Cravedi,¹ W. Zhang,¹ D. Salomon,² M. Fribourg,¹ G. Remuzzi,³ E. Gotti,³ F. Casiraghi,³ Z. Yi,¹ P. Heeger,¹ CTOT09, ATHENA Consortia.
¹Department of Medicine, Icahn School of Medicine at Mount Sinai, New York; ²Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla; ³Istituto di Ricerche Farmacologiche Mario Negri, Bergamo, Italy
CNI are effective in kidney transplantation but their off-target effects make CNI withdrawal (w/d) desirable. Published studies showed that clinical parameters cannot differentiate the ~50%…
2017 American Transplant Congress
Primary Hyperoxaluria Type-1 in Chinese Population: A Case Series and Review of Literature.
D. Du,^1,2 Q. Li,^1,2 H. Shi,^1,2 S. Chen,^1,2 B. Liu,^1,2 Z. Lin,^1,2 G. Chen,^1,2 F. Zeng,^1,2 W. Zhang,^1,2 Z. Chen.^1,2
¹Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; ²Key Laboratory of Organ Transplantation, Ministry of Health/Education, Wuhan, Hubei, China
Background: Primary hyperoxaluria type 1 (PH1) is rare but devastating autosomal recessive inherited disease and cause to graft failure after kidney transplant (KT). We report…
2017 American Transplant Congress
Genomic Analysis of Gene Expression in Human Kidney Transplants Identifies Moxd1 as a Key Driver for Renal Fibrosis.
C. Wei,¹ M. Menon,¹ W. Zhang,¹ C. Woytovich,¹ N. Philippe,¹ J. He,^1,2 B. Murphy,¹ C. Wei.
¹Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Renal Section, James J Peter Veterans Affairs Medical Center, New York, NY
Chronic allograft injury (CAI), characterized histologically by high chronic allograft dysfunction index (CADI) score on biopsy, is known to be a major determinant of graft…

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