2018 American Transplant Congress
Identification of Anti-Inflammatory and Pro-Inflammatory Gut Microbiota That Determine Graft Survival
Introduction: The gut microbiota induce and train the host immune system. Whether microbiota from contrasting environments of colitic or pregnant mice are pro- or anti-inflammatory…2018 American Transplant Congress
Longitudinal Molecular Assessment of Renal Allograft and Short-Term Outcome: Markers of Injury and Recovery
1Surgery, UVA, Charlottesville; 2NWU, Chicago.
Background: Ischemia reperfusion (I/R) is influenced by both donor and recipient characteristics and affects early graft function and the recovery process. To understand underlying mechanisms…2018 American Transplant Congress
Whole-Transcriptome Sequencing to Identify Macaque Immune Gene Variants
Macaque monkeys are critical in transplantation studies, yet macaque genomics lags significantly behind human genomics. While reliable genotyping methods have been developed for some macaque…2018 American Transplant Congress
Genome-Wide Association Study of Tacrolimus Dose in Pediatric Solid Organ Transplant Recipients in the CNTRP POSITIVE Study
PURPOSE: There are significant challenges in achieving therapeutic tacrolimus (Tac) concentrations after transplant. We explored variants associated with tacrolimus dose requirements in pediatric solid organ…2018 American Transplant Congress
Normothermic Ex-Vivo Kidney Perfusion Restores the Genetic Profile of Marginal Kidney Grafts Subjected to Warm Ischemia
1University Health Network, Toronto, ON, Canada; 2SickKids Hospital, Toronto, ON, Canada.
Background: Increasing evidence demonstrates the superiority of normothermic ex-vivo kidney perfusion (NEVKP) over cold storage (CS) for marginal renal grafts. To account for this improvement,…2018 American Transplant Congress
Shared Genetic Ancestry as a Predictor of Medium Term Renal Transplant Outcome in Deceased Donor Transplants
Sibling transplant pairs have better transplant outcomes than unrelated donor recipient (DR) pairs indicating that shared genetic ancestry between donors and recipients can aid in…2018 American Transplant Congress
Identification of Novel Genetic Variants Associated with Tacrolimus Metabolism in Kidney Transplant Recipients Using Next Generation Sequencing
Tacrolimus (Tac) pharmacogenomics studies have identified common genetic variants that alter Tac troughs and developed specific dosing strategies for specific populations. Known common variants and…2017 American Transplant Congress
Genome-Wide Genotyping in 1022 Heart Transplantation Recipients & 758 Donors Reveal Association with Acute Allograft Rejection.
Introduction: Acute rejection (AR) in the 1st year post-cardiac transplant remains a significant clinical issue, and predisposes recipients to subsequent chronic allograft vasculopathy. Genetic factors…2017 American Transplant Congress
A Pilot Trial of Genotype-Guided Dosing versus Standard Clinical Dosing in Pediatric Solid Organ Transplants.
The Hospital for Sick Children, Toronto, ON, Canada
Purpose: Tacrolimus pharmacokinetics are influenced by age and variation in the CYP3A5 gene with CYP3A5 expressors (AA/AG) being fast metabolizers. The purpose of this trial…2017 American Transplant Congress
A Universal Strategy to Characterize Allograft Infiltrating Cells by Bioinformatics Deconvolution of Next Generation Sequencing Data.
1Weill Cornell Medicine-Qatar, Doha, Qatar; 2Weill Cornell Medicine, New York
RNA sequencing characterizes mRNA transcriptome at an unprecedented level of precision. Because organ transplantation is a unique situation of mRNAs encoded by two (donor and…
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