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Articles tagged "Genomics"

  • 2015 American Transplant Congress

    Influence of POR*28 Genotype on Tacrolimus Disposition in Heart Transplant Recipients

    T. Alford,1 R. Page,1 J. Lindenfeld,2 C. Aquilante.1

    1University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; 2University of Colorado School of Medicine, Aurora, CO.

    Polymorphisms in P450 oxidoreductase (POR) have been shown to modulate CYP3A activity and alter the pharmacokinetics of CYP3A substrates, such as tacrolimus (TAC). The objective…
  • 2015 American Transplant Congress

    Donor Apolipoprotein L1 Genotype Associates With Glomerular Lesions and Graft Loss in Kidney Transplants

    T. Srinivas, P. Baliga, K. Chavin, M. Gebrezhiaber, L. Egede, D. Taber.

    Medical University of South Carolina, Charleston, SC.

    Introduction/Aims: Previous studies have associated donor apolipoproteinL1 (APOL1) risk genotypes with risk of graft loss among kidney transplants. APOL1 risk genotypes have also been associated…
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