2015 American Transplant Congress
Validation of a Blood and Biopsy Gene Expression-Based Molecular Diagnostics for Subclinical Acute Rejection: Comparing DNA Microarrays Vs. Next-Generation RNA Sequencing
1The Scripps Research Institute, La Jolla, CA; 2Northwestern University, Chicago, IL.
Background: Microarray-based gene expression signatures for clinical diagnostics are well described. However, microarrays lack advantages offered by newer technologies such as Next Generation Sequencing (NGS):…2015 American Transplant Congress
Single Nucleotide Polymorphisms (SNPs) Associated With Acute Rejection in European American Kidney Transplant Recipients: A Genome Wide Association Study (GWAS)
Purpose: Acute rejection (AR) is associated with increased risk of allograft loss. Therefore, we conducted a GWAS to determine SNPs associated with AR in a…2015 American Transplant Congress
Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients
Introduction: In our effort to personalize immunosuppressive therapies we performed RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) after kidney transplant (tx) and the…2015 American Transplant Congress
Influence of POR*28 Genotype on Tacrolimus Disposition in Heart Transplant Recipients
Polymorphisms in P450 oxidoreductase (POR) have been shown to modulate CYP3A activity and alter the pharmacokinetics of CYP3A substrates, such as tacrolimus (TAC). The objective…2015 American Transplant Congress
Donor Apolipoprotein L1 Genotype Associates With Glomerular Lesions and Graft Loss in Kidney Transplants
Medical University of South Carolina, Charleston, SC.
Introduction/Aims: Previous studies have associated donor apolipoproteinL1 (APOL1) risk genotypes with risk of graft loss among kidney transplants. APOL1 risk genotypes have also been associated…2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…2015 American Transplant Congress
DNA Methylation of the IFNγ Promoter in CD8+ T Cell Subsets Is Modulated by CMV Infection but not by Alloreactivity in Kidney Transplantation Patients
Introduction DNA methylation plays a critical role in the function of cells, including cells of the immune system. Little is known about the methylation status…2015 American Transplant Congress
Precision Diagnosis in Kidney Transplantation
Dept of Medicine, Univ of Illinois Chicago, Chicago, IL.
ObjectiveA major objective in clinical practice, including transplantation, is to develop more focused and “personalized” approaches for both diagnosis and treatment. There have been several…2015 American Transplant Congress
Distinct Blood and Biopsy Meta-Signatures for Acute Rejection Post Kidney Transplant
Acute rejection (AR) is a major cause of allograft dysfunction. Molecular signatures of AR from blood and biopsy have been identified by several independent cohort…2015 American Transplant Congress
Development of a Targeted Genetic Renal Disease Panel With NexGen Sequencing for Unbiased Testing of Living Kidney Donors for Genetic Kidney Disease
Recent studies indicate that living donors biologically related to their transplant recipient may be at higher risk of ESRD compared to unrelated donors, possibly secondary…
American Transplant Congress abstracts