ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomics"

  • 2015 American Transplant Congress

    Molecular Features of Kidney Transplant Biopsies Without Allograft Injury in Relation With Type of Induction Therapy

    M. Ajaimy,1 P. O Broin,2 M. Lubetzky,1 Y. Bao,1 A. Golden,2 E. Akalin.1

    1Transplantation, Einstein/Montefiore Transplant Center, Bronx; 2Computational Genomics Facility, Albert/Einstein College of Medicine, Bronx.

    Objective: Molecular evidence of allograft injury might precede histopathological findings of allograft injury. We aimed to investigate if the type of induction therapy effect intragraft…
  • 2015 American Transplant Congress

    Longitudinal Multi-Omic Profiling of Genes and Pathways Underlying Cardiac Allograft Rejection

    B. Piening,1 Y. Li,2 A. Shaked,2 B. Keating,2 M. Snyder.1

    1Genetics, Stanford University School of Medicine, Stanford, CA; 2University of Pennsylvania, Philadelphia, PA.

    Our ability to treat cardiac allograft rejection in both acute and chronic states is typically limited by poor existing biomarkers to predict the occurrence of…
  • 2015 American Transplant Congress

    The Design and Implementation of a Genome-Wide Genotyping Array Tailored for Transplantation

    B. Keating,1 A. Israni,2 Y. Li,1 M. Holmes,1 K. Birdwell,3 F. Asselbergs,4 A. Shaked.1

    1Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; 2University of Minnesota, Minneapolis, MN; 3Nephrology, Vanderbilt University, Nashville, TN; 4Cardiology (Division Heart and Lungs), University Medical Center Utrecht, Utrecht, Netherlands.

    Over 570,000 solid organ transplants have been performed in the United States since 1988. Despite significant improvements in transplant outcomes, chronic organ rejection affects up…
  • 2015 American Transplant Congress

    Interrogation of Plasma Cell-Rich Acute Rejection in Human Kidney Allografts by Whole Transcriptome Sequencing

    L. Mesnard, F. Campagne, H. Yang, D. Dadhania, J. Lee, S. Seshan, M. Suthanthiran, T. Muthukumar.

    Weill Medical College of Cornell University, New York.

    Plasma cell-rich acute rejection (PCRAR, plasma cells constituting >20% of the allograft infiltrating cells) portends poor prognosis.To gain better mechanistic insights and develop diagnostic biomarkers,…
  • 2015 American Transplant Congress

    Validation of a Blood and Biopsy Gene Expression-Based Molecular Diagnostics for Subclinical Acute Rejection: Comparing DNA Microarrays Vs. Next-Generation RNA Sequencing

    S. Kurian,1 J. Friedewald,2 F. Harrison,1 T. Gelbart,1 S. Head,1 P. Ordoukhanian,1 M. Abecassis,2 D. Salomon.1

    1The Scripps Research Institute, La Jolla, CA; 2Northwestern University, Chicago, IL.

    Background: Microarray-based gene expression signatures for clinical diagnostics are well described. However, microarrays lack advantages offered by newer technologies such as Next Generation Sequencing (NGS):…
  • 2015 American Transplant Congress

    Single Nucleotide Polymorphisms (SNPs) Associated With Acute Rejection in European American Kidney Transplant Recipients: A Genome Wide Association Study (GWAS)

    A. Israni,1 C. Dorr,1 M. Miller,2 D. Schladt,1 K. Sanghavi,3 A. Muthusamy,1 R. Remmel,3 W. Guan,4 B. Wu,4 W. Oetting,3 P. Jacobson,3 A. Matas,5 For DeKAF Genomics & GEN03 Investigators.1

    1Medicine, MMRF, Hennepin County Medical Center, Minneapolis, MN; 2Psychology, University of MN, Minneapolis, MN; 3Pharmacy, University of MN, Minneapolis, MN; 4Biostatistics, University of MN, Minneapolis, MN; 5Surgery, University of MN, Minneapolis, MN.

    Purpose: Acute rejection (AR) is associated with increased risk of allograft loss. Therefore, we conducted a GWAS to determine SNPs associated with AR in a…
  • 2015 American Transplant Congress

    Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients

    C. Dorr,1 B. Wu,2 W. Guan,2 A. Muthusamy,1 K. Sanghavi,3 P. Jacobson,3 W. Oetting,3 D. Schladt,1 R. Remmel,3 J. Maltzman,5 A. Matas,4 For DeKAF Genomics Investigators,1 A. Israni.1

    1Medicine, MMRF, HCMC, Minneapolis, MN; 2Biostatistics, University of MN, Minneapolis, MN; 3Pharmacy, University of MN, Minneapolis, MN; 4Surgery, University of MN, Minneapolis, MN; 5Medicine, University of PA, Philadelphia, PA.

    Introduction: In our effort to personalize immunosuppressive therapies we performed RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) after kidney transplant (tx) and the…
  • 2015 American Transplant Congress

    Influence of POR*28 Genotype on Tacrolimus Disposition in Heart Transplant Recipients

    T. Alford,1 R. Page,1 J. Lindenfeld,2 C. Aquilante.1

    1University of Colorado Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, CO; 2University of Colorado School of Medicine, Aurora, CO.

    Polymorphisms in P450 oxidoreductase (POR) have been shown to modulate CYP3A activity and alter the pharmacokinetics of CYP3A substrates, such as tacrolimus (TAC). The objective…
  • 2015 American Transplant Congress

    Donor Apolipoprotein L1 Genotype Associates With Glomerular Lesions and Graft Loss in Kidney Transplants

    T. Srinivas, P. Baliga, K. Chavin, M. Gebrezhiaber, L. Egede, D. Taber.

    Medical University of South Carolina, Charleston, SC.

    Introduction/Aims: Previous studies have associated donor apolipoproteinL1 (APOL1) risk genotypes with risk of graft loss among kidney transplants. APOL1 risk genotypes have also been associated…
  • 2015 American Transplant Congress

    Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS

    W. Oetting,1 D. Schladt,2 W. Guan,1 A. Israni,2 R. Remmel,1 C. Dorr,2 K. Sanghavi,1 R. Mannon,3 B. Herrera,4 A. Matas,1 D. Salomon,5 P. Kwok,4 P. Jacobson,1 for DeKAF Genomics.1

    1Univ. of Minnesota, Minneapolis; 2Minneapolis Medical Research Foundation, Minneapolis; 3Univ. of Alabama, Birmingham; 4Univ. of California, San Francisco; 5Scripps Research Center, La Jolla.

    African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…
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