2016 American Transplant Congress
Impact of Ethnicity on Tacrolimus Trough/Dose Ratios Following Solid Organ Transplantation.
Mount Sinai Hospital, New York.
Objective: to assess tacrolimus dosing requirements based upon ethnicity in order to help guide future decisions regarding dosage initiation and titration among Hispanic and African…2016 American Transplant Congress
A Genome Wide Association Study of New Onset Diabetes After Transplant in Kidney Transplantation.
Purpose: New-onset diabetes after transplantation (NODAT) is associated increased mortality. Using a DNA biobank linked to electronic medical records (EMR) at Vanderbilt University (BioVU), we…2016 American Transplant Congress
Differences in Tacrolimus Troughs and Doses Between Caucasians and African Americans with Two CYP3A5 Loss-of-Function Alleles: Looking Beyond CYP3A5 Expression.
Higher tacrolimus (TAC) dose requirements and lower TAC troughs (TT) in African Americans (AA) relative to Caucasians (CA) have been presumed to be due to…2016 American Transplant Congress
Development of a Sequencing-Based Cytomegalovirus UL55 Glycoprotein B (gB) Genotyping Assay.
Viracor-IBT Laboratories, Lee's Summit, MO.
Background: Human cytomegalovirus (hCMV) is an important agent of serious viral infection in the solid organ transplant and allogeneic hematopoietic stem cell transplant populations. Severe…2016 American Transplant Congress
Alloimmunity Through Non-HLA Epitopes in Kidney Transplantation.
Introduction: An unexpected diversity in the human genome has been identified including more than 2,500 nonsynonymous single nucleotide polymorphisms (nsSNP) and up to 20 homozygous…2016 American Transplant Congress
The Heterogenous Genomic Landscape of Unresectable Hepatoblastoma Requiring Liver Transplantation: Prognostic Implications.
Surgery, Children's Hospital of Pittsburgh of UPMC and University of Pittsburgh, Pittsburgh, PA.
Background: Hepatoblastoma, the most common pediatric liver malignancy, is cured by chemotherapy and surgical resection. Locally invasive/multifocal tumors require liver transplantation (LTx). A unique tumor…2016 American Transplant Congress
Urinary Virome in Human Kidney Transplants Reveals Multiple Virus Subtypes with Distinct Genome Polymorphisms.
Recent studies have established that human urine has its own unique microbiome, but little is known about the virome. The human virome is the collection…2015 American Transplant Congress
Identification of Genetic Variants Associated With Variation of Tacrolimus Levels in African Americans Using GWAS
African American kidney transplant recipients (AA) have a higher incidence of allograft failure when compared to Caucasians. We have previously reported that tacrolimus troughs (TT)…2015 American Transplant Congress
DNA Methylation of the IFNγ Promoter in CD8+ T Cell Subsets Is Modulated by CMV Infection but not by Alloreactivity in Kidney Transplantation Patients
Introduction DNA methylation plays a critical role in the function of cells, including cells of the immune system. Little is known about the methylation status…2015 American Transplant Congress
Precision Diagnosis in Kidney Transplantation
Dept of Medicine, Univ of Illinois Chicago, Chicago, IL.
ObjectiveA major objective in clinical practice, including transplantation, is to develop more focused and “personalized” approaches for both diagnosis and treatment. There have been several…
American Transplant Congress abstracts