2018 American Transplant Congress
Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients
Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…2018 American Transplant Congress
Comparative Analysis of Alloantigen-Stimulated Gene Expression in HIV(+) Liver Transplant Rejectors versus Non-Rejectors
Surgery, University of California, San Francisco, San Francisco, CA.
In a multi-center, prospective trial of solid-organ transplantation in persons with HIV, recipients had a 2-3x increased rejection rate when compared to historical data on…2018 American Transplant Congress
Short-Term Outcome Prediction Model in Deceased Donor Kidney Transplant Recipients
1OSU, Columbus; 2UVA, Charlottesville; 3Montefiore, New York; 4NWU, Chicago.
Background: Lack of accurate outcome prediction models may be a reason for the increase in organ discard rate that further burdens the growing kidney transplant…2018 American Transplant Congress
Prognostic Value and Biological Significances of Five Long Non-Coding RNAs in Hepatocellular Carcinoma
Objectives Increasing evidence suggests that long non-coding RNA (lncRNA) plays a vital role in metastasis and development in hepatocellular carcinoma (HCC). Tumor progression severely affect…2017 American Transplant Congress
Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.
Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…2017 American Transplant Congress
Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.
Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…2017 American Transplant Congress
Deciphering the Mechanism of Remote Ischemic Preconditioning and Its Potential Benefits in Ischemia/Reperfusion Injury by Metabolomics.
Surgery, Seoul National University Hospital, Seoul, Korea
IntroductionRemote ischemic preconditioning (RIPC) is a strategy inducing resistance against ischemia and reperfusion(IR) injury. But the mechanism and the time window of protection representing RIPC…2017 American Transplant Congress
TACI Polymorphisms Associated with De Novo Alloantibodies in Humans and Allograft Rejection in Mice.
A. Trans-membrane Activator and CAML Interactor (TACI) controls B cell differentiation and memory and exists as numerous allelic variants among healthy individuals and individuals with…2017 American Transplant Congress
Genome-Wide Genotyping in 1022 Heart Transplantation Recipients & 758 Donors Reveal Association with Acute Allograft Rejection.
Introduction: Acute rejection (AR) in the 1st year post-cardiac transplant remains a significant clinical issue, and predisposes recipients to subsequent chronic allograft vasculopathy. Genetic factors…2017 American Transplant Congress
Epigenetic Modifications in the Progression to Chronic Renal Allograft Injury.
1UVA, Charlottesville; 2VCU, Richmond; 3OSU, Columbus; 4NWU, Chicago
Background: The renal allograft is exposed to a milieu of environmental/metabolic stimuli that trigger epigenetic modifications and thereby gene expression patterns which influence function and…
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