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American Transplant Congress abstracts

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Articles tagged "Genomic markers"

  • 2018 American Transplant Congress

    Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)

    T. Whisenant,1 S. Kurian,1 M. Kandpal,2 L. Zhao,2 D. Ikle,3 B. Armstrong,3 J. Friedewald,2 R. Heilman,4 E. Poggio,5 C. Marsh,1 P. Baliga,6 N. Bridges,7 J. Odim,7 M. Brown,7 J. Charette,2 S. Brietigam,2 N. Sustento-Reodica,2 D. Salomon,1 M. Abecassis.2

    1Scripps, La Jolla; 2Northwestern, Chicago; 3Rho, Chapel Hill; 4Mayo AZ, Scottsdale; 5Cleveland Clinic, Cleveland; 6MUSC, Charleston; 7NIAID, Bethesda.

    Sub-clinical acute rejection (subAR) following KT is associated with poor long-term graft outcomes and can only be detected using invasive surveillance biopsies (SBx). Non-invasive biomarker…
  • 2018 American Transplant Congress

    Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas

    V. Tubita,1 M. Ramírez-Bajo,1 J. Lozano,2 D. Moya-Rull,1 J. Rovira,3 J. Campistol,4,5,6 F. Diekmann,1,4,5,6 I. Revuelta.1,4,5,6

    1Experimental Laboratory of Nefrology and Kidney Transplant (LENIT). Biomedical Research Clinic Foundation (FCRB), Barcelona, Spain; 2Bioinformatics Platform, CIBEREHD, Barcelona, Spain; 3Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; 4Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; 5REDinREN, Madrid, Spain; 6Barcelona University, Barcelona, Spain.

    The aggressiveness of colorectal cancer (CRC) in kidney transplantation is much more significant than the increase in its incidence compared with the general population. The…
  • 2018 American Transplant Congress

    Association of CYP3A5*3*6*7 Metabolic Composites to Tacrolimus Pharmacokinetics in African American and Caucasian Renal Transplant Recipients

    K. Tornatore,1,5 D. Brazeau,2 C. Meaney,1 K. Attwood,3,4 G. Wilding,4 S. Chang,5 R. Venuto.5

    1Pharmacy, School of Pharmacy, University at Buffalo(UB), Buffalo; 2Pharmaceutical Sciences, College of Pharmacy; University of New England, Portland; 3Biostatistics, Roswell Park Cancer Institute, Buffalo; 4Biostatistics, UB School of Public Health, Buffalo; 5Nephrology, UB School of Medicine, Buffalo.

    Background: Interpatient variability in tacrolimus pharmacokinetics(PK) is due primarily to metabolism by cytochrome P-450 3A5(CYP3A5) isoenzymes. African Americans(AA) require higher tacrolimus doses to achieve comparable…
  • 2018 American Transplant Congress

    Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection

    J. Whitlam,1 L. Ling,2 F. Ierino,3 D. Bruno,2 H. Slater,2 D. Power.1

    1Austin Health, Heidelberg, Victoria, Australia; 2Murdoch Childrens Research Institute, Parkville, Victoria, Australia; 3St Vincent's Health, Fitzroy, Victoria, Australia.

    Aim: To study the performance of droplet digital PCR absolute measurement of graft-derived cell-free DNA (gdcfDNA) for the diagnosis of kidney allograft rejection.Methods: Homozygous deletion…
  • 2017 American Transplant Congress

    Epigenetic Modifications in the Progression to Chronic Renal Allograft Injury.

    V. Bontha,1 D. Maluf,1 M. Dozmorov,2 K. Archer,3 L. Gallon,4 V. Mas.1

    1UVA, Charlottesville; 2VCU, Richmond; 3OSU, Columbus; 4NWU, Chicago

    Background: The renal allograft is exposed to a milieu of environmental/metabolic stimuli that trigger epigenetic modifications and thereby gene expression patterns which influence function and…
  • 2017 American Transplant Congress

    Genomic Diversity of Epstein-Barr Virus in Post-Transplant Lymphoproliferative Disorder.

    E. Maloney, O. Martinez.

    Program in Immunology, Stanford University School of Medicine, Stanford, CA

    Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We used next-generation sequencing…
  • 2017 American Transplant Congress

    Clusterin Levels at 3-Months Associate with DGF and 12-Month Fibrosis – Reinforcing the Early Injury to Fibrosis Continuum.

    M. Menon,1 L. Liriano-Ward,2 N. Philippe,1 C. Wei,1 W. Zhang,1 Z. Yi,1 K. Keung,2 P. O'Connell,2 B. Murphy.1

    1Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; 2Medicine, Westmead Millenium Institute, Sydney, NSW, Australia

    The Genomics of Chronic Allograft Rejection (GoCAR) is a multicenter study investigating the ability of gene expression to predict the development of Chronic allograft nephropathy.…
  • 2017 American Transplant Congress

    Validation of CYP4F11 as a Marker of Accommodation in Biopsies from Recipients of an ABO-Incompatible Renal Transplant.

    K. Dominy,1 M. Willicombe,3 T. Al Johani,2 J. Galliford,3 A. McLean,3 T. Cook,3 C. Roufosse.3

    1Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; 2King Saud University, Riyadh, Saudi Arabia; 3Imperial College Healthcare NHS Trust, London, United Kingdom

    Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…
  • 2017 American Transplant Congress

    Genome-Wide Genotyping in > 1500 Liver Allograft Recipient and Donor Pairs Reveals Several Associations with Acute Cellular Rejection.

    B. Keating,1 B.-L. Chang,1 J. van Setten,2 B. Cole,1 L. Jennings,1 G. Klintmalm,3 A. Shaked.1

    1University of Pennsylvania, Philadelphia, PA; 2University Medical Center of Utrecht, UtrechT, Netherlands; 3Baylor Simmons Transplant Institute, Baylor University Medical Center, Dallas, TX

    Introduction:Despite higher survival rates of liver allograft recipients through improvements in post-transplant surgery treatments, acute cellular rejection (ACR) remains a frequent & significant complication impacting…
  • 2017 American Transplant Congress

    Next-Generation Sequencing-Based Exosome MicroRNA Profiling for Specific Identification of Islet Damage.

    P. Saravanan,1 J. Gu,1 X. Wang,1 P. Nguyen,1 G. Yoshimatsu,1 M. Lawrence,1 B. Naziruddin.2

    1Baylor Scott and White Research Institute, Dallas, TX; 2Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: A significant mass of intraportally transplanted islets undergo damage due to various stress conditions including hypoxia and inflammation. Development of innovative ultrasensitive tests to…
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