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American Transplant Congress abstracts

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Articles tagged "Genomic markers"

  • 2022 American Transplant Congress

    A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients

    S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali

    University of Wisconsin, Madison, WI

    *Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…
  • 2022 American Transplant Congress

    RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy

    W. Yicun, W. Yuxuan, H. Xiaopeng

    Department of Urology, Beijing Chaoyang Hospital, Beijing, China

    *Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…
  • 2022 American Transplant Congress

    The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors

    M. Liao1, Q. Fu2, L. Wei3, H. Yang3, G. Zhao3, S. Deng3, J. F. Markmann2

    1School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 3University of Electronic Science and Technology of China, Chengdu, China

    *Purpose: The study aims to develop RNA signature predictors using preemptive biopsy transcriptome data to predict future allograft rejection and reveal the predictors' time-dependent features.*Methods:…
  • 2022 American Transplant Congress

    Comparative Analysis of kSORT Assay for Predicting Acute Renal Allograft Rejection Under Belatacept-Based Immunosuppression

    H. Hames1, M. Sarwal2, I. Damm2, E. Yanqui1, A. Burg1, A. Christianson1, A. R. Shields1, D. Hildeman1, R. R. Alloway1, E. S. Woodle1

    1University of Cincinnati, Cincinnati, OH, 2University of California San Francisco, San Francisco, CA

    *Purpose: The kSORT (Kidney Solid Organ Response Test) assay uses transcriptomic profiling of peripheral blood to predict the presence of acute rejection (AR) in renal…
  • 2022 American Transplant Congress

    Donor-Derived Cell-Free DNA Trends Before and After Rejection Vary Based on Timing of Rejection

    C. Rebello1, K. Guo1, S. Park2, B. Kinsella1, L. Zhao1, J. Friedewald1

    1Northwestern University, Chicago, IL, 2Transplant Nephrology, Northwestern University, Chicago, IL

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been used for acute rejection detection and trending levels may help predict future rejection and assess the adequacy of…
  • 2022 American Transplant Congress

    Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles

    I. Sedej1, M. Štalekar2, M. Tušek Žnidarič2, K. Goričar3, N. Kojc4, P. Kogovšek2, V. Dolžan3, M. Lenassi3, M. Arnol1

    1Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia, 3Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 4Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    *Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…
  • 2022 American Transplant Congress

    Infection Impacts dd-cfDNA in Lung Transplant Recipients

    D. Levine1, C. Giner1, C. Pham2, R. Woodward2, A. Roux3

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…
  • 2022 American Transplant Congress

    Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection

    K. Guo1, J. Friedewald1, C. Rebello1, B. Kinsella1, S. Park2, L. Zhao1

    1Northwestern University, Chicago, IL, 2Transplant nephrology, Northwestern University, Chicago, IL

    *Purpose: The TRAC dd-cfDNA test was developed to detect acute kidney transplant rejection but can also detect subclinical rejection with improved performance in antibody-mediated rejection…
  • 2022 American Transplant Congress

    An Initial Analysis of Baseline Levels of Dd-cfdna After Pancreas Transplantation: A Prospective Study from High-Volume Centers in the United States

    A. Yoo1, I. Qian1, A. Riedel1, G. Kibria1, A. Bartosic1, R. Soltani2, O. Nduanya3, M. Omidi3, J. S. Odorico2, P. L. Abrams3, M. Cooper3, J. S. Bromberg1, J. R. Scalea1

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Wisconsin School of Medicine, Madison, WI, 3Georgetown University School of Medicine, Washington, DC

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) testing, which has been validated for monitoring kidney transplant (KTx) rejection, may provide an alternative to pancreas biopsy that prevents…
  • 2022 American Transplant Congress

    Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration

    N. M. Ali1, S. Mehta1, V. Tatapudi1, A. Mattoo1, I. Soomro1, J. Benstein1, H. Neumann1, F. Zervou1, J. Miles2, R. Montgomery1

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, CA

    *Purpose: Evolving data suggests booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccines in solid organ transplant recipients with higher IgG responses, neutralizing antibodies titers,…
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