ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomic markers"

  • 2022 American Transplant Congress

    Donor-Derived Cell-Free DNA Trends Before and After Rejection Vary Based on Timing of Rejection

    C. Rebello1, K. Guo1, S. Park2, B. Kinsella1, L. Zhao1, J. Friedewald1

    1Northwestern University, Chicago, IL, 2Transplant Nephrology, Northwestern University, Chicago, IL

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been used for acute rejection detection and trending levels may help predict future rejection and assess the adequacy of…
  • 2022 American Transplant Congress

    Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles

    I. Sedej1, M. Štalekar2, M. Tušek Žnidarič2, K. Goričar3, N. Kojc4, P. Kogovšek2, V. Dolžan3, M. Lenassi3, M. Arnol1

    1Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, 2Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia, 3Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, 4Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia

    *Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…
  • 2022 American Transplant Congress

    Infection Impacts dd-cfDNA in Lung Transplant Recipients

    D. Levine1, C. Giner1, C. Pham2, R. Woodward2, A. Roux3

    1University of Texas Health System San Antonio, San Antonio, TX, 2CareDX, South San Francisco, CA, 3Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France

    *Purpose: Infection is the leading cause of death within 1 year post lung transplant. Graft injury secondary to infection is affected by both source and…
  • 2022 American Transplant Congress

    Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection

    K. Guo1, J. Friedewald1, C. Rebello1, B. Kinsella1, S. Park2, L. Zhao1

    1Northwestern University, Chicago, IL, 2Transplant nephrology, Northwestern University, Chicago, IL

    *Purpose: The TRAC dd-cfDNA test was developed to detect acute kidney transplant rejection but can also detect subclinical rejection with improved performance in antibody-mediated rejection…
  • 2022 American Transplant Congress

    An Initial Analysis of Baseline Levels of Dd-cfdna After Pancreas Transplantation: A Prospective Study from High-Volume Centers in the United States

    A. Yoo1, I. Qian1, A. Riedel1, G. Kibria1, A. Bartosic1, R. Soltani2, O. Nduanya3, M. Omidi3, J. S. Odorico2, P. L. Abrams3, M. Cooper3, J. S. Bromberg1, J. R. Scalea1

    1University of Maryland School of Medicine, Baltimore, MD, 2University of Wisconsin School of Medicine, Madison, WI, 3Georgetown University School of Medicine, Washington, DC

    *Purpose: Donor-derived cell-free DNA (dd-cfDNA) testing, which has been validated for monitoring kidney transplant (KTx) rejection, may provide an alternative to pancreas biopsy that prevents…
  • 2022 American Transplant Congress

    Kinetics of dd-cfDNA in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination Booster Administration

    N. M. Ali1, S. Mehta1, V. Tatapudi1, A. Mattoo1, I. Soomro1, J. Benstein1, H. Neumann1, F. Zervou1, J. Miles2, R. Montgomery1

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, CA

    *Purpose: Evolving data suggests booster vaccine doses enhance the immunogenicity of SARS-CoV-2 vaccines in solid organ transplant recipients with higher IgG responses, neutralizing antibodies titers,…
  • 2022 American Transplant Congress

    Longitudinal Monitoring of Simultaneous Pancreas and Kidney Transplant and Pancreas After Kidney Recipients Using Donor-Derived Cell-Free DNA

    N. M. Ali1, J. Miles2, Z. Stewart3

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY, 3Transplant Institute, NYU Langone Health, New York, NM

    *Purpose: The utility of dd-cfDNA in patients undergoing pancreas transplantation has not been well studied. Pancreatic rejection remains a major clinical concern. Early identification of…
  • 2022 American Transplant Congress

    Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination

    N. M. Ali1, J. Miles2, S. Mehta1, V. Tatapudi1, Z. Stewart1, B. Lonze1, M. Mangiola1, C. DiMaggio1, E. Weldon1, I. Saeed1, J. Leonard1, R. Herati1, J. Thomas1, J. Michael1, C. Hickson1, K. Cartiera1, R. Montgomery1

    1Transplant Institute, NYU Langone Health, New York, NY, 2CareDx, Brisbane, NY

    *Purpose: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection after SARS-CoV-2 vaccination have…
  • 2022 American Transplant Congress

    Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants

    B. Keating1, B. Piening2, M. Mangiola3, J. Stern4, W. Zhang5, A. Griesemer6, B. Lonze7, M. Snyder8, J. Boeke5, R. Montgomery7

    1University of Pennsylvania, Philadelphia, PA, 2Providence Cancer Center, Portland, OR, 3New York University Langone Medical Center, New York, NY, 4Department of Surgery, NYU Langone, New York, NY, 5Institute of Systems Genetics, NYU Langone, New York, NY, 6Surgery, NYU Langone, New York, NY, 7NYU Langone Transplant Institute, New York, NY, 8Genetics, Stanford, Palo Alto, CA

    *Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
  • 2022 American Transplant Congress

    Month 1 Donor Derived Cell Free DNA Levels Predict Future Kidney Transplant Rejection

    B. M. Kinsella1, K. Guo1, C. Rebello1, L. Zhao1, S. Park2, J. Friedewald1

    1Northwestern University, Chicago, IL, 2Transplant Nephrology, Northwestern University, Chicago, IL

    *Purpose: The purpose of this study was to determine if donor-derived cell-free DNA (dd-cfDNA) can be used one-month post-transplant to predict later allograft rejection.*Methods: Retrospective…
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