Articles tagged "Genomic markers"

2018 American Transplant Congress
Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients
T. Papaz,¹ S. Min,¹ O. Lee,¹ T. Blydt-Hansen,³ U. Allen,¹ Y. Avitzur,¹ P. Birk,² B. Foster,⁴ H. Grasemann,¹ L. Hamiwka,⁵ R. Parekh,¹ V. Phan,⁶ S. Urschel,⁷ S. Mital.¹
¹SickKids Hospital, Toronto, ON, Canada; ²Winnipeg Children's Hospital, Winnipeg, MB, Canada; ³BC Children's Hospital, Vancouver, BC, Canada; ⁴Montreal Children's Hospital, Montreal, QC, Canada; ⁵Alberta Children's Hospital, Calgary, AB, Canada; ⁶CHU Sainte Justines, Montreal, QC, Canada; ⁷Stollery Children's Hospital, Edmonton, AB, Canada.
Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…
2018 American Transplant Congress
Comparative Analysis of Alloantigen-Stimulated Gene Expression in HIV(+) Liver Transplant Rejectors versus Non-Rejectors
S. Chu, K. Lee, C. Ward, P. Stock, Q. Tang.
Surgery, University of California, San Francisco, San Francisco, CA.
In a multi-center, prospective trial of solid-organ transplantation in persons with HIV, recipients had a 2-3x increased rejection rate when compared to historical data on…
2018 American Transplant Congress
Short-Term Outcome Prediction Model in Deceased Donor Kidney Transplant Recipients
K. Archer,¹ Y. Zhang,¹ S. Bontha,² E. Akalin,³ L. Gallon,⁴ D. Maluf,² V. Mas.²
¹OSU, Columbus; ²UVA, Charlottesville; ³Montefiore, New York; ⁴NWU, Chicago.
Background: Lack of accurate outcome prediction models may be a reason for the increase in organ discard rate that further burdens the growing kidney transplant…
2018 American Transplant Congress
Prognostic Value and Biological Significances of Five Long Non-Coding RNAs in Hepatocellular Carcinoma
Y. Hou,¹ Z. Yu,² N. Tam,¹ S. Huang,¹ J. Yang,¹ L. Wu,¹ Y. Ma,¹ X. He.¹
¹Department of Organ Transplantation, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; ²Laboratory of Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
Objectives Increasing evidence suggests that long non-coding RNA (lncRNA) plays a vital role in metastasis and development in hepatocellular carcinoma (HCC). Tumor progression severely affect…
2018 American Transplant Congress
TP53 Mutations Lead to Increased Transcription of Circular RNAs in Exosomes Enhancing Tumor Invasiveness in Hepatocellular Carcinoma Bases on Bioinformatics Analysis
Z. Yu, Y. Hou, R. Wang, X. Huang.
The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.
Objective Increasing evidence suggests that cicular RNAs play an important role in tumor. A recent study found the enrichment of cicular RNAs in HCC derived…
2018 American Transplant Congress
Sub-Clinical Acute Rejection (subAR) Detected by Both Surveillance Biopsy (SBx) and a Peripheral Blood Molecular Biomarker Correlates with De Novo Donor Specific Antibody (dnDSA) Following Kidney Transplant (KT)
R. Heilman,¹ J. Friedewald,² K. Kurian,⁵ T. Whisemant,⁵ E. Poggio,³ C. Marsh,⁵ P. Baliga,⁷ N. Bridges,⁴ J. Odim,⁴ M. Brown,⁴ D. Ikle,³ B. Armstrong,³ L. Zhao,² D. Salomon,⁵ M. Abecassis.²
¹Mayo Clinic, Phoenix; ²Northwestern University, Chicago; ³Rho Federal Systems, Chapel Hill; ⁴National Institute of Allergy and Infectious Disease, Bethesda; ⁵Scripps Health, La Jolla; ⁶Cleveland Clinic, Cleveland; ⁷Medical University of South Carolina, Charleston.
AIMWe investigated the correlation between subAR diagnosed by SBx or by a newly-defined biomarker, and the development of dnDSA.METHODS307 KT patients enrolled into a multi-center…
2018 American Transplant Congress
Genes with Housekeeping Function (GHF) in Renal Allograft Tissue: An RNA-Seq Analysis
Z. Wang,¹ L. Pan,² Z. Lyu,² G. Zeng,¹ P. Randhawa.¹
¹Department of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; ²Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; ³Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
RNA-sequencing (RNA-seq) is poised to play a major role in the management of kidney transplant patients. It is very desirable to develop a set of…
2018 American Transplant Congress
Molecular Assessment of Post-Transplant Glomerular Disease Comparing to Transplant Glomerulopathy
E. Akalin,¹ M. e Silva,² Y. Bao,¹ V. Bontha,³ M. Ajaimy,¹ V. Mas,³ P. [Oacute] Broin.²
¹Montefiore Medical Center, Bronx, NY; ²National University of Ireland Galway, Galway, Ireland; ³University of Virginia, Charlottesville.
Background: Intragraft gene expression profiles of glomerular disease after kidney transplantation has not been well described other than transplant glomerulopathy (TGP) which develops due to…
2018 American Transplant Congress
A Transcriptomic Signature in PBMC from Kidney Transplant Recipients at Baseline Predicts Early Acute Rejection
W. Zhang,¹ Z. Yi,¹ P. Cravedi,¹ L. Li,¹ K. Keung,² C. Wei,¹ M. Menon,¹ J. Dudley,¹ P. O'Connell,² B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, The University of Sydney, Sydney, Australia.
Background: Our multi-center study (Genomics of Chronic Allograft Rejection, GoCAR) revealed that early acute rejection (EAR, developed before 6 months post-transplant) is associated with later…
2018 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
J. Assaker,¹ A. Srivastava,¹ J. Hurley,² B. Al Doujailan,¹ S. Eskandari,¹ C. Coticchia,² M. Mohamed,¹ S. Bentink,² V. Tadigotla,² L. Riella,¹ A. Chandraker,¹ J. Skog,² J. Azzi.¹
¹Transplantation Renal Center, BWH and BCH, Boston; ²Exosome Diagnostic Inc., Cambridge.
Kidney transplant rejection leads to short and long-term adverse clinical outcomes. Serum creatinine is a suboptimal late biomarker for rejection. Exosomes are nanometer-sized vesicles released…