ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Genomic markers"

  • 2018 American Transplant Congress

    Association of CYP3A5*3*6*7 Metabolic Composites to Tacrolimus Pharmacokinetics in African American and Caucasian Renal Transplant Recipients

    K. Tornatore,1,5 D. Brazeau,2 C. Meaney,1 K. Attwood,3,4 G. Wilding,4 S. Chang,5 R. Venuto.5

    1Pharmacy, School of Pharmacy, University at Buffalo(UB), Buffalo; 2Pharmaceutical Sciences, College of Pharmacy; University of New England, Portland; 3Biostatistics, Roswell Park Cancer Institute, Buffalo; 4Biostatistics, UB School of Public Health, Buffalo; 5Nephrology, UB School of Medicine, Buffalo.

    Background: Interpatient variability in tacrolimus pharmacokinetics(PK) is due primarily to metabolism by cytochrome P-450 3A5(CYP3A5) isoenzymes. African Americans(AA) require higher tacrolimus doses to achieve comparable…
  • 2018 American Transplant Congress

    Absolute Quantification of Plasma Graft-Derived Cell-Free DNA for Diagnosis of Kidney Transplant Rejection

    J. Whitlam,1 L. Ling,2 F. Ierino,3 D. Bruno,2 H. Slater,2 D. Power.1

    1Austin Health, Heidelberg, Victoria, Australia; 2Murdoch Childrens Research Institute, Parkville, Victoria, Australia; 3St Vincent's Health, Fitzroy, Victoria, Australia.

    Aim: To study the performance of droplet digital PCR absolute measurement of graft-derived cell-free DNA (gdcfDNA) for the diagnosis of kidney allograft rejection.Methods: Homozygous deletion…
  • 2018 American Transplant Congress

    Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients

    T. Papaz,1 S. Min,1 O. Lee,1 T. Blydt-Hansen,3 U. Allen,1 Y. Avitzur,1 P. Birk,2 B. Foster,4 H. Grasemann,1 L. Hamiwka,5 R. Parekh,1 V. Phan,6 S. Urschel,7 S. Mital.1

    1SickKids Hospital, Toronto, ON, Canada; 2Winnipeg Children's Hospital, Winnipeg, MB, Canada; 3BC Children's Hospital, Vancouver, BC, Canada; 4Montreal Children's Hospital, Montreal, QC, Canada; 5Alberta Children's Hospital, Calgary, AB, Canada; 6CHU Sainte Justines, Montreal, QC, Canada; 7Stollery Children's Hospital, Edmonton, AB, Canada.

    Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…
  • 2018 American Transplant Congress

    Comparative Analysis of Alloantigen-Stimulated Gene Expression in HIV(+) Liver Transplant Rejectors versus Non-Rejectors

    S. Chu, K. Lee, C. Ward, P. Stock, Q. Tang.

    Surgery, University of California, San Francisco, San Francisco, CA.

    In a multi-center, prospective trial of solid-organ transplantation in persons with HIV, recipients had a 2-3x increased rejection rate when compared to historical data on…
  • 2018 American Transplant Congress

    Short-Term Outcome Prediction Model in Deceased Donor Kidney Transplant Recipients

    K. Archer,1 Y. Zhang,1 S. Bontha,2 E. Akalin,3 L. Gallon,4 D. Maluf,2 V. Mas.2

    1OSU, Columbus; 2UVA, Charlottesville; 3Montefiore, New York; 4NWU, Chicago.

    Background: Lack of accurate outcome prediction models may be a reason for the increase in organ discard rate that further burdens the growing kidney transplant…
  • 2018 American Transplant Congress

    Prognostic Value and Biological Significances of Five Long Non-Coding RNAs in Hepatocellular Carcinoma

    Y. Hou,1 Z. Yu,2 N. Tam,1 S. Huang,1 J. Yang,1 L. Wu,1 Y. Ma,1 X. He.1

    1Department of Organ Transplantation, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China; 2Laboratory of Surgery, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.

    Objectives Increasing evidence suggests that long non-coding RNA (lncRNA) plays a vital role in metastasis and development in hepatocellular carcinoma (HCC). Tumor progression severely affect…
  • 2018 American Transplant Congress

    TP53 Mutations Lead to Increased Transcription of Circular RNAs in Exosomes Enhancing Tumor Invasiveness in Hepatocellular Carcinoma Bases on Bioinformatics Analysis

    Z. Yu, Y. Hou, R. Wang, X. Huang.

    The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China.

    Objective Increasing evidence suggests that cicular RNAs play an important role in tumor. A recent study found the enrichment of cicular RNAs in HCC derived…
  • 2018 American Transplant Congress

    Sub-Clinical Acute Rejection (subAR) Detected by Both Surveillance Biopsy (SBx) and a Peripheral Blood Molecular Biomarker Correlates with De Novo Donor Specific Antibody (dnDSA) Following Kidney Transplant (KT)

    R. Heilman,1 J. Friedewald,2 K. Kurian,5 T. Whisemant,5 E. Poggio,3 C. Marsh,5 P. Baliga,7 N. Bridges,4 J. Odim,4 M. Brown,4 D. Ikle,3 B. Armstrong,3 L. Zhao,2 D. Salomon,5 M. Abecassis.2

    1Mayo Clinic, Phoenix; 2Northwestern University, Chicago; 3Rho Federal Systems, Chapel Hill; 4National Institute of Allergy and Infectious Disease, Bethesda; 5Scripps Health, La Jolla; 6Cleveland Clinic, Cleveland; 7Medical University of South Carolina, Charleston.

    AIMWe investigated the correlation between subAR diagnosed by SBx or by a newly-defined biomarker, and the development of dnDSA.METHODS307 KT patients enrolled into a multi-center…
  • 2018 American Transplant Congress

    Genes with Housekeeping Function (GHF) in Renal Allograft Tissue: An RNA-Seq Analysis

    Z. Wang,1 L. Pan,2 Z. Lyu,2 G. Zeng,1 P. Randhawa.1

    1Department of Pathology, The Thomas E Starzl Transplantation Institute, University of Pittsburgh, School of Medicine, Pittsburgh, PA; 2Department of Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China; 3Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.

    RNA-sequencing (RNA-seq) is poised to play a major role in the management of kidney transplant patients. It is very desirable to develop a set of…
  • 2018 American Transplant Congress

    Molecular Assessment of Post-Transplant Glomerular Disease Comparing to Transplant Glomerulopathy

    E. Akalin,1 M. e Silva,2 Y. Bao,1 V. Bontha,3 M. Ajaimy,1 V. Mas,3 P. [Oacute] Broin.2

    1Montefiore Medical Center, Bronx, NY; 2National University of Ireland Galway, Galway, Ireland; 3University of Virginia, Charlottesville.

    Background: Intragraft gene expression profiles of glomerular disease after kidney transplantation has not been well described other than transplant glomerulopathy (TGP) which develops due to…
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