Articles tagged "Genomic markers"

2019 American Transplant Congress
CNV Screening For End-stage Renal Disease
C. E. Fishman, B. Chang, A. Shaked, B. J. Keating
Surgery, University of Pennsylvania, Philadelphia, PA
*Purpose: The prevalence of ESRD in the United States was 2,160.7 cases per one million individuals in 2016, and a primary cause of ESRD was…
2019 American Transplant Congress
Subclinical Antibody Mediation Rejection in Stable Kidney Recipients with De Novo Donor Specific Antibodies and Correlation with Donor Derived Cell Free DNA Testing
A. P. Bregman, E. J. Stites, J. Gralla, A. Wiseman, J. E. Cooper
Kidney and Pancreas Transplant, University of Colorado-Denver, Aurora, CO
*Purpose: Subclinical antibody mediated rejection (sAMR) is associated with inferior graft outcomes but its diagnosis relies on the presence of biomarkers as well as histology.…
2019 American Transplant Congress
Multi-Center Validation of TruGraf V2 – A Peripheral Blood Diagnostic for Subclincal Kidney Rejection
C. Marsh¹, S. Kurian¹, C. Schieve², R. Heilman³, M. Stegall⁴, S. Rose², J. Case¹, J. Friedewald⁵, M. Abecassis⁵, R. First²
¹Scripps Health, La Jolla, CA, ²Transplant Genomics Inc., Mansfield, MA, ³Mayo Clinic, Scottsdale, AZ, ⁴Mayo Clinic, Rochester, MN, ⁵Northwestern University, Chicago, IL
*Purpose: Unsuspected subclinical acute rejection (subAR) is currently only detectable in 15-25% of invasive surveillance biopsies (SB) and can lead to chronic rejection and poor…
2019 American Transplant Congress
Intrinsic Organ Quality Assessment Using Integrative Short Outcome Prediction Composite Scores
K. Archer¹, V. Bontha², Y. Zhang¹, J. Eason³, A. Bajwa², L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas⁶
¹OSU, Columbus, OH, ²UTHSC, Memphis, TN, ³UTHSC Director of Transplant Institute, Memphis, TN, ⁴NWU, Chicago, IL, ⁵Albert Einstein College of Medicine, NYC, NY, ⁶UTHSC Director of Transplant Research Institute, Memphis, TN
*Purpose: Organs discards continue to be high due to lack of accurate tools to assess donor quality and predict organ function.To identify characteristics associated with…
2019 American Transplant Congress
Discovery and Validation of Blood Genomic Signatures of Acute Rejection in Liver Transplant Recipients
J. Levitsky¹, N. Bridges², J. Odim², M. Brown², D. Ikle³, B. Armstrong³, A. Demetris⁴, S. Asrani⁵, G. Klintmalm⁵, T. Schiano⁶, A. Moss⁷, K. Chavin⁸, C. Miller⁹, M. Kandpal¹⁰, L. Zhao¹⁰, S. Kurian¹¹, M. Abecassis¹⁰
¹Div of Gastroenterology & Comprehensive Tx Cnt, Chicago, IL, ²NIAID, Bethesda, MD, ³Rho, Chapel Hill, NC, ⁴UPMC, Pittsburgh, PA, ⁵Baylor, Dallas, TX, ⁶Mount Sinai, New York, NY, ⁷Mayo Arizona, Phoenix, AZ, ⁸Case Western, Cleveland, OH, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Comprehensive Transplant Center, Chicago, IL, ¹¹Scripps, San Diego, CA
*Purpose: Biomarker profiles diagnostic of acute rejection (AR) could enhance the management of liver transplant (LT) recipients. Our aim was to discover and validate blood…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA for Surveillance in Simultaneous Pancreas and Kidney Transplant Recipients, Can We Extrapolate from Kidney Transplant Alone?
O. K. Olaitan¹, S. Loeb¹, E. Hetterman², V. Peev¹, S. Saltzberg¹, M. Hertl¹, S. Dholakia²
¹Rush University Medical Center, Chicago, IL, ²CareDx, Brisbane, CA
*Purpose: Assessment and identification of early organ injury in Simultaneous Pancreas and Kidney (SPK) patients has clear clinical utility. This analysis was performed to establish…
2019 American Transplant Congress
Shroom3 Regulates Glomerular Hypertrophy after Uninephrectomy via mTOR
K. Banu, F. Garzon, C. Wei, Z. Yi, W. Zhang, C. He, B. Murphy, M. C. Menon
Mount Sinai School of Medicine, New York, NY
*Purpose: A Shroom3 intronic risk locus & Shroom3 protein have been associated with increased fibrosis but reduced albuminuria in recipients of allografts with the risk…
2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
J. Fair¹, N. Liu¹, S. G. Widen², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…
2018 American Transplant Congress
A Transcriptomic Signature in PBMC from Kidney Transplant Recipients at Baseline Predicts Early Acute Rejection
W. Zhang,¹ Z. Yi,¹ P. Cravedi,¹ L. Li,¹ K. Keung,² C. Wei,¹ M. Menon,¹ J. Dudley,¹ P. O'Connell,² B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Medicine, The University of Sydney, Sydney, Australia.
Background: Our multi-center study (Genomics of Chronic Allograft Rejection, GoCAR) revealed that early acute rejection (EAR, developed before 6 months post-transplant) is associated with later…
2018 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
J. Assaker,¹ A. Srivastava,¹ J. Hurley,² B. Al Doujailan,¹ S. Eskandari,¹ C. Coticchia,² M. Mohamed,¹ S. Bentink,² V. Tadigotla,² L. Riella,¹ A. Chandraker,¹ J. Skog,² J. Azzi.¹
¹Transplantation Renal Center, BWH and BCH, Boston; ²Exosome Diagnostic Inc., Cambridge.
Kidney transplant rejection leads to short and long-term adverse clinical outcomes. Serum creatinine is a suboptimal late biomarker for rejection. Exosomes are nanometer-sized vesicles released…

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