Articles tagged "Genomic markers"

2019 American Transplant Congress
Spindle and Kinetochore Associated Complex Subunit 3 Promotes Tumor Growth by Regulating CDK2/p53 Phosphorylation in Hepatocellular Carcinoma
Y. Hou¹, Z. Wang², L. Wu³
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ²The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ³Organ transplant center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: Spindle and kinetochore-related complex subunit 3 (SKA3) is a part of the spindle and kinetochore-related complexes, which are crucial for the proper timing of…
2019 American Transplant Congress
Integrated Analysis of Messenger RNA and Micro RNA Profiles in Fatty Liver Donors: Molecular Networks during Ischemia Reperfusion Injury
D. Maluf¹, A. Bajwa¹, S. K. Satapathy², V. Sai Bontha¹, A. Kadimella¹, J. Eason³, V. Mas⁴
¹UTHSC, Memphis, TN, ²UTHSC, memphis, TN, ³Director of Transplant Institute - UTHSC, Memphis, TN, ⁴Director of Transplant Research Institute, Memphis, TN
*Purpose: Liver steatosis is a known risk factor for exacerbated ischemia-reperfusion injury (IRI) and poor outcomes after liver transplantation (LT). RNA profiling was performed to…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA in Urine Identifies BKVN with Graft Injury in BK Viruria Kidney Transplant Recipients
G. Huang¹, X. Chen¹, S. Yang², W. Chen², P. Chen³, X. Hou⁴, T. Jiang⁵, H. Liu⁵, X. Li⁵, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of clinical laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁴Guangzhou KingMed Center for Clinical Laboratory Co.,Ltd., Guangzhou, China, ⁵Research and Development, AlloDx Biotech Co.Ltd., Suzhou, China
*Purpose: BK Polyomavirus nephropathy (BKVN) is an important cause of dysfunction and failure of renal transplants. Elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the…
2019 American Transplant Congress
Pre-Transplant Transcriptomic Signature in Peripheral Blood Predicts Early Acute Rejection after Kidney Transplant
W. Zhang¹, Z. Yi¹, C. Wei¹, K. Keung², Z. Sun¹, C. Xi¹, C. Woytovich¹, S. Farouk¹, L. Gallon³, M. Menon¹, C. Magee⁴, N. Najafian⁴, M. Samaniego⁵, A. Djamali⁶, S. Alexander², I. Rosales⁷, R. Smith⁷, P. O'Connell², R. Colvin⁷, P. Cravedi¹, B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Henry Ford Hospital, Detroit, MI, ⁶University of Wisconsin, Madison, WI, ⁷Massachusetts General Hospital, Boston, MA
*Purpose: Early development of acute rejection after kidney transplantation is associated with diminished long-term graft survival. Predicting early acute rejection (EAR) at the time of…
2019 American Transplant Congress
Donor-derived Cell-free Dna In Donor Specific Antibody Positive Kidney Transplant Recipients
D. Cheng¹, X. Li², T. Jiang², H. Liu², Y. Zhou³, H. Shi³
¹National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China, ²Research and Development, AlloDx Biotech Co.Ltd., Suzhou, China, ³Precise Medicine Center, Biology and Science School, JiangSu University, Zhenjiang, China
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is an emerging biomarker of kidney allograft injury. Studies examining the clinical validity of this biomarker have identified cut off…
2019 American Transplant Congress
Predicting Post-Transplant Graft Function in Deceased Donor Kidney Transplant Recipients
K. Archer¹, Y. Zhang¹, V. Bontha², J. Eason³, L. Gallon⁴, E. Akalin⁵, D. Maluf², V. Mas²
¹OSU, Columbus, OH, ²UTHSC, Memphis, TN, ³UTHSC Director of Transplant Institute, Memphis, TN, ⁴NWU, Chicago, IL, ⁵Albert Einstein College of Medicine, NYC, NY
*Purpose: Discarding donor organs lengthens time patients spend on the kidney transplant (KT) wait list. To identify characteristics associated with short-term outcome in deceased donor…
2019 American Transplant Congress
Involvement of Genetic Variation and Related Gene Expression Changes on Acute Rejection in Renal Transplant Recipients
H. Hwang¹, J. Seo¹, J. Kim¹, Y. Kim¹, J. Moon¹, K. Jeong¹, C. Kim², J. Park³, B. Chung⁴, Y. Kim⁵, S. Lee¹
¹Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ²Division of Nephrology, Department of Internal Medicine, Kyungpook National University Hospital, Daegu, Korea, Republic of, ³Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ⁴Division of Nephrology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Korea, Seoul, Korea, Republic of, ⁵Division of Nephrology, Department of Internal Medicine, College of Medicine, Inje University, Pusan, Korea, Republic of
*Purpose: Acute rejection (AR) is one of the major risk factors for renal allograft loss. The effect of genetic factors on the transplant outcomes has…
2019 American Transplant Congress
Subclinical Rejection by Biopsy or Gene Expression Profile Predicts Long Term Kidney Function in Patients in the CTOT08 Trial
R. Heilman¹, D. Taber², K. Guo³, S. Brietigam³, j. charette³, S. Kurian⁴, M. Abecassis³, J. Friedewald³
¹Mayo Clinic AZ, Scottsdale, AZ, ²MUSC, Charleston, SC, ³Northwestern University, Chicago, IL, ⁴Scripps, La Jolla, CA
*Purpose: The CTOT08 trial showed that either histological subAR or positive gene expression profile (GEP) in the blood associated with histological subAR correlated with a…
2018 American Transplant Congress
Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients
T. Papaz,¹ S. Min,¹ O. Lee,¹ T. Blydt-Hansen,³ U. Allen,¹ Y. Avitzur,¹ P. Birk,² B. Foster,⁴ H. Grasemann,¹ L. Hamiwka,⁵ R. Parekh,¹ V. Phan,⁶ S. Urschel,⁷ S. Mital.¹
¹SickKids Hospital, Toronto, ON, Canada; ²Winnipeg Children's Hospital, Winnipeg, MB, Canada; ³BC Children's Hospital, Vancouver, BC, Canada; ⁴Montreal Children's Hospital, Montreal, QC, Canada; ⁵Alberta Children's Hospital, Calgary, AB, Canada; ⁶CHU Sainte Justines, Montreal, QC, Canada; ⁷Stollery Children's Hospital, Edmonton, AB, Canada.
Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…
2018 American Transplant Congress
Comparative Analysis of Alloantigen-Stimulated Gene Expression in HIV(+) Liver Transplant Rejectors versus Non-Rejectors
S. Chu, K. Lee, C. Ward, P. Stock, Q. Tang.
Surgery, University of California, San Francisco, San Francisco, CA.
In a multi-center, prospective trial of solid-organ transplantation in persons with HIV, recipients had a 2-3x increased rejection rate when compared to historical data on…

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