Articles tagged "Genomic markers"

2019 American Transplant Congress
Discovery and Validation of Blood Genomic Signatures of Acute Rejection in Liver Transplant Recipients
J. Levitsky¹, N. Bridges², J. Odim², M. Brown², D. Ikle³, B. Armstrong³, A. Demetris⁴, S. Asrani⁵, G. Klintmalm⁵, T. Schiano⁶, A. Moss⁷, K. Chavin⁸, C. Miller⁹, M. Kandpal¹⁰, L. Zhao¹⁰, S. Kurian¹¹, M. Abecassis¹⁰
¹Div of Gastroenterology & Comprehensive Tx Cnt, Chicago, IL, ²NIAID, Bethesda, MD, ³Rho, Chapel Hill, NC, ⁴UPMC, Pittsburgh, PA, ⁵Baylor, Dallas, TX, ⁶Mount Sinai, New York, NY, ⁷Mayo Arizona, Phoenix, AZ, ⁸Case Western, Cleveland, OH, ⁹Cleveland Clinic, Cleveland, OH, ¹⁰Comprehensive Transplant Center, Chicago, IL, ¹¹Scripps, San Diego, CA
*Purpose: Biomarker profiles diagnostic of acute rejection (AR) could enhance the management of liver transplant (LT) recipients. Our aim was to discover and validate blood…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA for Surveillance in Simultaneous Pancreas and Kidney Transplant Recipients, Can We Extrapolate from Kidney Transplant Alone?
O. K. Olaitan¹, S. Loeb¹, E. Hetterman², V. Peev¹, S. Saltzberg¹, M. Hertl¹, S. Dholakia²
¹Rush University Medical Center, Chicago, IL, ²CareDx, Brisbane, CA
*Purpose: Assessment and identification of early organ injury in Simultaneous Pancreas and Kidney (SPK) patients has clear clinical utility. This analysis was performed to establish…
2019 American Transplant Congress
Shroom3 Regulates Glomerular Hypertrophy after Uninephrectomy via mTOR
K. Banu, F. Garzon, C. Wei, Z. Yi, W. Zhang, C. He, B. Murphy, M. C. Menon
Mount Sinai School of Medicine, New York, NY
*Purpose: A Shroom3 intronic risk locus & Shroom3 protein have been associated with increased fibrosis but reduced albuminuria in recipients of allografts with the risk…
2019 American Transplant Congress
RNA Splicing and Lineage Progression: Identification of an Integrated Splicing Pattern in Endodermal Lineage Progression
J. Fair¹, N. Liu¹, S. G. Widen², W. S. Fagg¹
¹Surgery, University of Texas Medical Branch, Galveston, TX, ²Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX
*Purpose: Epigenetic states such as histone modifications and DNA methylation that influence transcription are well-characterized regulators of stem cell pluripotency and differentiation to specific lineages.…
2019 American Transplant Congress
Spindle and Kinetochore Associated Complex Subunit 3 Promotes Tumor Growth by Regulating CDK2/p53 Phosphorylation in Hepatocellular Carcinoma
Y. Hou¹, Z. Wang², L. Wu³
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ²The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China, ³Organ transplant center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China
*Purpose: Spindle and kinetochore-related complex subunit 3 (SKA3) is a part of the spindle and kinetochore-related complexes, which are crucial for the proper timing of…
2019 American Transplant Congress
Integrated Analysis of Messenger RNA and Micro RNA Profiles in Fatty Liver Donors: Molecular Networks during Ischemia Reperfusion Injury
D. Maluf¹, A. Bajwa¹, S. K. Satapathy², V. Sai Bontha¹, A. Kadimella¹, J. Eason³, V. Mas⁴
¹UTHSC, Memphis, TN, ²UTHSC, memphis, TN, ³Director of Transplant Institute - UTHSC, Memphis, TN, ⁴Director of Transplant Research Institute, Memphis, TN
*Purpose: Liver steatosis is a known risk factor for exacerbated ischemia-reperfusion injury (IRI) and poor outcomes after liver transplantation (LT). RNA profiling was performed to…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA in Urine Identifies BKVN with Graft Injury in BK Viruria Kidney Transplant Recipients
G. Huang¹, X. Chen¹, S. Yang², W. Chen², P. Chen³, X. Hou⁴, T. Jiang⁵, H. Liu⁵, X. Li⁵, C. Wang¹
¹Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ²Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of clinical laboratory, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ⁴Guangzhou KingMed Center for Clinical Laboratory Co.,Ltd., Guangzhou, China, ⁵Research and Development, AlloDx Biotech Co.Ltd., Suzhou, China
*Purpose: BK Polyomavirus nephropathy (BKVN) is an important cause of dysfunction and failure of renal transplants. Elevated levels of donor-derived cell-free DNA (dd-cfDNA) in the…
2019 American Transplant Congress
Pre-Transplant Transcriptomic Signature in Peripheral Blood Predicts Early Acute Rejection after Kidney Transplant
W. Zhang¹, Z. Yi¹, C. Wei¹, K. Keung², Z. Sun¹, C. Xi¹, C. Woytovich¹, S. Farouk¹, L. Gallon³, M. Menon¹, C. Magee⁴, N. Najafian⁴, M. Samaniego⁵, A. Djamali⁶, S. Alexander², I. Rosales⁷, R. Smith⁷, P. O'Connell², R. Colvin⁷, P. Cravedi¹, B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia, ³Northwestern University Feinberg School of Medicine, Chicago, IL, ⁴Brigham and Women's Hospital, Boston, MA, ⁵Henry Ford Hospital, Detroit, MI, ⁶University of Wisconsin, Madison, WI, ⁷Massachusetts General Hospital, Boston, MA
*Purpose: Early development of acute rejection after kidney transplantation is associated with diminished long-term graft survival. Predicting early acute rejection (EAR) at the time of…
2018 American Transplant Congress
Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)
T. Whisenant,¹ S. Kurian,¹ M. Kandpal,² L. Zhao,² D. Ikle,³ B. Armstrong,³ J. Friedewald,² R. Heilman,⁴ E. Poggio,⁵ C. Marsh,¹ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ J. Charette,² S. Brietigam,² N. Sustento-Reodica,² D. Salomon,¹ M. Abecassis.²
¹Scripps, La Jolla; ²Northwestern, Chicago; ³Rho, Chapel Hill; ⁴Mayo AZ, Scottsdale; ⁵Cleveland Clinic, Cleveland; ⁶MUSC, Charleston; ⁷NIAID, Bethesda.
Sub-clinical acute rejection (subAR) following KT is associated with poor long-term graft outcomes and can only be detected using invasive surveillance biopsies (SBx). Non-invasive biomarker…
2018 American Transplant Congress
Different Expression Patterns of Exosomal miRNAs under Cyclosporin A and Rapamycin Treatment in Distinct Aggressiveness Colorectal Carcinomas
V. Tubita,¹ M. Ramírez-Bajo,¹ J. Lozano,² D. Moya-Rull,¹ J. Rovira,³ J. Campistol,^4,5,6 F. Diekmann,^1,4,5,6 I. Revuelta.^1,4,5,6
¹Experimental Laboratory of Nefrology and Kidney Transplant (LENIT). Biomedical Research Clinic Foundation (FCRB), Barcelona, Spain; ²Bioinformatics Platform, CIBEREHD, Barcelona, Spain; ³Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain; ⁴Renal Transplant Unit. Department of Nephrology and Kidney Transplant. Hospital Clinic, Barcelona, Spain; ⁵REDinREN, Madrid, Spain; ⁶Barcelona University, Barcelona, Spain.
The aggressiveness of colorectal cancer (CRC) in kidney transplantation is much more significant than the increase in its incidence compared with the general population. The…

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