Articles tagged "Genomic markers"

2021 American Transplant Congress
Urinary Exosome Mrna Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, J. Hurley², V. Tadigotla², A. Alghamdi³, A. Srivastava⁴, C. Coticchia², J. Choi¹, H. Allos⁵, k. yatim⁵, J. Alhaddad⁵, S. Eskandari⁵, P. Chu⁵, A. Mihali⁵, I. Lape⁵, M. Lima Filho⁵, B. Ayoma⁵, A. Chandraker⁵, K. Safa⁶, J. Markmann⁶, L. Riella⁶, R. Formica⁷, J. Skog², J. Azzi⁵
¹Medecine, Brigham and Women Hospital, Boston, MA, ²Exosome Diagnostics, Boston, MA, ³Boston Children Hospital, Boston, MA, ⁴Center for Translational Metabolism and Health, Chicago, IL, ⁵Transplantation Research Center, Boston, MA, ⁶Massachusetts General Hospital, Boston, MA, ⁷Yale School of Medicine, New Haven, CT
*Purpose: Traditional biomarkers currently used to monitor the kidney allograft, such as creatinine and proteinuria, are late markers of injury and lack sensitivity, specificity and…
2021 American Transplant Congress
Blood Gene Expression and Donor-derived Cell Free DNA for Diagnosing Subclinical Acute Rejection in Stable Kidney Transplant Recipients
S. Park¹, K. Guo², H. Raymond³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁸, J. Holman⁹, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹⁰, J. Friedewald¹
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Transplant Genomics, Inc, Mansfield, MA, ¹⁰University of Arizona College of Medicine, Tucson, AZ
*Purpose: A blood gene expression profile (GEP) has been established as a non-invasive screen for subclinical acute rejection (subAR). For patients with allograft dysfunction, donor-derived…
2020 American Transplant Congress
Small RNA Extracellular Vesicles Isolated from Liver Perfusate Provides Assessment of Organ Quality and Post Transplantation Graft Function
A. Bajwa, C. Kuscu, C. Kuscu, A. R. Wolen, J. D. Eason, D. Maluf, V. Mas
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Donor quality plays a critical role during IRI and early graft outcomes. Extracellular vesicles (EVs) provide a novel source of valuable biomarkers that may…
2020 American Transplant Congress
Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk
W. S. Oetting¹, G. Weihua¹, C. R. Dorr¹, R. B. Mannon², A. J. Matas¹, P. A. Jacobson¹, A. K. Israni¹
¹University of Minnesota, Minneapolis, MN, ²University of Alabama, Birmingham, AL
*Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
2020 American Transplant Congress
Circulating MicroRNA Signatures in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Transplantation
S. Vasu, C. M. Darden, K. Kumano, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: Chronic pancreatitis (CP) is characterized by exocrine insufficiency and severe abdominal pain. Total pancreatectomy with islet autotransplantation (TPIAT) relieves chronic pain and aids restoration…
2020 American Transplant Congress
Validation of Single Nucleotide Polymorphisms for Acute Renal Graft Rejection
H. Hwang¹, J. Kong¹, J. Kim¹, Y. Kim¹, J. Moon¹, K. Jeong¹, J. Park², J. Park³, T. Ban⁴, J. Yang⁵, C. Ahn⁶, S. Lee¹
¹Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, ²Konkuk University School of Medicine, Seoul, Korea, Republic of, ³Yeungnam University Hospital, Seoul, Korea, Republic of, ⁴Eunpyeong St. Mary's Hospital The Catholic University of Korea, College of Medicine, Seoul, Korea, Republic of, ⁵Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, ⁶Division of Nephrology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Genome-wide association studies (GWAS) has identified potential single nucleotide polymorphisms (SNPs), which is associated with acute rejection in renal transplant recipients. We sought to…
2020 American Transplant Congress
Tolerant Liver Transplant Patients Have Higher Level of Y RNA Fragments in the Circulation
C. Kuscu¹, A. Wolen¹, A. Bajwa¹, C. Kuscu¹, J. Eason², B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Tolerance post transplantation continue to be the ultimate goal in transplantation. Circulating small RNAs are one of the best candidates for biomarker studies. To…
2020 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, A. Alghamdi¹, J. Hurley², C. Coticchia², J. Choi¹, H. Allos¹, S. Eskandari¹, S. Bentink², V. Tadigotla², L. Riella¹, J. Markmann³, K. Safa³, R. Formica⁴, J. Skog², J. Azzi¹
¹Medecine, Brigham and Women's Hospital, Boston, MA, ²Exosome Diagnostics Inc., Waltham, MA, ³Massachusetts General Hospital, Boston, MA, ⁴Yale School of Medecine, New Haven, CT
*Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…
2020 American Transplant Congress
Combining Pharmacy and Genome-Wide Genotyping Data to Examine Medication Regimen Complexity Indices (MRCI), Drug-Drug and Gene-Drug Interactions in Transplant Patients
L. Callans, J. Obayemi, H. Gao, A. Shaked, B. Chang, B. Keating
Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, USA, Philadelphia, PA
*Purpose: Polypharmacy, typically defined as the use of five or more medications, is a barrier to adherence, and the resulting complex medication regimens result in…
2020 American Transplant Congress
Role of Genetic Studies in Reclassifying Cause of End Stage Kidney Disease among Kidney Transplant Candidates
M. El Ters¹, F. Pinto e Vairo², F. C. Fervenza¹, M. Alexander³, F. G. Cosio¹, H. Amer¹, M. Hogan¹
¹Division of Nephrology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ²Department of Clinical Genomics, Mayo Clinic, Rochester, MN, ³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: Recent studies evaluating genetic causes of kidney disease have reclassified a subgroup of focal segmental glomerulosclerosis (FSGS) into collagenopathies. This knowledge has implication in…

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