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Articles tagged "Genomic markers"

  • 2021 American Transplant Congress

    Dd-cfdna Can Guide Safe Reintroduction of Immunosuppression in Kidney Transplant Recipients with Covid-19

    J. Miles1, J. Leonard2, V. Tatapudi2, M. Fei1, R. Montgomery2, N. M. Ali2

    1CareDx, Brisbane, CA, 2Transplant Institute, NYU Langone Health, New York, NY

    *Purpose: COVID-19 infection is associated with 25% mortality in kidney transplant recipients (KTRs). Reduction of anti-metabolite immunosuppressants during the acute COVID-19 illness is a common…
  • 2021 American Transplant Congress

    Cellular Landscape of Steatotic Livers Revealed by Single-nuclei Rna Sequencing

    C. Kuscu1, C. Kuscu1, A. Shetty2, E. Bardhi3, T. Rousselle4, J. Eason1, M. Sraj5, D. Maluf6, V. Mas4

    1Surgery, James D Eason Transplant Institute, Memphis, TN, 2University of Maryland, Institute for Genome Sciences, Baltimore, MD, 3Program in Transplantation - University of Maryland, Baltimore, MD, 4Surgery, Division of Surgical Science, Baltimore, MD, 5Surgery, University of Maryland, Baltimore, MD, 6Surgery, Program in Transplantation - University of Maryland, Baltimore, MD

    *Purpose: Hepatic IRI represents a barrier to the use of available organs for transplant, particularly fatty livers. We aimed to discern the cellular subsets and…
  • 2020 American Transplant Congress

    Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection

    R. El Fekih1, A. Alghamdi1, J. Hurley2, C. Coticchia2, J. Choi1, H. Allos1, S. Eskandari1, S. Bentink2, V. Tadigotla2, L. Riella1, J. Markmann3, K. Safa3, R. Formica4, J. Skog2, J. Azzi1

    1Medecine, Brigham and Women's Hospital, Boston, MA, 2Exosome Diagnostics Inc., Waltham, MA, 3Massachusetts General Hospital, Boston, MA, 4Yale School of Medecine, New Haven, CT

    *Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…
  • 2020 American Transplant Congress

    Combining Pharmacy and Genome-Wide Genotyping Data to Examine Medication Regimen Complexity Indices (MRCI), Drug-Drug and Gene-Drug Interactions in Transplant Patients

    L. Callans, J. Obayemi, H. Gao, A. Shaked, B. Chang, B. Keating

    Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, USA, Philadelphia, PA

    *Purpose: Polypharmacy, typically defined as the use of five or more medications, is a barrier to adherence, and the resulting complex medication regimens result in…
  • 2020 American Transplant Congress

    Role of Genetic Studies in Reclassifying Cause of End Stage Kidney Disease among Kidney Transplant Candidates

    M. El Ters1, F. Pinto e Vairo2, F. C. Fervenza1, M. Alexander3, F. G. Cosio1, H. Amer1, M. Hogan1

    1Division of Nephrology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, 2Department of Clinical Genomics, Mayo Clinic, Rochester, MN, 3Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN

    *Purpose: Recent studies evaluating genetic causes of kidney disease have reclassified a subgroup of focal segmental glomerulosclerosis (FSGS) into collagenopathies. This knowledge has implication in…
  • 2020 American Transplant Congress

    Combined Phenotyping to Identify Kidney Transplants at Greatest Risk after Subclinical Acute Rejection

    S. Park1, R. Heilman2, E. Poggio3, D. Taber4, L. Zhao1, K. Guo1, S. Kurian5, C. Rebello1, S. Brietigam1, M. Abecassis6, J. Friedewald1

    1Northwestern University, Chicago, IL, 2Mayo Clinic, Scottsdale, AZ, 3Cleveland Clinic, Cleveland, OH, 4MUSC, Charleston, SC, 5Scripps, La Jolla, CA, 6University of Arizona, Tucson, AZ

    *Purpose: We hypothesize that the combination of protocol biopsy histology and gene expression profiles (GEP) for subclinical acute rejection (subAR) in the blood will improve…
  • 2020 American Transplant Congress

    Small RNA Extracellular Vesicles Isolated from Liver Perfusate Provides Assessment of Organ Quality and Post Transplantation Graft Function

    A. Bajwa, C. Kuscu, C. Kuscu, A. R. Wolen, J. D. Eason, D. Maluf, V. Mas

    Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Donor quality plays a critical role during IRI and early graft outcomes. Extracellular vesicles (EVs) provide a novel source of valuable biomarkers that may…
  • 2020 American Transplant Congress

    Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk

    W. S. Oetting1, G. Weihua1, C. R. Dorr1, R. B. Mannon2, A. J. Matas1, P. A. Jacobson1, A. K. Israni1

    1University of Minnesota, Minneapolis, MN, 2University of Alabama, Birmingham, AL

    *Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
  • 2020 American Transplant Congress

    Circulating MicroRNA Signatures in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Transplantation

    S. Vasu, C. M. Darden, K. Kumano, M. Lawrence, B. Naziruddin

    Baylor University Medical Ctr, Dallas, TX

    *Purpose: Chronic pancreatitis (CP) is characterized by exocrine insufficiency and severe abdominal pain. Total pancreatectomy with islet autotransplantation (TPIAT) relieves chronic pain and aids restoration…
  • 2020 American Transplant Congress

    Validation of Single Nucleotide Polymorphisms for Acute Renal Graft Rejection

    H. Hwang1, J. Kong1, J. Kim1, Y. Kim1, J. Moon1, K. Jeong1, J. Park2, J. Park3, T. Ban4, J. Yang5, C. Ahn6, S. Lee1

    1Division of Nephrology, Department of Internal Medicine, College of Medicine, Kyung Hee University, Seoul, Korea, Republic of, 2Konkuk University School of Medicine, Seoul, Korea, Republic of, 3Yeungnam University Hospital, Seoul, Korea, Republic of, 4Eunpyeong St. Mary's Hospital The Catholic University of Korea, College of Medicine, Seoul, Korea, Republic of, 5Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of, 6Division of Nephrology, Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of

    *Purpose: Genome-wide association studies (GWAS) has identified potential single nucleotide polymorphisms (SNPs), which is associated with acute rejection in renal transplant recipients. We sought to…
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