Articles tagged "Genomic markers"

2021 American Transplant Congress
Early Experience with Broad Renal Genetic Testing in an Academic Transplant Center
E. Tantisattamo¹, K. Brossart², N. Ioannou², S. McCormick², P. R. Billings², H. Tabriziani²
¹Division of Nephrology, Hypertension and Kidney Transplantation, Division of Nephrology, Hypertension and Kidney Transplantation, Department of Medicine, University of California Irvine School of Medicine, Orange, CA, ²Natera, Inc., San Carlos, CA
*Purpose: Genetic testing is an emerging tool in kidney transplantation (KT), particularly to assess risk of recurrent disease in patients with KT and for selection…
2021 American Transplant Congress
Detection of Rejection in Kidney Transplant Patients Using an Algorithm That Combines Donor Fraction and Absolute Donor-derived Cell-free DNA
S. Bunnapradist¹, E. Ahmed², M. Maninder², Z. P. Demko², P. R. Billings², H. Tabriziani², P. Gauthier³
¹David Geffen Sch of Med @ UCLA, Los Angeles, CA, ²Natera, Inc., San Carlos, CA, ³Natera, Inc., Los Angeles, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the plasma of renal allograft patients is a clinically validated biomarker for allograft injury and rejection. Several dd-cfDNA assays…
2020 American Transplant Congress
Tolerant Liver Transplant Patients Have Higher Level of Y RNA Fragments in the Circulation
C. Kuscu¹, A. Wolen¹, A. Bajwa¹, C. Kuscu¹, J. Eason², B. Ramaswami³, D. Maluf¹, G. Mazariegos³, G. Chalasani³, V. Mas¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, University of Tennessee Health Science Center, Memphis, TN, ³Thomas E. Starzl Transplantation Institute, Children's Hospital of Pittsburgh, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Tolerance post transplantation continue to be the ultimate goal in transplantation. Circulating small RNAs are one of the best candidates for biomarker studies. To…
2020 American Transplant Congress
Discovery and Validation of a Urinary Exosome mRNA Signature for the Diagnosis of Human Kidney Transplant Rejection
R. El Fekih¹, A. Alghamdi¹, J. Hurley², C. Coticchia², J. Choi¹, H. Allos¹, S. Eskandari¹, S. Bentink², V. Tadigotla², L. Riella¹, J. Markmann³, K. Safa³, R. Formica⁴, J. Skog², J. Azzi¹
¹Medecine, Brigham and Women's Hospital, Boston, MA, ²Exosome Diagnostics Inc., Waltham, MA, ³Massachusetts General Hospital, Boston, MA, ⁴Yale School of Medecine, New Haven, CT
*Purpose: Monitoring kidney transplant rejection by repeated biopsies might result in increased procedural complications and cost. Exosomes are nanometer-sized vesicles released by cells carrying trans…
2020 American Transplant Congress
Combining Pharmacy and Genome-Wide Genotyping Data to Examine Medication Regimen Complexity Indices (MRCI), Drug-Drug and Gene-Drug Interactions in Transplant Patients
L. Callans, J. Obayemi, H. Gao, A. Shaked, B. Chang, B. Keating
Penn Transplant Institute, Hospital of the University of Pennsylvania, Philadelphia, USA, Philadelphia, PA
*Purpose: Polypharmacy, typically defined as the use of five or more medications, is a barrier to adherence, and the resulting complex medication regimens result in…
2020 American Transplant Congress
Role of Genetic Studies in Reclassifying Cause of End Stage Kidney Disease among Kidney Transplant Candidates
M. El Ters¹, F. Pinto e Vairo², F. C. Fervenza¹, M. Alexander³, F. G. Cosio¹, H. Amer¹, M. Hogan¹
¹Division of Nephrology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, ²Department of Clinical Genomics, Mayo Clinic, Rochester, MN, ³Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN
*Purpose: Recent studies evaluating genetic causes of kidney disease have reclassified a subgroup of focal segmental glomerulosclerosis (FSGS) into collagenopathies. This knowledge has implication in…
2020 American Transplant Congress
Combined Phenotyping to Identify Kidney Transplants at Greatest Risk after Subclinical Acute Rejection
S. Park¹, R. Heilman², E. Poggio³, D. Taber⁴, L. Zhao¹, K. Guo¹, S. Kurian⁵, C. Rebello¹, S. Brietigam¹, M. Abecassis⁶, J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Mayo Clinic, Scottsdale, AZ, ³Cleveland Clinic, Cleveland, OH, ⁴MUSC, Charleston, SC, ⁵Scripps, La Jolla, CA, ⁶University of Arizona, Tucson, AZ
*Purpose: We hypothesize that the combination of protocol biopsy histology and gene expression profiles (GEP) for subclinical acute rejection (subAR) in the blood will improve…
2020 American Transplant Congress
Small RNA Extracellular Vesicles Isolated from Liver Perfusate Provides Assessment of Organ Quality and Post Transplantation Graft Function
A. Bajwa, C. Kuscu, C. Kuscu, A. R. Wolen, J. D. Eason, D. Maluf, V. Mas
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Donor quality plays a critical role during IRI and early graft outcomes. Extracellular vesicles (EVs) provide a novel source of valuable biomarkers that may…
2020 American Transplant Congress
Attempted Validation of Lims1 Variant Rs893403 with Acute Rejection Risk
W. S. Oetting¹, G. Weihua¹, C. R. Dorr¹, R. B. Mannon², A. J. Matas¹, P. A. Jacobson¹, A. K. Israni¹
¹University of Minnesota, Minneapolis, MN, ²University of Alabama, Birmingham, AL
*Purpose: Acute rejection (AR) in kidney allograft recipients is a significant risk factor for reduced graft survival. Identifying individuals at risk for AR could facilitate…
2020 American Transplant Congress
Circulating MicroRNA Signatures in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Transplantation
S. Vasu, C. M. Darden, K. Kumano, M. Lawrence, B. Naziruddin
Baylor University Medical Ctr, Dallas, TX
*Purpose: Chronic pancreatitis (CP) is characterized by exocrine insufficiency and severe abdominal pain. Total pancreatectomy with islet autotransplantation (TPIAT) relieves chronic pain and aids restoration…

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