2022 American Transplant Congress
dd-cfDNA Varies Among Diagnostics Groups of Pulmonary AMR
*Purpose: Antibody mediated rejection (AMR) in lung transplant remains complex, with differential diagnosis often overlapping with other causes of lung dysfunction. Diagnostic certainty declines to…2022 American Transplant Congress
Do Early Trends of Donor-Derived Cell Free DNA Predict Long Term Kidney Allograft Outcomes?
1Transplant Nephrology, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been studied and established for acute rejection detection but the impact of early dd-cfDNA changes on graft outcomes has…2022 American Transplant Congress
The Unique Course of dd-cfDNA After Lung Transplant
*Purpose: The time necessary for dd-cfDNA to reach baseline levels following transplantation has been reported in kidney, heart, and liver as 14-21 days. We explored…2022 American Transplant Congress
Single-cell Transcriptomic Analysis Of Peripheral Blood Reveals The Disparate Subsets Of Innate Immune Cells In Kidney Transplant Recipient With BK Virus Infection
*Purpose: BK virus (BKV) infection is a common problem in kidney transplant recipients receiving immunosuppressive therapy, resulting in a serious complications including BKV-associated nephropathy and…2022 American Transplant Congress
Using a Unique Repository of Pancreas Transplant Biopsies to Validate the Tissue Common Response Module (tCRM) Score as a Tool to Assess the Severity of Pancreas Transplant Rejection
*Purpose: Analysis of transcriptional data from kidney, heart, liver, and lung transplant rejection led to development of the tissue Common Response Module (tCRM) score based…2022 American Transplant Congress
Identification Of A Novel Peripheral Blood Six-gene Signature Diagnosing Subclinical Acute Rejection After Renal Transplantation
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Given the insensitivity and nonspecificity of serum creatinine, invasive surveillance biopsies are the main way to detect subclinical acute rejection (subAR) in the absence…2022 American Transplant Congress
Use of Ancestral Genetic SNP Phenotyping to Define Genotypic Ethnicity in Solid Organ Transplant Patients
Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Transplantation research has mainly categorized ethnicity into four main groups African American, Caucasian, Hispanic, and Asian Pacific Islander. Our world has increased in admixure…2022 American Transplant Congress
A Three-gene Peripheral Blood Potential Diagnosis Signature Associated With Autophagy For Antibody-mediated Rejection In Renal Transplantation
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Antibody-mediated rejection (AMR) is emerging as a major cause of graft loss in renal transplantation. Nowadays, non-invasive diagnosis of AMR with high accuracy is…2022 American Transplant Congress
RNA Sequencing Profiling of Pretransplant Blood Identified Variant Allele Specific Expression of Leukocyte Immunoglobulin-Like Receptors (LILRs) Genes Associated with Graft Loss in Kidney Transplant Recipients
*Purpose: The RNA sequencing has the possibility of detecting overall gene expression as well as allele-specific expression. Here, we reported a study of genome-wide allele…2022 American Transplant Congress
The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients
*Purpose: In our previous studies, blood-based gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) have been independently validated in liver transplant recipients (LTR) to…
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