Articles tagged "Genomic markers"

2022 American Transplant Congress
Longitudinal Monitoring of Simultaneous Pancreas and Kidney Transplant and Pancreas After Kidney Recipients Using Donor-Derived Cell-Free DNA
N. M. Ali¹, J. Miles², Z. Stewart³
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY, ³Transplant Institute, NYU Langone Health, New York, NM
*Purpose: The utility of dd-cfDNA in patients undergoing pancreas transplantation has not been well studied. Pancreatic rejection remains a major clinical concern. Early identification of…
2022 American Transplant Congress
Antibody Response and Molecular Graft Surveillance in Kidney Transplant Recipients Following Sars-CoV-2 Vaccination
N. M. Ali¹, J. Miles², S. Mehta¹, V. Tatapudi¹, Z. Stewart¹, B. Lonze¹, M. Mangiola¹, C. DiMaggio¹, E. Weldon¹, I. Saeed¹, J. Leonard¹, R. Herati¹, J. Thomas¹, J. Michael¹, C. Hickson¹, K. Cartiera¹, R. Montgomery¹
¹Transplant Institute, NYU Langone Health, New York, NY, ²CareDx, Brisbane, NY
*Purpose: Preliminary studies suggest that kidney transplant recipients (KTRs) show diminished humoral responses to SARS-CoV-2 vaccination. Although reports of allograft rejection after SARS-CoV-2 vaccination have…
2022 American Transplant Congress
Multiomic Analyses Of Two Pig Kidney To Human Xenotransplants
B. Keating¹, B. Piening², M. Mangiola³, J. Stern⁴, W. Zhang⁵, A. Griesemer⁶, B. Lonze⁷, M. Snyder⁸, J. Boeke⁵, R. Montgomery⁷
¹University of Pennsylvania, Philadelphia, PA, ²Providence Cancer Center, Portland, OR, ³New York University Langone Medical Center, New York, NY, ⁴Department of Surgery, NYU Langone, New York, NY, ⁵Institute of Systems Genetics, NYU Langone, New York, NY, ⁶Surgery, NYU Langone, New York, NY, ⁷NYU Langone Transplant Institute, New York, NY, ⁸Genetics, Stanford, Palo Alto, CA
*Purpose: Organ shortage remains a major limitation within transplantation, with waiting lists greatly outpacing the number of donors available. Pig organs offer significant advantages for…
2022 American Transplant Congress
Month 1 Donor Derived Cell Free DNA Levels Predict Future Kidney Transplant Rejection
B. M. Kinsella¹, K. Guo¹, C. Rebello¹, L. Zhao¹, S. Park², J. Friedewald¹
¹Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: The purpose of this study was to determine if donor-derived cell-free DNA (dd-cfDNA) can be used one-month post-transplant to predict later allograft rejection.*Methods: Retrospective…
2022 American Transplant Congress
dd-cfDNA Varies Among Diagnostics Groups of Pulmonary AMR
D. Levine¹, C. Giner¹, C. Pham², R. Woodward³, A. Roux⁴
¹University of Texas Health System San Antonio, San Antonio, TX, ²CareDX, South San Francisco, CA, ³CareDx, South San Francisco, CA, ⁴Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France
*Purpose: Antibody mediated rejection (AMR) in lung transplant remains complex, with differential diagnosis often overlapping with other causes of lung dysfunction. Diagnostic certainty declines to…
2022 American Transplant Congress
Do Early Trends of Donor-Derived Cell Free DNA Predict Long Term Kidney Allograft Outcomes?
S. Park¹, K. Guo², L. Zhao², C. Rebello², J. Friedewald²
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Northwestern University, Chicago, IL
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) has been studied and established for acute rejection detection but the impact of early dd-cfDNA changes on graft outcomes has…
2022 American Transplant Congress
The Unique Course of dd-cfDNA After Lung Transplant
D. Levine¹, C. Giner¹, C. Pham², R. Woodward³, A. Roux⁴
¹University of Texas Health System San Antonio, San Antonio, TX, ²CareDX, South San Francisco, CA, ³CareDx, South San Francisco, CA, ⁴Pneumology, Adult CF Center and Lung Transplantation Department, Foch Hospital, Suresnes, France
*Purpose: The time necessary for dd-cfDNA to reach baseline levels following transplantation has been reported in kidney, heart, and liver as 14-21 days. We explored…
2022 American Transplant Congress
Single-cell Transcriptomic Analysis Of Peripheral Blood Reveals The Disparate Subsets Of Innate Immune Cells In Kidney Transplant Recipient With BK Virus Infection
H. BAE¹, J. Ryu², J. Jang¹, J. Lee¹, G. Ko¹, H. PARK¹, E. Oh³
¹Department of Biomedical Science, Graduate School, College of medicine, The Catholic university of Korea, Seoul, Seoul, Korea, Republic of, ²Department of Laboratory Medicine, College of Medicine, Seoul St. Mary’s hospital, the Catholic University of Korea, seoul, Korea, Republic of, ³Catholic University Department of Laboratory Medicine, Seoul 137-040, Korea, Republic of
*Purpose: BK virus (BKV) infection is a common problem in kidney transplant recipients receiving immunosuppressive therapy, resulting in a serious complications including BKV-associated nephropathy and…
2022 American Transplant Congress
Using a Unique Repository of Pancreas Transplant Biopsies to Validate the Tissue Common Response Module (tCRM) Score as a Tool to Assess the Severity of Pancreas Transplant Rejection
Y. Kelly¹, A. Zarinsefat¹, R. Meier², M. Sarwal¹, P. Stock¹, Z. Laszik¹, T. Sigdel¹
¹University of California, San Francisco, San Francisco, CA, ²University of Maryland Medical Center, Baltimore, MD
*Purpose: Analysis of transcriptional data from kidney, heart, liver, and lung transplant rejection led to development of the tissue Common Response Module (tCRM) score based…
2022 American Transplant Congress
Identification Of A Novel Peripheral Blood Six-gene Signature Diagnosing Subclinical Acute Rejection After Renal Transplantation
H. Zhang, Y. Xu, Y. Wang, X. Hu
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Given the insensitivity and nonspecificity of serum creatinine, invasive surveillance biopsies are the main way to detect subclinical acute rejection (subAR) in the absence…