Articles tagged "Genomic markers"

2015 American Transplant Congress
Plasma Levels of Donor-Derived Cell-Free DNA Increase With Rejection and Often Decrease After Treatment in Organ Transplant Recipients
M. Grskovic,¹ J. Beausang,¹ D. Hiller,¹ R. Sit,¹ B. Christie,¹ J. Elechko,¹ R. Woodward,¹ J. Yee,¹ J. Kobashigawa.²
¹CareDx, Inc, Brisbane, CA; ²Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a potential biomarker of acute cellular rejection (ACR) in organ transplant recipients. dd-cfDNA levels in longitudinal plasma samples from…
2015 American Transplant Congress
Can Gene-Expression Profiling Score Help Explain the Adverse Clinical Outcomes Seen in Gender-Mismatched Heart Transplants?
N. Sulemanjee,¹ P. Prasad,² T. Wolf,² V. Thohan,¹ J. Teuteberg.³
¹Aurora Research Institute, St. Luke's Medical Center, Milwaukee, WI; ²CareDx, Inc., Brisbane, CA; ³University of Pittsburgh Medical Center, Pittsburgh, PA.
Background: Gene-expression profiling (GEP) testing, in conjunction with clinical assessment, is an established laboratory test intended to aid in the identification of acute cellular rejection…
2015 American Transplant Congress
Donor-Derived Cell-Free DNA Is Stable in Non-Rejecting Heart Transplant Recipients in the CARGO II Multicenter Trial
D. Hiller,¹ M. Grskovic,¹ J. Beausang,¹ R. Sit,¹ B. Christie,¹ J. Elechko,¹ R. Woodward,¹ J. Yee,¹ H. Eisen.²
¹CareDx, Inc, Brisbane, CA; ²Drexel University, University of Philadelphia, Philadelphia, PA.
Purpose: An elevated fraction of donor-derived cell-free DNA (dd-cfDNA) detected in the venous blood of recipients has been shown to be correlated to rejection of…