2015 American Transplant Congress
Validation of a Peripheral Blood Gene Expression Profile for SubClinical Acute Rejection in Kidney Transplant Recipients – Findings from the CTOT 08 Study
1Northwestern University, Chicago; 2Scripps Research Institute, La Jolla.
Background: Sub-clinical acute rejection (SCAR) is histologic acute cellular rejection in the presence of a normal/stable serum creatinine, and is associated with worse graft survival.…2015 American Transplant Congress
Non-Invasive Panel of MicroRNAs Predict Long-Term Outcomes Post-Kidney Transplantation
1Surgery and Pathology, UVA, Charlottesville, VA; 2VCU, Richmond, VA.
Background. Currently available methods for evaluating kidney graft function post-transplantation (KT) are either ineffective or inaccurate (e.g., serum creatinine) or highly invasive (e.g., biopsies). We…2015 American Transplant Congress
Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing
Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…2015 American Transplant Congress
APOL1 High-Risk Genotype in African American Live Kidney Donors Is Not Associated With Post-Donation Development of Hypertension and Kidney Disease
African Americans (AA) with two apolipoprotein L1 (APOL1) risk alleles have more kidney disease than compared to those with one or zero risk alleles. A…2015 American Transplant Congress
Correlation of Longitudinal Gene-Expression Profiling Score to Cytomegalovirus Infection: Results from the Outcomes AlloMap® Registry
Purpose: Cytomegalovirus (CMV) infection has been implicated in the pathogenesis of allograft rejection, which is reflected by high gene-expression profiling (GEP) scores. In the IMAGE…2015 American Transplant Congress
Plasma Levels of Donor-Derived Cell-Free DNA Increase With Rejection and Often Decrease After Treatment in Organ Transplant Recipients
1CareDx, Inc, Brisbane, CA; 2Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a potential biomarker of acute cellular rejection (ACR) in organ transplant recipients. dd-cfDNA levels in longitudinal plasma samples from…2015 American Transplant Congress
Clinical Use of Gene-Expression Profiling to Monitor for Rejection After Cardiac Transplantation – Which Patients and When?
Background: Gene-expression profiling (GEP), in place of endomyocardial biopsy, is increasing. GEP testing is intended for low-risk asymptomatic patients (pts); thus, the profile of pts…2015 American Transplant Congress
Donor-Derived Cell-Free DNA Is Stable in Non-Rejecting Heart Transplant Recipients in the CARGO II Multicenter Trial
1CareDx, Inc, Brisbane, CA; 2Drexel University, University of Philadelphia, Philadelphia, PA.
Purpose: An elevated fraction of donor-derived cell-free DNA (dd-cfDNA) detected in the venous blood of recipients has been shown to be correlated to rejection of…2015 American Transplant Congress
Can Gene-Expression Profiling Score Help Explain the Adverse Clinical Outcomes Seen in Gender-Mismatched Heart Transplants?
Background: Gene-expression profiling (GEP) testing, in conjunction with clinical assessment, is an established laboratory test intended to aid in the identification of acute cellular rejection…2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…
American Transplant Congress abstracts