2015 American Transplant Congress
Correlation of Longitudinal Gene-Expression Profiling Score to Cytomegalovirus Infection: Results from the Outcomes AlloMap® Registry
Purpose: Cytomegalovirus (CMV) infection has been implicated in the pathogenesis of allograft rejection, which is reflected by high gene-expression profiling (GEP) scores. In the IMAGE…2015 American Transplant Congress
Plasma Levels of Donor-Derived Cell-Free DNA Increase With Rejection and Often Decrease After Treatment in Organ Transplant Recipients
1CareDx, Inc, Brisbane, CA; 2Cedars-Sinai Medical Center, Los Angeles, CA.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a potential biomarker of acute cellular rejection (ACR) in organ transplant recipients. dd-cfDNA levels in longitudinal plasma samples from…2015 American Transplant Congress
Clinical Use of Gene-Expression Profiling to Monitor for Rejection After Cardiac Transplantation – Which Patients and When?
Background: Gene-expression profiling (GEP), in place of endomyocardial biopsy, is increasing. GEP testing is intended for low-risk asymptomatic patients (pts); thus, the profile of pts…2015 American Transplant Congress
Donor-Derived Cell-Free DNA Is Stable in Non-Rejecting Heart Transplant Recipients in the CARGO II Multicenter Trial
1CareDx, Inc, Brisbane, CA; 2Drexel University, University of Philadelphia, Philadelphia, PA.
Purpose: An elevated fraction of donor-derived cell-free DNA (dd-cfDNA) detected in the venous blood of recipients has been shown to be correlated to rejection of…2015 American Transplant Congress
Can Gene-Expression Profiling Score Help Explain the Adverse Clinical Outcomes Seen in Gender-Mismatched Heart Transplants?
Background: Gene-expression profiling (GEP) testing, in conjunction with clinical assessment, is an established laboratory test intended to aid in the identification of acute cellular rejection…2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…2015 American Transplant Congress
Non-Chimeric HLA-Identical Renal Transplant Tolerance: Regulatory Immunophenotypic/Genomic Biomarkers
Background. We previously described 3-year results of a non-chimeric tolerance protocol in HLA-identical living donor renal transplant (RT) recipients and now report on longer term,…2015 American Transplant Congress
APOL1 Risk Alleles in Live and Deceased Kidney Donors Are Associated With Shorter Renal Allograft Survival
Kidneys from African American (AA) donors with two Apolipoprotein L1 (APOL1) risk alleles may be at higher risk of allograft loss after transplant. We sought…2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…2015 American Transplant Congress
Incorporating Markers of Donor Organ Intrinsic Biology Into Donor Quality Evaluation
UVA, Charlottesville, VA; Northwestern University, Chicago, IL; VCU, Richmond, VA.
Background. We aimed to identify a reliable composite scoring system (clinical / biological) to evalute organ quality and predict outcomes post-kidney transplantation (KT).Methods. 233 deceased…
American Transplant Congress abstracts