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Articles tagged "Genomic markers"

  • 2017 American Transplant Congress

    Genomic Diversity of Epstein-Barr Virus in Post-Transplant Lymphoproliferative Disorder.

    E. Maloney, O. Martinez.

    Program in Immunology, Stanford University School of Medicine, Stanford, CA

    Purpose: In transplant recipients, Epstein-Barr Virus (EBV) is associated with the development of B cell lymphomas in post-transplant lymphoproliferative disorder (PTLD). We used next-generation sequencing…
  • 2017 American Transplant Congress

    Clusterin Levels at 3-Months Associate with DGF and 12-Month Fibrosis – Reinforcing the Early Injury to Fibrosis Continuum.

    M. Menon,1 L. Liriano-Ward,2 N. Philippe,1 C. Wei,1 W. Zhang,1 Z. Yi,1 K. Keung,2 P. O'Connell,2 B. Murphy.1

    1Medicine, Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; 2Medicine, Westmead Millenium Institute, Sydney, NSW, Australia

    The Genomics of Chronic Allograft Rejection (GoCAR) is a multicenter study investigating the ability of gene expression to predict the development of Chronic allograft nephropathy.…
  • 2017 American Transplant Congress

    Validation of CYP4F11 as a Marker of Accommodation in Biopsies from Recipients of an ABO-Incompatible Renal Transplant.

    K. Dominy,1 M. Willicombe,3 T. Al Johani,2 J. Galliford,3 A. McLean,3 T. Cook,3 C. Roufosse.3

    1Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; 2King Saud University, Riyadh, Saudi Arabia; 3Imperial College Healthcare NHS Trust, London, United Kingdom

    Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…
  • 2016 American Transplant Congress

    Non-Invasive – Minimalistic Approach Using Cell-Free MicroRNAs in Paired Plasma and Urine Samples for Early Diagnosis of Chronic Renal Allograft Dysfunction.

    S. Bontha,1 R. Gehrau,1 E. Rhone,1 A. King,2 L. Gallon,3 K. Brayman,1 D. Maluf,1 V. Mas.1

    1Surgery, UVA, Charlottesville, VA; 2VCU, Richmond; 3NWU, Chicago.

    Background: Reducing use of tissue biopsy by efficiently using non-invasive samples for continuous monitoring and evaluation of graft function would be ideal. Reports indicate continuous…
  • 2016 American Transplant Congress

    A Non-Invasive Blood Transcriptional Assay, Ksort, Monitors Alloimmune Response in the Sailor Randomized Multicenter Trial.

    J. Ekberg,1 B. Jespersen,2 K. Skov,2 M. Sarwal,3 T. Sigdel,3 S. Hsieh,3 P. Lindner.1

    1Transplantation, Sahlgrenska University Hospital, Gothenburg, Sweden; 2Nephrology, Skejby Hospital, Aarhus, Denmark; 3Surgery, University of California, San Francisco.

    Non-invasive diagnosis and prediction of acute rejection (AR) is a critical unmet need. A In a randomized multicenter trial of 222 renal transplant recipients a…
  • 2016 American Transplant Congress

    Common Molecular Features of Human Kidney Transplant Rejection Reflect Mechanistic Sharing Between T Cell-Mediated and Antibody-Mediated Rejection.

    J. Venner,1,2 P. Halloran.2

    1University of Queensland, Brisbane, Australia; 2University of Australia, Edmonton, Canada.

    We previously reported the molecular features of human kidney transplant biopsies with T cell-mediated rejection (TCMR) (Am J Transplant 14(11):2565-76) and antibody-mediated rejection (ABMR) (Am…
  • 2016 American Transplant Congress

    The Impact of Allograft Rejection on DNA Methylation After Kidney Transplantation.

    K. Boer, E. de Wit, D. Hesselink, L. Hofland, M. Betjes, C. Baan.

    ErasmusMC, University Medical Center Rotterdam, Rotterdam, Netherlands.

    Introduction DNA methylation is a well-known epigenetic mechanism which plays a critical role in cell function by regulating gene expression. Variations in DNA methylation are…
  • 2016 American Transplant Congress

    Liver Graft Steatosis Associates with an Increase of Circulating Immune Response Chemokines.

    R. Gehrau, V. Mas, A. Sharma, V. Bontha, D. Maluf.

    University of Virginia, Charlottesville.

    Background: Liver graft steatosis, especially macrosteatosis induces severe graft injury post-liver transplantation (LT) by activating cell-mediated immunity and inflammation. This study aimed to determine differential…
  • 2016 American Transplant Congress

    Down-Regulated of Circulating miR-29b, miR-185 and NR_073415.2 in Post-Transplanted Patients with Cytomegalovirus Infection May Serve as Novel Biomarkers for Early Diagnosis.

    A. Yang, W. Ju, Z. Guo, C. Wu, J. Lin, M. Chen, R. Deng, E. Chen, Y. Gao, X. Zhu, X. He.

    Organ Transplantation Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.

    Aims: Mortality of CMV infection in post-transplanted patients was quite high, which severely influencing the long-term survival of recipients. For giving them early treatment and…
  • 2016 American Transplant Congress

    IgM Treatment Successfully Prevents Type 1 Diabetes by Dysregulation of Pancreatic MicroRNAs with Immunomodulatory Roles.

    P. Chhabra, R. Gehrau, V. Mas, D. Bower, D. Maluf, K. Brayman.

    UVA, Charlottesville.

    Type 1 Diabetes (T1D) is hallmarked by beta-cells destruction. We aimed to identify specific pancreatic microRNAs (miRNA) as potential biomarkers for T1D prediction and diagnosis,…
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