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Articles tagged "Genomic markers"

  • 2022 American Transplant Congress

    Using a Unique Repository of Pancreas Transplant Biopsies to Validate the Tissue Common Response Module (tCRM) Score as a Tool to Assess the Severity of Pancreas Transplant Rejection

    Y. Kelly1, A. Zarinsefat1, R. Meier2, M. Sarwal1, P. Stock1, Z. Laszik1, T. Sigdel1

    1University of California, San Francisco, San Francisco, CA, 2University of Maryland Medical Center, Baltimore, MD

    *Purpose: Analysis of transcriptional data from kidney, heart, liver, and lung transplant rejection led to development of the tissue Common Response Module (tCRM) score based…
  • 2022 American Transplant Congress

    Identification Of A Novel Peripheral Blood Six-gene Signature Diagnosing Subclinical Acute Rejection After Renal Transplantation

    H. Zhang, Y. Xu, Y. Wang, X. Hu

    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

    *Purpose: Given the insensitivity and nonspecificity of serum creatinine, invasive surveillance biopsies are the main way to detect subclinical acute rejection (subAR) in the absence…
  • 2022 American Transplant Congress

    Use of Ancestral Genetic SNP Phenotyping to Define Genotypic Ethnicity in Solid Organ Transplant Patients

    P. Jindra, T. Tu, N. D'Silva, C. T. Stewart, J. Magana, N. Chitnis

    Surgery, Baylor College of Medicine, Houston, TX

    *Purpose: Transplantation research has mainly categorized ethnicity into four main groups African American, Caucasian, Hispanic, and Asian Pacific Islander. Our world has increased in admixure…
  • 2022 American Transplant Congress

    A Three-gene Peripheral Blood Potential Diagnosis Signature Associated With Autophagy For Antibody-mediated Rejection In Renal Transplantation

    Y. Wang, Y. Xu, H. Zhang, X. Hu

    Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China

    *Purpose: Antibody-mediated rejection (AMR) is emerging as a major cause of graft loss in renal transplantation. Nowadays, non-invasive diagnosis of AMR with high accuracy is…
  • 2022 American Transplant Congress

    RNA Sequencing Profiling of Pretransplant Blood Identified Variant Allele Specific Expression of Leukocyte Immunoglobulin-Like Receptors (LILRs) Genes Associated with Graft Loss in Kidney Transplant Recipients

    Z. Sun1, Z. Yi1, Z. Zhang1, P. Cravedi1, M. Menon2, B. Murphy1, S. Chen3, W. Zhang1

    1Icahn School of Medicine at Mount Sinai, New York City, NY, 2Yale University School of Medicine, New Heaven, CT, 3Methodist Hospital, Houston, TX

    *Purpose: The RNA sequencing has the possibility of detecting overall gene expression as well as allele-specific expression. Here, we reported a study of genome-wide allele…
  • 2022 American Transplant Congress

    The Role Of Combined Gene Expression Profiling And Donor-derived Cell-free Dna In Differentiating Acute Rejection In Liver Transplant Recipients

    S. Park1, M. Kandpal2, K. Guo2, S. Kleiboeker3, R. Sinha4, M. Abecassis5, J. Levitsky6

    1Transplant nephrology, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Eurofins Viracor, Lee's Summit, MO, 4Eurofins Viracor, Lee's summit, MO, 5University of Arizona, Tucson, AZ, 6Northwestern University Feinberg School of Medicine, Chicago, IL

    *Purpose: In our previous studies, blood-based gene expression profiling (GEP) and donor-derived cell-free DNA (dd-cfDNA) have been independently validated in liver transplant recipients (LTR) to…
  • 2022 American Transplant Congress

    Induction of Tacrolimus Clearance by Steroids Varies by Cyp3a5 Genotype in Kidney Transplant Recipients: A Drug-Drug-Gene Interaction

    P. A. Jacobson1, A. Saqr1, M. Al-Kofahi1, D. P. Schladt2, W. Guan3, W. S. Oetting1, R. Mannon4, C. R. Dorr5, R. P. Remmel1, G. C. Onyeaghala6, B. Wu3, A. K. Israni7, A. Matas8

    1Univ of MN, College of Pharmacy, Minneapolis, MN, 2Hennepin Health Research Institute, Minneapolis, MN, 3Univ of MN, Biostatistics, Minneapolis, MN, 4Univ of Nebraska, Dept of Medicine, Omaha, NE, 5Hennepin Health Research Institute and Dept of Medicine, Minneapolis, MN, 6Hennepin Healthcare Research Institute, Minneapolis, MN, 7Hennepin Health Dept of Medicine and Univ of MN, Minneapolis, MN, 8University of MN, Dept of Surgery, Minneapolis, MN

    *Purpose: Tacrolimus (TAC) is the primary immunosuppressant used in organ transplantation. TAC is a substrate for CYP3A4/5. These enzymes are inhibited or induced by multiple…
  • 2022 American Transplant Congress

    A Novel Approach to Non-Invasive Multimodality Testing with Allosure and Allomap Predicts Microvascular Inflammation with High Accuracy in Kidney Transplant Recipients

    S. Parajuli, F. Aziz, N. Garg, S. E. Panzer, K. Van Hyfte, K. Degner, S. Reese, L. Ptak, N. Wilson, A. Djamali

    University of Wisconsin, Madison, WI

    *Purpose: The most prominent histologic lesion in antibody-mediated rejection (ABMR) is microvascular inflammation (MVI); however, its recognition and scoring can be challenging and poorly reproducible…
  • 2022 American Transplant Congress

    RBBP7 as a Novel Biomarker for the Molecular Diagnosis of BK Virus-Associated Nephropathy

    W. Yicun, W. Yuxuan, H. Xiaopeng

    Department of Urology, Beijing Chaoyang Hospital, Beijing, China

    *Purpose: BK virus-associated nephropathy (BKVN) remains a major infectious complication of kidney transplantation, and its histologic appearance can mimic rejection, leading to a diagnostic dilemma…
  • 2022 American Transplant Congress

    The Prediction of Renal Allograft Rejection by Time-Dependent Two-Signature Predictors

    M. Liao1, Q. Fu2, L. Wei3, H. Yang3, G. Zhao3, S. Deng3, J. F. Markmann2

    1School of Medicine, University of Electronic Science and Technology of China, Chengdu, China, 2Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 3University of Electronic Science and Technology of China, Chengdu, China

    *Purpose: The study aims to develop RNA signature predictors using preemptive biopsy transcriptome data to predict future allograft rejection and reveal the predictors' time-dependent features.*Methods:…
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