Articles tagged "Gene polymorphism"

2015 American Transplant Congress
Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction
A. Goncalves-Primo,^1,2 E. Campos,^1,2 J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2
¹Immunogenetics Institute, AFIP, São Paulo, SP, Brazil; ²Universidade Federal de São Paulo, São Paulo, SP, Brazil; ³Hospital do Rim e Hipertensão- FOR, São Paulo, SP, Brazil.
In this study we sought to determine the risk for delayed graft function (DGF) in kidney transplants (Tx) with deceased donors (DD) through the analysis…
2015 American Transplant Congress
The Significant Association Between the Functional Polymorphism (Rs3761548) of Foxp3 Gene and the Severity of Acute Cellular Rejection in Liver Transplantation
S. Verma, Y. Tanaka, S. Shimizu, L. Das, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Aim- Acute cellular rejection (ACR) accounts for 15-25% of graft failure in living donor liver transplantation (LDLT). T regulatory cells (Treg) play an important role…
2015 American Transplant Congress
Development and Validation of a Genotype Guided Tacrolimus Dosing Equation for African American (AA) Kidney Transplant Recipients
K. Sanghavi,¹ R. Brundage,¹ M. Miller,² D. Schaldt,³ A. Israni,³ W. Guan,⁴ W. Oetting,¹ R. Mannon,⁵ R. Remmel,¹ A. Matas,⁶ P. Jacobson.¹
¹College of Pharmacy, University of MN, Minneapolis, MN; ²Dept of Psychology, University of MN, Minneapolis, MN; ³Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Dept of Biostatistics, University of MN, Minneapolis, MN; ⁵Dept of Nephrology, University of AL, Birmingham, AL; ⁶Dept of Surgery, University of MN, Minneapolis, MN.
Tacrolimus (tac) has a strong exposure-response relationship with high inter-individual variability in troughs and dose. Tac dose requirements for AA patients are higher than Caucasians,…
2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
B. Keating,¹ Y. Li,¹ K. Olthoff,¹ J. Wang,² A. Shaked.¹
¹Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; ³Genomics, BGI, Shenzhen, China.
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…
2015 American Transplant Congress
The Impact of FcγRIIA, FcγRIIIA and C1QA Genes Polymorphism On Infectious Complications Following Renal Transplantation
L. Das, Y. Tanaka, S. Verma, S. Shimizu, K. Ide, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
AIM- Infectious complication is the leading cause of graft and patient loss after renal transplantation (RT). Under immunosuppressive condition when acquired immunity is suppressed, components…
2015 American Transplant Congress
Differences in Genetic Variants That Influence Long-Term Graft Function Between Pancreas Transplant Donors and Recipients
M. Simmonds,¹ C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough.^1,4
¹Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; ³Nufﬁeld Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ⁴Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.
Genetic variation in caveolin-1, involved in signal transduction and tissue fibrosis, within pancreas transplant donors has been previously shown to correlate with decreased long-term graft…
2015 American Transplant Congress
Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing
T. Elnahhas,^1,2 E. de Jonge,⁴ T. Lee,² B. van Zelst,⁴ J. Popoola,³ R. Ramkhelawon,³ R. van Schaik,⁴ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St.George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom; ⁴Clinical Chemistry, Erasmus MC Rotterdam, Rotterdam, Netherlands.
Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…
2015 American Transplant Congress
Influence of Race on P-Glycoprotein Function in Peripheral Blood Mononuclear Cells
K. Tornatore,¹ H. Minderman,² K. O'Loughlin,² K. Attwood,³ D. Brazeau,⁴ R. Venuto.⁵
¹NYS Center of Excellence in Bioinformatics & Life Science, School of Pharmacy, Buffalo; ²Flow Cytometry Laboratories, Roswell Park Cancer Institute, Buffalo; ³Biostatistics, School of Public Health, Buffalo; ⁴University of New England; School of Pharmacy, Portland, ME; ⁵Medicine, School of Medicine; University at Buffalo, Buffalo, NY.
Purpose: African Americans (AA) renal transplant recipients (RTR) have poorer long term allograft survival compared to Caucasians(C) which may be attributed to racial differences in…
2015 American Transplant Congress
Influence of CYP3A5 and ABCB1 Genotypes on Pharmacokinetics of Immediate and Prolonged Release Tacrolimus Preparations
T. Elnahhas,^1,2 T. Lee,² M. Moreton,² D. McKeown,² J. Popoola,³ R. Ramkhelawon,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St.George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom.
Background. Tacrolimus is available in two formulations, immediate-release, (Prograf®) and prolonged -release formulation of tacrolimus (Advagraf®). Tacrolimus has a narrow therapeutic index with wide variation…
2015 American Transplant Congress
hTERT, BICD1 and Chromosome 18 Polymorphisms Affecting Telomere Length Are Associated With Kidney Transplantation Outcome
L. Domanski,¹ K. Kloda,¹ K. Safranow,² A. Drozd,³ K. Ciechanowski,¹ A. Ciechanowicz.⁴
¹Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland; ²Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Szczecin, Poland; ³Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Szczecin, Poland; ⁴Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Telomere length (TL) has been analyzed in regard to cell senescence and ageing of animals and humans, including age-related diseases. There have been also attempts…