Articles tagged "Gene polymorphism"

2015 American Transplant Congress
The Impact of FcγRIIA, FcγRIIIA and C1QA Genes Polymorphism On Infectious Complications Following Renal Transplantation
L. Das, Y. Tanaka, S. Verma, S. Shimizu, K. Ide, H. Ohdan.
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
AIM- Infectious complication is the leading cause of graft and patient loss after renal transplantation (RT). Under immunosuppressive condition when acquired immunity is suppressed, components…
2015 American Transplant Congress
Differences in Genetic Variants That Influence Long-Term Graft Function Between Pancreas Transplant Donors and Recipients
M. Simmonds,¹ C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough.^1,4
¹Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; ³Nufﬁeld Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ⁴Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.
Genetic variation in caveolin-1, involved in signal transduction and tissue fibrosis, within pancreas transplant donors has been previously shown to correlate with decreased long-term graft…
2015 American Transplant Congress
Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing
T. Elnahhas,^1,2 E. de Jonge,⁴ T. Lee,² B. van Zelst,⁴ J. Popoola,³ R. Ramkhelawon,³ R. van Schaik,⁴ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St.George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom; ⁴Clinical Chemistry, Erasmus MC Rotterdam, Rotterdam, Netherlands.
Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…
2015 American Transplant Congress
Influence of Race on P-Glycoprotein Function in Peripheral Blood Mononuclear Cells
K. Tornatore,¹ H. Minderman,² K. O'Loughlin,² K. Attwood,³ D. Brazeau,⁴ R. Venuto.⁵
¹NYS Center of Excellence in Bioinformatics & Life Science, School of Pharmacy, Buffalo; ²Flow Cytometry Laboratories, Roswell Park Cancer Institute, Buffalo; ³Biostatistics, School of Public Health, Buffalo; ⁴University of New England; School of Pharmacy, Portland, ME; ⁵Medicine, School of Medicine; University at Buffalo, Buffalo, NY.
Purpose: African Americans (AA) renal transplant recipients (RTR) have poorer long term allograft survival compared to Caucasians(C) which may be attributed to racial differences in…
2015 American Transplant Congress
Influence of CYP3A5 and ABCB1 Genotypes on Pharmacokinetics of Immediate and Prolonged Release Tacrolimus Preparations
T. Elnahhas,^1,2 T. Lee,² M. Moreton,² D. McKeown,² J. Popoola,³ R. Ramkhelawon,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St.George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom.
Background. Tacrolimus is available in two formulations, immediate-release, (Prograf®) and prolonged -release formulation of tacrolimus (Advagraf®). Tacrolimus has a narrow therapeutic index with wide variation…
2015 American Transplant Congress
hTERT, BICD1 and Chromosome 18 Polymorphisms Affecting Telomere Length Are Associated With Kidney Transplantation Outcome
L. Domanski,¹ K. Kloda,¹ K. Safranow,² A. Drozd,³ K. Ciechanowski,¹ A. Ciechanowicz.⁴
¹Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland; ²Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Szczecin, Poland; ³Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Szczecin, Poland; ⁴Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Telomere length (TL) has been analyzed in regard to cell senescence and ageing of animals and humans, including age-related diseases. There have been also attempts…
2015 American Transplant Congress
Association Between Polymorphisms of PPM1E Gene and Tumor Size of Hepatocellular Carcinoma Patients
M.-S. Park,¹ S.-K. Kim.²
¹Surgery, Kyung Hee University Hospital, Seoul, Korea; ²Pharmacology, Kyung Hee University, Seoul, Korea.
The protein phosphatase, Mg2+/Mn2+ dependent, 1E (PPM1E) inactivates multiple substrates including 5'-AMP activate protein kinases (AMPK) which inhibits the growth and survival of cancer cells.…
2015 American Transplant Congress
Impact of HMOX1 Genetic Variation in Pancreas Transplant Recipients On Long-Term Graft Outcome
C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough,^1,4 M. Simmonds.¹
¹Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; ³Nufﬁeld Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ⁴Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.
Variation within the heme oxygenase 1 (HMOX1) gene, essential for heme catabolism and a known inflammatory and immune regulator, is proposed to play a role…
2015 American Transplant Congress
New Insights in Clinical and Genetic Determinants of Longitudinal Dose-Corrected CNI Exposure in Children After Renal Transplantation
N. Knops,¹ M. van Dyck,¹ E. Levtchenko,¹ D. Kuypers,² J. Herman.¹
¹Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
Purpose: Calcineurin-inhibitors (CNI) have a narrow therapeutic index and dosing is difficult due to inter- and intra-individual variation in pharmacokinetics (PK). Polymorphisms in genes involved…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…