2015 American Transplant Congress
The Design and Implementation of a Genome-Wide Genotyping Array Tailored for Transplantation
Over 570,000 solid organ transplants have been performed in the United States since 1988. Despite significant improvements in transplant outcomes, chronic organ rejection affects up…2015 American Transplant Congress
Adoptive Immunotherapy Using Activated NK Cells Ameliorates the FcγRIIIa Gene Polymorphism-Associated Susceptibility to Post Transplant Bloodstream Infection
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: At ATC 2014, we demonstrated that detection of single nucleotide polymorphisms (SNP) of FcγRIIIa helps predict the susceptibility of liver transplant (LT) recipients to…2015 American Transplant Congress
Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study
Tacrolimus (tac) is dependent on CYP3A4/5 for metabolism. Variability in the metabolism is influenced by CYP3A5*3 alleles. This variant and clinical factors explain around 50%…2015 American Transplant Congress
Pharmacogenomic Predictors of Acute Rejection in Kidney Transplant Recipients Identified Using a DNA Biobank Linked to Electronic Medical Records
Purpose: Risk for acute rejection (AR) complicating transplant immunosuppression may be affected by frequent variants in pharmacogenes. Using a DNA biobank linked to electronic medical…2015 American Transplant Congress
Donor Apolipoprotein L1 Genotype Associates With Glomerular Lesions and Graft Loss in Kidney Transplants
Medical University of South Carolina, Charleston, SC.
Introduction/Aims: Previous studies have associated donor apolipoproteinL1 (APOL1) risk genotypes with risk of graft loss among kidney transplants. APOL1 risk genotypes have also been associated…2015 American Transplant Congress
Genetic Diversity Epstein-Barr Virus Latent Gene EBNA-1 Among Transplant Patients and Patients With Infectious Mononucleosis
Introduction:-The distribution of Epstein Barr Virus (EBV)-associated pathologies varies worldwide. It is associated with the majority of cases of post-transplant lymphoproliferative disorder (PTLD). The EBNA-1…2015 American Transplant Congress
Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction
In this study we sought to determine the risk for delayed graft function (DGF) in kidney transplants (Tx) with deceased donors (DD) through the analysis…2015 American Transplant Congress
The Significant Association Between the Functional Polymorphism (Rs3761548) of Foxp3 Gene and the Severity of Acute Cellular Rejection in Liver Transplantation
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Aim- Acute cellular rejection (ACR) accounts for 15-25% of graft failure in living donor liver transplantation (LDLT). T regulatory cells (Treg) play an important role…2015 American Transplant Congress
Development and Validation of a Genotype Guided Tacrolimus Dosing Equation for African American (AA) Kidney Transplant Recipients
Tacrolimus (tac) has a strong exposure-response relationship with high inter-individual variability in troughs and dose. Tac dose requirements for AA patients are higher than Caucasians,…2015 American Transplant Congress
Application of Second Generation Sequencing and AlloAntibody Screening to the Organ Transplantation Arena
Over the last two decades, over 300,000 solid organ transplantations have been performed in the USA alone. While there has been considerable progress with immunosuppression…
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