Articles tagged "Gene polymorphism"

2015 American Transplant Congress
Influence of CYP3A5 and ABCB1 Genotypes on Pharmacokinetics of Immediate and Prolonged Release Tacrolimus Preparations
T. Elnahhas,^1,2 T. Lee,² M. Moreton,² D. McKeown,² J. Popoola,³ R. Ramkhelawon,³ A. Johnston,^1,2 I. MacPhee.³
¹Clinical Pharmacology Department, Queen Mary University of London, London, United Kingdom; ²Analytical Services International, St.George's University of London, London, United Kingdom; ³Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom.
Background. Tacrolimus is available in two formulations, immediate-release, (Prograf®) and prolonged -release formulation of tacrolimus (Advagraf®). Tacrolimus has a narrow therapeutic index with wide variation…
2015 American Transplant Congress
hTERT, BICD1 and Chromosome 18 Polymorphisms Affecting Telomere Length Are Associated With Kidney Transplantation Outcome
L. Domanski,¹ K. Kloda,¹ K. Safranow,² A. Drozd,³ K. Ciechanowski,¹ A. Ciechanowicz.⁴
¹Clinical Department of Nephrology, Transplantology and Internal Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland; ²Department of Biochemistry and Medical Chemistry, Pomeranian Medical University in Szczecin, Szczecin, Poland; ³Department of Biochemistry and Human Nutrition, Pomeranian Medical University in Szczecin, Szczecin, Poland; ⁴Department of Laboratory Diagnostics and Molecular Medicine, Pomeranian Medical University in Szczecin, Szczecin, Poland.
Telomere length (TL) has been analyzed in regard to cell senescence and ageing of animals and humans, including age-related diseases. There have been also attempts…
2015 American Transplant Congress
Association Between Polymorphisms of PPM1E Gene and Tumor Size of Hepatocellular Carcinoma Patients
M.-S. Park,¹ S.-K. Kim.²
¹Surgery, Kyung Hee University Hospital, Seoul, Korea; ²Pharmacology, Kyung Hee University, Seoul, Korea.
The protein phosphatase, Mg2+/Mn2+ dependent, 1E (PPM1E) inactivates multiple substrates including 5'-AMP activate protein kinases (AMPK) which inhibits the growth and survival of cancer cells.…
2015 American Transplant Congress
Impact of HMOX1 Genetic Variation in Pancreas Transplant Recipients On Long-Term Graft Outcome
C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough,^1,4 M. Simmonds.¹
¹Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; ³Nufﬁeld Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ⁴Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.
Variation within the heme oxygenase 1 (HMOX1) gene, essential for heme catabolism and a known inflammatory and immune regulator, is proposed to play a role…
2015 American Transplant Congress
New Insights in Clinical and Genetic Determinants of Longitudinal Dose-Corrected CNI Exposure in Children After Renal Transplantation
N. Knops,¹ M. van Dyck,¹ E. Levtchenko,¹ D. Kuypers,² J. Herman.¹
¹Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
Purpose: Calcineurin-inhibitors (CNI) have a narrow therapeutic index and dosing is difficult due to inter- and intra-individual variation in pharmacokinetics (PK). Polymorphisms in genes involved…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…
2015 American Transplant Congress
MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ A. Perkowska Ptasińska,¹ A. Sadowska,¹ M. Nowaczyk,⁵ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.
MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…
2015 American Transplant Congress
CYP3A4 Polymorphisms Correlate With Time to Achieve Tacrolimus Steady State Concentration in Lung Transplant Patients
I. Timofte, A. Iacono, J. Kim, P. Sanchez, R. Reed, K. Rajagopal, M. Mclenon, B. Griffith, R. Pierson, S. Pham.
Pulmonary and Critical Care, University of Maryland, Baltimore; Surgery, University of Maryland, Baltimore.
Introduction:Tacrolimus is the main component of the immunosuppressive regimen used in patients with solid organ transplants. Tacrolimus requires blood concentration monitoring due a narrow therapeutic…
2015 American Transplant Congress
The Design and Implementation of a Genome-Wide Genotyping Array Tailored for Transplantation
B. Keating,¹ A. Israni,² Y. Li,¹ M. Holmes,¹ K. Birdwell,³ F. Asselbergs,⁴ A. Shaked.¹
¹Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; ²University of Minnesota, Minneapolis, MN; ³Nephrology, Vanderbilt University, Nashville, TN; ⁴Cardiology (Division Heart and Lungs), University Medical Center Utrecht, Utrecht, Netherlands.
Over 570,000 solid organ transplants have been performed in the United States since 1988. Despite significant improvements in transplant outcomes, chronic organ rejection affects up…
2015 American Transplant Congress
Adoptive Immunotherapy Using Activated NK Cells Ameliorates the FcγRIIIa Gene Polymorphism-Associated Susceptibility to Post Transplant Bloodstream Infection
S. Shimizu, Y. Tanaka, H. Tazawa, S. Verma, H. Ohdan.
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Background: At ATC 2014, we demonstrated that detection of single nucleotide polymorphisms (SNP) of FcγRIIIa helps predict the susceptibility of liver transplant (LT) recipients to…