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Articles tagged "Gene polymorphism"

  • 2015 American Transplant Congress

    MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy

    J. Pazik,1 M. Oldak,2 Z. Lewandowski,3 D. Ozieblo,4 K. Michalska,5 A. Perkowska Ptasińska,1 A. Sadowska,1 M. Nowaczyk,5 J. Malejczyk,4 M. Durlik.1

    1Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; 2Institute of Physiology and Pathology of Hearing, Warsaw, Poland; 3Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; 4Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; 5Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.

    MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…
  • 2015 American Transplant Congress

    CYP3A4 Polymorphisms Correlate With Time to Achieve Tacrolimus Steady State Concentration in Lung Transplant Patients

    I. Timofte, A. Iacono, J. Kim, P. Sanchez, R. Reed, K. Rajagopal, M. Mclenon, B. Griffith, R. Pierson, S. Pham.

    Pulmonary and Critical Care, University of Maryland, Baltimore; Surgery, University of Maryland, Baltimore.

    Introduction:Tacrolimus is the main component of the immunosuppressive regimen used in patients with solid organ transplants. Tacrolimus requires blood concentration monitoring due a narrow therapeutic…
  • 2015 American Transplant Congress

    The Design and Implementation of a Genome-Wide Genotyping Array Tailored for Transplantation

    B. Keating,1 A. Israni,2 Y. Li,1 M. Holmes,1 K. Birdwell,3 F. Asselbergs,4 A. Shaked.1

    1Surgery (Division of Transplantation), University of Pennsylvania, Philadelphia, PA; 2University of Minnesota, Minneapolis, MN; 3Nephrology, Vanderbilt University, Nashville, TN; 4Cardiology (Division Heart and Lungs), University Medical Center Utrecht, Utrecht, Netherlands.

    Over 570,000 solid organ transplants have been performed in the United States since 1988. Despite significant improvements in transplant outcomes, chronic organ rejection affects up…
  • 2015 American Transplant Congress

    Adoptive Immunotherapy Using Activated NK Cells Ameliorates the FcγRIIIa Gene Polymorphism-Associated Susceptibility to Post Transplant Bloodstream Infection

    S. Shimizu, Y. Tanaka, H. Tazawa, S. Verma, H. Ohdan.

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Background: At ATC 2014, we demonstrated that detection of single nucleotide polymorphisms (SNP) of FcγRIIIa helps predict the susceptibility of liver transplant (LT) recipients to…
  • 2015 American Transplant Congress

    Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study

    P. Jacobson,1 M. Miller,2 D. Schladt,3 A. Israni,3 K. Sanghavi,1 C. Dorr,3 R. Remmel,1 W. Guan,4 A. Matas,5 W. Oetting.1

    1College of Pharmacy, University of MN, Minneapolis, MN; 2Department of Psychology, University of MN, Minneapolis, MN; 3Department of Nephrology and Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; 4Department of Biostatistics, University of MN, Minneapolis, MN; 5Department of Surgery, University of MN, Minneapolis, MN.

    Tacrolimus (tac) is dependent on CYP3A4/5 for metabolism. Variability in the metabolism is influenced by CYP3A5*3 alleles. This variant and clinical factors explain around 50%…
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