Articles tagged "Gene polymorphism"

2015 American Transplant Congress
Association Between Polymorphisms of PPM1E Gene and Tumor Size of Hepatocellular Carcinoma Patients
M.-S. Park,¹ S.-K. Kim.²
¹Surgery, Kyung Hee University Hospital, Seoul, Korea; ²Pharmacology, Kyung Hee University, Seoul, Korea.
The protein phosphatase, Mg2+/Mn2+ dependent, 1E (PPM1E) inactivates multiple substrates including 5'-AMP activate protein kinases (AMPK) which inhibits the growth and survival of cancer cells.…
2015 American Transplant Congress
Impact of HMOX1 Genetic Variation in Pancreas Transplant Recipients On Long-Term Graft Outcome
C. Duff,¹ A. Hamilton,¹ S. Mittal,^2,3,4 M. Barnardo,^2,3 S. Fuggle,^2,3 P. Friend,^2,3 S. Gough,^1,4 M. Simmonds.¹
¹Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; ²Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; ³Nufﬁeld Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; ⁴Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.
Variation within the heme oxygenase 1 (HMOX1) gene, essential for heme catabolism and a known inflammatory and immune regulator, is proposed to play a role…
2015 American Transplant Congress
New Insights in Clinical and Genetic Determinants of Longitudinal Dose-Corrected CNI Exposure in Children After Renal Transplantation
N. Knops,¹ M. van Dyck,¹ E. Levtchenko,¹ D. Kuypers,² J. Herman.¹
¹Pediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; ²Nephrology and Renal Transplantation, University Hospitals Leuven, Leuven, Belgium.
Purpose: Calcineurin-inhibitors (CNI) have a narrow therapeutic index and dosing is difficult due to inter- and intra-individual variation in pharmacokinetics (PK). Polymorphisms in genes involved…
2015 American Transplant Congress
The Impact of MYH9 Polymorphic Variant rs5756168 on Kidney Allograft Function
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ E. Sitarek,¹ A. Sadowska,¹ M. Nowaczyk,⁵ T. Grochowiecki,⁶ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland; ⁶General, Vascular and Transplant Surgery, Medical University of Warsaw, Warsaw, Poland.
The MYH9 gene was identified as a susceptibility locus associated with diminished filtration rate in the course of chronic nephropathies: primary focal segmental glomerulosclerosis (FSGS),…
2015 American Transplant Congress
MYH9 Polymorphic Variants and Chronic Lesions in Transplanted Kidney Biopsy
J. Pazik,¹ M. Oldak,² Z. Lewandowski,³ D. Ozieblo,⁴ K. Michalska,⁵ A. Perkowska Ptasińska,¹ A. Sadowska,¹ M. Nowaczyk,⁵ J. Malejczyk,⁴ M. Durlik.¹
¹Department of Nephrology and Transplantation Medicine, Medical University of Warsaw, Warsaw, Poland; ²Institute of Physiology and Pathology of Hearing, Warsaw, Poland; ³Department of Epidemiology, Medical University of Warsaw, Warsaw, Poland; ⁴Department of Histology and Embryology, Medical University of Warsaw, Warsaw, Poland; ⁵Department of Clinical Immunology, Medical University of Warsaw, Warsaw, Poland.
MYH9 encoding a non-muscle myosin heavy chain IIA is expressed in podocytes, mesangial, tubular, capillary endothelial cells and vascular wall. Intronic variants of MYH9 associate…