ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Gene polymorphism"

  • 2015 American Transplant Congress

    The Impact of FcγRIIA, FcγRIIIA and C1QA Genes Polymorphism On Infectious Complications Following Renal Transplantation

    L. Das, Y. Tanaka, S. Verma, S. Shimizu, K. Ide, H. Ohdan.

    Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    AIM- Infectious complication is the leading cause of graft and patient loss after renal transplantation (RT). Under immunosuppressive condition when acquired immunity is suppressed, components…
  • 2015 American Transplant Congress

    Differences in Genetic Variants That Influence Long-Term Graft Function Between Pancreas Transplant Donors and Recipients

    M. Simmonds,1 C. Duff,1 A. Hamilton,1 S. Mittal,2,3,4 M. Barnardo,2,3 S. Fuggle,2,3 P. Friend,2,3 S. Gough.1,4

    1Oxford Centre for Diabetes, Endocrinology and Metabolism (OCDEM), University of Oxford, Oxford, United Kingdom; 2Oxford Transplant Centre, Oxford University Hospitals NHS Trust, Oxford, United Kingdom; 3Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom; 4Oxford National Institute for Health Research Biomedical Research Centre, Oxford, United Kingdom.

    Genetic variation in caveolin-1, involved in signal transduction and tissue fibrosis, within pancreas transplant donors has been previously shown to correlate with decreased long-term graft…
  • 2015 American Transplant Congress

    Plasma 4β-Hydroxycholesterol Measurement as a Potential Biomarker for CYP3A5 Activity in Informing Tacrolimus Dosing

    T. Elnahhas,1,2 E. de Jonge,4 T. Lee,2 B. van Zelst,4 J. Popoola,3 R. Ramkhelawon,3 R. van Schaik,4 A. Johnston,1,2 I. MacPhee.3

    1Clinical Pharmacology, Queen Mary University of London, London, United Kingdom; 2Analytical Services International, St.George's University of London, London, United Kingdom; 3Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom; 4Clinical Chemistry, Erasmus MC Rotterdam, Rotterdam, Netherlands.

    Background—Recently, 4β-hydroxycholesterol (4β-OHC) has been shown to be an endogenous marker of P450 3A activity in clinical practice (Diczfalusy et al, 2011). 4β-OHC concentration increases…
  • 2015 American Transplant Congress

    Influence of Race on P-Glycoprotein Function in Peripheral Blood Mononuclear Cells

    K. Tornatore,1 H. Minderman,2 K. O'Loughlin,2 K. Attwood,3 D. Brazeau,4 R. Venuto.5

    1NYS Center of Excellence in Bioinformatics & Life Science, School of Pharmacy, Buffalo; 2Flow Cytometry Laboratories, Roswell Park Cancer Institute, Buffalo; 3Biostatistics, School of Public Health, Buffalo; 4University of New England; School of Pharmacy, Portland, ME; 5Medicine, School of Medicine; University at Buffalo, Buffalo, NY.

    Purpose: African Americans (AA) renal transplant recipients (RTR) have poorer long term allograft survival compared to Caucasians(C) which may be attributed to racial differences in…
  • 2015 American Transplant Congress

    Influence of CYP3A5 and ABCB1 Genotypes on Pharmacokinetics of Immediate and Prolonged Release Tacrolimus Preparations

    T. Elnahhas,1,2 T. Lee,2 M. Moreton,2 D. McKeown,2 J. Popoola,3 R. Ramkhelawon,3 A. Johnston,1,2 I. MacPhee.3

    1Clinical Pharmacology Department, Queen Mary University of London, London, United Kingdom; 2Analytical Services International, St.George's University of London, London, United Kingdom; 3Institute of Medical and Biomedical Education-Renal Medicine, St.George's University of London, London, United Kingdom.

    Background. Tacrolimus is available in two formulations, immediate-release, (Prograf®) and prolonged -release formulation of tacrolimus (Advagraf®). Tacrolimus has a narrow therapeutic index with wide variation…
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