Articles tagged "Gene polymorphism"

2015 American Transplant Congress
Variants Associated With Tacrolimus Troughs in European American Kidney Transplant Recipients: A Genome Wide Association Study
P. Jacobson,¹ M. Miller,² D. Schladt,³ A. Israni,³ K. Sanghavi,¹ C. Dorr,³ R. Remmel,¹ W. Guan,⁴ A. Matas,⁵ W. Oetting.¹
¹College of Pharmacy, University of MN, Minneapolis, MN; ²Department of Psychology, University of MN, Minneapolis, MN; ³Department of Nephrology and Chronic Disease Research Group, Minneapolis Medical Research Foundation, Hennepin County Medical Center, Minneapolis, MN; ⁴Department of Biostatistics, University of MN, Minneapolis, MN; ⁵Department of Surgery, University of MN, Minneapolis, MN.
Tacrolimus (tac) is dependent on CYP3A4/5 for metabolism. Variability in the metabolism is influenced by CYP3A5*3 alleles. This variant and clinical factors explain around 50%…
2015 American Transplant Congress
Pharmacogenomic Predictors of Acute Rejection in Kidney Transplant Recipients Identified Using a DNA Biobank Linked to Electronic Medical Records
K. Birdwell,¹ D. Velez-Edwards,² G. Vranic,⁵ J. Denny,^1,3 L. Choi,⁴ T. Ikizler,¹ D. Haas.¹
¹Medicine, Vanderbilt University Medical Center, Nashville, TN; ²Vanderbilt Epidemiology Center, Vanderbilt University Medical Center, Nashville, TN; ³Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN; ⁴Biostatistics, Vanderbilt University Medical Center, Nashville, TN; ⁵Medicine, University of Virginia, Charlottesville, VA.
Purpose: Risk for acute rejection (AR) complicating transplant immunosuppression may be affected by frequent variants in pharmacogenes. Using a DNA biobank linked to electronic medical…
2015 American Transplant Congress
Donor Apolipoprotein L1 Genotype Associates With Glomerular Lesions and Graft Loss in Kidney Transplants
T. Srinivas, P. Baliga, K. Chavin, M. Gebrezhiaber, L. Egede, D. Taber.
Medical University of South Carolina, Charleston, SC.
Introduction/Aims: Previous studies have associated donor apolipoproteinL1 (APOL1) risk genotypes with risk of graft loss among kidney transplants. APOL1 risk genotypes have also been associated…
2015 American Transplant Congress
Genetic Diversity Epstein-Barr Virus Latent Gene EBNA-1 Among Transplant Patients and Patients With Infectious Mononucleosis
K. Sullivan,¹ S. Isabel,¹ E. Maria,¹ P. Tara,¹ Y. Simon,¹ K. Nasser,¹ N. Vicky,² A. Upton.¹
¹Department of Infections Diseases, Hospital for Sick Children, Toronto, ON, Canada; ²Transplant Centre, Hospital for Sick Children, Toronto, ON, Canada.
Introduction:-The distribution of Epstein Barr Virus (EBV)-associated pathologies varies worldwide. It is associated with the majority of cases of post-transplant lymphoproliferative disorder (PTLD). The EBNA-1…
2015 American Transplant Congress
Combination of Clinical and Genetic Factors for Delayed Kidney Graft Function Prediction
A. Goncalves-Primo,^1,2 E. Campos,^1,2 J. Medina-Pestana,^2,3 H. Tedesco-Silva,³ M. Gerbase-DeLima.^1,2
¹Immunogenetics Institute, AFIP, São Paulo, SP, Brazil; ²Universidade Federal de São Paulo, São Paulo, SP, Brazil; ³Hospital do Rim e Hipertensão- FOR, São Paulo, SP, Brazil.
In this study we sought to determine the risk for delayed graft function (DGF) in kidney transplants (Tx) with deceased donors (DD) through the analysis…