Articles tagged "Gene expression"

2021 American Transplant Congress
Integrative Analyses of Circulating Small Rnas and Paired Kidney Graft Transcriptome in Transplant Glomerulopathy
C. Kuscu¹, K. Manjari², M. Akram³, C. Kuscu⁴, A. Wolen,⁴, A. Bajwa⁴, J. Eason⁴, D. G. Maluf⁵, V. Mas⁶, E. Akalin⁷
¹Surgery, James D Eason Transplant Institute, UTHSC, Memphis, TN, ²Department of Systems and Computational Biology, School of Life Sciences, University of Hyderabad,, Hyderabad,, India, ³Center for Biomedical Informatics, University of Tennessee Health Science Center, Memphis, TN, ⁴Surgery, James D Eason Transplant Institute, Memphis, TN, ⁵Surgery, Program in Transplantation, University of Maryland, Baltimore, MD, ⁶Surgery, Division Surgical Science, University of Maryland, Baltimore, MD, ⁷Medicine, Montefiore Medical Center, Abdominal Transplant Program, Albert Einstein College of Medicine,, NYC, NY
*Purpose: Transplant glomerulopathy (TG) develops through multiple mechanisms including donor-specific antibodies, T cells and innate immunity. We investigate the role of circulating small RNAs (sRNAs)…
2021 American Transplant Congress
Laminins Differentially Regulate Tolerogenic T Cell Migration and Homing to Lymph Nodes
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena², T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MA
*Purpose: Laminin α5 (Lama5) and α4 (Lama4), which are produced by lymph node (LN) stromal cells, influence CD4 T cell migration and stimulation. We hypothesized…
2021 American Transplant Congress
A Molecular Classifier Identifies Antibody-Mediated Rejection-Associated Changes in Lung Transplant Biopsies
K. S. Madill-Thomsen¹, K. M. Halloran², M. Parkes¹, P. F. Halloran¹, &. the INTERLUNG Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Identifying lung transplant antibody-mediated rejection (ABMR) has been controversial. We compared gene expression in donor-specific antibody (DSA) positive vs. DSA negative lung transbronchial biopsies…
2021 American Transplant Congress
Single Cell RNAq-seq Analysis of Paired Peripheral and Intragraft T Cells Reveals Biopsy Specific Fc Receptor Gene Expression in Rejection Only
A. Malone, A. Leckie-Harre, I. Silverman, A. Chadha, H. Wu, B. Humphreys
Washington University School of Medicine, St Louis, MO
*Purpose: Antibody mediated rejection (AMR) remains one of the major causes of allograft failure and our understanding of this disease process is poor. Transcriptomics studies…
2021 American Transplant Congress
Molecular Classifiers for Chronic Lung Allograft Dysfunction Transbronchial and Mucosal Biopsies Predict Clinical CLAD and Graft Loss
M. D. Parkes¹, P. F. Halloran², K. M. Halloran³, &. the INTERLUNG Study Group⁴
¹Alberta Transplant Applied Genomics Centre, Edmonton AB, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³University of Alberta, Edmonton AB, AB, Canada, ⁴., ., AB, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) portends poor outcomes yet is poorly understood. In the multi-center INTERLUNG study we measured transcripts in transbronchial biopsies (TBBs)…
2021 American Transplant Congress
HTFPI.hCD47 and Adhesion Inhibition in GTKO.hCD46 Pig Lung Xenograft Injury
S. Miura¹, L. Burdorf¹, Z. Habibabady¹, A. Dandro², M. Connolly¹, S. Pratts¹, C. Phelps², W. Eyestone², D. Ayares², A. Azimzadeh¹, R. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Charlestown, MA, ²Revivicor, Inc, Blacksburg, VA
*Purpose: We evaluate whether genetic expression of human tissue factor pathway inhibitor (TFPI, extrinsic coagulation pathway inhibitor) and human CD47 ("don’t eat me" immunoregulator), alone…
2021 American Transplant Congress
A Multimodal Interrogation of Human Renal Allografts
D. Dadhania¹, R. Ding¹, H. Xu², C. Lee¹, C. Snopkowski¹, T. Salinas¹, T. Muthukumar¹, J. Lee¹, R. Woodward², M. Grskovic², S. Dholakia², M. Suthanthiran¹
¹Weill Cornell Medicine - NYPH, New York, NY, ²CareDx, New York, NY
*Purpose: Development and validation of noninvasive biomarkers of kidney allograft rejection should improve transplant outcomes. CTOT-04 study validated urinary cell mRNA signature (CTOT04-Sig) for T-cell…
2021 American Transplant Congress
Single-cell Rna Sequencing of Latent Murine Cytomegalovirus Infected Lung Transplants
L. A. VanOsdol¹, S. Han¹, M. Kandpul², J. J. Wang¹, L. Qiu³, Z. J. Zhang¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Department of Surgery, Northwestern University, Chicago, IL, ³School of Medicine, University of California, San Fransisco, San Fransisco, CA
*Purpose: Analyze the transcriptomics of mouse lung cells with and without latent infection of cytomegalovirus (CMV) before and after transplantation and identify key cell types…
2021 American Transplant Congress
Clinical and Molecular Profiling Can Help in Predicting the Response to Alemtuzumab Treatment in Kidney Transplant Recipients with Severe or Glucocorticoid-Resistant Acute Rejection
D. M. Peelen¹, M. van der Zwan¹, M. C. Clahsen-van Groningen², D. A. Mustafa², C. C. Baan¹, D. A. Hesselink¹
¹Internal Medicine - Nephrology & Transplantation, Erasmus MC, Rotterdam, Netherlands, ²Pathology, Erasmus MC, Rotterdam, Netherlands
*Purpose: Alemtuzumab is an effective drug for the treatment of severe or glucocorticoid-resistant acute kidney allograft rejection (AR), but can also cause severe adverse events.…
2021 American Transplant Congress
Gene Expression Profiles Assessed by the Nanostring nCounter® Platform May Differentiate Different Types of Rejection, and Importantly, T-Cell Mediated Rejection from BK Virus Nephropathy
K. R. Degner¹, K. J. Swanson¹, S. Parajuli¹, D. Mandelbrot¹, N. Garg¹, F. Aziz¹, M. Mohamed¹, W. Zhong¹, L. Ptak¹, N. A. Wilson¹, R. Woodward², A. Djamali¹
¹University of Wisconsin, Madison, WI, ²CareDx, Inc., San Francisco, CA
*Purpose: Allograft biopsies are considered the gold standard for diagnosis and therapeutic guidance in kidney transplant recipients. Expanding current biopsy assessments to include gene expression…

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