Articles tagged "Gene expression"

2021 American Transplant Congress
Dysregulation of Immune Cell Glycolysis and Oxidative Phosphorylation Correlates with Development of Pre-liver Transplant Immune Dysfunction and Post-transplant Mortality
G. Panayotova¹, L. Jin¹, A. Lemenze¹, S. Simonishvili¹, Y. Qin¹, L. Minze², G. Dikdan¹, F. Paterno¹, X. C. Li², M. Ghobrial², J. V. Guarrera¹, K. E. Lunsford¹
¹Transplant Surgery, Rutgers NJMS, Newark, NJ, ²Transplant Surgery, Houston Methodist Hospital, Houston, TX
*Purpose: Cirrhosis-related immune dysfunction contributes to early morbidity and mortality following liver transplant (LT). We have previously identified a pre-LT biomarker panel, the immune frailty…
2021 American Transplant Congress
Life-supporting Multi-gene Cardiac Xenografts From Swine Demonstrate Survival >8 Months and Preclinical Efficacy for Human Clinical Trials
C. Goerlich¹, B. Griffith¹, A. Singh¹, T. Zhang¹, I. Tatarov¹, B. Lewis¹, F. Sentz¹, A. Hershfeld¹, P. Odonkor¹, B. Williams¹, E. Strauss¹, A. Tabatabai², A. Bhutta³, D. Ayares⁴, D. Kaczorowski¹, M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Department of Medicine, Division of Pulmonary and Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, ³Pediatrics, Pediatric Critical Care Medicine, University of Maryland School of Medicine, Baltimore, MD, ⁴Revivicor, Inc., Blacksburg, VA
*Purpose: Cardiac xenotransplantation has been proposed to bridge the gap in organ shortage for those in end-stage heart failure without the opportunity to receive a…
2021 American Transplant Congress
Initial Experience with Trugraf^Tm Gene Expression Profile and Trac^Tm Dd-cfdna Testing in Kidney Transplant Recipients Suggests Synergy and Enhanced Management within the First Year Post-transplant and Beyond
V. Paramasivam, B. Greco, M. Germain
Nephrology, Baystate Medical Center, Springfield, MA
*Purpose: Non-invasive validated rejection biomarkers are now available to monitor kidney transplant patients (KTRs). Two such biomarkers are; TruGrafTM (TG) gene expression profile validated to…
2021 American Transplant Congress
Laminin Alpha 4 and Alpha5 Differentially Regulate Lymph Node Tolerogenic Structure
L. Li¹, M. Shirkey¹, W. Piao¹, Y. Xiong¹, V. Saxena¹, T. Zhang¹, J. Iyyathurai², R. Lakhan¹, R. Abdi³, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²CVID, UMB, Baltimore, MD, ³Harvard University, Boston, MD
*Purpose: Lymph node (LN) stromal laminins α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We hypothesized that stromal Lama4 and Lama5…
2021 American Transplant Congress
Analysis of Single Cell RNA Sequencing Data to Define Biomarkers of Human Liver Immune Tolerance
B. Rocque¹, A. Barbetta¹, P. Singh¹, C. Goldbeck¹, D. G. Helou², E. Loh³, N. Ung⁴, J. S. Lee⁴, O. Akbari², J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Molecular Microbiology and Immunology, University of Southern California, Los Angeles, CA, ³Norris Medical Library, University of Southern California Keck School of Medicine, Los Angeles, CA, ⁴Ellison Institute, University of Southern California, Los Angeles, CA
*Purpose: The liver is unique in its ability to maintain immune homeostasis and promote operational tolerance following solid organ transplantation. Single-cell RNA sequencing (scRNA seq)…
2021 American Transplant Congress
Digital Spatial Mrna Profiling Reveals Distinct Endothelial Transcripts in Dsa+ and Dsa- Endarteritis in Kidney Allografts
K. Tomaszewski¹, M. Araujo Medina¹, A. Bruce¹, P. Divakar², R. Smith¹, T. Kawai³, R. Colvin¹, I. Rosales¹
¹Department of Pathology, Massachusetts General Hospital, Boston, MA, ²NanoString Technologies, Inc., Seattle, WA, ³Department of Surgery, Massachusetts General Hospital, Boston, MA
*Purpose: Renal allograft biopsy transcript analysis is typically performed by microarray, which lacks spatial resolution. We initiated a systematic program using the NanoString GeoMx® Digital…
2021 American Transplant Congress
Nonadherence Post-kidney Transplant is Associated with Increased Immune Activation Detected by Peripheral Blood Gene Expression Assay
N. Singh¹, A. Palermini¹, M. S. Naseer¹, T. Le¹, S. Tandukar¹, D. Aultman², H. Shokouh-Amiri², G. Zibari²
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Nonadherence to immunosuppression medications is common post-transplantation. We hypothesize that nonadherence results in a heightened alloimmune response in kidney transplant recipients (KTRs) which in…
2021 American Transplant Congress
Molecular Assessment of Fibrosis and Steatohepatitis in the INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran¹, &. the INTERLIVER Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We previously reported a molecular system for assessing rejection in liver transplants and recently expanded this system to assess injury. Fibrosis is associated with…
2021 American Transplant Congress
Trugraf Gene Expression Testing Can Discriminate Rejection in the Setting of Acute Kidney Injury
N. Singh¹, M. S. Naseer¹, D. Aultman², H. Shokouh-Amiri², G. Zibari²
¹Nephrology, John C. McDonald Regional Transplant Center - Willis Knighton Medical Center, Shreveport, LA, ²Advanced Surgery, John C. McDonald Regional Transplant Center - Willis Knighton Medical Center, Shreveport, LA
*Purpose: The TruGraf kidney blood gene expression test is a well-validated non-invasive biomarker to detect immune quiescence thus ruling out silent subclinical rejection in stable…
2021 American Transplant Congress
Single Cell Analysis of Living Donor Kidneys Reveals Sex-based Diversity in Proximal Tubulargene Expression
C. M. McEvoy¹, J. M. Szusz², S. Clotet-Freixas¹, J. An², S. MacParland², G. Bader³, S. Q. Crome², A. Konvalinka¹
¹Ajmera Transplant Centre, Toronto General Hospital Research Institute, Toronto, ON, Canada, ²Immunology and Molecular Genetics, University of Toronto, Toronto General Hospital Research Institute, Toronto, ON, Canada, ³Donnolly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, ON, Canada
*Purpose: Males with chronic kidney disease (CKD) experience a more rapid decline in kidney function and progression to end-stage kidney disease than females. In vitro…

« Previous Page
1
…
5
6
7
8
9
…
36
Next Page »