Articles tagged "Gene expression"

2015 American Transplant Congress
The Onset of Post-Transplant Malignancies Is Related to a Change in Gene Expression Profiles in Peripheral Blood Mononuclear Cells
G. Stallone,¹ R. Federica,¹ P. Pontrelli,² M. Accetturo,² A. Oranger,² M. Gigante,² G. Castellano,² A. Schena,² M. Fiorentino,² B. Infante,¹ L. Gesualdo,² G. Grandaliano.¹
¹Dept.of Surgical and Medical Sciences, Nephrology Unit, University of Foggia, Foggia, Italy; ²Dept. of Emergency and Organ Transplantation, Nephrology Unit, University of Bari, Bari, Italy.
Malignancies are the third leading cause of death in renal transplant recipients and their incidence is increasing. Although the role of the immune system in…
2015 American Transplant Congress
DNA Methytransferase 1 Inhibition Potently Suppresses T Cell Cycle Progression Through Demethylation of the Key Cell Cycle Inhibitors p15, p16, p21 and p27
T. Ma, Y. Pei, R. Tao.
Department of Hepatobiliary-Pancreatic Surgery, Zhejiang Provincial Peoples' Hospital, Hangzhou, Zhejiang Province, China.
Background: Epigenetic mechanisms like acetylation and methylation have been gradually appreciated to play a critical role in the generation and function of various immune cells.…
2015 American Transplant Congress
The Role of Inflammasome Components in Renal Tubular Epithelial Cell Injury
S. Kasimsetty, A. Shigeoka, D. McKay.
Medicine, UCSD, La Jolla, CA.
Background:Inflammasomes are multiprotein complexes of pattern recognition receptors (PRRs) recognized as key triggers of cellular injury. TLRs provide the first signal for induction of the…
2015 American Transplant Congress
Gene Expression Monitoring in Pediatric Heart Transplant Recipients
C. Sutton,¹ R. Butts,² A. Burnette,³ A. Savage,² W. Uber,¹ A. Haney.¹
¹Pharmacy, Medical University of South Carolina, Charleston, SC; ²Pediatric Cardiology, Medical University of South Carolina, Charleston, SC; ³Pediatric Heart Transplant, Medical University of South Carolina, Charleston, SC.
Allomap® gene expression testing is a non-invasive screening tool approved for use in heart transplant recipients age 15 and older. Experience with Allomap® in pediatric…
2015 American Transplant Congress
Clusterin-Regulated Transcriptome in the Kidney During Ischemia-Reperfusion
G. Dairi, Q. Guan, A. Haegert, C. Collins, M. Gleave, C. Nguan, C. Du.
Department of Urological Sciences, Vancouver, Canada; The University of British Columbia, Vancouver, Canada; Immunity and Infection Research Centre, Vancouver, Canada; Vancouver Coastal Health Research Institute, Vancouver, Canada.
BACKGROUND: Ischemia-reperfusion injury (IRI) has a significate impact on both short and long-term transplant outcomes, and is a major cause of delayed graft function in…
2015 American Transplant Congress
Liver Allografts from Living Donors Demonstrate High Expression of Hepatic Functional Genes Compared With Deceased Donors
R. Gehrau,¹ J. Suh,¹ K. Brayman,¹ S. Rasmussen,¹ C. Dumur,² V. Mas,¹ D. Maluf.¹
¹Surgery, UVA, Charlottesville, VA; ²Pathology, VCU, Richmond, VA.
Background: Donor shortage motivated alternative practices including living donor liver transplantation (LTx). This study aimed to identify molecular profiles and characteristics in living donor versus…
2015 American Transplant Congress
NFAT Regulated Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Recipients
V. Tatapudi, A. Webber, C. Leung, F. Vincenti.
Div. of Nephrology, Dept. of Medicine, University of California, San Francisco Medical Center, San Francisco, CA.
Purpose of Study:To demonstrate that profiling kidney transplant recipients (KTR) on Tacrolimus (Tac) based immunosuppression based on quantitative analysis of NFAT (nuclear factor of activated…