Articles tagged "Gene expression"

2015 American Transplant Congress
Late Antibody-Mediated Rejection in a Large Cross-Sectional Cohort of Kidney Transplant Recipients – Results of the Screening Phase of the BORTEJECT Study
F. Eskandary,¹ G. Bond,¹ H. Regele,² N. Kozakowski,² Z. Kikic,¹ M. Wahrmann,¹ H. Haslacher,³ R. Oberbauer,¹ V. Ramassar,⁴ P. Halloran,⁴ G. Böhmig.¹
¹Nephrology and Dialysis, Medical University Vienna, Vienna, Austria; ²Clinical Institute of Pathology, Medical University Vienna, Vienna, Austria; ³Department of Laboratory Medicine, Medical University Vienna, Vienna, Austria; ⁴4Division of Nephrology and Transplant Immunology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Antibody-mediated rejection (ABMR) is well established to be a leading cause of graft failure. Here, we investigated the prevalence of late ABMR in a large…
2015 American Transplant Congress
Interrogation of Plasma Cell-Rich Acute Rejection in Human Kidney Allografts by Whole Transcriptome Sequencing
L. Mesnard, F. Campagne, H. Yang, D. Dadhania, J. Lee, S. Seshan, M. Suthanthiran, T. Muthukumar.
Weill Medical College of Cornell University, New York.
Plasma cell-rich acute rejection (PCRAR, plasma cells constituting >20% of the allograft infiltrating cells) portends poor prognosis.To gain better mechanistic insights and develop diagnostic biomarkers,…
2015 American Transplant Congress
Pre-Trasplant Perfusion With Mesenchymal Stromal Cells of Renal Graft Prevents Ischemia Injury Upregulating Gene Involved in Energy Saving
V. Corradetti,¹ S. Milanesi,¹ E. Pattonieri,¹ C. Rocca,¹ T. Valsania,¹ M. Gregorini,¹ L. De Cecco,² I. Benzoni,³ C. Bianco,³ M. Avanzini,⁴ M. Maestri,³ P. Esposito,¹ T. Rampino,¹ A. Dal Canton.
¹Unit of Nephrology, Dialysis and Transplantation, IRCCS Fondazione Policlinico San Matteo And University of Pavia, Pavia, Italy; ²Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy; ³Unit of General Surgery, IRCCS Fondazione Policlinico San Matteo And University of Pavia, Pavia, Italy; ⁴Cell Factory Pediatric Oncohaematology, IRCCS Fondazione Policlinico San Matteo, Pavia, Italy.
Background. Kidney ischemia from Donation after Circulatory Death shifts cells to anaerobic metabolism. Mesenchymal Stromal Cells (MSC) have immunomodulatory properties that are mediated by soluble…
2015 American Transplant Congress
Hepatocyte-Related miR-193a-3p Is Over-Expressed in Allograft Biopsy from Liver Tolerant Recipients
R. Danger, J. Lozano, E. Bonaccorsi-Riani, E. Kodela, R. Mas-Malavila, M.-C. Londono, M. Martinez, A. Rimola, M. Martinez-Llordella, A. Sanchez-Fueyo.
Department of Liver Sciences, Faculty of Life Sciences & Medicine, MRC Transplant Centre, King's College London, London, United Kingdom; Liver Unit and Bioinformatic Platform, IDIBAPS, University of Barcelona and Hospital Clinic Barcelona, Barcelona, Spain.
While liver transplantation is the treatment of choice for end-stage liver diseases, its success is compromised by the need to administer life-long immunosuppression, which negatively…
2015 American Transplant Congress
Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients
C. Dorr,¹ B. Wu,² W. Guan,² A. Muthusamy,¹ K. Sanghavi,³ P. Jacobson,³ W. Oetting,³ D. Schladt,¹ R. Remmel,³ J. Maltzman,⁵ A. Matas,⁴ For DeKAF Genomics Investigators,¹ A. Israni.¹
¹Medicine, MMRF, HCMC, Minneapolis, MN; ²Biostatistics, University of MN, Minneapolis, MN; ³Pharmacy, University of MN, Minneapolis, MN; ⁴Surgery, University of MN, Minneapolis, MN; ⁵Medicine, University of PA, Philadelphia, PA.
Introduction: In our effort to personalize immunosuppressive therapies we performed RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) after kidney transplant (tx) and the…
2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
D. Baron,^1,2,3 G. Ramstein,⁴ M. Chesneau,^1,2,3 Y. Echasseriau,^1,2,3 A. Pallier,^1,2,3 C. Paul,^1,2,3 N. Degauque,^1,2,3 M. Hernandez-Fuentes,⁵ A. Sanchez-Fueyo,⁶ K. Newell,⁷ M. Giral,^1,2,3 J.-P. Soulillou,^1,2,3 R. Houlgatte,^8,9 S. Brouard.^1,2,3
¹UMR 1064 - CRTI, INSERM, Nantes, Loire Atlantique (44), France; ²ITUN, CHU de Nantes, Nantes, Loire Atlantique (44), France; ³Faculté de Médecine, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁴UMR 6241 - LINA, Université de Nantes, Nantes, Loire Atlantique (44), France; ⁵MRC Centre for Transplantation, King's College London, London, United Kingdom; ⁶Institute of Liver Studies, King's College Hospital, London, United Kingdom; ⁷Department of Surgery, Emory University, Atlanta, GA; ⁸U954 - LNGERE, INSERM, Nancy, France; ⁹DRCI, CHU de Nancy, Nancy, France.
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…
2015 American Transplant Congress
Gene Expression of Kidney Biopsies Reveals Common Mechanisms of Rejection and a Cluster of Co-Expressed Genes Predictive of Long-term Outcomes
B. Modena,¹ S. Kurian,¹ J. Friedewald,² F. Harrison,¹ T. Gelbart,¹ S. Head,¹ M. Abecassis,² D. Salomon.¹
¹The Scripps Research Institute, La Jolla; ²Northwestern University, Chicago.
Purpose: Acute rejection (AR) still affects 8-14% of kidney transplants and rates of 10-year graft loss remain unchanged in part due to chronic rejection (CR).…