2015 American Transplant Congress
Distinct Clinical Relevance of BAFF Expression Within the Kidney Graft and Soluble BAFF Serum Levels Indicate Confined Alloimmune Responses Disconnected from the Periphery
As soluble B-cell activating factor (BAFF) serum levels (sBAFF) may not reflect BAFF concentrations within the graft, what could be related to the inconsistencies in…2015 American Transplant Congress
Small RNA Sequencing-Enabled Discovery of Circulating Extracellular MicroRNAs as Noninvasive Biomarkers of Liver Allograft Status
1Weill Cornell Medical Center, New York; 2Rockefeller University, New York.
MicroRNAs are ideal candidates as blood-based biomarkers. Comprehensive profiling of microRNAs is challenging. We overcame the existing challenges by developing robust protocols for isolation of…2015 American Transplant Congress
DNA Methylation of the IFNγ Promoter in CD8+ T Cell Subsets Is Modulated by CMV Infection but not by Alloreactivity in Kidney Transplantation Patients
Introduction DNA methylation plays a critical role in the function of cells, including cells of the immune system. Little is known about the methylation status…2015 American Transplant Congress
Constitutively Upregulated Expression of Complement and Matrix Transcripts in Kidney Transplant Recipients Who Develop Acute Rejection
Identification of kidney transplants at elevated risk of acute rejection (AR) and/or chronic injury prior to loss of kidney function (GFR) could guide therapies to…2015 American Transplant Congress
Differentially Expressed IL-6Rα and GP130 Genes in Kidney Biopsies (Bxs) Suggests Different Roles of IL-6 Signaling in Antibody (ABMR)- and Cell (CMR)-Mediated Rejection
Background: IL-6 exerts immunoregulatory properties through IL-6 receptors, IL-6Rα and gp130. Our previous studies suggested the involvement of antibody-dependent cellular cytotoxicity (ADCC) and its related…2015 American Transplant Congress
Normothemic Machine Perfusion of Liver Grafts Promotes Liver Regeneration and Inhibits Tissue Inflammation
Background & aim: liver transplantation I/R injury is associated with inflammation, affecting graft outcome. Ex-vivo normothermic machine perfusion (NMP) to donor livers before transplantation reduces…2015 American Transplant Congress
OX40 Gene: A Potential Target for the Care of Chronic T-Cell Mediated Rejection (TCMR)
Introduction:TCMR is characterized by the reduction of vessel lumen with marked intimal thickening, fibrous hyperplasia and a strong component of leukocyte infiltrate. Aim of our…2015 American Transplant Congress
Epigenetic Reprogramming of Murine Cytomegalovirus Immediate Early Genes Induced By Renal Transplantation
Background: Reactivation of latent CMV is a significant infectious complication in solid organ transplant recipients. MCMV is a valuable model for studying molecular mechanisms controlling…2015 American Transplant Congress
IFNγ Is Required for nTreg Afferent Lymphatic Migration
Surgery, University of Maryland, Baltimore, MD.
Background: Natural Treg (nTreg) must migrate from graft to draining lymph node (LN) to prolong islet allograft survival, and we previously showed that the transcription…2015 American Transplant Congress
Molecular Features of Isolated Arteriolar Hyalinosis in Renal Transplant Biopsies
Background: Arteriolar hyalinosis (ah) is characterized by deposition of hyaline material in the vascular wall that may be caused by different insults including diabetes, hypertension…
American Transplant Congress abstracts