2015 American Transplant Congress
Differentially Expressed Genes in Immunosuppressed Kidney Transplant Recipients
Introduction: In our effort to personalize immunosuppressive therapies we performed RNA sequencing (RNAseq) to identify differentially expressed genes (DEGs) after kidney transplant (tx) and the…2015 American Transplant Congress
A Common Gene Signature Across Multiple Studies Identifies Biomarkers and Functional Regulation in Tolerance to Renal Allograft
Patients tolerant to a kidney graft display a specific blood transcriptional pattern but reported results from five distinct studies hardly overlapped, raising the question of…2015 American Transplant Congress
Gene Expression of Kidney Biopsies Reveals Common Mechanisms of Rejection and a Cluster of Co-Expressed Genes Predictive of Long-term Outcomes
1The Scripps Research Institute, La Jolla; 2Northwestern University, Chicago.
Purpose: Acute rejection (AR) still affects 8-14% of kidney transplants and rates of 10-year graft loss remain unchanged in part due to chronic rejection (CR).…2015 American Transplant Congress
The Forgotten Cell: Renal Fibroblasts Are Activated By Anti-MHC Class I Antibody
Medicine and Surgery, University of Alabama at Birmingham, Birmingham, AL.
Chronic antibody-mediated (CAMR) rejection remains a major obstacle in the long term survival of kidney transplants, and is associated in part with interstitial fibrosis (IF)…2015 American Transplant Congress
Perturbation of Polyomavirus Nephropathy-Specific Gene Expression in Kidney Allografts
Polyomavirus nephropathy (PVAN) is a common cause of kidney allograft dysfunction and loss. Microscopic observations of PVAN are similar to T-cell mediated rejection (TCMR), with…2015 American Transplant Congress
Structure/Function Insights Into Treg Biology: Hdac11 Is a Foxp3 Deacetylase Whose Targeting Promotes and Stabilizes Foxp3 Expression and Leads to Long-Term Allograft Survival
1CHOP & UPenn, Philadelphia; 2Uni of Illinois at Chicago, Chicago.
Aim: There are huge scientific, economic and practical advantages in developing pharmacologic approaches to enhance Foxp3+ Treg function in allograft recipients versus simply injecting enormous…2015 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Enables Accurate Discrimination of Acute Rejection in Kidney Transplant Patients
A common rejection module (CRM) consisting of 11 genes expressed on allograft biopsies was recently shown to be highly accurate to discriminate patients undergoing acute…2015 American Transplant Congress
Increased Cytotoxic and Regulatory T Cell and B Cell Associated Gene Transcripts in Transplant Kidney Biopsies With Non-Specific IFTA and Interstitial Inflammation
Background: Patients with non –specific interstitial fibrosis/tubular atrophy (IFTA) have lower graft survival if their biopsies have interstitial inflammation, described as “ i” in Banff…2015 American Transplant Congress
Blood Gene Expression at 3 Months Post-Transplantation Predicts 1-Year Histological Features in Renal Transplantation
Histological analysis of biopsy at one year is proposed as a reliable tool for assessing renal allograft status, however, a non-invasive method for early prediction…2015 American Transplant Congress
Blood Gene Expression Profiling in a Randomized Controlled Trial of rATG Vs. IL2RA Induction Reveals the Differences in Immune Impact and Mechanisms
1MUSC, Charleston, SC; 2Scripps Research Institute, La Jolla, CA.
We performed global gene expression profiling using microarrays on samples from a prospective, RCT designed to study the safety & efficacy of induction with antithymocyte…
American Transplant Congress abstracts