Articles tagged "Gene expression"

2016 American Transplant Congress
Marked Alterations in Gene Expression in Peripheral Blood Leukocytes of Kidney Transplant (tx) Recipients Following Mycophenolic Acid (MPA) Treatment.
K. Sanghavi,¹ B. Wu,¹ C. Dorr,² A. Muthuswamy,² W. Guan,¹ D. Schladt,² R. Remmel,¹ D. Ilke,³ A. Matas,¹ A. Israni,² W. Oetting,¹ P. Jacobson.¹
¹University of Minnestoa, Minneapolis; ²MMRC, Hennepin County Medical Center, Minneapolis; ³Rho.
MPA exerts its immunosuppressive activity by inhibiting IMPDH2 enzyme, halting DNA synthesis in T and B lymphocytes. Cell culture models have shown MPA effects on…
2016 American Transplant Congress
Molecular Assessment of Kidney Transplant Biopsies Performs Similarly in Medulla and Cortex.
K. Madill-Thomsen,¹ J. Reeve,¹ G. Bohmig,² F. Eskandary,² P. Halloran.^1,3
¹Alberta Transplant Applied Genomics Center, Edmonton, AB, Canada; ²Department of Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ³Department of Medicine, Division of Nephrology and Transplant Immunology, University of Alberta, Edmonton, AB, Canada.
Histologic assessment of kidney biopsies is usually unable to interpret medulla, but molecular changes associated with rejection likely occur in both medulla and cortex. Analysis…
2016 American Transplant Congress
Gene Expression Levels of Advanced Heart Failure Patients in Terms of Coagulation and Its Effect within Multiple Organ Dysfunction Syndrome.
R. Togashi, E. Chang, N. Wisniewski, M. Cadeiras, G. Bondar, E. Reed, M. Deng.
Medicine Cardiology, UCLA, Los Angeles, CA.
MOD is progressive organ failure amongst 2 or more organs. Innate-immunity/inflammation-related coagulopathies can cause disseminated clotting in vasculature leading to organ failure. Purpose is to…
2016 American Transplant Congress
Serial Peripheral Blood Mononuclear Cell Expression Profiling Reveals Inflammatory Genomic Storm Following Mechanical Circulatory Support Surgery.
G. Godoy,¹ G. Bondar,¹ A. Esmaeili,¹ E. Arellano,¹ E. Chang,¹ M. Bakir,¹ J. Chittoor,¹ R. Togashi,¹ N. Fazli,¹ C. Starling,¹ E. Oh,¹ S. Toluie,¹ Z. Yang,² D. Tran,¹ M. Cadeiras,¹ N. Wisniewski,¹ M. Kwon,¹ J. Schaenman,¹ Y. Korin,¹ M. Rosetti,¹ E. Reed,¹ M. Deng.¹
¹University of California, Los Angeles, Los Angeles, CA; ²Shanxi Medical University First Hospital, Taiyuan, Shanxi, China.
Introduction: The main cause of death in patients with Advanced Heart Failure (AdHF) is the Multi-Organ Dysfunction (MOD) Syndrome. Immune system aberrancy after Mechanical Circulatory…
2016 American Transplant Congress
Molecular Profiles of Renal Allograft Rejection.
Z. Hajjiri, P. Finn, D. Perkins.
Internal Medicine/Renal Medicine, University of Illinois at Chicago, Chicago, Il.
Introduction: The gold standard for the diagnosis of allograft rejection is the Banff Classification, yet it shows substantial variability among pathologists. Using molecular signatures of…
2016 American Transplant Congress
Gene Expression Profiling Score and the Risk of Infection in Heart Transplant Recipients.
J. Teuteberg,¹ D. Budge,² M. Shullo,¹ S. Hall,³ J. Kobashigawa.⁴
¹University of Pittsburg, Pittsburgh, PA; ²Intermountain Medical Center, South Lake City, UT; ³Baylor University Medical Center, Dallas, TX; ⁴Cedars-Sinai Heart Institute, Los Angeles, CA.
Purpose: This study assessed the association of gene expression profiling (GEP, AlloMap®) score with infections in heart transplant recipients (HTR). Although a GEP score below…
2016 American Transplant Congress
A New Diagnostic Score for Microvascular Inflammation in Antibody-Mediated Rejection in Heart Transplantation.
M. Racapé,¹ A. Loupy,² R. Guillemain,¹ A. François,³ P. Rouvier,⁴ C. Toquet,⁵ X. Jouven,¹ J. Venner,⁶ L. Hidalgo,⁶ J. Reeve,⁶ P. Bruneval,¹ J. Duong Van Huyen,² P. Halloran.²
¹European Georges Pompidou Hospital, Paris, France; ²Necker Hospital, Paris, France; ³Rouen University Hospital, Rouen, France; ⁴La Pitié Salpêtrière Hospital, Paris, France; ⁵Laennec Hospital, Nantes, France; ⁶University of Alberta, Edmonton, Canada.
BackgroundThe ISHLT working formulation defines Intravascular Activated Mononuclear Cells (IAMC) as one of the histopathologic features of antibody-mediated rejection (ABMR) in heart transplantation. However, no…
2016 American Transplant Congress
mRNA Expression of BAFF and APRIL Receptors Increases in Acute Rejection in Kidney Transplant Recipients.
M. Minz,¹ R. Dhital,¹ R. Minz,² A. Sharma,¹ R. Nada,³ S. Singh,¹ D. Kenwar.¹
¹Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ²Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ³Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Introduction:BAFF and APRIL are known survival and growth of B- cells.BAFF and APRIL share two receptors i-TACI and ii- BCMA. Additionally, BAFF has strong affinity…
2016 American Transplant Congress
Inflammation Amplifier, a Chemokine Inducer in Non-Immune Cells in Kidney Transplantation Graft.
H. Higuchi,^1,2 H. Bando,² J. Jing-Jing,² T. Atsumi,² D. Iwami,¹ K. Morita,¹ N. Shinohara,¹ M. Murakami.²
¹Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Japan; ²Molecular Neuroimmunology, Institute of Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Introduction: Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by the simultaneous activation of NFκB and STATs (IL-17, TNFα, and IL-6)…
2016 American Transplant Congress
The Impact of Sequential Gene Modifications on Cardiac Xenograft Survival.
K. Horvath,¹ A. Singh,¹ J. Chan,¹ M. Thomas,² B. Lewis,² D. Ayares,³ P. Corcoran,¹ M. Mohiuddin.¹
¹CSRP, NHLBI/NIH, Bethesda, MD; ²DVR / ORS, NIH, Bethesda, MD; ³Revivicor, Inc, Blacksburg, VA.
Introduction: One of the major advances in xenotransplantation is the ability to modify donor pig genetics. Using rapidly evolving techniques of pig cloning and gene…