2017 American Transplant Congress
Transcript Changes Associated with Graft Rejection Are Not Specific for Rejection Because They Are Shared with Tissue Responses to Wounding.
University of Alberta, Edmonton, Canada
The diagnosis of rejection by histology is based on the presence of relatively non-specific lesions. This is because the histology lesions are actually non-specific, but…2017 American Transplant Congress
Gene Expression Signature of Subclinical Allograft Kidney ABMR Compared to Clinical ABMR.
BackgroundAntibody-mediated rejection (ABMR) is characterized by a heterogeneous presentation. It occurs in clinically stable patients (sABMR) or in patients with allograft dysfunction (ABMR), but only…2017 American Transplant Congress
Increased Pro-Inflammatory and Decreased Interferon-Related Gene Expression in Older as Compared with Younger Kidney Transplant Recipients.
David Geffen School of Medicine at UCLA, Los Angeles, CA
Older transplant recipients experience increased rates of death and infection as compared with younger patients. Our previous studies demonstrated increased frequency of terminally differentiated and…2017 American Transplant Congress
Microarray Analysis of Rejection in Formalin-Fixed Paraffin-Embedded Biopsies: Similarities and Disparities with Conventionally Stabilized Biopsies.
Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
Despite potential for performing molecular diagnostics on formalin-fixed paraffin embedded (FFPE) biopsies, there has been no systematic comparison of microarray gene expression data obtained from…2017 American Transplant Congress
MicroRNAs and Long Non-Coding RNAs as Potential Novel Biomarkers in Transplanted Patients with Candida Infection.
There is an urgent need to develop sensitive and specific biomarkers for the early diagnosis of candida infection in transplanted patients. miRNAs and lncRNAs are…2017 American Transplant Congress
CD16a-Activated NK Cells in ABMR Are Highly Similar to CD3-Activated Effector T Cells in TCMR.
University of Alberta, Edmonton, Canada
BACKGROUND: NK cell CD16a and T cell CD3 activate shared pathways. Since NK cell CD16a activation occurs in antibody-mediated rejection (ABMR) and T cell CD3…2017 American Transplant Congress
mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.
Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…2017 American Transplant Congress
Inflammation, Impaired Energy Metabolism and Synthetic Failure Characterize the Liver Transcriptome of End-Stage Idiopathic Pediatric Acute Liver Failure (PALF).
Background: PALF requiring liver transplantation (LTx) often has no known etiology, and could result from undiagnosed metabolic disorders. Mitochondrial dysfunction is common in PALF, but…2016 American Transplant Congress
NanoString Detection of Gene Signatures in Urine During Acute Cellular Rejection of Kidney Grafts.
1Cleveland Clinic, Cleveland; 2UAB, Birmingham; 3Emory, Atlanta; 4MSSM, New York.
Considerable effort has focused on identification of gene expression patterns that may assist in diagnosis of acute cellular rejection. The NanoString platform offers a novel…2016 American Transplant Congress
ESM1 Gene Promotes Hepatocyte Proliferation Through NF-κB Signal Pathway.
BACKGROUND: Effective and timely liver regeneration is pivotal in the prevention of fetal small-for-size syndrome after living donor liver transplantation or split liver transplantation. Our…
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