ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Gene expression"

  • 2017 American Transplant Congress

    Identification of Novel Diagnostic Biomarkers in Liver Transplantation Tolerance.

    G.-Q. Shen,1 M. Morita,1 C. Miller,1 K. Hashimoto,1 L. Lu,1 S. Qian,1 J. Fung.2

    1Cleveland Clinic, Cleveland; 2University of Chicago, Chicago

    Current success in liver transplantation (LTX) relies on life-time administration of non-specific immunosuppressive drugs, leaving patients prone to infection and cancer. Previous reports indicated about…
  • 2017 American Transplant Congress

    Routine Surveillance of Heart Transplant Recipients with Gene Expression Profiling: Lack of an Impact of Race on Outcomes.

    J. Teuteberg,1 M. Shullo,1 D. Rinde-Hoffman,2 M. Wigger,3 Y. Wang,4 T. Wolf,4 P. Arnold,4 J. Sninsky,4 P. Berman.2

    1University of Pittsburgh Medical Center, Pittsburgh, PA; 2Tampa General Hospital, Tampa, FL; 3Vanderbilt Heart and Vascular Institution, Nashville, TN; 4CareDx, Brisbane, CA

    Purpose: Patients of African descent have been reported to have less favorable outcomes after heart transplantation than patients of European descent. However, the impact of…
  • 2017 American Transplant Congress

    Molecular Analysis of Acute Rejection in Formalin-Fixed Paraffin-Embedded Clinical Face Transplant Biopsies.

    T. Win,1 B. Dyring-Andersen,1 V. Barrera,2 S. Ho Sui,2 R. Lopdrup,1 H. Kiwanuka,1 N. Murakami,1 J. Teague,1 E. Lowry,1 E. Bueno,1 A. Chandraker,1 L. Riella,1 B. Pomahac,1 R. Clark.1

    1Brigham and Women's Hospital, Boston, MA; 2Harvard T.H. Chan School of Publich Health, Boston

    BackgroundDiagnosis of acute rejection in face transplants relies on the histological evaluation of allograft skin biopsies using BANFF classification, an approach with significant limitations including…
  • 2017 American Transplant Congress

    Quantitative Gene Expression Analysis of CRM-Panel Genes Using FFPE Kidney Tissues for Transplant Injuries.

    T. Sigdel, M. Nguyen, D. Dobi, S.-C. Hsieh, J. Liberto, F. Vincenti, M. Sarwal, Z. Laszik.

    University of California San Francisco, San Francisco

    Background: A common immune response module (CRM) of 11 genes was identified to define acute rejection (AR) through meta-analyses of 1030 different engrafted tissues including…
  • 2017 American Transplant Congress

    A Composite Score Associated with Spontaneous Operational Tolerance in Kidney Transplant Recipients.

    R. Danger,1 M. Chesneau,1 C. Paul,1 P. Guérif,1 M. Durand,1 K. Newell,2 S. Kanaparthi,3 L. Turka,4 J.-P. Soulillou,1 R. Houlgatte,5 M. Giral,1,6 G. Ramstein,7 S. Brouard.1,6

    1Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, Université de Nantes, Institut de Transplantation Urologie Néphrologie (ITUN), CHU Nantes, Nantes, France; 2Department of Surgery, Emory University, Atlanta, GA; 3Immune Tolerance Network, Bethesda, MD; 4Center for Transplantation Sciences, Department of Surgery, Massachusetts General Hospital and Harvard Medical School, Boston, MA; 5INSERM UMR 954,CHU de Nancy, DRCI, Nancy, France; 6CIC Biotherapy, CHU Nantes, Nantes, France; 7LINA DUKe, UMR 6241, Université de Nantes, Ecole des Mines de Nantes & CNRS, Nantes, France

    New challenges in renal transplantation include using biological information to devise a useful clinical test for discerning high- and low-risk patients for individual therapy and…
  • 2017 American Transplant Congress

    Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection.

    A. Loupy,1 J. Duong Van-Huyen,1 L. Hidalgo,2 J. Reeve,2 M. Racapé,1 O. Aubert,1 J. Venner,2 D. Viglietti,1 P. Bruneval,1 C. Lefaucheur,1 P. Halloran.2

    1Paris Translational Research Center for Organ Transplantation, Paris, France; 2University of Alberta, Edmonton, Canada

    Antibody-mediated rejection (AMR) is a major determinant of heart allograft loss. However, the specific effects of anti-HLA antibodies on heart allograft injury have not been…
  • 2017 American Transplant Congress

    Novel Therapies for Diabetic Kidney Disease.

    M. Nguyen, K. Kodama, M. Sarwal.

    University of California, San Francisco, San Francisco, CA

    Introduction: The development and progression of diabetic kidney disease (DKD) is thought to involve a combination of hemodynamic, metabolic, ischemic, and inflammatory factors; however, the…
  • 2017 American Transplant Congress

    Experimental Study of Hepatocyte Proliferation Regulated by miR26a.

    J. Zhou, X. Yuan, W. Ju, X. Jiao, D. Wang, X. Zhu, X. He.

    Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Objective To investigate mechanisms of regulation on hepatocyte proliferation by miRNAs. Methods Normal hepatocyte in ivtro was transfected with vectors harboring Ad5/anti-miR26a or Ad5/miR26a, and…
  • 2016 American Transplant Congress

    Effect of Complement Inhibition Therapy (Eculizumab) in Patients with C1q-Binding Donor-Specific Anti-HLA Antibodies: A Molecular Appraisal.

    C. Lefaucheur,1 L. Hidalgo,2 J. Reeve,2 D. Viglietti,1 C. Gosset,1 O. Aubert,3 C. Ulloa,3 C. Legendre,3 D. Glotz,1 P. Halloran,2 A. Loupy.3

    1Saint-Louis Hospital, Paris, France; 2University of Alberta, Edmonton, Canada; 3Necker Hospital, Paris, France.

    Complement-binding anti-HLA DSA have demonstrated higher rejection rate and decreased allograft outcome. We investigated the effect of terminal complement inhibition (Eculizumab) in a cohort of…
  • 2016 American Transplant Congress

    Assessment of Molecular Mechanisms of Non-Transplant Cardiac Hypertrophy in Cardiac Allograft Hypertrophy – An Exploratory Gene Array Study of Myocardial Biopsy Samples.

    R. Araujo-Gutiérrez,1,2 S. Ibarra-Cortez,1,2 M. Park,1 J. Estep,1 G. Ashrith,1 B. Trachtenberg,1 G. Torre-Amione,1 K. Youker,1,2 A. Bhimaraj.1

    1Houston Methodist DeBakey Heart & Vascular Center, Houston, TX; 2Houston Methodist Research Institute, Houston, TX.

    Cardiac Allograft Hypertrophy (CAH) develops in up to 80% of patients as early as six months post-transplant, and is associated with decreased quality of life…
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