2018 American Transplant Congress
Changes in Gene Expression of Selected Genes in Patient with Type 1 Diabetes in Peripheral Blood
Foundation for Research and Science Development, Warsaw, Poland.
Insulin, a main anabolic peptide hormone, regulates metabolism of carbohydrates, proteins, lipids and affects DNA synthesis or apoptosis. Lack of insulin secretion by destroyed beta…2018 American Transplant Congress
Expression of the Senescence Marker P16/INK4A in Kidney Implantation Biopsies is Uniquely Associated with Poor Late Graft Function
University of Alberta, Edmonton, Canada.
With the aging donor population, accurate assessment of tissue quality of deceased donor kidneys is required to determine the intermediate and long term graft performance,…2018 American Transplant Congress
Predicting Pediatric Liver Transplant Rejection with Peripheral Blood Leukocyte (PBL) Transcripts-Considerations and Design Limitations
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: Optimizing immunosuppression requires individualized rejection-risk assessment in children with liver transplantation (LTx). PBL transcripts are a desirable non-invasive solution. Purpose: To characterize PBL transcriptome…2018 American Transplant Congress
PD-L1 May Serve as a Biomarker for Chimerism-Induced Tolerance in Kidney Transplant Recipients
1University of Louisville, Louisville, KY; 2Northwestern Memorial Hospital, Chicago, IL.
Durable chimerism is currently the most reliable biomarker of donor specific tolerance. Identifying and validating other predictive biomarkers is therefore a high priority. Since 2009…2018 American Transplant Congress
Increased Expression of HLA-DPB1 in Pre-Implantation Kidney Biopsies is Associated with Poor Late Graft Function
In a previous gene expression microarray study in pre-implantation biopsies (PIB) from kidneys of 53 deceased donors (GeneChip® Human Gene 1.0 ST Arrays, Affymetrix; GEO…2017 American Transplant Congress
The Natural History of Kidney Rejection: How Do Molecular Disease States Change Over Time in Patients with Repeat Indication Biopsies?
University of Alberta, Edmonton, AB, Canada
Molecular phenotypes are highly reproducible, but how do they evolve over time? In an unsupervised microarray analysis, 1208 kidney transplant biopsies were assigned to one…2017 American Transplant Congress
A New and Potent Distal Enhancer of the IL2 Gene.
Interleukin-2 is a potent T cell growth factor with crucial roles in both immunity and tolerance. Genetic studies in humans and mice demonstrate a role…2017 American Transplant Congress
Mechanistic Insights by RNA Profiling on Rejecting Vascularized Composite Allotransplants.
Background: Detailed molecular changes associated with rejection to vascularized composite allotransplants (VCA) are not well understood. Materials and Methods: peripheral blood was drawn from the…2017 American Transplant Congress
Gene Expression During Development of Chronic Antibody-Mediated Rejection in Renal Allografts from Non-Human Primates: Validation of Markers Used in Humans and Sequential Changes in Protocol Biopsies.
Background: RNA transcript measurement is a promising adjunct for the diagnosis and classification of antibody-mediated rejection (ABMR), however most technologies require specially processed biopsy samples.…2017 American Transplant Congress
Molecular Classifier of Antibody-Mediated Rejection Is a Better Predictor of Histologic Rejection Than a Corresponding Transcript Set and Is Further Improved When Combined with Classifiers of Rejection Syndromes.
University of Alberta, Edmonton, AB, Canada
Molecular and histologic changes in graft rejection are not completely specific, often being induced by injuries and other diseases. We examined various methods for using…
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