2018 American Transplant Congress
In-Situ Tissue-Based Gene Expression Profiling is a Reliable Method to Detect Gene Transcripts in Human Kidney Transplant Biopsies
Purpose. Validation studies that would enable the clinical application of quantitative in situ tissue-based gene expression profiling in renal transplantation are lacking. In this study,…2018 American Transplant Congress
Modification of Macrophage Phenotype by the Magnetic Field
Objective. Macrophages play a crucial role in health, disease and chronic rejection of transplanted organs. Chronic rejection of transplanted organs remains unresolved issue in organ…2018 American Transplant Congress
Molecular Profiling of the Injury-Repair Response in Early Subclinical Inflammation
UAB School of Medicine, Birmingham.
Purpose: Surveillance biopsies can detect subclinical T-cell mediated rejection (SC-TCMR) or subclinical borderline rejection (SC-B-TCMR) in kidney transplants with normal/stable creatinine. Some consider SC-B-TCMR to…2018 American Transplant Congress
Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)
Sub-clinical acute rejection (subAR) following KT is associated with poor long-term graft outcomes and can only be detected using invasive surveillance biopsies (SBx). Non-invasive biomarker…2018 American Transplant Congress
Activation Requirements of Costimulation Blockade-Resistant CD4 T Cells
T cells lose costimulation dependence following primary activation and many phenotypes of terminally differentiated cells have been identified as contributing to costimulation blockade (CoB)-resistant rejection…2017 American Transplant Congress
Identification of Antibody-Mediated Rejection After Kidney Transplantation by Specific MicroRNAs.
Antibody-mediated rejection (ABMR) is the major cause for allograft failure, since a curative therapy is lacking. There are also still challenges in ABMR diagnosis. The…2017 American Transplant Congress
Transcript Changes Associated with Graft Rejection Are Not Specific for Rejection Because They Are Shared with Tissue Responses to Wounding.
University of Alberta, Edmonton, Canada
The diagnosis of rejection by histology is based on the presence of relatively non-specific lesions. This is because the histology lesions are actually non-specific, but…2017 American Transplant Congress
Gene Expression Signature of Subclinical Allograft Kidney ABMR Compared to Clinical ABMR.
BackgroundAntibody-mediated rejection (ABMR) is characterized by a heterogeneous presentation. It occurs in clinically stable patients (sABMR) or in patients with allograft dysfunction (ABMR), but only…2017 American Transplant Congress
Increased Pro-Inflammatory and Decreased Interferon-Related Gene Expression in Older as Compared with Younger Kidney Transplant Recipients.
David Geffen School of Medicine at UCLA, Los Angeles, CA
Older transplant recipients experience increased rates of death and infection as compared with younger patients. Our previous studies demonstrated increased frequency of terminally differentiated and…2017 American Transplant Congress
Microarray Analysis of Rejection in Formalin-Fixed Paraffin-Embedded Biopsies: Similarities and Disparities with Conventionally Stabilized Biopsies.
Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton, AB, Canada
Despite potential for performing molecular diagnostics on formalin-fixed paraffin embedded (FFPE) biopsies, there has been no systematic comparison of microarray gene expression data obtained from…
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