2018 American Transplant Congress
Inflammation in Scarred Areas (I-IFTA) is a Reflection of Parenchymal Injury (Response to Wounding) Not T Cell-Mediated Rejection
Medicine, University of Alberta, Edmonton, AB, Canada.
Inflammation in fibrotic renal parenchyma (i-IFTA) is associated with decreased graft survival but by Banff rules is not diagnostic for rejection. Some researchers believe that…2018 American Transplant Congress
Time and Perfusate Dependent Molecular Response in Ex Vivo Lung Perfusion
Lung transplantation has limited organ utilization and high rates of primary graft dysfunction, in part due to acute lung injury (ALI). Cold static preservation (CSP)…2018 American Transplant Congress
Highly Correlative Whole-Tissue Gene/protein Signatures to Score FFPE Transplant Biopsies with Inflammation and Acute Rejection
Unversity of California San Francisco, San Francisco.
Background: We have previously reported the quantification of a common immune response module (CRM) of 11 genes to identify and score acute rejection (AR) across…2018 American Transplant Congress
RNA-Seq Based Analysis of Renal Allograft Biopsies Reveals Key Mediators of Interstitial Fibrosis/Tubular Atrophy
Interstitial Fibrosis/Tubular Atrophy(IFTA) is the final common pathway of most progressive renal diseases and is a potent predictors of renal outcome in both native and…2018 American Transplant Congress
Tacrolimus Exposure in Human Proximal Tubule Cells Results in Differentially Increased CTGF Expression in Relation to Pharmacogenetic Variants of CYP3A5 and ABCB1
AIM: Clinical studies have demonstrated the importance of genetic variation for tacrolimus disposition and suggested a role in the development of renal fibrosis associated with…2017 American Transplant Congress
Molecular Profiles of Renal Allograft Biopsies at 12 Months Post Renal Transplant in Patients Exposed to Low Dose CNI and Everolimus vs. Patients Exposed to Full Dose CNI and MMF.
CNIs serve as the cornerstone of immunosuppression (IS) after kidney transplant. However chronic CNI nephrotoxicity has been implicated in allograft dysfunction. We hypothesize that lower…2017 American Transplant Congress
Validation of CYP4F11 as a Marker of Accommodation in Biopsies from Recipients of an ABO-Incompatible Renal Transplant.
Recipients of an ABO incompatible transplant have circulating anti-AB antibodies, A and/or B antigens expressed on endothelium and usually C4d deposition on the endothelium, yet…2017 American Transplant Congress
Distinctive Molecular Features of Antibody-Mediated versus T-Cell Mediated Rejection in Facial Transplantation.
Brigham and Women's Hospital, Boston, MA
BackgroundA single case of antibody-mediated rejection in a clinical face transplant has been reported worldwide. The availability of repeated allograft biopsies from this patient allowed…2017 American Transplant Congress
Pre-Transplant Evaluation of KSORTSM to Assess Risk for Rejection in Highly Sensitized Patients.
Study purpose: To investigate the kSORTSM molecular expression assay for immune risk assessment in renal transplant (tx) recipients prior to tx for correlation of pre-tx…2017 American Transplant Congress
Identification of Novel Diagnostic Biomarkers in Liver Transplantation Tolerance.
1Cleveland Clinic, Cleveland; 2University of Chicago, Chicago
Current success in liver transplantation (LTX) relies on life-time administration of non-specific immunosuppressive drugs, leaving patients prone to infection and cancer. Previous reports indicated about…
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