Articles tagged "Gene expression"

2018 American Transplant Congress
Overexpression of BAX, NOL3, and XIAP Apoptotic Genes Participates in Calcineurin Inhibitors Nephrotoxicity: New Insights into Chronic Allograft Dysfunction
L. Garcia-Covarrubias,¹ G. Queipo,² M. Fonseca,² D. Alcantara,¹ P. Prieto,¹ H. Diliz,¹ A. Garcia,¹ H. Hinojosa,¹ A. Cicero,¹ G. Melendez,³ M. Alamilla,³ R. Lascurain,⁴ V. Soto.⁵
¹Transplantation, Hospital General de Mexico, Mexico City, Mexico; ²Genetics, Hospital General de Mexico, Mexico City, Mexico; ³Research, Hospital General de Mexico, Mexico City, Mexico; ⁴Faculty of Medicine, UNAM, Mexico City, Mexico; ⁵Pathology, Hospital General de Mexico, Mexico City, Mexico.
Introduction: Calcineurin inhibitors toxicity (CNIT) is a factor that limit the outcome of renal transplantation graft. The hypoxia causes histological data as nodular hyalinosis, hyalinosis,…
2018 American Transplant Congress
Hypothermic Machine Perfusion Protects DCD Liver Graft through Metabolism of Xenobiotics by Cytochrome P450 Pathway
Q. Ye,^1,2 W. Liang,¹ Z. Zhong,¹ S. Ye,¹ B. Tang,¹ Q. Hu,¹ J. Liang,¹ Y. Wang.¹
¹Transplant Center of Wuhan University, Zhongnan Hospital of Wuhan University, Wuhan, China; ²The 3rd Xiangya Hospital of Central South Unversity, Changsha, China.
Background: Donation after cardiac death (DCD) is the mainly resource to relieve organ-transplantation shortage. Our previous research have confirmed that the function of DCD liver…
2018 American Transplant Congress
Molecular Assessment of Pre-Implantation Donor Biopsies: Effects of Prolonged Cold Ischemia Time and Development of Delayed Graft Function
E. Akalin,¹ Y. Bao,¹ V. Bontha,² M. e Silva,³ M. Ajaimy,¹ P. [Oacute] Broin,³ V. Mas.²
¹Montefiore Medical Center, Bronx; ²University of Virginia, Charlottesville; ³National University of Ireland Galway, Galway, Ireland.
Background: Deceased-donor (DD) kidneys are at higher risk for ischemia/reperfusion injury leading to increased inflammatory mediators and innate immune response. We aimed to investigate the…
2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² A. Vo,³ S. Jordan,³ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Pathology, Cedars-Sinai Medical Center, Los Angeles, CA; ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…
2018 American Transplant Congress
Hypothermic Machine Perfusion Protects Rabbit Kidney Graft through Down Regulation SPP1-MMP7 Signaling Axis
Q. Hu,¹ Z. Zhong,¹ S. Xue,¹ W. Liang,¹ J. Lan,¹ J. Liang,¹ Y. Xiong,¹ Y. Wang,¹ Q. Ye.^1,2
¹Zhongnan Hospital of Wuhan University, Transplant Center of Wuhan University, Hubei Key Laboratory of Medical Technology on Transplantation, Wuhan, China; ²The 3rd Xiangya Hospital of Central Sourth University, Changsha, China.
Background: Multicenter studies have indicated that hypothermic machine perfusion(HMP) can be used to prolong cold ischemia time with high-quality preservation and allow utilization of kidney…
2017 American Transplant Congress
Noninvasive Prognostication of Renal Allograft Failure Following BK Virus Associated Nephropathy – A Validation Study.
E. Abuhelaiqa, C. Snopkowski, C. Li, J. Lee, T. Muthukumar, H. Yang, M. Suthanthiran, D. Dadhania.
Transplant Medicine, Weill Cornell Medicine, NY, NY
Introduction. Identification of kidney transplant (KTx) recipients at risk for graft loss following BKVN diagnosis may allow personalization of immunosuppressive protocols. Previous study demonstrated that…
2017 American Transplant Congress
GSK3β and VDAC in Endoplasmic Reticulum Stress and Apoptosis Modulation During Orthotropic Liver Transplantation.
M. Zaouali,^1,5 A. Panisello Roselló,¹ E. Folch Puy,¹ A. Lopez,² A. Rolo,³ C. Castro,² C. Palmeira,³ A. Garcia-Gil,⁴ R. Adam,² J. Roselló-Catafau.¹
¹Experimental Pathology, Institute of Biomedical Research of Barcelona (IIBB-CSIC), Barcelona, Spain; ²Hepato-Biliare,, Hôpital Paul Brousse, INSERM U-776,Université Paris Sud, Paris, France; ³Center for Neurosciences and Cell Biology, University of Coimbra, Coimbra, Portugal; ⁴Liver Surgery, Hospital Clínico, Zaragoza, Spain; ⁵Research Unit of Biology and Molecular Anthropology Applied to Development and Health (UR12ES11), Faculty of Pharmacy, University of Monastir, Monastir, Tunisia
Ischemia reperfusion injury(IRI) is a major cause of graft non-function following liver transplantation (LT). Mitochondrial dysfunction plays a central role in preventing liver IRI), associated…
2017 American Transplant Congress
Novel Biomarkers for Segregating Lung Transplant Rejection Phenotypes.
J. Yang,¹ B. Vanaudenaerde,² T. Sigdel,¹ J. Liberto,¹ S. Verlden,² M. Sarwal.¹
¹Department of Surgery, University of California, San Francisco, San Francisco, CA; ²Department of Pneumology, University of Leuven, Leuven, Flemish Brabant, Belgium
We sought to investigate biomarkers in BAL fluid and tissue for segregating BOS and RAS chronic rejection phenotypes in lung allografts. We had previously identified…
2017 American Transplant Congress
APOL1 Genotype Does Not Affect Donor Renal Function Post Live Kidney Donation.
K. Koutroutsos,¹ R. Sergeant,² F. Powell,² C. Freeman,² R. Charif,¹ J. Galliford,¹ P. Brookes,² D. Taube,¹ M. Loucaidou.¹
¹Kidney and Transplant Center, Imperial College Healthcare NHS Trust, London, United Kingdom; ²Histocompatibility and Immunogenetics Laboratory, Imperial College Healthcare NHS Trust, London, United Kingdom
Background: Apolipoprotein-L1 (APOL1) risk variants have emerged as a predictor of renal disease in individuals of African Ancestry (AA). The effect of APOL1 risk variants…
2017 American Transplant Congress
α-Lipoc Acid Improve the Short Term Outcomes in Human Liver Transplantation.
P. Casciato,¹ N. Ambrosi,² C. Fiorella,² M. Vasquez,¹ A. Gadano,¹ M. de Santibañes,¹ E. de Santibañes,¹ M. Zandomeni,¹ M. Chahdi,¹ J. Laquinandi,¹ P. Santofimia Castaño,³ J. Iovanna,³ E. Chuluyan,² C. Incardona.⁴
¹Liver Transplantation Unit, Hospital Italiano, Buenos Aires, Argentina; ²CEFYBO, UBA-CONICET, Facultad de Medicina, Buenos Aires, Argentina; ³INSERM, Center of Research in Cancerology of Marseille (CRCM), Marseille, France; ⁴Fundación GADOR, GADOR, Buenos Aires, Argentina
In liver transplantation (LT) the postreperfusion syndrome (PRS) is a serious intraoperative complication. The effect of α-lipoic acid (ALA) has not been evaluated. A double…