2019 American Transplant Congress
Timing and Donor-Specific Antibodies, but Not C4d Deposition, Determine Leukocyte Infiltration in Renal Allograft Biopsies with the Histological Picture of Antibody-Mediated Rejection
*Purpose: Diagnosis of antibody-mediated rejection following kidney transplantation can be challenging, given the limited specificity of individual histological parameters and time-dependent occurrence of histological confounders.…2019 American Transplant Congress
A Robust and Portable Protocol for RNA Isolation from Urinary Cells for Noninvasive Monitoring of Kidney Allograft Recipients
*Purpose: Urinary cell mRNA abundance, assessed by RT-qPCR assay, is a robust monitoring tool. In the CTOT-04 study, urine processed by 5 transplant sites were…2019 American Transplant Congress
Gene Expression Profiles in CD8+ T Cells in Chronic Antibody-Mediated Rejection (CAMR) of Kidney Transplantation
*Purpose: CAMR is the main cause of chronic graft injury and subsequent graft loss. Most of the studies on the subject focused their attention to…2019 American Transplant Congress
microRNA-375 Provides an Objective Measure of Pancreas Quality in Organ Donors
*Purpose: Donor pancreatic beta cells are at high risk from apoptosis. Objective methods for assessing the quality of donor pancreases for transplantation are limited. We…2019 American Transplant Congress
Heterozygous Gene Mutations In The Complement Factor I (cfi) Was Susceptibility Gene For The C3 Glomerulonephritis In Native Kidney And Renal Allograft
*Purpose: We previously reported heterozygous c.848A > G and c.1339C > T gene mutations in the complement factor I (CFI) gene (NM_000204.3) in a kidney transplant recipient with C3…2019 American Transplant Congress
The Molecular Profile of Kidney Allografts Unveil Specific Biomarkers for Subclinical Acute Rejection (SAR). Towards an Early Detection and a Targeted Treatment
Schena Foundation, Valenzano-Bari, Italy
*Purpose: SAR diagnosed by protocol biopsy is an independent risk factor for chronic allograft injury. We organized a molecular study on 24 AB0 compatible cadaveric…2019 American Transplant Congress
A Regulatory T Cell-Intrinsic Role for Ikaros in Acquired Transplant Tolerance
The Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: Ikaros is a transcriptional repressor encoded by the Ikzf1 gene that was recently identified as the pharmacologic target of thalidomide analogs in successful therapy…2019 American Transplant Congress
A Metagene Signature of Lymphocytic Bronchitis Following Lung Transplantation
*Purpose: Lymphocytic bronchitis (LB) precedes chronic lung allograft dysfunction (CLAD). Peri-vascular (A-grade) and peri-bronchiolar (B-grade) lymphocytic inflammation are traditional markers of acute cellular rejection. The…2019 American Transplant Congress
Transcriptome Profiling Of Renal Transplant Biopsies With Acute Cellular Rejection From Patients On Calcineurin Inhibitor-based Or Cni-avoidance Immunosuppression
*Purpose: Despite their suboptimal toxicity profile, calcineurin-inhibitors (CNIs) remain the cornerstone of renal transplant immunosuppression. Previous efforts to completely eliminate CNIs failed, because CNI-avoidance protocols…2019 American Transplant Congress
The Negative Costimulatory Pd-1/pd-l1 Pathway Is Upregulated In Early Cell-mediated Rejection
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: Extensive transcript analysis has been performed on grafts at the time of rejection, but gene expression preceding overt rejection is less well studied.*Methods: We…
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