2018 American Transplant Congress
Assessment of Peak Levels and Metabolism Rates in African American (AA) and Non-AA Kidney Transplant Recipients (KTR) on Immediate-Release Tacrolimus (IR-tac)
Trough-to-daily dose (C/D) ratio has been used as a simple method for evaluation of IR-tac metabolism rate. Recent studies have shown that fast metabolizers defined…2017 American Transplant Congress
Functional Mystacial Pad Allograft Tolerance Induced and Maintained by Vascularized Bone Marrow Transplant.
Background: Accumulating findings indicate that vascularized bone marrow (VBM) transplantation plays a critical role to promote tolerance of vascularized composite allografts (VCA) without life-long immunosuppression.…2017 American Transplant Congress
Population Pharmacokinetic Profiling of Tacrolimus in Renal Transplant Recipients (RTRs) Taking Diltiazem.
Background: Over the past 6 years we have prospectively used pharmacokinetic (PK) profiling of Tacrolimus (TAC) in “stable” RTR's to individualise future dosing. This study…2017 American Transplant Congress
One Year Outcomes of Low-Dose vs Very Low-Dose Extended-Release Tacrolimus/Mycophenolate mofetil in De Novo Kidney Transplantation: A Multi-Center Randomized Controlled Trial.
Purpose: Once-daily tacrolimus extended-release formulation (TACER) has now been widely accepted in kidney transplant field. However, the optimal dosage for TACER is still not known.Patients…2017 American Transplant Congress
Tacrolimus Pharmacogenomics: Association of Genetic Variants with Clinical Factors Including Tacrolimus Requirement, Clearance, Intraindividual Variability, and Coefficient Variation.
Background: Tacrolimus, which plays a backbone in immunosuppressive therapy, has a different effect in absorption according to intraindividual and interindividual variability, and it is a…2017 American Transplant Congress
Tacrolimus and Mycophenolate Exposure and Subclinical Tubulo-Interstitial Inflammation in Low Immunological Risk Renal Transplants.
The aim is to evaluate the relationship between maintenance immunosuppression, subclinical inflammation (i-score plus t-score) and interstitial fibrosis/tubular atrophy (IF/TA) (ci-score plus ct-score) in paired…2017 American Transplant Congress
Association with Tacrolimus Intraindividual Variability, Acute Microinflammation Based on 1 Year-Transplanted Kidney Biopsy After Transplantation, and Biopsy-Proven Acute Rejection.
Surgery, Seoul National University College of Medicine, Seoul, Korea
Background: The purpose of this study was to investigate relationship between tacrolimus intraindividual variability (IIV), acute microinflammation (AMI) based on 1 year-transplanted kidney biopsy, and…2017 American Transplant Congress
Changes in Peripheral Blood Gene Expression Profile After Calcineurin Inhibitor (CNI) Withdrawal in Kidney Transplant Recipients.
CNI are effective in kidney transplantation but their off-target effects make CNI withdrawal (w/d) desirable. Published studies showed that clinical parameters cannot differentiate the ~50%…2017 American Transplant Congress
Immunosuppressive Treatment Alters Gut Microbiota and Modified Gut Microbiota Affects Immune Status.
Department of Urology, Beijing Chaoyang Hospital, CCMU, Beijing, China
Objectives: Immunosuppressive therapies could change the host-microbial interactions, especially gut microbiota, which is an important component in systemic immunity. We evaluated the relationship between immunosuppression…2017 American Transplant Congress
Short-Term Combination Treatment of FK506 and Anti-CD40 Ligand Remarkably Prolong Allograft Survival Time in Mouse Skin Transplantation.
Background: It is well established that skin are more prone than kidney to rejection after transplantation and is difficult to archive allograft acceptance following normal…
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