ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "FK506"

  • 2022 American Transplant Congress

    NecroX-7 Ameliorate FK506-Induced Nephrotoxicity in LLC-PK1 Cells (Pig Kidney Epithelial Cells)

    H. J. Jang

    Surgery, University of Ulsan, Gangneung Asan Hospital, Gangneung, Korea, Republic of

    *Purpose: Tacrolimus (FK506) is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and…
  • 2022 American Transplant Congress

    The Impact of Long-Term Exposure to Tacrolimus on Chronic Kidney Disease Following Lung Transplantation: A Retrospective Analysis from a Single Transplantation Center

    D. Xiong, J. Zhang, J. Chen

    Lung Transplantation Center, Department of Thoracic Surgery, Wuxi People’s Hospital Affiliated to Nanjing Medical Univer, Wuxi, China

    *Purpose: Chronic kidney disease (CKD) is a progressive and irreversible complication in lung transplant patients who have received long-term treatment with tacrolimus. This study aimed…
  • 2022 American Transplant Congress

    Influence of Converting Kidney Transplant Recipients with High Tacrolimus Variability to the Once Daily LCP Tac Formulation

    D. Taber, F. Bartlett, N. Patel, T. Sprague, S. Patel, J. Newman, E. Andrade, N. Rao, A. Posadas, V. Rao, M. Casey, D. Dubay, V. Rohan

    Med Univ of South Carolina, Charleston, SC

    *Purpose: Tacrolimus (Tac) is the cornerstone of immunosuppression used in kidney transplant recipients (KTRs). Tac high variability, low time in therapeutic range and non-adherence are…
  • 2022 American Transplant Congress

    The Impact of Tacrolimus Trough Variability on Acute Rejection Following Lung Transplantation

    K. Evans1, K. Beermann1, H. Lee2, M. Harris1, C. W. Frankel3, H. Berry1, H. Ali3

    1Pharmacy, Duke Health, Durham, NC, 2Biostatistics and Bioinformatics, Duke University, Durham, NC, 3Pulmonary, Allergy, and Critical Care, Duke Health, Durham, NC

    *Purpose: This study aimed to evaluate the association of tacrolimus coefficient of variation (CV) with biopsy-proven acute cellular rejection in the first year following lung…
  • 2022 American Transplant Congress

    Impact of Sub-therapeutic Tacrolimus Troughs at Discharge from Index Admission on Short-Term Outcomes in Kidney Transplant Recipients Receiving Rabbit Anti-Thymocyte Globulin Induction

    X. Liu1, J. Trofe-Clark2, D. Sawinski3, B. Steiner1, S. Sharma1, S. Witek1, T. Fallah2, M. Norris2, C. Sammons2, G. Malat2

    1Pharmacy, Hosp of Univ of Pennsylvania, Philadelphia, PA, 2Penn Transplant Institute and Pharmacy Dept, Hosp of Univ of Pennsylvania, Philadelphia, PA, 3Penn Transplant Institute, Hosp of Univ of Pennsylvania, Philadelphia, PA

    *Purpose: Kidney transplant (KTx) recipients are often discharged with subtherapeutic tacrolimus (TAC) troughs due to short hospital lengths of stay (LOS) for index KTx admissions.…
  • 2022 American Transplant Congress

    Prevention of the Progression in Chronic Calcineurin Inhibitors Nephrotoxicity via Steroids Anti-Inflammatory Effects

    N. Iwahara1, K. Hotta1, Y. Tanaka1, I. Takahashi1, R. Hasebe1, H. Okada1, T. Tsuji2, Y. Takada2, H. Higuchi2, H. Sasaki1, T. Tanabe1, D. Iwami3, N. Shinohara1, M. Murakami1

    1Hokkaido Univercity, Sapporo, Japan, 2Sapporo City General Hospital, Sapporo, Japan, 3Jichi Medical University, Shimotsuke, Japan

    *Purpose: Calcineurin inhibitors (CNI) lead to an excellent short-term kidney allograft outcome. However, chronic nephrotoxicity is a major concern, which affects a long-term allograft survival.…
  • 2022 American Transplant Congress

    Association Between De Novo Donor Specific Antibody and Tacrolimus Trough Levels in Long Term Follow Up Renal Transplantation

    N. Fujiyama1, M. Saito2, R. Yamamoto2, R. Sagehashi2, T. Saito2, Y. Aoyama2, K. Numakura2, T. Habuchi2, S. Satoh1

    1Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan, 2Department of Urology, Akita University Graduate School of Medicine, Akita, Japan

    *Purpose: In this study, we aimed to identify the risk factors contributing to the development of donor-specific anti-HLA antibody (DSA) during long-term follow-up of patients…
  • 2022 American Transplant Congress

    The Effect of Tacrolimus and Mycophenolic Acid on Torque Teno Virus Loads in Kidney Transplant Recipients

    A. van Rijn, S. Meziyerh, D. van der Helm, T. van Gelder, A. Kroes, J. de Fijter, D. Moes, J. Rotmans, A. de Vries, M. Feltkamp

    Leiden University Medical Center, Leiden, Netherlands

    *Purpose: Measuring immune function in kidney transplant recipients (KTRs) remains challenging given the precarious balance between over- and underimmunosuppression. This is primarily due to high…
  • 2022 American Transplant Congress

    Detection of Early Graft Injury After Liver Transplantation with Blood-Bile Ratio of Tacrolimus: The TUBE Trial

    M. M. Pascale1, G. Bianco1, L. Ferri1, F. Giovinazzo1, A. Liguori2, G. Marrone2, A. Grieco2, S. Agnes1

    1General Surgery and Liver Transplant Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy, 2Transplant Hepatology Unit, Fondazione IRCSS - Policlinico "A. Gemelli", Roma, Italy

    *Purpose: The aim of the“Tacrolimus in Bile”(TUBE)Trial is the creation of a laboratory parameter for the early detection of hepatic injury after liver transplant.*Methods: TUBE…
  • 2022 American Transplant Congress

    Effect of Schisandra Sphenanthera Extract on Pharmacokinetics of Tacrolimus in Pediatric Renal Transplant Recipients

    J. Jiang1, H. Zhang1, X. Su1, S. Wu1, Y. Chen2, W. Chen2, J. Li2, C. Wu2, L. Yang2, L. Liu2, C. Wang2

    1Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, 2The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

    *Purpose: Wuzhi tablet (Schisandra sphenanthera extract) is a promising tacrolimus-sparing agent in adult renal transplant recipients, while its effect in pediatric recipients remains unclear. The…
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