ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2019 American Transplant Congress

    Donor Renal Macrophages in Post-Transplant Ischemia/Reperfusion Injury (IRI): Role of IL-1R8 in Modulating Fate, Phenotype and Function

    S. Aiello, P. Rodriguez, N. Azzollini, F. Casiraghi, M. Noris, G. Remuzzi, A. Benigni

    Mario Negri Institute, Ranica, Italy

    *Purpose: Post-transplant (tx) IRI activates TLR/IL-1R on tissue resident leukocytes initiating innate immune response. We studied how donor renal resident macrophages (rMF) respond to post-tx…
  • 2019 American Transplant Congress

    Effects of Pretreated Bortezomib on Renal Function after Renal Ischemia – Reperfusion Injury in Mice

    X. Zheng

    Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

    *Purpose: To observe the effects of pretreated bortezomib at different points on renal function and renal histology after renal ischemia-reperfusion injury in mice.*Methods: A mice…
  • 2019 American Transplant Congress

    Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation

    N. Navarro-Alvarez1, A. R. Andrews1, Z. DeFilipp2, Y. A. Chen2, V. T. Ho3, J. Ritz3, T. R. Spitzer4, C. A. Huang5

    1Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, 2Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, 3Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, 4Hematology/Oncology, Massachusetts General Hospital, Boston, MA, 5Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO

    *Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
  • 2019 American Transplant Congress

    Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation

    S. Angara, R. Ravichandran, H. Sodawalla, M. Smith, R. Bremner, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Immunological mechanisms leading to chronic rejection, bronchiolitis obliterans syndrome (BOS), following human lung transplantation remains unclear though a strong correlation have been identified between…
  • 2019 American Transplant Congress

    Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients

    W. Zhang1, Z. Yi1, Z. Sun1, K. Keung2, C. Wei1, C. Xi1, S. Farouk1, M. Menon1, P. Cravedi1, P. O'Connell2, B. Murphy1

    1Icahn School of Medicine at Mount Sinai, New York, NY, 2The University of Sydney, Sydney, Australia

    *Purpose: Whole blood and graft biopsy RNA expression analyses are limited by the heterogeneous cell composition of the samples. Cell coding is an analytical tool…
  • 2019 American Transplant Congress

    Non-Invasive Monitoring of the Kidney Allograft

    S. Bontha1, G. Darville1, C. Kuscu1, C. Kuscu2, A. Bajwa1, J. Eason3, D. Maluf4, V. Mas5

    1Surgery, UTHSC, Memphis, TN, 2Surgery, UTHSC, memphis, TN, 3Surgery, Director of Transplant Institute - UTHSC, Memphis, TN, 4UTHSC, Memphis, TN, 5Surgery, Director of Transplant Research Institute, Memphis, TN

    *Purpose: A major issue in kidney transplantation is the lack of validated non-invasive biomarkers for monitoring graft function, current biochemical markers (i.e., creatinine) have poor…
  • 2019 American Transplant Congress

    Urinary Extracellular Vesicles-Related Protein Biomarkers for the Non-Invasive Monitoring of Rejection in Kidney Transplanted Patients

    L. Carreras-Planella1, I. Bancu2, D. Cucchiari3, L. Cañas2, J. Juega2, M. Franquesa1, M. Perez-Mir2, I. Revuelta3, F. Diekman4, R. Lauzurica2, F. Borràs1

    1REMAR-IVECAT Group, Institut Germans Trias i Pujol, Badalona, Spain, 2Nephrology- Renal Transplant Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, 3Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Barcelona, Spain, 4Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Badalona, Spain

    *Purpose: Chronic kidney rejection is currently the main cause of graft losses. Blood and urine analyses to monitor kidney transplanted patients are not specific, and…
  • 2018 American Transplant Congress

    Liver Biopsy Fibrosis Not Liver Imaging Predicts Survival after Heart Transplant

    J. Patel, M. Kittleson, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Hepatic dysfunction is common in patients with cardiomyopathy being evaluated for heart transplant (HT). ISHLT guidelines highlight the need for liver evaluation in patients…
  • 2018 American Transplant Congress

    Cardiac MRI May Help to Determine When to Refer Heart Transplant Patients for Redo Heart Transplant

    M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Small vessel coronary artery disease is known to cause fibrosis. However, it is not clear whether myocardial fibrosis detected on MRI is associated with…
  • 2018 American Transplant Congress

    Krüppel-Like Factor 15 is a Key Suppressor of the Glomerular Epithelial Cell Fibrosis under Centrifugal Force Driven Pressure

    M. Yu,1 Y. Kim,1 H. Lee,1 J. Lee,2 R. Cha,3 C. Lee,4 Y. Kim,1 S. Yang.5

    1Seoul National University Hospital, Seoul, Korea; 2Seoul National University Boramae Medical Center, Seoul, Korea; 3National Medical Center, Seoul, Korea; 4Cheju Halla General Hospital, Jeju, Korea; 5Seoul National University Kidney Research Institue, Seoul, Korea.

    Hypertension is known to be responsible for a reduction in the number of functional nephrons of glomeruli due to fibrosis, which develops into a chronic…
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