Articles tagged "Fibrosis"

2019 American Transplant Congress
Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients
W. Zhang¹, Z. Yi¹, Z. Sun¹, K. Keung², C. Wei¹, C. Xi¹, S. Farouk¹, M. Menon¹, P. Cravedi¹, P. O'Connell², B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia
*Purpose: Whole blood and graft biopsy RNA expression analyses are limited by the heterogeneous cell composition of the samples. Cell coding is an analytical tool…
2019 American Transplant Congress
Non-Invasive Monitoring of the Kidney Allograft
S. Bontha¹, G. Darville¹, C. Kuscu¹, C. Kuscu², A. Bajwa¹, J. Eason³, D. Maluf⁴, V. Mas⁵
¹Surgery, UTHSC, Memphis, TN, ²Surgery, UTHSC, memphis, TN, ³Surgery, Director of Transplant Institute - UTHSC, Memphis, TN, ⁴UTHSC, Memphis, TN, ⁵Surgery, Director of Transplant Research Institute, Memphis, TN
*Purpose: A major issue in kidney transplantation is the lack of validated non-invasive biomarkers for monitoring graft function, current biochemical markers (i.e., creatinine) have poor…
2019 American Transplant Congress
Urinary Extracellular Vesicles-Related Protein Biomarkers for the Non-Invasive Monitoring of Rejection in Kidney Transplanted Patients
L. Carreras-Planella¹, I. Bancu², D. Cucchiari³, L. Cañas², J. Juega², M. Franquesa¹, M. Perez-Mir², I. Revuelta³, F. Diekman⁴, R. Lauzurica², F. Borràs¹
¹REMAR-IVECAT Group, Institut Germans Trias i Pujol, Badalona, Spain, ²Nephrology- Renal Transplant Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Barcelona, Spain, ⁴Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Badalona, Spain
*Purpose: Chronic kidney rejection is currently the main cause of graft losses. Blood and urine analyses to monitor kidney transplanted patients are not specific, and…
2019 American Transplant Congress
Chemokine Ligand 14 is a Novel Therapeutic Target in Kidney Fibrosis
S. Lee¹, Y. Kim¹, J. Moon¹, H. Lee¹, S. Han¹, J. Lee², R. Cha³, D. Kim¹, C. Lee⁴, K. Kim⁵, Y. Kim¹, S. Yang⁶
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Boramae Medical Center, Seoul, Korea, Republic of, ³Internal Medicine, National Medical Center, Seoul, Korea, Republic of, ⁴Internal Medicine, Cheju Halla University Hospital, Jeju, Korea, Republic of, ⁵Biomedical Science, Seoul National University, Seoul, Korea, Republic of, ⁶Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Chemokine ligand 14 (CCL14), a ligand for CCR1, has been known as a M2 polarizing marker and chemotactic cytokine, which is expressed by fibroblast,…
2019 American Transplant Congress
Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation
G. Queipo¹, M. Fonsecha-Sanchez¹, J. Sanchez¹, L. Garcia¹, M. Carmona², E. Villanueva¹, G. Melendez¹, L. Morales-Buenrostro³, M. Alamilla¹
¹Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, ²Facultad de Medicina UNAM, Mexico City, Mexico, ³Instituto Nacional de Ciencias Médicas Salvador Zubirán, Mexico City, Mexico
*Purpose: Calcineurin inhibitors (CNI) remain the most effective and widely used immunosuppressive agents in kidney transplantation. Nephrotoxicity is a major secondary effect, and renal biopsy…
2019 American Transplant Congress
Activation of Renal Fibroblasts by Anti- Major Histocompatibility Complex Antibody: A Missing Link in Allograft Fibrosis
M. B. Oliver¹, J. Chen², A. Zmijewska¹, R. B. Mannon¹
¹Medicine, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL, ²Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, AL
*Purpose: Chronic antibody-mediated rejection (CAMR) is an important contributor to late kidney allograft loss, frequently accompanied by interstitial fibrosis and tubular atrophy. Donor-specific antibodies (DSA)…
2019 American Transplant Congress
A Novel Apparatus Mimicking Hypertensive Kidney With Primary Cultured Human Kidney Cells Using Rotational Force: Application To In Vitro Drug Screening In Kidney Transplant Recipients
Y. Kim¹, S. Lee², J. Moon¹, J. Kim¹, M. Yu³, C. Lee⁴, Y. Kim¹, S. Yang⁵, J. Jeong¹, J. Seon¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ⁴Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, ⁵Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Cell culture is an essential part of the development for various medical technologies such as identifying the cause of the disease and developing new…
2018 American Transplant Congress
Inflammation in Fibrotic Areas (i-IF/TA) Identifies a T Cell-Mediated Rejection Component of IF/TA with Poor Kidney Allograft Outcome
D. Viglietti, O. Aubert, J-.P. Duong Van Huyen, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France.
Addressing the etiological heterogeneity of interstitial fibrosis in kidney allografts represents an important challenge to improve long-term transplant outcomes. We investigated the determinants, clinical and…
2018 American Transplant Congress
Donor Acute Kidney Injury Does Not Affect Fibrosis on 1 Year Post-Transplant Kidney Biopsy
D. van der Windt, X. Chen, K. Lemon, C. Wu, N. Shah, R. Mehta, C. Puttarajappa, P. Sood, S. Hariharan, A. Ganoza, M. Wijkstrom, A. Humar, A. Tevar.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
PurposeThe use of kidneys from deceased donors with acute kidney injury (AKI) at the time of donation is a potential method by which to expand…
2018 American Transplant Congress
RNA-Seq Based Analysis of Renal Allograft Biopsies Reveals Key Mediators of Interstitial Fibrosis/Tubular Atrophy
C. McEvoy,^1,2,4 E. Brennan,^1,2 A. Dorman,^2,3 D. Sadlier,^1,2 A. Konvalinka,⁴ P. Conlon,^2,3 C. Godson.^1,2
¹Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland; ²North Dublin Renal Biobank, Dublin, Ireland; ³Beaumont Hospital & RCSI, Dublin, Ireland; ⁴University Health Network, Toronto, Canada.
Interstitial Fibrosis/Tubular Atrophy(IFTA) is the final common pathway of most progressive renal diseases and is a potent predictors of renal outcome in both native and…

« Previous Page
1
…
7
8
9
10
11
…
17
Next Page »