ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2019 American Transplant Congress

    Impact of DAA Treatment on Graft Fibrosis in HCV Positive Liver Transplantation

    J. Wellington1, A. Ma2, S. Kottilil3, J. Husson3, E. Wilson3, D. Bruno4

    1Gastroenterology & Hepatology, University of Maryland, Baltimore, MD, 2Internal Medicine, University of Maryland, Baltimore, MD, 3Institute of Human Virology, Division of Clinical Care and Research, University of Maryland, Baltimore, MD, 4Transplant Surgery, University of Maryland, Baltimore, MD

    *Purpose: Liver transplantation, LT, for HCV-related disease has the lowest five-year graft survival of all LT recipients, primarily due to accelerated fibrosis from unrestrained HCV…
  • 2019 American Transplant Congress

    Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury

    S. Lan1, B. Yang1, M. Dieudé1, J. Sabo-Vatasescu2, A. Karakeussian-Rimbaud2, J. Turgeon2, S. Qi3, N. Patey4, M. Hébert1

    1Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, 2CRCHUM, Montreal, QC, Canada, 3Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, 4Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
  • 2019 American Transplant Congress

    Fibrosis Scoring Correlates with Progression of Chronic Pancreatitis, Islet Isolation Yields and Transplant Outcomes in Patients Undergoing Islet Autotransplantation

    Y. Liu1, J. SoRelle2, K. Kumano3, S. Vasu3, M. Lawrence4, A. Gupta1, N. Onaca1, E. Beecherl1, B. Naziruddin4

    1Baylor Simmons Transplant Institute, Dallas, TX, 2UTSouthwestern Medical Center, Dallas, TX, 3Baylor Scott and White Research Institute, Dallas, TX, 4Baylor University Medical Ctr, Dallas, TX

    *Purpose: Total pancreatectomy with autologous islet transplantation (TPIAT) is a promising procedure for alleviating pain and maintaining glucose homeostasis in chronic pancreatitis (CP) patients. However,…
  • 2019 American Transplant Congress

    Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy

    D. Patel1, T. Divanyan1, E. Acosta1, K. Carnes2, D. Howard3, F. Jourd’heuil3, D. Jourd’heuil3, R. Lopez-Soler4

    1Albany Medical College, Albany, NY, 2Urology, Albany Medical College, Albany, NY, 3Molecular and Cellular Physiology, Albany Medical College, Albany, NY, 4Surgery, Section of Transplantation, Albany Medical College, Albany, NY

    *Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…
  • 2019 American Transplant Congress

    Vimentin Inhibition Improves Post-Transplant Survival in a Mouse Renal Transplant Model

    R. Lopez-Soler1, Z. Zhang2, H. Chin3, J. Wang4, K. Ridge5

    1Albany Medical College, Albany, NY, 2Microsurgery Core, Comprehensive Transplant Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, 3Molecular and Cellular Physiology, Albany Medical College, Albany, NY, 4Microsurgery Core, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern Univesity, Feinberg School of Medicine, Chicago, IL

    *Purpose: Most renal transplants ultimately fail secondary to chronic allograft nephropathy (CAN). The development of Epithelial to Mesenchymal Transition (EMT) in renal tubular epithelial cells…
  • 2019 American Transplant Congress

    Donor Renal Macrophages in Post-Transplant Ischemia/Reperfusion Injury (IRI): Role of IL-1R8 in Modulating Fate, Phenotype and Function

    S. Aiello, P. Rodriguez, N. Azzollini, F. Casiraghi, M. Noris, G. Remuzzi, A. Benigni

    Mario Negri Institute, Ranica, Italy

    *Purpose: Post-transplant (tx) IRI activates TLR/IL-1R on tissue resident leukocytes initiating innate immune response. We studied how donor renal resident macrophages (rMF) respond to post-tx…
  • 2019 American Transplant Congress

    Effects of Pretreated Bortezomib on Renal Function after Renal Ischemia – Reperfusion Injury in Mice

    X. Zheng

    Beijing Chaoyang Hospital, Capital Medical University, Beijing, China

    *Purpose: To observe the effects of pretreated bortezomib at different points on renal function and renal histology after renal ischemia-reperfusion injury in mice.*Methods: A mice…
  • 2018 American Transplant Congress

    Urine AngiotensinII Signature Proteins as Biomarkers of Fibrosis in Kidney Transplant Recipients

    Z. Mohammed-Ali,1 S. Reid,1,3 T. Tokar,1 A. Tavares,2 P. Yip,1 H. Cardinal,2 Y. Li,1 S. Kim,1,3 I. Jurisica,1,3 R. John,1 A. Konvalinka.1,3

    1University Health Network, Toronto, ON, Canada; 2Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Montréal, QC, Canada; 3University of Toronto, Toronto, ON, Canada.

    AngiotensinII (AngII), the main effector of the renin-angiotensin system (RAS), causes kidney interstitial fibrosis/tubular atrophy (IFTA). However, there are presently no markers of AngII renal…
  • 2018 American Transplant Congress

    Long-Term HIF-1α Stabilization is Associated with Fibrosis in Rat Lung Allografts

    K. Freischlag,1 B. Ezekian,1 P. Schroder,1 J. Everitt,1 J. Yoon,1 M. Swiderska-Syn,3 W. Parker,1 A. Diehl,1 J. Kwun,1 S. Knechtle.1

    1Duke Transplant Center, Duke University, Durham, NC; 2Medical University of South Carolina, Charleston, SC.

    Introduction: HIF-1α is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) and functions as a master transcriptional regulator of cellular and developmental…
  • 2018 American Transplant Congress

    Tacrolimus Exposure in Human Proximal Tubule Cells Results in Differentially Increased CTGF Expression in Relation to Pharmacogenetic Variants of CYP3A5 and ABCB1

    N. Knops,1 Y. Ramazani,2 B. Van den Heuvel,2 R. Goldschmeding,3 T. Nguyen,3 E. Levtchenko,1 D. Kuypers.4

    1Paediatric Nephrology and Solid Organ Transplantation, University Hospitals Leuven, Leuven, Belgium; 2Laboratory of Paediatrics, KU Leuven, Leuven, Belgium; 3Pathology, University Medical Center Utrecht, Utrecht, Netherlands; 4Nephrology, University Hospitals Leuven, Leuven, Belgium.

    AIM: Clinical studies have demonstrated the importance of genetic variation for tacrolimus disposition and suggested a role in the development of renal fibrosis associated with…
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