Articles tagged "Fibrosis"

2019 American Transplant Congress
Effects of Pretreated Bortezomib on Renal Function after Renal Ischemia – Reperfusion Injury in Mice
X. Zheng
Beijing Chaoyang Hospital, Capital Medical University, Beijing, China
*Purpose: To observe the effects of pretreated bortezomib at different points on renal function and renal histology after renal ischemia-reperfusion injury in mice.*Methods: A mice…
2019 American Transplant Congress
Galectin-3 Levels Are Associated with the Incidence and Severity of Chronic GVHD One Year after Allogeneic Hematopoietic Cell Transplantation
N. Navarro-Alvarez¹, A. R. Andrews¹, Z. DeFilipp², Y. A. Chen², V. T. Ho³, J. Ritz³, T. R. Spitzer⁴, C. A. Huang⁵
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²Blood and Marrow Transplant Program, Massachusetts General Hospital, Boston, MA, ³Hematologic Malignancies, Dana-Farber Cancer Institute, Boston, MA, ⁴Hematology/Oncology, Massachusetts General Hospital, Boston, MA, ⁵Plastic & Reconstructive Surgery and Transplant Surgery Divisions, University of Colorado, Denver, Aurora, CO
*Purpose: Chronic graft-versus-host disease (cGVHD) is a frequent complication of allogeneic hematopoietic cell transplantation (HCT) and a leading cause of late morbidity and mortality. T-…
2019 American Transplant Congress
Role of RIPK3 in Chronic Rejection Following Human Lung Transplantation
S. Angara, R. Ravichandran, H. Sodawalla, M. Smith, R. Bremner, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Immunological mechanisms leading to chronic rejection, bronchiolitis obliterans syndrome (BOS), following human lung transplantation remains unclear though a strong correlation have been identified between…
2019 American Transplant Congress
Cell Coding Transcriptomic Analysis Of Serial Blood And Biopsy Samples In A Large Cohort Of Kidney Transplant Recipients
W. Zhang¹, Z. Yi¹, Z. Sun¹, K. Keung², C. Wei¹, C. Xi¹, S. Farouk¹, M. Menon¹, P. Cravedi¹, P. O'Connell², B. Murphy¹
¹Icahn School of Medicine at Mount Sinai, New York, NY, ²The University of Sydney, Sydney, Australia
*Purpose: Whole blood and graft biopsy RNA expression analyses are limited by the heterogeneous cell composition of the samples. Cell coding is an analytical tool…
2019 American Transplant Congress
Non-Invasive Monitoring of the Kidney Allograft
S. Bontha¹, G. Darville¹, C. Kuscu¹, C. Kuscu², A. Bajwa¹, J. Eason³, D. Maluf⁴, V. Mas⁵
¹Surgery, UTHSC, Memphis, TN, ²Surgery, UTHSC, memphis, TN, ³Surgery, Director of Transplant Institute - UTHSC, Memphis, TN, ⁴UTHSC, Memphis, TN, ⁵Surgery, Director of Transplant Research Institute, Memphis, TN
*Purpose: A major issue in kidney transplantation is the lack of validated non-invasive biomarkers for monitoring graft function, current biochemical markers (i.e., creatinine) have poor…
2019 American Transplant Congress
Urinary Extracellular Vesicles-Related Protein Biomarkers for the Non-Invasive Monitoring of Rejection in Kidney Transplanted Patients
L. Carreras-Planella¹, I. Bancu², D. Cucchiari³, L. Cañas², J. Juega², M. Franquesa¹, M. Perez-Mir², I. Revuelta³, F. Diekman⁴, R. Lauzurica², F. Borràs¹
¹REMAR-IVECAT Group, Institut Germans Trias i Pujol, Badalona, Spain, ²Nephrology- Renal Transplant Unit, Hospital Universitari Germans Trias i Pujol, Badalona, Spain, ³Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Barcelona, Spain, ⁴Dept. Nefrologia i Trasplantament Renal, Institut Clínicde Nefrologia i Urologia (ICNU), Hospital Clinic, Badalona, Spain
*Purpose: Chronic kidney rejection is currently the main cause of graft losses. Blood and urine analyses to monitor kidney transplanted patients are not specific, and…
2019 American Transplant Congress
Chemokine Ligand 14 is a Novel Therapeutic Target in Kidney Fibrosis
S. Lee¹, Y. Kim¹, J. Moon¹, H. Lee¹, S. Han¹, J. Lee², R. Cha³, D. Kim¹, C. Lee⁴, K. Kim⁵, Y. Kim¹, S. Yang⁶
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Boramae Medical Center, Seoul, Korea, Republic of, ³Internal Medicine, National Medical Center, Seoul, Korea, Republic of, ⁴Internal Medicine, Cheju Halla University Hospital, Jeju, Korea, Republic of, ⁵Biomedical Science, Seoul National University, Seoul, Korea, Republic of, ⁶Seoul National University College of Medicine, Seoul, Korea, Republic of
*Purpose: Chemokine ligand 14 (CCL14), a ligand for CCR1, has been known as a M2 polarizing marker and chemotactic cytokine, which is expressed by fibroblast,…
2019 American Transplant Congress
Nephrotoxicity Caused by Calcineurin Inhibitors is Meditated by BAX, NOL3 and XIAP Apoptotic Genes Dysregulation
G. Queipo¹, M. Fonsecha-Sanchez¹, J. Sanchez¹, L. Garcia¹, M. Carmona², E. Villanueva¹, G. Melendez¹, L. Morales-Buenrostro³, M. Alamilla¹
¹Hospital General de Mexico-Eduardo Liceaga Facultad de Medicina UNAM, Mexico City, Mexico, ²Facultad de Medicina UNAM, Mexico City, Mexico, ³Instituto Nacional de Ciencias Médicas Salvador Zubirán, Mexico City, Mexico
*Purpose: Calcineurin inhibitors (CNI) remain the most effective and widely used immunosuppressive agents in kidney transplantation. Nephrotoxicity is a major secondary effect, and renal biopsy…
2019 American Transplant Congress
Activation of Renal Fibroblasts by Anti- Major Histocompatibility Complex Antibody: A Missing Link in Allograft Fibrosis
M. B. Oliver¹, J. Chen², A. Zmijewska¹, R. B. Mannon¹
¹Medicine, Division of Nephrology, The University of Alabama at Birmingham, Birmingham, AL, ²Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, The University of Alabama at Birmingham, Birmingham, AL
*Purpose: Chronic antibody-mediated rejection (CAMR) is an important contributor to late kidney allograft loss, frequently accompanied by interstitial fibrosis and tubular atrophy. Donor-specific antibodies (DSA)…
2019 American Transplant Congress
A Novel Apparatus Mimicking Hypertensive Kidney With Primary Cultured Human Kidney Cells Using Rotational Force: Application To In Vitro Drug Screening In Kidney Transplant Recipients
Y. Kim¹, S. Lee², J. Moon¹, J. Kim¹, M. Yu³, C. Lee⁴, Y. Kim¹, S. Yang⁵, J. Jeong¹, J. Seon¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Hanyang University Medical Center, Seoul, Korea, Republic of, ⁴Internal Medicine, Cheju Halla General Hospital, Cheju, Korea, Republic of, ⁵Kidney Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Cell culture is an essential part of the development for various medical technologies such as identifying the cause of the disease and developing new…

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