ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2019 American Transplant Congress

    Occult Liver Graft Fibrosis Prior to Transplantation Influences Clinical Outcomes

    H. Hirao, T. Ito, K. Kadono, S. Kageyama, K. Nakamura, K. J. Dery, B. Ke, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec‐Weglinski

    Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA

    *Purpose: Liver transplantation (LT) has become a standard therapy for the management of end-stage liver disease, while early allograft dysfunction (EAD) remains a serious problem.…
  • 2019 American Transplant Congress

    Effect of Paricalcitol on Markers of Inflammation in De Novo Renal Transplant Recipients

    H. K. Pihlstrøm1, T. Ueland2, A. E. Michelsen2, G. Mjøen1, K. Midtvedt1, H. Holdaas1

    1Department of Surgery, Inflammation Medicine and Transplantation, Oslo University Hospital, Oslo, Norway, 2Institiute for Clinical Medicine, University of Oslo, Oslo, Norway

    *Purpose: Despite the reduction of systemic inflammation associated with receiving a functioning transplant, markers of inflammation may remain somewhat elevated in renal transplant recipients, and…
  • 2019 American Transplant Congress

    Galectin-3 and Long-Term Graft Failure in Renal Transplant Recipients: A Prospective Cohort Study

    C. G. Sotomayor1, C. A. Keyzer1, J. L. Anderson1, R. O. Gans2, I. M. Nolte3, M. H. de Borst1, S. P. Berger1, G. J. Navis1, R. A. de Boer4, S. J. Bakker1

    1Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, 2Department of Internal Medicine, University Medical Center Groningen, Groningen, Netherlands, 3Department of Epidemiology, University Medical Center Groningen, Groningen, Netherlands, 4Department of Cardiology, University Medical Center Groningen, Groningen, Netherlands

    *Purpose: Galectin-3 has been associated with renal fibrosis and decline of renal function. We aimed to determine the association of galectin-3 with long-term risk of…
  • 2019 American Transplant Congress

    Long-term Impact of Antihypertensive Treatment and Tacrolimus Dose in Renal Allograft Recipients 5 Years Post-Transplantation

    D. Rush1, S. Cockfield2, S. Wilson3, J. Schwartz4

    1University of Manitoba, Winnipeg, MB, Canada, 2University of Alberta Hopspital, Edmonton, AB, Canada, 3Astellas Pharma Global Development, Northbrook, IL, 4Astellas Pharma US, Northbrook, IL

    *Purpose: Inflammation and fibrosis after renal transplantation may be modulated by optimizing tacrolimus exposure, or by use of angiotensin-converting enzyme inhibitors (ACEi), or angiotensin receptor…
  • 2019 American Transplant Congress

    Clinical Implications of Serum Mac-2 Binding Protein in Regular Follow Up after Pediatric Living Donor Liver Transplantation

    T. Ueno1, T. Kodama1, Y. Noguchi1, M. Nomura1, R. Saka1, Y. Takama1, Y. Tazuke1, K. Bessho2, H. Okuyama1

    1Pediatric Surgery, Osaka University Graduate School of Medicine, Suita, Japan, 2Pediatrics, Osaka University Graduate School of Medicine, Suita, Japan

    *Purpose: Pediatric living donor liver transplant (LDLT) patients sometimes develops graft fibrosis. They showed graft fibrosis even if their liver function tests were within normal…
  • 2019 American Transplant Congress

    Impact of DAA Treatment on Graft Fibrosis in HCV Positive Liver Transplantation

    J. Wellington1, A. Ma2, S. Kottilil3, J. Husson3, E. Wilson3, D. Bruno4

    1Gastroenterology & Hepatology, University of Maryland, Baltimore, MD, 2Internal Medicine, University of Maryland, Baltimore, MD, 3Institute of Human Virology, Division of Clinical Care and Research, University of Maryland, Baltimore, MD, 4Transplant Surgery, University of Maryland, Baltimore, MD

    *Purpose: Liver transplantation, LT, for HCV-related disease has the lowest five-year graft survival of all LT recipients, primarily due to accelerated fibrosis from unrestrained HCV…
  • 2019 American Transplant Congress

    Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury

    S. Lan1, B. Yang1, M. Dieudé1, J. Sabo-Vatasescu2, A. Karakeussian-Rimbaud2, J. Turgeon2, S. Qi3, N. Patey4, M. Hébert1

    1Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, 2CRCHUM, Montreal, QC, Canada, 3Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, 4Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
  • 2019 American Transplant Congress

    Fibrosis Scoring Correlates with Progression of Chronic Pancreatitis, Islet Isolation Yields and Transplant Outcomes in Patients Undergoing Islet Autotransplantation

    Y. Liu1, J. SoRelle2, K. Kumano3, S. Vasu3, M. Lawrence4, A. Gupta1, N. Onaca1, E. Beecherl1, B. Naziruddin4

    1Baylor Simmons Transplant Institute, Dallas, TX, 2UTSouthwestern Medical Center, Dallas, TX, 3Baylor Scott and White Research Institute, Dallas, TX, 4Baylor University Medical Ctr, Dallas, TX

    *Purpose: Total pancreatectomy with autologous islet transplantation (TPIAT) is a promising procedure for alleviating pain and maintaining glucose homeostasis in chronic pancreatitis (CP) patients. However,…
  • 2019 American Transplant Congress

    Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy

    D. Patel1, T. Divanyan1, E. Acosta1, K. Carnes2, D. Howard3, F. Jourd’heuil3, D. Jourd’heuil3, R. Lopez-Soler4

    1Albany Medical College, Albany, NY, 2Urology, Albany Medical College, Albany, NY, 3Molecular and Cellular Physiology, Albany Medical College, Albany, NY, 4Surgery, Section of Transplantation, Albany Medical College, Albany, NY

    *Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…
  • 2019 American Transplant Congress

    Vimentin Inhibition Improves Post-Transplant Survival in a Mouse Renal Transplant Model

    R. Lopez-Soler1, Z. Zhang2, H. Chin3, J. Wang4, K. Ridge5

    1Albany Medical College, Albany, NY, 2Microsurgery Core, Comprehensive Transplant Center, Northwestern University, Feinberg School of Medicine, Chicago, IL, 3Molecular and Cellular Physiology, Albany Medical College, Albany, NY, 4Microsurgery Core, Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL, 5Northwestern Univesity, Feinberg School of Medicine, Chicago, IL

    *Purpose: Most renal transplants ultimately fail secondary to chronic allograft nephropathy (CAN). The development of Epithelial to Mesenchymal Transition (EMT) in renal tubular epithelial cells…
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