2020 American Transplant Congress
Activation of YAP Attenuates Hepatic Damage and Fibrosis in Liver Ischemia-Reperfusion Injury: From Bench to Bedside
1Dumont-UCLA Transplant Center, Los Angeles, CA, 2Shanghai Jiaotong University, Shanghai, China
*Purpose: Hepatic ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver resection and transplantation. YAP, the effector of Hippo pathway, is essential in…2020 American Transplant Congress
Interstitial Inflammation with Chronic Allograft Injury Best Predicts Graft Loss
Einstein-Montefiore Transplant Center, Bronx, NY
*Purpose: We aimed to identify clinical, serological and histopathological predictors of graft loss in kidney transplant recipients who underwent clinically indicated graft biopsies for worsening…2020 American Transplant Congress
Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice
*Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…2019 American Transplant Congress
Bortezomib Attenuates the Progression of Epithelial to Mesenchymal Transition through Smurf1 Akt mTOR P70S6K Pathway in Rat Allograft Renal Interstitial Fibrosis Model
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was to detect the effects of Bortezomib and Smurf1 in the EMT and allograft renal interstitial fibrosis.*Methods: Biomarkers of EMT, as well…2019 American Transplant Congress
Cytomegalovirus (CMV) Infection Induces an Angiogenic Response through Hepatic Stellate Cells (HSCs) and Leads to Early Post-Transplant Liver Fibrosis (LF) and Poor Graft Survival
1Pathology, Baskent University, Ankara, Turkey, 2Transplantation, Baskent University, Ankara, Turkey
*Purpose: The ability of the CMV to infect the endothelial cells (ECs) is critical. CMV can increase EC adhesion, permeability, and create a pro-inflammatory environment…2019 American Transplant Congress
Initial Peritoneal sST2 Levels Are Associated with Peritoneal Failure and ST2 Blockade Mitigates TGF-β and High Glucose-Induced Peritoneal Fibrosis
*Purpose: Peritoneal fibrosis (PF) is an intractable complication which leads to peritoneal membrane failure in peritoneal dialysis (PD). The aim of this study was to…2019 American Transplant Congress
Occult Liver Graft Fibrosis Prior to Transplantation Influences Clinical Outcomes
Surgery, Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: Liver transplantation (LT) has become a standard therapy for the management of end-stage liver disease, while early allograft dysfunction (EAD) remains a serious problem.…2019 American Transplant Congress
Effect of Paricalcitol on Markers of Inflammation in De Novo Renal Transplant Recipients
*Purpose: Despite the reduction of systemic inflammation associated with receiving a functioning transplant, markers of inflammation may remain somewhat elevated in renal transplant recipients, and…2019 American Transplant Congress
Galectin-3 and Long-Term Graft Failure in Renal Transplant Recipients: A Prospective Cohort Study
*Purpose: Galectin-3 has been associated with renal fibrosis and decline of renal function. We aimed to determine the association of galectin-3 with long-term risk of…2019 American Transplant Congress
Long-term Impact of Antihypertensive Treatment and Tacrolimus Dose in Renal Allograft Recipients 5 Years Post-Transplantation
*Purpose: Inflammation and fibrosis after renal transplantation may be modulated by optimizing tacrolimus exposure, or by use of angiotensin-converting enzyme inhibitors (ACEi), or angiotensin receptor…
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