2020 American Transplant Congress
Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion
*Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…2020 American Transplant Congress
Fibrosing Cholestatic Hepatatitis in Post Renal Transplant and Successful Treatment with Newer DAA Therapy
Nephrology, Manipal Hospital, Bangalore, India
*Purpose: Fibrosing cholestatic hepatitis is often fatal post renal transplantation. we report a case of successful treatment of FCH and complete recovery*Methods: A 53 year…2020 American Transplant Congress
Molecular Phenotypes of Liver Transplant Injury: The INTERLIVER Study
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: Liver parenchymal injury phenotypes are difficult to evaluate by histology but could be amenable to molecular assessment. Having developed a Molecular Microscope® Diagnostic System…2019 American Transplant Congress
Clinical Implications of Serum Mac-2 Binding Protein in Regular Follow Up after Pediatric Living Donor Liver Transplantation
*Purpose: Pediatric living donor liver transplant (LDLT) patients sometimes develops graft fibrosis. They showed graft fibrosis even if their liver function tests were within normal…2019 American Transplant Congress
Impact of DAA Treatment on Graft Fibrosis in HCV Positive Liver Transplantation
*Purpose: Liver transplantation, LT, for HCV-related disease has the lowest five-year graft survival of all LT recipients, primarily due to accelerated fibrosis from unrestrained HCV…2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…2019 American Transplant Congress
Fibrosis Scoring Correlates with Progression of Chronic Pancreatitis, Islet Isolation Yields and Transplant Outcomes in Patients Undergoing Islet Autotransplantation
*Purpose: Total pancreatectomy with autologous islet transplantation (TPIAT) is a promising procedure for alleviating pain and maintaining glucose homeostasis in chronic pancreatitis (CP) patients. However,…2019 American Transplant Congress
Determining the Molecular Nature and Role of Cytoglobin in Chronic Allograft Nephropathy
*Purpose: Although it is usually accepted that the kidney is prone to hypoxic injury, the importance of hypoxia in chronic kidney disease (CKD) as well…2019 American Transplant Congress
Vimentin Inhibition Improves Post-Transplant Survival in a Mouse Renal Transplant Model
*Purpose: Most renal transplants ultimately fail secondary to chronic allograft nephropathy (CAN). The development of Epithelial to Mesenchymal Transition (EMT) in renal tubular epithelial cells…2019 American Transplant Congress
Donor Renal Macrophages in Post-Transplant Ischemia/Reperfusion Injury (IRI): Role of IL-1R8 in Modulating Fate, Phenotype and Function
Mario Negri Institute, Ranica, Italy
*Purpose: Post-transplant (tx) IRI activates TLR/IL-1R on tissue resident leukocytes initiating innate immune response. We studied how donor renal resident macrophages (rMF) respond to post-tx…
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