Articles tagged "Fibrosis"

2020 American Transplant Congress
Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice
D. Choi¹, D. Kim², E. Kim², J. Jeong², J. Kim¹, Y. Ham¹, Y. Chang³, K. Na¹, K. Lee¹
¹Nephrology, Chungnam National University, Daejeon, Korea, Republic of, ²Department of Medical Science, Chungnam National University, Daejeon, Korea, Republic of, ³Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of
*Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…
2020 American Transplant Congress
Exosomes Released from Natural Killer Cells Activation of Immune Responses: Role in Chronic Lung Allograft Dysfunction
R. Ravichandran, Y. Itabashi, W. Liu, M. Rahman, S. Bansal, R. Bremner, M. Smith, T. Mohanakumar
Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Recent studies demonstrated natural killer (NK) cells can induce cytotoxicity both by direct cytotoxic mechanisms and antibody (Ab) dependent cytotoxicity; however its role in…
2020 American Transplant Congress
The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model
S. Lee¹, J. Lee², H. Park², Y. Kim², S. Lee¹
¹Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, ²Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
2020 American Transplant Congress
Mass-Spectrometry Based Discovery of Tubular Injury Marker in Chronic Kidney Disease
J. Kim¹, D. Han¹, J. Jeong², J. Moon¹, S. Lee³, Y. Kim¹, K. Yoo⁴, D. Kim¹, Y. Kim¹, S. Yang¹
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Veterans Health Service Medical Center, Seoul, Korea, Republic of, ³Kangwon National University Hospital, Kangwon-do, Korea, Republic of, ⁴Ulsan National University Hospital, Ulsan, Korea, Republic of
*Purpose: Renal tubular injury and interstitial fibrosis are inevitable processes in the progression of chronic kidney disease (CKD). The purpose of this study is to…
2020 American Transplant Congress
Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation
L. Fan¹, X. Zhang¹, T. Li¹, L. R. Mathews¹, G. K. Dwyer², M. J. Calderon³, K. E. Helfrich³, M. A. Ross³, S. C. Watkins³, H. R. Turnquist¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Immunology, University of Pittsburgh, Pittsburgh, PA, ³Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA
*Purpose: Chronic rejection (CR) after organ transplantation (Tx) manifests as function-limiting allograft fibrosis and vasculopathy. Current immunosuppressants fail to prevent CR and insights into the…
2020 American Transplant Congress
Characterization of Gut Microbiome in Liver Transplant Recipients with Non-Alcoholic Steatohepatitis
S. Sataphaty¹, P. Banerjee², J. Pierre³, R. Heda³, S. Dutta³, D. D. Higgins⁴, V. Mas⁵, S. Khan⁶, V. Mupparaju³, S. R. Nair⁷, J. D. Eason⁸, D. Kleiner⁹, D. Maluf¹⁰
¹Department of Surgery, Division of Hepatology and Sandra Atlas Bass Center for Liver Diseases, Northwell Health, NYC, NY, ²School of Public Health, University of Memphis, Memphis, TN, ³University of Tennessee Health Science Center, Memphis, TN, ⁴University of Memphis, Memphis, TN, ⁵James D Eason Transplant Institute, Memphis, TN, ⁶Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, NYC, NY, ⁷Department of Surgery, James D Eason Transplant Institute, Memphis, TN, ⁸Department of Surgery, James D Eason Transplant Institute, NYC, TN, ⁹Laboratory of Pathology/National Cancer Institute, Bethesda, WA, ¹⁰Department of Surgery_ University of Tennessee, James D Eason Transplant Institute, NYC, TN
*Purpose: Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH) is a growing problem globally and recurs even after liver transplant (LT).…
2020 American Transplant Congress
Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion
Y. Kim¹, K. Kim¹, J. Lee¹, J. Moon¹, J. Kim¹, J. Lee², Y. Kim¹, S. Yang¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of
*Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
2020 American Transplant Congress
Fibrosing Cholestatic Hepatatitis in Post Renal Transplant and Successful Treatment with Newer DAA Therapy
V. Siddini
Nephrology, Manipal Hospital, Bangalore, India
*Purpose: Fibrosing cholestatic hepatitis is often fatal post renal transplantation. we report a case of successful treatment of FCH and complete recovery*Methods: A 53 year…
2020 American Transplant Congress
Molecular Phenotypes of Liver Transplant Injury: The INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran¹, &. the INTERLIVER Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Liver parenchymal injury phenotypes are difficult to evaluate by histology but could be amenable to molecular assessment. Having developed a Molecular Microscope® Diagnostic System…
2020 American Transplant Congress
Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction
H. B. Moore¹, T. Nydam¹, J. Pomposelli¹, C. Walker¹, A. Schulick¹, R. Choudhury¹, H. Yaffe¹, M. Adams², M. Cohen³, E. Pomfret¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital, Aurora, CO, ³Denver Health Medical Center, Denver, CO
*Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…

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