Articles tagged "Fibrosis"

2020 American Transplant Congress
Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway
W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
2020 American Transplant Congress
The Impact of Thy1 Expression of Fibroblast for Chronic Lung Allograft Dysfunction
A. Hata¹, Y. Guo¹, D. Li¹, Z. Mei¹, A. Manafi¹, A. Banerjee¹, B. Mahgoub¹, T. H. Barker², A. S. Krupnick¹
¹Surgery, University of Virginia, Charlottesville, VA, ²Biomedical Engineering, University of Virginia, Charlottesville, VA
*Purpose: Chronic lung allograft dysfunction (CLAD) result from excessive immune activation and excessive collagen deposition by fibroblasts within the lung parenchyma or airway.Bronchiolitis obliterans (OB)…
2020 American Transplant Congress
Elucidating the Genetic Background of End Stage Renal Disease of Unknown Aetiology in Patients Listed for Kidney Transplantation
E. Leenen¹, B. Beck², A. Joerres¹, A. Weidemann¹
¹Department of Medicine I - Nephrology, Transplantation & Medical Intensive Care, Medical Center Cologne-Merheim, Cologne, Germany, ²Institute of Human Genetics University Hospital Cologne, Medical Center Cologne-Merheim, Cologne, Germany
*Purpose: The prevalence of end stage renal disease (ESRD) of unknown aetiology in adult patients accounts for almost 20% of all dialysis patients in Europe.…
2020 American Transplant Congress
Development of DSA Class II is Associated with Immunosuppressive Monotherapy and Increased Risk for Graft Fibrosis, Chronic Rejection and Graft Loss
M. Sterneck¹, B. Sultani¹, A. Ozga², S. Weidemann³, J. Hermann⁴, E. Grabhorn⁵, U. Herden⁶, L. Fischer⁶
¹University Medical Center Hamburg Eppendorf, Hamburg, Germany, ²Insitute of Medical Biometry, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ³Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁴Pediatric Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁵Pediatric Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, ⁶Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
*Purpose: Recent studies have suggested a negative impact of class 2 DSA on short term outcome of OLT recipients. The aim of this study was…
2020 American Transplant Congress
A Mouse Model of Non-MHC Mismatches Recapitulates Chronic Allograft Dysfunction and I-IFTA
V. Pavlov¹, F. Garzon¹, R. Haroon Al Rasheed², K. Banu¹, F. ElSalem¹, L. Li¹, E. Cody¹, M. Planoutene¹, N. Chun¹, Z. Zhang¹, J. Leventhal¹, B. Murphy¹, P. Heeger¹, M. C. Menon¹
¹Medicine, Mount Sinai School of Medicine, New York, NY, ²Pathology, Mount Sinai School of Medicine, New York, NY
*Purpose: Fibrotic and atrophic changes or IF/TA is an important cause of graft loss. We reported that genome-wide donor-recipient non-HLA mismatches independently correlate with Banff…
2020 American Transplant Congress
Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury
S. Lan¹, B. Yang¹, J. Sabo-Vatasescu², M. Bourgault², A. Karakeussian-Rimbaud³, J. Turgeon³, S. Qi¹, N. Patey⁴, M. Dieudé⁵, M. Hébert¹
¹Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³CRCHUM, CDTRP, Montreal, QC, Canada, ⁴Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, ⁵CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
2020 American Transplant Congress
Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy
V. Kung¹, M. Haas¹, M. Gillespie², E. Huang², R. Sandhu²
¹Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
2020 American Transplant Congress
Identification of Molecular Markers for Liver Cirrhosis (NASH) by Single-Nucleus RNA Sequencing
C. Kuscu¹, A. Mouhammed², C. Kuscu³, A. R. Wolen³, J. D. Eason³, D. Maluf³, V. Mas³
¹Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, ²Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, ³Department of Surgery, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease and it constitutes a significant portion of the chronic liver diseases that affected more than…
2020 American Transplant Congress
Impact of Donor Noninvasive Liver Fibrotic Score on Graft Injury in Liver Transplantation
S. M. Younan, T. Ito, H. Hirao, A. Aziz, A. E. Murray, J. DiNorcia III, V. G. Agopian, D. G. Farmer, R. W. Busuttil, F. M. Kaldas
The Dumont-UCLA Transplant Center, UCLA, Los Angeles, CA
*Purpose: The increasing prevalence of obesity and metabolic syndrome, has led to a corresponding increase in steatotic livers being utilized in liver transplantation (LT). These…
2020 American Transplant Congress
Hematopoietic Cell Kinase Promotes Kidney Fibrosis Through Autophagy Pathway
C. Wei, L. Mou, K. Banu, M. Menon, W. Zhang, C. He, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: In our previous studies, we identified hematopoietic cell kinase (HCK) as a key driver of renal fibrosis through TGFβ/Smad3 pathway. Here in this study,…

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