Articles tagged "Fibrosis"

2020 American Transplant Congress
Characterization of Gut Microbiome in Liver Transplant Recipients with Non-Alcoholic Steatohepatitis
S. Sataphaty¹, P. Banerjee², J. Pierre³, R. Heda³, S. Dutta³, D. D. Higgins⁴, V. Mas⁵, S. Khan⁶, V. Mupparaju³, S. R. Nair⁷, J. D. Eason⁸, D. Kleiner⁹, D. Maluf¹⁰
¹Department of Surgery, Division of Hepatology and Sandra Atlas Bass Center for Liver Diseases, Northwell Health, NYC, NY, ²School of Public Health, University of Memphis, Memphis, TN, ³University of Tennessee Health Science Center, Memphis, TN, ⁴University of Memphis, Memphis, TN, ⁵James D Eason Transplant Institute, Memphis, TN, ⁶Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, NYC, NY, ⁷Department of Surgery, James D Eason Transplant Institute, Memphis, TN, ⁸Department of Surgery, James D Eason Transplant Institute, NYC, TN, ⁹Laboratory of Pathology/National Cancer Institute, Bethesda, WA, ¹⁰Department of Surgery_ University of Tennessee, James D Eason Transplant Institute, NYC, TN
*Purpose: Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH) is a growing problem globally and recurs even after liver transplant (LT).…
2020 American Transplant Congress
Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion
Y. Kim¹, K. Kim¹, J. Lee¹, J. Moon¹, J. Kim¹, J. Lee², Y. Kim¹, S. Yang¹
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of
*Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
2020 American Transplant Congress
Fibrosing Cholestatic Hepatatitis in Post Renal Transplant and Successful Treatment with Newer DAA Therapy
V. Siddini
Nephrology, Manipal Hospital, Bangalore, India
*Purpose: Fibrosing cholestatic hepatitis is often fatal post renal transplantation. we report a case of successful treatment of FCH and complete recovery*Methods: A 53 year…
2020 American Transplant Congress
Molecular Phenotypes of Liver Transplant Injury: The INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran¹, &. the INTERLIVER Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: Liver parenchymal injury phenotypes are difficult to evaluate by histology but could be amenable to molecular assessment. Having developed a Molecular Microscope® Diagnostic System…
2020 American Transplant Congress
Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction
H. B. Moore¹, T. Nydam¹, J. Pomposelli¹, C. Walker¹, A. Schulick¹, R. Choudhury¹, H. Yaffe¹, M. Adams², M. Cohen³, E. Pomfret¹
¹University of Colorado, Aurora, CO, ²Childrens Hospital, Aurora, CO, ³Denver Health Medical Center, Denver, CO
*Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…
2020 American Transplant Congress
Automatic Quantification of Interstitial Fibrosis in Renal Allograft
J. Hogan¹, J. Vizcarra², M. A. Tageldin², L. A. Cooper³, D. A. Gutman², A. B. Farris⁴
¹Transplant Research Center, Department of Surgery, Emory University, Atlanta, GA, ²Computer Science Department, Emory University, Atlanta, GA, ³Pathology Department, Northwestern University, Evanston, IL, ⁴Pathology Department, Emory University, Atlanta, GA
*Purpose: Renal allografts are typically assessed by pathologists using the Banff classification with known interobserver variability. We previously demonstrated the utility of image analysis in…
2020 American Transplant Congress
Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients
M. Mandurah, M. A. Levine, A. Sener, P. Luke
Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada
*Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…
2020 American Transplant Congress
Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein
C. Suo, Z. Gui, Z. Wang, J. Zhou, M. Zheng, H. Chen, S. Fei, L. Sun, X. Zhang, M. Gu, R. Tan
Jiangsu Province Hospital, Nanjing, China
*Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…
2020 American Transplant Congress
Autophagy Attenuates Renal Allograft Interstitial Fibrosis by Regulating the EndMT Induced by TNF-α
Z. Gui, C. Suo, Z. Wang, S. Fei, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Kidney interstitial fibrosis is a significant cause of allograft failure in kidney transplantation. Autophagy is a self-digestive process that eliminates impaired or aged proteins…
2020 American Transplant Congress
Divergent Molecular Pathways Underlie the Evolution of Allograft Fibrosis in Two Mouse Models of Chronic Lung Allograft Dysfunction
T. Watanabe, J. Allen, K. Boonstra, Z. Guan, K. Bei, S. Keshavjee, J. Yeung, T. Martinu, S. Juvet
Latner Thoracic Surgery Research Laboratories, Toronto Lung Transplant Program / University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is potentiated by activation of the innate immune system and occurs in two patterns: diffuse…

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