ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2020 American Transplant Congress

    Autophagy Attenuates Renal Allograft Interstitial Fibrosis by Regulating the EndMT Induced by TNF-α

    Z. Gui, C. Suo, Z. Wang, S. Fei, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Kidney interstitial fibrosis is a significant cause of allograft failure in kidney transplantation. Autophagy is a self-digestive process that eliminates impaired or aged proteins…
  • 2020 American Transplant Congress

    Divergent Molecular Pathways Underlie the Evolution of Allograft Fibrosis in Two Mouse Models of Chronic Lung Allograft Dysfunction

    T. Watanabe, J. Allen, K. Boonstra, Z. Guan, K. Bei, S. Keshavjee, J. Yeung, T. Martinu, S. Juvet

    Latner Thoracic Surgery Research Laboratories, Toronto Lung Transplant Program / University Health Network, Toronto, ON, Canada

    *Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is potentiated by activation of the innate immune system and occurs in two patterns: diffuse…
  • 2020 American Transplant Congress

    Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway

    W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
  • 2020 American Transplant Congress

    The Impact of Thy1 Expression of Fibroblast for Chronic Lung Allograft Dysfunction

    A. Hata1, Y. Guo1, D. Li1, Z. Mei1, A. Manafi1, A. Banerjee1, B. Mahgoub1, T. H. Barker2, A. S. Krupnick1

    1Surgery, University of Virginia, Charlottesville, VA, 2Biomedical Engineering, University of Virginia, Charlottesville, VA

    *Purpose: Chronic lung allograft dysfunction (CLAD) result from excessive immune activation and excessive collagen deposition by fibroblasts within the lung parenchyma or airway.Bronchiolitis obliterans (OB)…
  • 2020 American Transplant Congress

    Elucidating the Genetic Background of End Stage Renal Disease of Unknown Aetiology in Patients Listed for Kidney Transplantation

    E. Leenen1, B. Beck2, A. Joerres1, A. Weidemann1

    1Department of Medicine I - Nephrology, Transplantation & Medical Intensive Care, Medical Center Cologne-Merheim, Cologne, Germany, 2Institute of Human Genetics University Hospital Cologne, Medical Center Cologne-Merheim, Cologne, Germany

    *Purpose: The prevalence of end stage renal disease (ESRD) of unknown aetiology in adult patients accounts for almost 20% of all dialysis patients in Europe.…
  • 2020 American Transplant Congress

    Development of DSA Class II is Associated with Immunosuppressive Monotherapy and Increased Risk for Graft Fibrosis, Chronic Rejection and Graft Loss

    M. Sterneck1, B. Sultani1, A. Ozga2, S. Weidemann3, J. Hermann4, E. Grabhorn5, U. Herden6, L. Fischer6

    1University Medical Center Hamburg Eppendorf, Hamburg, Germany, 2Insitute of Medical Biometry, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 3Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 4Pediatric Radiology, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 5Pediatric Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany, 6Transplant Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany

    *Purpose: Recent studies have suggested a negative impact of class 2 DSA on short term outcome of OLT recipients. The aim of this study was…
  • 2020 American Transplant Congress

    A Mouse Model of Non-MHC Mismatches Recapitulates Chronic Allograft Dysfunction and I-IFTA

    V. Pavlov1, F. Garzon1, R. Haroon Al Rasheed2, K. Banu1, F. ElSalem1, L. Li1, E. Cody1, M. Planoutene1, N. Chun1, Z. Zhang1, J. Leventhal1, B. Murphy1, P. Heeger1, M. C. Menon1

    1Medicine, Mount Sinai School of Medicine, New York, NY, 2Pathology, Mount Sinai School of Medicine, New York, NY

    *Purpose: Fibrotic and atrophic changes or IF/TA is an important cause of graft loss. We reported that genome-wide donor-recipient non-HLA mismatches independently correlate with Banff…
  • 2020 American Transplant Congress

    Predominant Role of Microvascular Injury and Rarefaction Function as Drivers of Progressive Renal Damage and Fibrosis Post Mild and Severe Acute Ischemia-Reperfusion Injury

    S. Lan1, B. Yang1, J. Sabo-Vatasescu2, M. Bourgault2, A. Karakeussian-Rimbaud3, J. Turgeon3, S. Qi1, N. Patey4, M. Dieudé5, M. Hébert1

    1Medicine Faculty, CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada, 2CRCHUM, Montreal, QC, Canada, 3CRCHUM, CDTRP, Montreal, QC, Canada, 4Medicine Faculty, CRCHUM, Saint Justine Hospital, University of Montreal, Montreal, QC, Canada, 5CRCHUM, CDTRP, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Here, we characterize the different cell deaths in tubular and microvascular compartments…
  • 2020 American Transplant Congress

    Chronic Active T-Cell Mediated Rejection is Variably Responsive to Immunosuppressive Therapy

    V. Kung1, M. Haas1, M. Gillespie2, E. Huang2, R. Sandhu2

    1Pathology, Cedars-Sinai Medical Center, Los Angeles, CA, 2Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA

    *Purpose: Chronic active T cell-mediated rejection (CACMR) is a newly described variant of kidney allograft rejection associated with long-term graft loss. A key histologic feature…
  • 2020 American Transplant Congress

    Identification of Molecular Markers for Liver Cirrhosis (NASH) by Single-Nucleus RNA Sequencing

    C. Kuscu1, A. Mouhammed2, C. Kuscu3, A. R. Wolen3, J. D. Eason3, D. Maluf3, V. Mas3

    1Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN, 2Bioinformatics, University of Tennessee Health Science Center, Memphis, TN, 3Department of Surgery, University of Tennessee Health Science Center, Memphis, TN

    *Purpose: Non-alcoholic fatty liver disease (NAFLD) is a progressive disease and it constitutes a significant portion of the chronic liver diseases that affected more than…
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