ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2020 American Transplant Congress

    Hematopoietic Cell Kinase Promotes Kidney Fibrosis Through Autophagy Pathway

    C. Wei, L. Mou, K. Banu, M. Menon, W. Zhang, C. He, B. Murphy

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: In our previous studies, we identified hematopoietic cell kinase (HCK) as a key driver of renal fibrosis through TGFβ/Smad3 pathway. Here in this study,…
  • 2020 American Transplant Congress

    Activation of YAP Attenuates Hepatic Damage and Fibrosis in Liver Ischemia-Reperfusion Injury: From Bench to Bedside

    Y. Liu1, T. Lu2, C. Zhang1, Z. Xue1, R. Busuttil1, J. Kupiec-Weglinski1, H. Ji1

    1Dumont-UCLA Transplant Center, Los Angeles, CA, 2Shanghai Jiaotong University, Shanghai, China

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) is a major complication of hemorrhagic shock, liver resection and transplantation. YAP, the effector of Hippo pathway, is essential in…
  • 2020 American Transplant Congress

    Interstitial Inflammation with Chronic Allograft Injury Best Predicts Graft Loss

    M. Ajaimy, M. Parides, A. Colovai, Y. Azzi, L. Liriano Ward, P. Nandigam, J. Rocca, M. Kinkhabwala, S. Greenstein, J. Graham, E. Akalin

    Einstein-Montefiore Transplant Center, Bronx, NY

    *Purpose: We aimed to identify clinical, serological and histopathological predictors of graft loss in kidney transplant recipients who underwent clinically indicated graft biopsies for worsening…
  • 2020 American Transplant Congress

    Hypothermia Attenuates Renal Fibrosis after Renal Ischemia Reperfusion in Mice

    D. Choi1, D. Kim2, E. Kim2, J. Jeong2, J. Kim1, Y. Ham1, Y. Chang3, K. Na1, K. Lee1

    1Nephrology, Chungnam National University, Daejeon, Korea, Republic of, 2Department of Medical Science, Chungnam National University, Daejeon, Korea, Republic of, 3Nephrology, Catholic University of Korea, Daejeon, Korea, Republic of

    *Purpose: Recently, acute kidney injury is a important cause of chronic kidney injury, characterized by glomerular sclerosis and tubular fibrosis. Hypothermia attenuates the acute kidney…
  • 2020 American Transplant Congress

    Exosomes Released from Natural Killer Cells Activation of Immune Responses: Role in Chronic Lung Allograft Dysfunction

    R. Ravichandran, Y. Itabashi, W. Liu, M. Rahman, S. Bansal, R. Bremner, M. Smith, T. Mohanakumar

    Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: Recent studies demonstrated natural killer (NK) cells can induce cytotoxicity both by direct cytotoxic mechanisms and antibody (Ab) dependent cytotoxicity; however its role in…
  • 2020 American Transplant Congress

    The Therapeutic Potential of Human Liver-Derived Stem Cells Transplantation in Carbon Tetrachloride-Induced Rat Liver Cirrhotic Model

    S. Lee1, J. Lee2, H. Park2, Y. Kim2, S. Lee1

    1Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of, 2Stem Cell and Regenerative Medicine Center, Research Institute for Future Medicine, Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Cirrhosis is a long-term consequence of chronic hepatic injury and there are no effective treatment methods. Mesenchymal stem cells (MSCs) have been reported to…
  • 2020 American Transplant Congress

    Mass-Spectrometry Based Discovery of Tubular Injury Marker in Chronic Kidney Disease

    J. Kim1, D. Han1, J. Jeong2, J. Moon1, S. Lee3, Y. Kim1, K. Yoo4, D. Kim1, Y. Kim1, S. Yang1

    1Seoul National University Hospital, Seoul, Korea, Republic of, 2Veterans Health Service Medical Center, Seoul, Korea, Republic of, 3Kangwon National University Hospital, Kangwon-do, Korea, Republic of, 4Ulsan National University Hospital, Ulsan, Korea, Republic of

    *Purpose: Renal tubular injury and interstitial fibrosis are inevitable processes in the progression of chronic kidney disease (CKD). The purpose of this study is to…
  • 2020 American Transplant Congress

    Regulatory T Cell-Derived Amphiregulin Activates Fibroblasts to Promote Chronic Rejection after Heart Transplantation

    L. Fan1, X. Zhang1, T. Li1, L. R. Mathews1, G. K. Dwyer2, M. J. Calderon3, K. E. Helfrich3, M. A. Ross3, S. C. Watkins3, H. R. Turnquist1

    1Surgery, University of Pittsburgh, Pittsburgh, PA, 2Immunology, University of Pittsburgh, Pittsburgh, PA, 3Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA

    *Purpose: Chronic rejection (CR) after organ transplantation (Tx) manifests as function-limiting allograft fibrosis and vasculopathy. Current immunosuppressants fail to prevent CR and insights into the…
  • 2020 American Transplant Congress

    Characterization of Gut Microbiome in Liver Transplant Recipients with Non-Alcoholic Steatohepatitis

    S. Sataphaty1, P. Banerjee2, J. Pierre3, R. Heda3, S. Dutta3, D. D. Higgins4, V. Mas5, S. Khan6, V. Mupparaju3, S. R. Nair7, J. D. Eason8, D. Kleiner9, D. Maluf10

    1Department of Surgery, Division of Hepatology and Sandra Atlas Bass Center for Liver Diseases, Northwell Health, NYC, NY, 2School of Public Health, University of Memphis, Memphis, TN, 3University of Tennessee Health Science Center, Memphis, TN, 4University of Memphis, Memphis, TN, 5James D Eason Transplant Institute, Memphis, TN, 6Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, NYC, NY, 7Department of Surgery, James D Eason Transplant Institute, Memphis, TN, 8Department of Surgery, James D Eason Transplant Institute, NYC, TN, 9Laboratory of Pathology/National Cancer Institute, Bethesda, WA, 10Department of Surgery_ University of Tennessee, James D Eason Transplant Institute, NYC, TN

    *Purpose: Non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH) is a growing problem globally and recurs even after liver transplant (LT).…
  • 2020 American Transplant Congress

    Graphene Quantum Dots Prevent Glomerular and Interstitial Injury in Murine Adriamycin Nephropathy Through Macrophage Depletion

    Y. Kim1, K. Kim1, J. Lee1, J. Moon1, J. Kim1, J. Lee2, Y. Kim1, S. Yang1

    1Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, 2Internal Medicine, Nephrology Clinic, National Cancer Center, Seoul, Korea, Republic of

    *Purpose: Macrophage infilatration is a key feature of the pathogenicity associated with glomerular and tubulo-interstitial injury in kidney disease. Graphene quantum dots (GQDs) are considered…
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