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American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2021 American Transplant Congress

    Perivenular Fibrosis After Pediatric Liver Transplant

    J. Lew, S. Cho, S. Feng, E. R. Perito

    UCSF, San Francisco, CA

    *Purpose: Graft fibrosis is a concerning long-term complication after pediatric liver transplant (LT) and though perivenular (PV) fibrosis is common, its likelihood of progression and…
  • 2021 American Transplant Congress

    Paired Surveillance Biopsies Over >4 Years from a Multi-Center Cohort of 78 Long-Term Pediatric Liver Transplant Recipients

    E. R. Perito1, E. Persyn2, J. Bucuvalas3, J. E. Squires4, M. Martinez5, S. Mohammad6, A. J. Demetris4, S. Feng1

    1UCSF, San Francisco, CA, 2King's College, London, United Kingdom, 3Mt. Sinai School of Medicine, NY, NY, 4U of Pittsburgh, Pittsburgh, PA, 5Columbia U, NY, NY, 6Northwestern U, Chicago, IL

    *Purpose: Progressive liver fibrosis threatens graft and patient longevity for children after liver transplantation (LT). Previous studies are limited to single-center, cross-sectional analyses. To address…
  • 2021 American Transplant Congress

    Liver Kinase B1 Knockdown Induces Platelet-Derived Growth Factor Receptor B Expression in Human Airway Epithelial Cells: A Potential Mechanism for Development of Fibrosis Leading to Chronic Lung Allograft Dysfunction

    M. Rahman, J. Lee, R. Ravichandran, T. Fleming, M. Smith, R. Bremner, T. Mohanakumar

    St. Joseph’s Hospital and Medical Center, Phoenix, AZ

    *Purpose: The platelet-derived growth factor and its receptor (PDGFRb) signaling pathway can be activated by epithelial mesenchymal transition which facilitates fibrosis. It is not known…
  • 2021 American Transplant Congress

    Non-Invasive Measurement of Transplant Kidney Fibrosis Using Photoacoustic Imaging

    E. Hysi1, X. He1, A. Krizova1, M. Ordon1, K. T. Pace1, M. Farcas1, M. C. Kolios2, D. A. Yuen1

    1St. Michael's Hospital, Toronto, ON, Canada, 2Ryerson University, Toronto, ON, Canada

    *Purpose: The presence of donor kidney fibrosis adversely impacts transplant outcome. Biopsy remains the only method that can assess fibrosis, despite being subjected to sampling…
  • 2021 American Transplant Congress

    Atg16l-Dependent Autophagy Attenuates Procession of Renal Interstitial Fibrosis in Chronic Renal Graft Dysfunction via Regulating Tumor Necrosis Factor Alpha (tnf-α) Induced Endmt

    Z. Gui, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Chronic renal graft dysfunction is characterized by inflammation, tubular injury, and interstitial fibrosis. We have confirmed that endothelial-mesenchymal transition (EndMT) was one of important…
  • 2021 American Transplant Congress

    Molecular Assessment of Fibrosis and Steatohepatitis in the INTERLIVER Study

    K. S. Madill-Thomsen1, P. F. Halloran1, &. the INTERLIVER Study Group2

    1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada

    *Purpose: We previously reported a molecular system for assessing rejection in liver transplants and recently expanded this system to assess injury. Fibrosis is associated with…
  • 2020 American Transplant Congress

    Autophagy Attenuates Renal Allograft Interstitial Fibrosis by Regulating the EndMT Induced by TNF-α

    Z. Gui, C. Suo, Z. Wang, S. Fei, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Kidney interstitial fibrosis is a significant cause of allograft failure in kidney transplantation. Autophagy is a self-digestive process that eliminates impaired or aged proteins…
  • 2020 American Transplant Congress

    Divergent Molecular Pathways Underlie the Evolution of Allograft Fibrosis in Two Mouse Models of Chronic Lung Allograft Dysfunction

    T. Watanabe, J. Allen, K. Boonstra, Z. Guan, K. Bei, S. Keshavjee, J. Yeung, T. Martinu, S. Juvet

    Latner Thoracic Surgery Research Laboratories, Toronto Lung Transplant Program / University Health Network, Toronto, ON, Canada

    *Purpose: Chronic lung allograft dysfunction (CLAD) after lung transplantation (LTx) is potentiated by activation of the innate immune system and occurs in two patterns: diffuse…
  • 2020 American Transplant Congress

    Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway

    W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu

    Jiangsu Province Hospital, Nanjing, China

    *Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
  • 2020 American Transplant Congress

    The Impact of Thy1 Expression of Fibroblast for Chronic Lung Allograft Dysfunction

    A. Hata1, Y. Guo1, D. Li1, Z. Mei1, A. Manafi1, A. Banerjee1, B. Mahgoub1, T. H. Barker2, A. S. Krupnick1

    1Surgery, University of Virginia, Charlottesville, VA, 2Biomedical Engineering, University of Virginia, Charlottesville, VA

    *Purpose: Chronic lung allograft dysfunction (CLAD) result from excessive immune activation and excessive collagen deposition by fibroblasts within the lung parenchyma or airway.Bronchiolitis obliterans (OB)…
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