2021 American Transplant Congress
Caspase-3 is a Predominant Regulator of Microvascular Dysfunction and Aki-ckd Transition Post Renal Ischemia-reperfusion Injury
CRCHUM, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within tubular epithelial…2021 American Transplant Congress
Identification and Validation of a Prognostic Index for Renal Allograft Survival Based on the Geo Database
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Chronic allograft injury (CAI) following kidney transplantation is still a threat to the allograft long-term survival. This study was designed to explore and analyze…2021 American Transplant Congress
Psmp is Discriminative for Chronic Active Antibody-Mediated Rejection and Predicts Graft Risk After Kidney Transplantation
Tianjin First Central Hospital, Tianjin, China
*Purpose: Chronic active antibody-mediated rejection (c-aABMR) is an intermediate process in the development of chronic antibody-mediated rejection (c-ABMR), a key problem in the long-term failure…2021 American Transplant Congress
The Role of Histone Acetylation/methylation Mediated Epigenetic Modifications in the Pathogenesis of Non-alcoholic Steatohepatitis-associated Liver Carcinogenesis
*Purpose: Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers and is characterized by an acquisition of multiple abnormal phenotypes driven by epigenetic…2021 American Transplant Congress
Perivenular Fibrosis After Pediatric Liver Transplant
*Purpose: Graft fibrosis is a concerning long-term complication after pediatric liver transplant (LT) and though perivenular (PV) fibrosis is common, its likelihood of progression and…2021 American Transplant Congress
Paired Surveillance Biopsies Over >4 Years from a Multi-Center Cohort of 78 Long-Term Pediatric Liver Transplant Recipients
*Purpose: Progressive liver fibrosis threatens graft and patient longevity for children after liver transplantation (LT). Previous studies are limited to single-center, cross-sectional analyses. To address…2020 American Transplant Congress
Persistent Fibrinolysis Shutdown in Liver Transplant Recipients is Associated with Early Allograph Dysfunction
*Purpose: Early allograph dysfunction (EAD) in liver transplantation has been attributed to microvascular thrombosis. Treating grafts at risk of EAD with tissue plasminogen activator (tPA)…2020 American Transplant Congress
Automatic Quantification of Interstitial Fibrosis in Renal Allograft
*Purpose: Renal allografts are typically assessed by pathologists using the Banff classification with known interobserver variability. We previously demonstrated the utility of image analysis in…2020 American Transplant Congress
Gross Morphological Score for Deceased Donor Kidneys Can Predict Delayed Graft Function in Kidney Transplant Recipients
Department of Kidney Transplantation, London Health Sciences Center, London, ON, Canada
*Purpose: Both microscopy and kidney donor profile index (KDPI) scoring systems have been used to predict kidney transplant outcomes. Utilizing gross renal morphology, we designed…2020 American Transplant Congress
Bortezomib Exhibits Therapeutic Implication in Renal Interstitial Fibrosis after Kidney Transplantation by Inhibiting Akt-mTOR-P70S6K-Smurf2 Pathway and Stabilizing IκBα Protein
Jiangsu Province Hospital, Nanjing, China
*Purpose: Allograft interstitial fibrosis and fibrogenesis significantly exacerbate the progression of chronic allograft disease (CAD) and are essential therapeutic targets. Epithelial‐mesenchymal transition (EMT) is recognized…
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