ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2022 American Transplant Congress

    Targeted Delivery of Costimulation Inhibitor to Lymph Nodes Promotes Transplant Tolerance via Fibroblastic Reticular Cells

    J. Zhao1, S. Jung1, X. Li1, H. Zhang1, S. Movahedi1, V. Kasinath1, M. Uehara1, J. Azzi1, P. Sage1, S. Tullius1, J. S. Bromberg2, R. Abdi1

    1Brigham and Women's Hospital, Boston, MA, 2University of Maryland School of Medicine, Baltimore, MD

    *Purpose: The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Fibroblastic reticular cells (FRCs), the prominent cells of the…
  • 2022 American Transplant Congress

    Preclinical Evaluation of Functional Survival of Stem Cell Derived Islets Microencapsulated in Alginate with CXCL12 in Non-Human Primates without Immunosuppression

    M. C. Poznansky

    Vaccine and Immunotherapy Center, Massachusetts General Hospital, Charlestwon, MA

    *Purpose: Human stem cell-derived islet-like cells (SC-islets) represent a sustainable source for beta-cell replacement to achieve a functional cure for type 1 diabetes. We previously…
  • 2022 American Transplant Congress

    More Than Just Drain Pipes, Pulmonary Lymphatics Play a Pivotal Role in the Development of Bronchiolitis Obliterans Syndrome

    L. Wang1, R. Han2, H. Outtz Reed3, W. W. Hancock2

    1Childrens Hospital of Phila, Philadelphia, PA, 2Children's Hospital of Philadelphia, Philadelphia, PA, 3Weill Cornell, New York, NY

    *Purpose: Chronic allograft dysfunction (CLAD) remains a major determinant of the generally poor long-term outcome of lung transplantation compared to that of other solid organ…
  • 2022 American Transplant Congress

    Kidney Transplant Alone Recipients with Advanced Liver Disease Have Similar Outcomes to Those without Advanced Liver Disease

    R. R. Nathani, S. M. Rutledge, C. Villarroel, R. Shapiro, G. Y. Im

    Icahn School of Medicine at Mount Sinai, New York, NY

    *Purpose: The prevalence of concomitant liver disease (CLD) in patients with ESRD is reported to be 7-40%. Safety of kidney transplant alone (KTA) in those…
  • 2021 American Transplant Congress

    Caspase-3 is a Predominant Regulator of Microvascular Dysfunction and Aki-ckd Transition Post Renal Ischemia-reperfusion Injury

    S. Lan, F. Migneault, J. Turgeon, M. Bourgault, M. Dieudé, N. Patey, H. Cardinal, M. Hébert

    CRCHUM, University of Montreal, Montreal, QC, Canada

    *Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for chronic renal failure. Caspase-3, an effector responsible for apoptosis execution, is activated within tubular epithelial…
  • 2021 American Transplant Congress

    Identification and Validation of a Prognostic Index for Renal Allograft Survival Based on the Geo Database

    X. Zhang, Z. Wang, Z. Han, J. Tao, X. Ju, R. Tan, M. Gu

    The First Affiliated Hospital of Nanjing Medical University, Nanjing, China

    *Purpose: Chronic allograft injury (CAI) following kidney transplantation is still a threat to the allograft long-term survival. This study was designed to explore and analyze…
  • 2021 American Transplant Congress

    Psmp is Discriminative for Chronic Active Antibody-Mediated Rejection and Predicts Graft Risk After Kidney Transplantation

    Y. Fu, P. Zhan

    Tianjin First Central Hospital, Tianjin, China

    *Purpose: Chronic active antibody-mediated rejection (c-aABMR) is an intermediate process in the development of chronic antibody-mediated rejection (c-ABMR), a key problem in the long-term failure…
  • 2021 American Transplant Congress

    The Role of Histone Acetylation/methylation Mediated Epigenetic Modifications in the Pathogenesis of Non-alcoholic Steatohepatitis-associated Liver Carcinogenesis

    P. K. Rajan1, U. Utibe-Abasi1, J. D. Sanabria1, M. Banerjee2, G. Smith1, M. S. Schade1, J. Sanabria1, K. Sodhi1, S. Pierre2, Z. Xie2, J. I. Shapiro2, J. Sanabria1

    1Department of Surgery, Marshall University, Huntington, WV, 2Marshall Institute for Interdisciplinary Research (MIIR), Marshall University, Huntington, WV

    *Purpose: Hepatocellular carcinoma (HCC) is one of the most aggressive human cancers and is characterized by an acquisition of multiple abnormal phenotypes driven by epigenetic…
  • 2021 American Transplant Congress

    Perivenular Fibrosis After Pediatric Liver Transplant

    J. Lew, S. Cho, S. Feng, E. R. Perito

    UCSF, San Francisco, CA

    *Purpose: Graft fibrosis is a concerning long-term complication after pediatric liver transplant (LT) and though perivenular (PV) fibrosis is common, its likelihood of progression and…
  • 2021 American Transplant Congress

    Paired Surveillance Biopsies Over >4 Years from a Multi-Center Cohort of 78 Long-Term Pediatric Liver Transplant Recipients

    E. R. Perito1, E. Persyn2, J. Bucuvalas3, J. E. Squires4, M. Martinez5, S. Mohammad6, A. J. Demetris4, S. Feng1

    1UCSF, San Francisco, CA, 2King's College, London, United Kingdom, 3Mt. Sinai School of Medicine, NY, NY, 4U of Pittsburgh, Pittsburgh, PA, 5Columbia U, NY, NY, 6Northwestern U, Chicago, IL

    *Purpose: Progressive liver fibrosis threatens graft and patient longevity for children after liver transplantation (LT). Previous studies are limited to single-center, cross-sectional analyses. To address…
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