Articles tagged "Fibrosis"

2022 American Transplant Congress
HCK is a Key Regulator for Macrophage Polarization in Kidney Fibrosis
C. Wei, M. Chen, Z. Sun, Z. Yi, C. He, W. Zhang
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Interstitial fibrosis and tubular atrophy (IF/TA) is common histological abnormality in biopsy of kidney transplants. Our previous study from a prospective human kidney transplant…
2022 American Transplant Congress
Association of Circulating microRNAs with Fibrosis and Metabolic Outcomes in Chronic Pancreatitis Patients Undergoing Total Pancreatectomy with Islet Autotransplantation
S. Vasu¹, G. Saracino², Y. Liu², J. Mattke³, C. Darden³, M. C. Lawrence², B. Naziruddin¹
¹Baylor University Medical Ctr, Dallas, TX, ²Baylor University Medical Center, Dallas, TX, ³Baylor University, Waco, TX
*Purpose: In patients with Chronic Pancreatitis (CP), specific microRNAs (miRNA) were elevated in circulation before, during islet infusion and after TPIAT. We selected a panel…
2022 American Transplant Congress
Angiotensin II-Regulated Proteins Production by Pulmonary Macrophages in Chronic Lung Allograft Dysfunction
S. Farkona¹, A. Duong², G. Berra², S. Moshkelgosha², S. Clotet-Freixas¹, S. Juvet², T. Martinu², A. Konvalinka¹
¹Toronto General Hospital Research Institute and Multi-Organ Transplant, University Health Network, Toronto, ON, Canada, ²Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada
*Purpose: Chronic lung allograft dysfunction (CLAD), characterized by fibrosis, is the most important cause of mortality after lung transplantation. CLAD mechanisms remain poorly understood and…
2022 American Transplant Congress
Galectin-3 Expression in Autoimmune Hepatitis
N. Limon-de la Rosa¹, C. Moreno-Ramírez², E. Cervantes-Alvarez³, D. Yoeli⁴, I. Vasic⁴, M. Kriss⁵, C. A. Huang⁴, N. Navarro-Alvarez¹
¹Gastroenterology, Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ²Universidad de Guadalajara , Centro Universitario de la Costa., Puerto Vallarta Jalisco, Mexico, ³Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico City, Mexico, ⁴University of Colorado Anschutz Medical Campus, Denver, CO, ⁵University of Colorado Anschutz Medical Campus, Aurora, CO
*Purpose: Autoimmune hepatitis (AIH) is characterized by chronic inflammation in which healthy liver cells are targeted by one’s immune system. The persistent inflammatory milieu can…
2022 American Transplant Congress
Molecular Characterization of Progressive Fibrosis in the Liver by Single-Nuclei RNA Sequencing
T. Rousselle¹, J. McDaniels¹, A. Shetty¹, E. Bardhi¹, D. Polsky¹, E. Williams¹, D. Maluf², V. Mas¹
¹Surgical Sciences, University of Maryland Baltimore, Baltimore, MD, ²Transplantation Program, University of Maryland Medical Center, Baltimore, MD
*Purpose: The prevalence of obesity is negatively affecting the availability of livers for transplantation. Non-alcoholic fatty liver disease (NAFLD) is associated with an increase in…
2022 American Transplant Congress
Anti-Fibrotic Property of Adipose Derived Regenerative Cells on Hydrogen Peroxide Induced Injury in Nrk-52e Cells
R. Chawangwongsanukun¹, R. Lathan¹, R. Pearson², M. Clancy², P. Mark¹
¹Institute of Cardiovascular and Medical Sciences, Glasgow, United Kingdom, ²Transplant Unit, Queen Elizabeth University Hospital, Glasgow, United Kingdom
*Purpose: Adipose derived regenerative cells (ADRCs) are a heterogenous cell population derived from adipose tissue. These cells are composed of endothelial progenitor cells, pericytes, and…
2022 American Transplant Congress
Single Nuclei RNA-Sequencing Identifies Distinct Immune Cell Profile in Kidney Allograft Fibrosis
J. McDaniels¹, A. Shetty¹, C. Kuscu², C. Kuscu², T. Rousselle¹, E. Bardhi¹, C. Drachenberg¹, M. Talwar², J. Eason², T. Muthukumar³, D. Maluf¹, V. Mas¹
¹University of Maryland Baltimore, Baltimore, MD, ²UTHSC, Memphis, TN, ³Weill Cornell Medicine, New York, NY
*Purpose: A major obstacle after kidney transplantation (KT) is chronic allograft dysfunction characterized by interstitial fibrosis and tubular atrophy (IFTA). Despite extensive research, the cellular…
2022 American Transplant Congress
A Comparison of Vibration Controlled Transient Elastography, FAST, AGILE-3 and AGILE-4 Scores in Liver Transplant Recipients
T. Arshad¹, M. Tseng², B. Anh³, T. Syed⁴, A. Miller⁵, V. Patel⁴, A. Asgharpour⁴, I. O. Michael⁶, S. Patel⁵, M. Muthiah⁷, M. S. Siddiqui⁴
¹Department of Internal Medicine, VCU, Richmond, VA, ²Internal Medicine, VCU, Richmond, VA, ³Department of Statistical Sciences & Operations Research, VCU, Richmond, VA, ⁴Division of Gastroenterology and Hepatology, VCU, Richmond, VA, ⁵VCU, Richmond, VA, ⁶Department of Pathology, VCU, Richmond, VA, ⁷National University of Singapore, Singapore, Singapore
*Purpose: Hepatic fibrosis is a strong predictor of clinical outcomes following liver transplantation (LT), however, non-invasive fibrosis assessment remains challenging. Vibration controlled transient elastography has…
2022 American Transplant Congress
Modification of Gut Microbiota Accelerates Kidney Repair After Experimental Ischemia Reperfusion Injury
S. Gharaie, K. Lee, S. Noel, L. Arend, H. Rabb
Johns Hopkins Medicine, Baltimore, MD
*Purpose: Kidney ischemia reperfusion injury (IRI) leads to changes in gut microbiome, and pre-IR microbiome changes can modify course of experimental tissue injury. There is…
2022 American Transplant Congress
Iguratimod Alleviates Endothelial to Mesenchymal Transition by Inducing AMBRA1/PARKIN-Dependent Mitophagy and Inhibiting NLRP3 Activation During Renal Allograft Interstitial Fibrosis
Z. Gui¹, W. Zijie², M. Zheng³, R. Tan³, M. Gu⁴
¹Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, China, ⁴Department of Urology, the Second Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: Chronic renal graft dysfunction (CAD) is caused by multiple factors, including glomerular sclerosis, inflammation, interstitial fibrosis and tubular atrophy (IF/TA). However, the most prominent…