Articles tagged "Fibrosis"

2016 American Transplant Congress
Delayed Graft Function (DGF) Does Not Accelerate Progression of Fibrosis During the First Year After Deceased Donor Kidney Transplantation.
R. Heilman, I. Qaqish, M. Smith, H. Khamash, B. Kaplan, K. Reddy.
Mayo Clinic, Phoenix, AZ.
BackgroundOur aim was to study the impact of DGF on the progression of interstitial fibrosis during the first post-transplant year.MethodsWe included all patients who received…
2016 American Transplant Congress
In Vivo and In Vitro Characterization of 1.5 mm Ba²⁺-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.
M. Bochenek,¹ J. McGarrigle,¹ J. Mendoza-Elias,¹ E. Marchese,¹ M. Nourmohammadzadeh,¹ Y. Wang,¹ A. Khan,¹ M. Omami,¹ C.-C. Yeh,¹ I. Lacik,² B. Strand,³ J. Oberholzer.¹
¹Transplant Surgery, University of Iliinois at Chicago, Chicago, IL; ²Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia (Slovak Republic); ³Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.
Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
2016 American Transplant Congress
Effect of Conversion to mTOR Inhibition on Allograft Fibrosis in Pediatric Liver Transplantation.
R. Fischer,¹ S. Foster,² A. Kats,¹ W. Andrews,¹ R. Hendrickson,¹ J. Daniel.¹
¹Children's Mercy Hospital, Kansas City, MO; ²University of Kansas Medical Center, Kansas City, KS.
Background: Serial surveillance biopsies demonstrate post-transplant inflammation and fibrosis in long-surviving liver allografts. These findings can lead to cirrhosis and graft failure. We compared two…
2016 American Transplant Congress
Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.
R. Kapoor, N. Sheerin, J. Kirby.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…
2016 American Transplant Congress
Renal Fibroblast Activation and Survival by Anti-MHC Class I Antibody: The Role of mTOR Signaling Pathway.
J. Chen, A. Zmijewska, R. Mannon.
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Antibody-mediated injury (AMI) is an important contributor to late kidney allograft loss, and is accompanied by interstitial fibrosis (IF) and tubular atrophy (TA). However,…
2016 American Transplant Congress
The Effect of Spironolactone on Calcineurininhibitor Induced Nephrotoxicity.
L. Mortensen,¹ H. Thiesson,¹ C. Bistrup,¹ F. Nielsen,³ U. Halekoh,² B. Jensen,³ N. Marcussen.⁴
¹Department of Nephrology, Odense University Hospital, Odense, Denmark; ²Department of Biostatistics, University of Southern Denmark, Odense, Denmark; ³Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; ⁴Department of Clinical Pathology, Odense University Hospital, Odense, Denmark.
Purpose: Evidence points towards activation of the mineralocorticoid receptor (MR) to be involved in CNI nephrotoxicity. The SPIREN trial was designed to test the hypothesis…
2016 American Transplant Congress
Identification of Biomarkers for Progressive Fibrosis in Renal Transplant Patients Using Novel Chemical Imaging Approaches.
V. Varma,¹ A. Kajdacsy-Balla,¹ S. Akkina,² S. Setty,¹ M. Walsh.¹
¹Pathology, University of Illinois at Chicago, Chicago, IL; ²Nephrology, University of Illinois at Chicago, Chicago, IL.
BackgroundThe main treatment for end-stage renal disease is kidney transplantation, however close monitoring of post-transplant biopsies is required to identify subclinical complications. In this study,…
2016 American Transplant Congress
Correlation of the Shear Wave Elastography with Renal Function in Kidney Transplant Recipients: A Proof of Concept Study.
J. Dosal-Bañuelos, A. Flores-Mendoza, L. Morales-Buenrostro, M. Díaz-Zamudio.
Radiology and Nephrology, National Institute of Medical Sciences and Nutrition SZ, México, Distrito Federal, Mexico.
Background: Non-invasive biomarker for kidney allograft fibrosis is needed. Shear wave elastography is a relatively new technique to assess tissue stiffness. Graft rejection and chronic…
2016 American Transplant Congress
A Selective Biomarker in Blood Cells Identifies IFTA After Kidney Transplantation.
M. Matz,¹ C. Lorkowski,¹ K. Wu,³ H.-H. Neumayer,¹ M.-F. Mashreghi,² K. Budde.¹
¹Nephrology, University Charité, Berlin, Germany; ²German Rheumatism Research Center (DRFZ), Berlin, Germany; ³Pathology, University Medicine Charité, Berlin, Germany.
Cellular and antibody-mediated rejection processes and also interstitial fibrosis/tubular atrophy (IFTA) lead to allograft dysfunction and loss. The search for accurate and specific diagnostic tools…