Articles tagged "Fibrosis"

2016 American Transplant Congress
Donor Interstitial Fibrosis and Tubular Atrophy (IFTA) Are Not Independent Risk Factors for a Lower GFR at One Year.
R. Heilman, I. Qaqish, M. Smith, H. Khamash, B. Kaplan, K. Reddy.
Mayo Clinic, Phoenix.
BackgroundDonor age is a determinant of allograft outcome after deceased donor kidney transplant (DDTx). Our aim was to determine if chronic changes on a reperfusion…
2016 American Transplant Congress
Don't Judge a Book by Its Cover: Normal Liver Enzymes After Transplantation Can Be Associated with Pathologies Requiring Intervention.
C. Sanchez,¹ S. Kumer,² S. Olson,¹ R. Gilroy,¹ T. Schmitt,² B. Kane,² R. Taylor.¹
¹Hepatology/Transplant, University of Kansas, Kansas City, KS; ²Surgery, University of Kansas, Kansas City, KS.
Background:Liver biopsies are employed post-transplant generally to evaluate abnormal liver enzymes (LE); however they are not without risk. Whether post-transplant protocol biopsies (PB) serve any…
2016 American Transplant Congress
Diffuse Extent of Peritubular Capillaritis in Late Antibody Mediated Rejection Is Associated with More Severe Chronic Allograft Damage.
Z. Kikić,¹ F. Eskandary,¹ H. Herkner,² R. Oberbauer,¹ G. Bond,¹ H. Regele,³ G. Böhmig,¹ N. Kozakowski.³
¹Nephrology and Dialysis, Medical University of Vienna, Vienna, Austria; ²Emergency Medicine, Medical University of Vienna, Vienna, Austria; ³Institute of Clinical Pathology, Medical University of Vienna, Vienna, Austria.
Peritubular capillaritis (ptc) is a widely accepted histologic criterion of antibody-mediated rejection (ABMR), and while the ptc score is incorporated in current diagnostic recommendations, the…
2016 American Transplant Congress
Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.
J. Uzarski,¹ C. Deaton,⁵ H. Ward,² A. Wandinger-Ness,³ W. Miller,⁴ J. Wertheim.¹
¹Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ²Department of Internal Medicine, University of New Mexico HSC, Albuquerque, NM; ³Department of Pathology, University of New Mexico HSC, Albuquerque, NM; ⁴Department of Chemical and Biological Engineering, Northwestern University, Evanston, IL; ⁵Department of Biology, University of Mexico, Albuquerque, NM.
Background: While the number of wait-listed patients suffering from kidney failure continues to rise, the number of kidney transplants performed each year has remained stagnant.…
2016 American Transplant Congress
HCK Is a Potential Mediator of Renal Fibrosis.
C. Wei,¹ M. Menon,¹ L. Li,² Z. Yi,¹ K. Keung,³ C. Woytovich,¹ I. Greene,¹ W. Zhang,¹ J. He,¹ B. Murphy.¹
¹Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY; ³Centre for Transplant and Renal Research, Westmead Millenium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia.
Background: Renal fibrosis is the consequence of excessive accumulation of extracellular matrix that occurs in patients with chronic kidney disease (CKD) and in kidney transplant…
2016 American Transplant Congress
Natural History of Response to Wounding in Human Kidney Transplants.
K. Famulski,¹ J. Venner,^2,1 J. Reeve,¹ P. Halloran.¹
¹University of Alberta, Edmonton, AB, Canada; ²University of Queensland, Brisbane, Queensland, Australia.
In both primary kidney diseases and kidney transplants, the extent of fibrosis is a key indicator of stage, progression, and prognosis. Much debate focuses, however,…
2016 American Transplant Congress
Chemokine Receptor CXCR4 Antagonist, a Novel Pathway to Prevent Chronic Allograft Nephropathy.
Y. Xu, Q. Zhang, X. Hu.
Department of Urology, Beijing Chaoyang Hospital, Beijing, China.
BackgroundChronic allograft nephropathy (CAN) remains a major problem for long term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4)…
2016 American Transplant Congress
Non-Invasive – Minimalistic Approach Using Cell-Free MicroRNAs in Paired Plasma and Urine Samples for Early Diagnosis of Chronic Renal Allograft Dysfunction.
S. Bontha,¹ R. Gehrau,¹ E. Rhone,¹ A. King,² L. Gallon,³ K. Brayman,¹ D. Maluf,¹ V. Mas.¹
¹Surgery, UVA, Charlottesville, VA; ²VCU, Richmond; ³NWU, Chicago.
Background: Reducing use of tissue biopsy by efficiently using non-invasive samples for continuous monitoring and evaluation of graft function would be ideal. Reports indicate continuous…
2016 American Transplant Congress
MiRNA-200b Inhibits Epithelial-Mesenchymal Transition in TGF-β1 Induced Human Bronchial Epithelial Cells.
S. Ladak, C. Ward, S. Ali.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
The role of TGF-β1 in mediating extracellular matrix remodeling during the pathogenesis of lung fibrosis has been well defined. Dysregulated expression of miRNA is increasingly…
2016 American Transplant Congress
Lower Renal Graft Function and Accelerated Fibrosis in HIV-Infected Transplant Recipients with Previous HIVAN Compared to Non HIVAN HIV-Positive Transplant Recipients.
M.-N. Peraldi,¹ H. Ayari,¹ M. Burbach,¹ C. Randoux,² E. Pillebout,¹ N. De Castro,³ J.-M. Molina,³ D. Glotz.¹
¹Nephrologie et Transplantation, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France; ²Néphrologie, Hôpital Bichat et Université Paris-Diderot, Paris, France; ³Service de Maladies Infectieuses, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France.
Several studies reported reduced renal allograft survival rates among HIV-infected transplant recipients. Few data focus on histological lesions and their progression in renal grafts from…