Articles tagged "Fibrosis"

2016 American Transplant Congress
HCK Is a Potential Mediator of Renal Fibrosis.
C. Wei,¹ M. Menon,¹ L. Li,² Z. Yi,¹ K. Keung,³ C. Woytovich,¹ I. Greene,¹ W. Zhang,¹ J. He,¹ B. Murphy.¹
¹Division of Nephrology, Icahn School of Medicine at Mount Sinai, New York, NY; ²Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY; ³Centre for Transplant and Renal Research, Westmead Millenium Institute, University of Sydney at Westmead Hospital, New South Wales, Australia.
Background: Renal fibrosis is the consequence of excessive accumulation of extracellular matrix that occurs in patients with chronic kidney disease (CKD) and in kidney transplant…
2016 American Transplant Congress
Natural History of Response to Wounding in Human Kidney Transplants.
K. Famulski,¹ J. Venner,^2,1 J. Reeve,¹ P. Halloran.¹
¹University of Alberta, Edmonton, AB, Canada; ²University of Queensland, Brisbane, Queensland, Australia.
In both primary kidney diseases and kidney transplants, the extent of fibrosis is a key indicator of stage, progression, and prognosis. Much debate focuses, however,…
2016 American Transplant Congress
Chemokine Receptor CXCR4 Antagonist, a Novel Pathway to Prevent Chronic Allograft Nephropathy.
Y. Xu, Q. Zhang, X. Hu.
Department of Urology, Beijing Chaoyang Hospital, Beijing, China.
BackgroundChronic allograft nephropathy (CAN) remains a major problem for long term graft survival and different pathways participate in its development. CXC chemokine receptor 4 (CXCR4)…
2016 American Transplant Congress
Non-Invasive – Minimalistic Approach Using Cell-Free MicroRNAs in Paired Plasma and Urine Samples for Early Diagnosis of Chronic Renal Allograft Dysfunction.
S. Bontha,¹ R. Gehrau,¹ E. Rhone,¹ A. King,² L. Gallon,³ K. Brayman,¹ D. Maluf,¹ V. Mas.¹
¹Surgery, UVA, Charlottesville, VA; ²VCU, Richmond; ³NWU, Chicago.
Background: Reducing use of tissue biopsy by efficiently using non-invasive samples for continuous monitoring and evaluation of graft function would be ideal. Reports indicate continuous…
2016 American Transplant Congress
MiRNA-200b Inhibits Epithelial-Mesenchymal Transition in TGF-β1 Induced Human Bronchial Epithelial Cells.
S. Ladak, C. Ward, S. Ali.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
The role of TGF-β1 in mediating extracellular matrix remodeling during the pathogenesis of lung fibrosis has been well defined. Dysregulated expression of miRNA is increasingly…
2016 American Transplant Congress
Lower Renal Graft Function and Accelerated Fibrosis in HIV-Infected Transplant Recipients with Previous HIVAN Compared to Non HIVAN HIV-Positive Transplant Recipients.
M.-N. Peraldi,¹ H. Ayari,¹ M. Burbach,¹ C. Randoux,² E. Pillebout,¹ N. De Castro,³ J.-M. Molina,³ D. Glotz.¹
¹Nephrologie et Transplantation, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France; ²Néphrologie, Hôpital Bichat et Université Paris-Diderot, Paris, France; ³Service de Maladies Infectieuses, Hôpital Saint-Louis et Université Paris-Diderot, Paris, France.
Several studies reported reduced renal allograft survival rates among HIV-infected transplant recipients. Few data focus on histological lesions and their progression in renal grafts from…
2016 American Transplant Congress
Everolimus Abrogates C5a and TGFβ Mediated Perycite-to-Myofibroblast Transition (PMT) Inhibiting Vascular Rarefaction.
G. Castellano, R. Franzin, A. Stasi, C. Divella, L. Gesualdo.
Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy.
Microvascular pericytes have detrimental effects on tubulo-interstitial fibrosis via PMT. However, therapeutic strategies that might interfere with this process are currently lacking. We aimed to…
2016 American Transplant Congress
Delayed Graft Function (DGF) Does Not Accelerate Progression of Fibrosis During the First Year After Deceased Donor Kidney Transplantation.
R. Heilman, I. Qaqish, M. Smith, H. Khamash, B. Kaplan, K. Reddy.
Mayo Clinic, Phoenix, AZ.
BackgroundOur aim was to study the impact of DGF on the progression of interstitial fibrosis during the first post-transplant year.MethodsWe included all patients who received…
2016 American Transplant Congress
In Vivo and In Vitro Characterization of 1.5 mm Ba²⁺-Alginate Macro-Encapsulated Cynomolgus Monkey Islets.
M. Bochenek,¹ J. McGarrigle,¹ J. Mendoza-Elias,¹ E. Marchese,¹ M. Nourmohammadzadeh,¹ Y. Wang,¹ A. Khan,¹ M. Omami,¹ C.-C. Yeh,¹ I. Lacik,² B. Strand,³ J. Oberholzer.¹
¹Transplant Surgery, University of Iliinois at Chicago, Chicago, IL; ²Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Bratislava, Slovakia (Slovak Republic); ³Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway.
Introduction:Micro-encapsulation of islets for the treatment of Type I diabetes has shown limited efficacy in small-scale clinical trials. The lack of success may be related…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…