2017 American Transplant Congress
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
A total pancreatectomy and islet autotransplant (TPIAT) offers substantial pain relief and improved quality of life for pancreatitis patients. Isolating a large quantity of islet…2017 American Transplant Congress
Sulfatide-Selective NKT Cells Mediate M2 to M1 Polarization Resulting in Amelioration of Kidney Fibrosis.
Background: Macrophage subtype polarization has been suggested as a key player related to kidney fibrosis. Moreover, myofibroblast, the principal cells that produce extracellular matrix in…2017 American Transplant Congress
Early Introduction of Oral Paricalcitol in Renal Transplant Recipients. An Open-Label Randomized Study.
In stable renal transplant recipients with hyperparathyroidism, the vitamin D agonist paricalcitol reduces level of proteinuria. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. The…2017 American Transplant Congress
Podocyte-Specific Knockdown of SHROOM3 Causes Albuminuria and Foot-Process Effacement by Interaction with FYN.
Nephrology, Medicine, Icahn School of Medicine, New York, NY
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular SHROOM3 expression correlated with the development of renal fibrosis post-transplant. The SNP…2017 American Transplant Congress
Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.
The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…2017 American Transplant Congress
Podocyte Participates in the ST2 Related Renal Fibrosis.
Objective Soluble ST2 (sST2) which is the receptor of IL-33 is involved in renal inflammation and it is also correlated with disease severity in chronic…2017 American Transplant Congress
Changes in Urinary Neutrophil Gelatinase Associated Lipocalin Combined with Urine Cytokines and Microalbuminuria as Predictors for Interstitial Fibrosis and Tubular Atrophy in Kidney Transplantation: A Matched-Pair Tissue Cohort Study.
Background: Late graft loss from interstitial fibrosis - tubular atrophy (IF/TA) continues to be the “Achilles' heel” of kidney transplantation (KT). Long-term calcineurin inhibitors (CNIs)…2017 American Transplant Congress
Quantitative Analysis of 10-Year Surveillance Renal Allograft Biopsies.
Introduction. Assessing late histologic changes in renal allografts is important to investigating etiology and devising treatment. Compared to the usual semi-quantitative reading by a renal…2016 American Transplant Congress
Diffuse Extent of Peritubular Capillaritis in Late Antibody Mediated Rejection Is Associated with More Severe Chronic Allograft Damage.
Peritubular capillaritis (ptc) is a widely accepted histologic criterion of antibody-mediated rejection (ABMR), and while the ptc score is incorporated in current diagnostic recommendations, the…2016 American Transplant Congress
Mechanisms of Cellular Repopulation within Healthy or Intrinsically Scarred Kidney Extracellular Matrix Scaffolds.
Background: While the number of wait-listed patients suffering from kidney failure continues to rise, the number of kidney transplants performed each year has remained stagnant.…
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