Articles tagged "Fibrosis"

2017 American Transplant Congress
Determinants of Severe Interstitial Fibrosis in Kidney Allografts: Major Impact of Circulating Donor-Specific Anti-HLA Antibodies.
C. Gosset, D. Viglietti, M. Rabant, E. Pillebout, J. Taupin, D. Glotz, C. Legendre, J. Duong Van-Huyen, A. Loupy, C. Lefaucheur.
Paris Translational Research Center for Organ Transplantation, Paris, France
Interstitial fibrosis represents a major cause of kidney allograft failure. We investigated the independent contribution of circulating donor-specific anti-HLA antibodies (DSA) in the development of…
2017 American Transplant Congress
Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).
A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.
KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda
Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…
2017 American Transplant Congress
HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.
P. Nguyen, N. Galvan, M. Kueht, C. O'Mahony, R. Cotton, A. Rana, J. Goss.
Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…
2017 American Transplant Congress
Post-Transplant Urinary Transglutaminase 2 Is a Potent Biomarker to Predict Kidney Allograft Inflammation or Fibrosis.
S. Shin,¹ Y.-M. Wee,¹ M. Choi,¹ Y. Cho,² H. Go,² Y. Kim,¹ D. Han.¹
¹Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ²Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested the hypothesis that quantification of urinary…
2017 American Transplant Congress
Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.
W. Zhang,¹ Z. Yi,¹ E. Stahl,² M. Menon,¹ K. Keung,³ K. Hao,² P. O'Connell,³ B. Murphy.¹
¹Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; ²Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; ³Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia
Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
2017 American Transplant Congress
RAS Inhibition Attenuates Urine Angiotensin II-Regulated Proteins Associated with Interstitial Fibrosis and Tubular Atrophy in Kidney Transplant Recipients.
Z. Mohammed-Ali,¹ S. Reid,³ P. Yip,¹ H. Cardinal,² M.-J. Hébert,² Y. Li,⁴ S. Kim,^1,3,4 A. Konvalinka.^1,3
¹University Health Network, Toronto, ON, Canada; ²Centre de Recherche du Centre Hospitalier de l'Université de Montréal - CRCHUM, Montréal, QC, Canada; ³Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ⁴Institute of Health Policy, University of Toronto, Toronto, ON, Canada
Angiotensin-II (AngII), the main effector of the renin-angiotensin system (RAS), can lead to interstitial fibrosis/ tubular atrophy (IFTA) in kidney transplant recipients, mainly through AT-1R…
2017 American Transplant Congress
TGF-β1 Induces Transplant Kidney Interstitial Fibrosis Through Endothelial-to-Mesenchymal Transition via TGF-β/Smad and Akt/mTOR/p70S6K Pathways.
Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Chronic allograft dysfunction (CAD) induced by kidney interstitial fibrosis is the main cause of allograft failure in kidney transplantation. Studies suggested that endothelial-to-mesenchymal transition…
2017 American Transplant Congress
Mechanisms of Fibrosis in the Allograft Kidney: RNA-seq Based Analysis Using Formalin Fixed Biopsies.
G. Zeng,² L. Pan,¹ Z. Lyu,¹ Y. Huang,² P. Randhawa.²
¹Department of Nephrology, Guangxi Medical University, Nanning, Guangxi, China; ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
Development of allograft fibrosis determines long term graft survival but our understanding of this important complication is incomplete. To gain further insight into this problem…
2016 American Transplant Congress
Role of TGF-β in Ischemia and Reperfusion Injury Induced Renal Fibrosis in Human Proximal Tubular Epithelial Cells.
R. Kapoor, N. Sheerin, J. Kirby.
Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.
Ischemia-reperfusion injury (IRI) leads to an irreversible damage to the tubular epithelium and promotes acute kidney injury (AKI) that is associated with progressive loss of…
2016 American Transplant Congress
Renal Fibroblast Activation and Survival by Anti-MHC Class I Antibody: The Role of mTOR Signaling Pathway.
J. Chen, A. Zmijewska, R. Mannon.
Medicine/Surgery, University of Alabama at Birmingham, Birmingham, AL.
Background: Antibody-mediated injury (AMI) is an important contributor to late kidney allograft loss, and is accompanied by interstitial fibrosis (IF) and tubular atrophy (TA). However,…