ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Fibrosis"

  • 2017 American Transplant Congress

    Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.

    B. Ozdemir,1 F. Ozdemir,2 E. Baskin,2 M. Haberal.3

    1Pathology, Baskent University, Ankara, Turkey; 2Nephrology, Baskent University, Ankara, Turkey; 3Transplant Surgery, Baskent University, Ankara, Turkey

    The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…
  • 2017 American Transplant Congress

    Podocyte Participates in the ST2 Related Renal Fibrosis.

    Y. Kim,1 S. Yang,2,3 R. Cha,4 M.-Y. Yu,1 S. Lee,3 H. Lee,1 J. Lee,5 D. Kim,1,3 S. Kim,3 Y. Kim.1,2,3

    1Internal Medicine, Seoul National University Hospital, Seoul, Republic of Korea; 2Seoul National University Biomedical Research Institute, Seoul, Republic of Korea; 3Kidney Research Institute, Seoul National University Hospital, Seoul, Republic of Korea; 4Internal Medicine, National Medical Center, Seoul, Republic of Korea; 5Internal Medicine, Seoul National University Boramae Medical Center, Seoul, Republic of Korea

    Objective Soluble ST2 (sST2) which is the receptor of IL-33 is involved in renal inflammation and it is also correlated with disease severity in chronic…
  • 2017 American Transplant Congress

    Changes in Urinary Neutrophil Gelatinase Associated Lipocalin Combined with Urine Cytokines and Microalbuminuria as Predictors for Interstitial Fibrosis and Tubular Atrophy in Kidney Transplantation: A Matched-Pair Tissue Cohort Study.

    W. Chancharoenthana,1 A. Leelahavanichkul,1 S. Wattanatorn,1 J. Issara-Amphorn,2 Y. Avihingsanon,1 K. Praditpornsilpa,1 N. Townamchai.1

    1Division of Nephrology, Department of Medicine, Chulalongkorn University, Bangkok, Thailand; 2Research Affairs, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Background: Late graft loss from interstitial fibrosis - tubular atrophy (IF/TA) continues to be the “Achilles' heel” of kidney transplantation (KT). Long-term calcineurin inhibitors (CNIs)…
  • 2017 American Transplant Congress

    Quantitative Analysis of 10-Year Surveillance Renal Allograft Biopsies.

    A. Denic, B. Smith, W. Park, A. Rule, L. Cornell, M. Stegall.

    Mayo Clinic, Rochester

    Introduction. Assessing late histologic changes in renal allografts is important to investigating etiology and devising treatment. Compared to the usual semi-quantitative reading by a renal…
  • 2017 American Transplant Congress

    Determinants of Severe Interstitial Fibrosis in Kidney Allografts: Major Impact of Circulating Donor-Specific Anti-HLA Antibodies.

    C. Gosset, D. Viglietti, M. Rabant, E. Pillebout, J. Taupin, D. Glotz, C. Legendre, J. Duong Van-Huyen, A. Loupy, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France

    Interstitial fibrosis represents a major cause of kidney allograft failure. We investigated the independent contribution of circulating donor-specific anti-HLA antibodies (DSA) in the development of…
  • 2017 American Transplant Congress

    Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).

    A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.

    KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda

    Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…
  • 2017 American Transplant Congress

    HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.

    P. Nguyen, N. Galvan, M. Kueht, C. O'Mahony, R. Cotton, A. Rana, J. Goss.

    Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX

    Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…
  • 2017 American Transplant Congress

    Post-Transplant Urinary Transglutaminase 2 Is a Potent Biomarker to Predict Kidney Allograft Inflammation or Fibrosis.

    S. Shin,1 Y.-M. Wee,1 M. Choi,1 Y. Cho,2 H. Go,2 Y. Kim,1 D. Han.1

    1Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested the hypothesis that quantification of urinary…
  • 2016 American Transplant Congress

    Non-Invasive – Minimalistic Approach Using Cell-Free MicroRNAs in Paired Plasma and Urine Samples for Early Diagnosis of Chronic Renal Allograft Dysfunction.

    S. Bontha,1 R. Gehrau,1 E. Rhone,1 A. King,2 L. Gallon,3 K. Brayman,1 D. Maluf,1 V. Mas.1

    1Surgery, UVA, Charlottesville, VA; 2VCU, Richmond; 3NWU, Chicago.

    Background: Reducing use of tissue biopsy by efficiently using non-invasive samples for continuous monitoring and evaluation of graft function would be ideal. Reports indicate continuous…
  • 2016 American Transplant Congress

    MiRNA-200b Inhibits Epithelial-Mesenchymal Transition in TGF-β1 Induced Human Bronchial Epithelial Cells.

    S. Ladak, C. Ward, S. Ali.

    Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, United Kingdom.

    The role of TGF-β1 in mediating extracellular matrix remodeling during the pathogenesis of lung fibrosis has been well defined. Dysregulated expression of miRNA is increasingly…
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