2017 American Transplant Congress
Digital Image Analysis of Pediatric Liver Allograft Biopsies Correlates with METAVIR Fibrosis Score.
1Children's Mercy Hospital, Kansas City, MO; 2University of Kansas Medical Center, Kansas City, KS
Background: Serial surveillance biopsies demonstrate post-transplant inflammation and fibrosis in long-surviving pediatric liver allografts. These changes can ultimately lead to cirrhosis and graft failure. However,…2017 American Transplant Congress
Epigenetic Modifications in the Progression to Chronic Renal Allograft Injury.
1UVA, Charlottesville; 2VCU, Richmond; 3OSU, Columbus; 4NWU, Chicago
Background: The renal allograft is exposed to a milieu of environmental/metabolic stimuli that trigger epigenetic modifications and thereby gene expression patterns which influence function and…2017 American Transplant Congress
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
A total pancreatectomy and islet autotransplant (TPIAT) offers substantial pain relief and improved quality of life for pancreatitis patients. Isolating a large quantity of islet…2017 American Transplant Congress
Sulfatide-Selective NKT Cells Mediate M2 to M1 Polarization Resulting in Amelioration of Kidney Fibrosis.
Background: Macrophage subtype polarization has been suggested as a key player related to kidney fibrosis. Moreover, myofibroblast, the principal cells that produce extracellular matrix in…2017 American Transplant Congress
Early Introduction of Oral Paricalcitol in Renal Transplant Recipients. An Open-Label Randomized Study.
In stable renal transplant recipients with hyperparathyroidism, the vitamin D agonist paricalcitol reduces level of proteinuria. Animal studies indicate possible anti-fibrotic and anti-inflammatory effects. The…2017 American Transplant Congress
Podocyte-Specific Knockdown of SHROOM3 Causes Albuminuria and Foot-Process Effacement by Interaction with FYN.
Nephrology, Medicine, Icahn School of Medicine, New York, NY
In the translational GoCAR study, we identified that a CKD-associated SHROOM3-SNP, and tubular SHROOM3 expression correlated with the development of renal fibrosis post-transplant. The SNP…2017 American Transplant Congress
Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.
The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…2017 American Transplant Congress
Podocyte Participates in the ST2 Related Renal Fibrosis.
Objective Soluble ST2 (sST2) which is the receptor of IL-33 is involved in renal inflammation and it is also correlated with disease severity in chronic…2017 American Transplant Congress
Changes in Urinary Neutrophil Gelatinase Associated Lipocalin Combined with Urine Cytokines and Microalbuminuria as Predictors for Interstitial Fibrosis and Tubular Atrophy in Kidney Transplantation: A Matched-Pair Tissue Cohort Study.
Background: Late graft loss from interstitial fibrosis - tubular atrophy (IF/TA) continues to be the “Achilles' heel” of kidney transplantation (KT). Long-term calcineurin inhibitors (CNIs)…2017 American Transplant Congress
Quantitative Analysis of 10-Year Surveillance Renal Allograft Biopsies.
Introduction. Assessing late histologic changes in renal allografts is important to investigating etiology and devising treatment. Compared to the usual semi-quantitative reading by a renal…
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