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Articles tagged "Fibrosis"

  • 2018 American Transplant Congress

    Liver Biopsy Fibrosis Not Liver Imaging Predicts Survival after Heart Transplant

    J. Patel, M. Kittleson, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Hepatic dysfunction is common in patients with cardiomyopathy being evaluated for heart transplant (HT). ISHLT guidelines highlight the need for liver evaluation in patients…
  • 2018 American Transplant Congress

    Cardiac MRI May Help to Determine When to Refer Heart Transplant Patients for Redo Heart Transplant

    M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Small vessel coronary artery disease is known to cause fibrosis. However, it is not clear whether myocardial fibrosis detected on MRI is associated with…
  • 2018 American Transplant Congress

    Krüppel-Like Factor 15 is a Key Suppressor of the Glomerular Epithelial Cell Fibrosis under Centrifugal Force Driven Pressure

    M. Yu,1 Y. Kim,1 H. Lee,1 J. Lee,2 R. Cha,3 C. Lee,4 Y. Kim,1 S. Yang.5

    1Seoul National University Hospital, Seoul, Korea; 2Seoul National University Boramae Medical Center, Seoul, Korea; 3National Medical Center, Seoul, Korea; 4Cheju Halla General Hospital, Jeju, Korea; 5Seoul National University Kidney Research Institue, Seoul, Korea.

    Hypertension is known to be responsible for a reduction in the number of functional nephrons of glomeruli due to fibrosis, which develops into a chronic…
  • 2018 American Transplant Congress

    Diagnostic Accuracy of Non-Invasive Test of Hepatic Fibrosis in Liver Transplant Recipients

    D. Galvez,1 C. Bhati,1 M. Siddiqui,2 C. Schmoyer,2 T. Arshad,2 A. Sharma,1 A. Cotterell,1 K. Yadav,1 T. Reichman,1 M. Levy.1

    1Department of Surgery, Virginia Commonwealth University Hospital, Richmond, VA; 2Department of Medicine, Virginia Commonwealth University Hospital, Richmond, VA.

    Background & Aims: Hepatic fibrosis is an important predictor of liver- and non-liver related outcomes in patients with chronic liver disease (CLD) and liver transplantation…
  • 2018 American Transplant Congress

    Multiparametric MRI for Assessment of Renal Transplant Fibrosis: A Pilot

    M. Menon, O. Bane, S. Lewis, R. Khaim, S. Florman, P. Kennedy, S. Hectors, V. Delaney, F. Salem, B. Taouli.

    Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

    Fibrosis in renal allografts confers risk of progression to allograft loss. The gold standard for evaluating renal fibrosis remains allograft biopsy, which is invasive, prone…
  • 2017 American Transplant Congress

    Determinants of Severe Interstitial Fibrosis in Kidney Allografts: Major Impact of Circulating Donor-Specific Anti-HLA Antibodies.

    C. Gosset, D. Viglietti, M. Rabant, E. Pillebout, J. Taupin, D. Glotz, C. Legendre, J. Duong Van-Huyen, A. Loupy, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France

    Interstitial fibrosis represents a major cause of kidney allograft failure. We investigated the independent contribution of circulating donor-specific anti-HLA antibodies (DSA) in the development of…
  • 2017 American Transplant Congress

    Tissue Transcriptional Profile of Portal Inflammation with Interface Activity in Pediatric Liver Transplant (LT) Recipients with Normal Liver Tests Closely Resembles T Cell Mediated Rejection (TCMR).

    A. Sanchez-Fueyo, S. Feng, A. Demetris, J. Bucuvalas, J. Lozano, J. Magee, K. Spain, S. Kanaparthi, iWITH Investigators.

    KCL, London, United Kingdom; UCSF, SF; Pittsburgh, Pittsburgh; Cincinnati, Cincinnati; CiberEHD, Barcelona, Spain; Michigan, Ann Arbor; Rho, Chapel Hill; ITN, Bethesda; NIDDK/NIAID/NIH, Bethesda

    Background: Significant inflammation±fibrosis is frequently seen in biopsies (bxs) of pediatric LT recipients with normal liver tests assessed for immunosuppression withdrawal. The pathogenesis of these…
  • 2017 American Transplant Congress

    HCC and Cardiac Cirrhosis After the Fontan Procedure in a Patient with Congenital Heart Disease and Situs Inversus.

    P. Nguyen, N. Galvan, M. Kueht, C. O'Mahony, R. Cotton, A. Rana, J. Goss.

    Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX

    Introduction. Hypoplastic left heart syndrome (HLHS) is a fatal congenital cardiac anomaly for which surgical palliation is needed, the Fontan procedure. HLHS accounts for <5%…
  • 2017 American Transplant Congress

    Post-Transplant Urinary Transglutaminase 2 Is a Potent Biomarker to Predict Kidney Allograft Inflammation or Fibrosis.

    S. Shin,1 Y.-M. Wee,1 M. Choi,1 Y. Cho,2 H. Go,2 Y. Kim,1 D. Han.1

    1Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 2Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

    Transglutaminase type 2 (TG2) is an extracellular matrix crosslinking enzyme with a pivotal role in kidney fibrosis. We tested the hypothesis that quantification of urinary…
  • 2017 American Transplant Congress

    Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.

    W. Zhang,1 Z. Yi,1 E. Stahl,2 M. Menon,1 K. Keung,3 K. Hao,2 P. O'Connell,3 B. Murphy.1

    1Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; 2Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; 3Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia

    Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
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