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Articles tagged "Fibrosis"

  • 2018 American Transplant Congress

    Gr1– Macrophages Play Critical Roles in Liver Inflammation Resolution after IRI via Efferocytosis

    M. Ni,1,2 H. Wang,1,2 R. Busuttil,1 J. Kupiec-Weglinski,1 X. Wang,2 Y. Zhai.1

    1Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; 2Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiansu, China.

    Inflammation resolution is an integral part of liver ischemia reperfusion injury (IRI), which affects not only the severity of tissue damage, but more importantly its…
  • 2018 American Transplant Congress

    Liver Biopsy Fibrosis Not Liver Imaging Predicts Survival after Heart Transplant

    J. Patel, M. Kittleson, E. Kransdorf, R. Levine, S. Dimbil, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Hepatic dysfunction is common in patients with cardiomyopathy being evaluated for heart transplant (HT). ISHLT guidelines highlight the need for liver evaluation in patients…
  • 2018 American Transplant Congress

    Cardiac MRI May Help to Determine When to Refer Heart Transplant Patients for Redo Heart Transplant

    M. Kittleson, J. Patel, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Small vessel coronary artery disease is known to cause fibrosis. However, it is not clear whether myocardial fibrosis detected on MRI is associated with…
  • 2018 American Transplant Congress

    Krüppel-Like Factor 15 is a Key Suppressor of the Glomerular Epithelial Cell Fibrosis under Centrifugal Force Driven Pressure

    M. Yu,1 Y. Kim,1 H. Lee,1 J. Lee,2 R. Cha,3 C. Lee,4 Y. Kim,1 S. Yang.5

    1Seoul National University Hospital, Seoul, Korea; 2Seoul National University Boramae Medical Center, Seoul, Korea; 3National Medical Center, Seoul, Korea; 4Cheju Halla General Hospital, Jeju, Korea; 5Seoul National University Kidney Research Institue, Seoul, Korea.

    Hypertension is known to be responsible for a reduction in the number of functional nephrons of glomeruli due to fibrosis, which develops into a chronic…
  • 2018 American Transplant Congress

    Diagnostic Accuracy of Non-Invasive Test of Hepatic Fibrosis in Liver Transplant Recipients

    D. Galvez,1 C. Bhati,1 M. Siddiqui,2 C. Schmoyer,2 T. Arshad,2 A. Sharma,1 A. Cotterell,1 K. Yadav,1 T. Reichman,1 M. Levy.1

    1Department of Surgery, Virginia Commonwealth University Hospital, Richmond, VA; 2Department of Medicine, Virginia Commonwealth University Hospital, Richmond, VA.

    Background & Aims: Hepatic fibrosis is an important predictor of liver- and non-liver related outcomes in patients with chronic liver disease (CLD) and liver transplantation…
  • 2018 American Transplant Congress

    Multiparametric MRI for Assessment of Renal Transplant Fibrosis: A Pilot

    M. Menon, O. Bane, S. Lewis, R. Khaim, S. Florman, P. Kennedy, S. Hectors, V. Delaney, F. Salem, B. Taouli.

    Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

    Fibrosis in renal allografts confers risk of progression to allograft loss. The gold standard for evaluating renal fibrosis remains allograft biopsy, which is invasive, prone…
  • 2018 American Transplant Congress

    Inflammation in Fibrotic Areas (i-IF/TA) Identifies a T Cell-Mediated Rejection Component of IF/TA with Poor Kidney Allograft Outcome

    D. Viglietti, O. Aubert, J-.P. Duong Van Huyen, A. Loupy, C. Lefaucheur.

    Paris Translational Research Center for Organ Transplantation, Paris, France.

    Addressing the etiological heterogeneity of interstitial fibrosis in kidney allografts represents an important challenge to improve long-term transplant outcomes. We investigated the determinants, clinical and…
  • 2018 American Transplant Congress

    Donor Acute Kidney Injury Does Not Affect Fibrosis on 1 Year Post-Transplant Kidney Biopsy

    D. van der Windt, X. Chen, K. Lemon, C. Wu, N. Shah, R. Mehta, C. Puttarajappa, P. Sood, S. Hariharan, A. Ganoza, M. Wijkstrom, A. Humar, A. Tevar.

    Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.

    PurposeThe use of kidneys from deceased donors with acute kidney injury (AKI) at the time of donation is a potential method by which to expand…
  • 2018 American Transplant Congress

    RNA-Seq Based Analysis of Renal Allograft Biopsies Reveals Key Mediators of Interstitial Fibrosis/Tubular Atrophy

    C. McEvoy,1,2,4 E. Brennan,1,2 A. Dorman,2,3 D. Sadlier,1,2 A. Konvalinka,4 P. Conlon,2,3 C. Godson.1,2

    1Diabetes Complications Research Centre, Conway Institute, School of Medicine, University College Dublin, Dublin, Ireland; 2North Dublin Renal Biobank, Dublin, Ireland; 3Beaumont Hospital & RCSI, Dublin, Ireland; 4University Health Network, Toronto, Canada.

    Interstitial Fibrosis/Tubular Atrophy(IFTA) is the final common pathway of most progressive renal diseases and is a potent predictors of renal outcome in both native and…
  • 2018 American Transplant Congress

    Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection

    Z. Zhang,1 Q. Liu,1 G. Hussey,2 J. Dziki,2 L. Mathews,1 H. Dai,1 G. Dwyer,1,3 A. Lucas,1 M. Oberbarnscheidt,1 S. Badylak,2 H. Turnquist.1,3

    1University of Pittsburgh, Starzl Transplant Institute, Pittsburgh, PA; 2University of Pittsburgh, McGowan Institute for Regenerative Medicine, Pittsburgh, PA; 3Immunology, University of Pittsburgh, Pittsburgh, PA.

    Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…
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