2018 American Transplant Congress
Diagnostic Accuracy of Non-Invasive Test of Hepatic Fibrosis in Liver Transplant Recipients
Background & Aims: Hepatic fibrosis is an important predictor of liver- and non-liver related outcomes in patients with chronic liver disease (CLD) and liver transplantation…2018 American Transplant Congress
Multiparametric MRI for Assessment of Renal Transplant Fibrosis: A Pilot
Recanati Miller Transplant Institute, Icahn School of Medicine at Mount Sinai, New York, NY.
Fibrosis in renal allografts confers risk of progression to allograft loss. The gold standard for evaluating renal fibrosis remains allograft biopsy, which is invasive, prone…2018 American Transplant Congress
Inflammation in Fibrotic Areas (i-IF/TA) Identifies a T Cell-Mediated Rejection Component of IF/TA with Poor Kidney Allograft Outcome
Paris Translational Research Center for Organ Transplantation, Paris, France.
Addressing the etiological heterogeneity of interstitial fibrosis in kidney allografts represents an important challenge to improve long-term transplant outcomes. We investigated the determinants, clinical and…2018 American Transplant Congress
Donor Acute Kidney Injury Does Not Affect Fibrosis on 1 Year Post-Transplant Kidney Biopsy
Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA.
PurposeThe use of kidneys from deceased donors with acute kidney injury (AKI) at the time of donation is a potential method by which to expand…2018 American Transplant Congress
RNA-Seq Based Analysis of Renal Allograft Biopsies Reveals Key Mediators of Interstitial Fibrosis/Tubular Atrophy
Interstitial Fibrosis/Tubular Atrophy(IFTA) is the final common pathway of most progressive renal diseases and is a potent predictors of renal outcome in both native and…2018 American Transplant Congress
Upregulated IL-33 in Heart Transplants Modulates Local Myeloid Populations to Protect against Chronic Allograft Rejection
Purpose: Interleukin-33 (IL-33) is an “alarmin”, or a self-derived molecule that triggers pleotropic immune responses after release from damaged tissue. Yet, how IL-33 shapes alloresponses…2018 American Transplant Congress
CD40 Signaling in Proximal Tubules Regulates Fibrosis in Both Hypertension and Chronic Allograft Rejection
University of Toledo College of Medicine and Life Sciences, Toledo, OH.
Background: We explored the role of CD40 signaling in kidney proximal tubule epithelial cells on renal interstitial fibrosis (IF) in two models: hypertension; and chronic…2018 American Transplant Congress
Liver Stiffness Measurement, but Not Controlled Attenuation Parameter, is Increased in Deceased Liver Donors at the Time of Transplant Procurement
Background & Aims: The growing obesity rate and IV drug use in the USA presage a higher usage of liver allografts with NAFLD or active…2018 American Transplant Congress
Role of C1q-Binding Donor-Specific Anti-HLA Antibodies in Premature and Accelerated Kidney Allograft Interstitial Fibrosis
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of a precise diagnosis of IF/TA in kidney recipients by addressing specific etiological factors. Recent studies…2018 American Transplant Congress
Long Term Histologic Allograft Health is Preserved Despite Rejection during Protocolized Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant Recipients
Background: Long term allograft health after rejection during ISW has not been previously assessed. We compare baseline and 4yr graft histology of 20 rejectors in…
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