2016 American Transplant Congress
The Bacterial Enzyme IdeS, Inhibits HLA Antibody-Mediated NK Cell Activation and Cell Cytotoxicity (ADCC) In Vitro.
Background: Antibody-mediated rejection (ABMR) is a major obstacle for successful transplantation in HLA-sensitized patients. ADCC is one of the primary mechanisms for ABMR. IdeS cleaves…2016 American Transplant Congress
An Improved Flow Cytometry Based Platelet Counting in Xeno Perfusion Models.
Aim: Human or baboon platelet sequestration and activation occurs during pig organ xenograft perfusion; its mechanism remains poorly understood. In the context of a regimen…2016 American Transplant Congress
Polyfunctionality of CD8 T Cell Responses to Cytomegalovirus in Transplant Patients.
Background: Cytomegalovirus (CMV) infection causes significant morbidity including allograft damage in transplant patients. Primary infection with CMV is rapidly resolved in healthy individuals; memory T…2015 American Transplant Congress
Evaluation of Natural Killer Cell Activation by NK Cell-Specific Interferon-Gamma-Releasing Assay
Introduction: Although NK cell activity (NKA) has a variety of measuring markers including chromiun release assay and flowcytometry-based cytolysis, limitations such as radioactivity and lack…2015 American Transplant Congress
Biomarker Panel Profile for Identification of High-Risk Patients After Heart Transplantation
Background: The first year after cardiac transplantation is critical for transplant survival and long-term outcome. Identification of suitable biomarkers for detection of rejection processes is…2015 American Transplant Congress
Transient Lymphopenia Breaks Costimulatory Blockade-Based Transplant Tolerance and Initiates Allograft Rejection
【Background and Objective】: Lymphopenia is induced by lymphoablative therapies and chronic viral infections. Lymphopenia is observed in some pathological and physiological processes, including chronic viral…2015 American Transplant Congress
Comprehensive Study of 3 Nomenclatures to Discriminate CD8 Subsets in Healthy Volunteers and in Kidney Transplant Recipients
Objective. Historical classification to distinguish central memory (CM), naïve, effector memory (EM), and terminally-differentiated effector memory (TEMRA) CD8 T cells is based on CD45RA and…2015 American Transplant Congress
Characterization of a Nude Mouse Model of Allosensitization Conditioned by Adoptive Transfer of Follicular T Helper Cells
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA.
Background Follicular T helper (Tfh) cells play a critical role in follicular B cell activation and maturation during antibody responses to allograft. Here we report…2015 American Transplant Congress
Intra-Renal Cytokine Measurement Detected During Kidney Allograft Biopsies Portend Severity of Histological Injury
Division of Nephrology, University of Washington, Seattle, WA.
Histological changes observed on renal allograft biopsies, although considered the current standard for evaluation of allograft injury, lack specificity and disease activity assessment. We devised…2015 American Transplant Congress
Kidney Plasmacytoid Dendritic Cells Display Distinct Cell Surface Markers and May Explain the Induction of Tolerance by Kidney Allografts
Massachusetts General Hospital, Boston, MA.
Achieving tolerance in heart allografts is an important area of research as the need for heart transplantations increase. Recent studies in non-human primates (NHPs) have…
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