ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "FACS analysis"

  • 2019 American Transplant Congress

    Effects of Thalidomide and Dexamethasone Co-Treatment on CD8+ T Cells

    J. Kim1, E. Kim2, Y. Cho1, H. Lee1, M. Kim3, Y. Kim3, K. Huh3, B. Kim4

    1The Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea, Republic of, 2Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, Korea, Republic of, 3Department of Transplantation Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, 4Nephrology Division, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of

    *Purpose: Thalidomide (TM) is known to have anti-cancer and anti-inflammatory effects and dexamethasone (DX) has been reported that it also reduces inflammation and inhibits inflammatory…
  • 2019 American Transplant Congress

    Examination of a Novel Immunoregulatory Marker in Kidney and Lung Transplant Recipients

    A. D. Desai1, G. J. Kavalam2, A. Chandraker2, S. Tripathi2

    11Harvard Summer Research Program for Kidney Medicine, Harvard Medical School,, Boston, MA, 2Schuster Family Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA

    *Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a co-inhibitory receptor mainly expressed on T cells and NK cells. TIGIT has…
  • 2019 American Transplant Congress

    A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity

    L. Qiu1, J. Wang2, R. Fernandez3, X. Yeap1, S. Han1, F. Zheng1, C. Lin2, Z. J. Zhang1

    1Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, 2Northwestern University, Chicago, IL, 3Department of Surgery, Northwestern University, Chicago, IL

    *Purpose: Spleen-derived lymphocytes and myeloid cell populations are critical to the development of organ transplant ischemia-reperfusion injury (IRI) and allograft rejection. In this study, we…
  • 2019 American Transplant Congress

    One Study: A Consortium Model of Clinical Trials Optimized for Comparing New Immune Therapies via Centralized Immune Monitoring

    B. Sawitzki1, S. Schlickeiser1, M. Streitz1, K. Jürchott1, J. Hutchinson2, E. Geissler2, P. Investigators3

    1Charite Universitätsmedizin, Berlin, Germany, 2University of Regensburg, Regensburg, Germany, 3ONE Study Consortium, EU, Germany

    *Purpose: Immune regulatory cell subpopulations can potentially control immune responses to allow immunosuppression (IS) drug minimization. In the ONE Study, an EU FP7-funded research group…
  • 2019 American Transplant Congress

    First Report and Mechanistic Analysis of Chronic GVHD after Solid Organ Transplantation

    J. Weiner, N. Svetlicky, J. Schmidt, J. Kang, M. Sadat, A. Karaballa, S. Moturi, O. Aguirre, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer

    Georgetown University Hospital, Washington, DC

    *Purpose: Chronic graft-versus-host disease (cGVHD) occurs late after bone marrow transplantation and is associated with a characteristic lichenoid rash (cutaneous sclerosis) and effects on multiple…
  • 2019 American Transplant Congress

    Elevated Podocyte-specific Urinary Extracellular Vesicles In Patients With Fsgs Recurrence After Kidney Transplantation

    H. Lau, A. Shimomura, E. Tantisattamo, U. G. Reddy, D. Dafoe, H. Ichii

    University of California Irvine, Orange, CA

    *Purpose: Kidney graft failure is a major concern in patients with kidney transplantation. Patients who suffered graft failure are at a higher risk for mortality…
  • 2019 American Transplant Congress

    Differences in CMV-Specific CD4 T Cell Population in De Novo Kidney Transplant Recipients Treated with Everolimus-Based Regimen Compared to a Standard Tacrolimus-MPA Regimen: Results from ATHENA

    I. A. Hauser1, S. Marx1, C. Sommerer1, B. Suwelack1, D. Dragun1, O. Witzke1, F. Lehner1, I. Kroeger2, M. Junge2, F. Thaiss1, B. Nashan1, M. Sester1

    1ATHENA, CMV Substudy Group, Germany, 2Novartis, Pharma GmbH, Germany

    *Purpose: The ATHENA trial was designed to compare everolimus [EVR] in combination with tacrolimus [TAC] or cyclosporine A [CyA] vs. a standard regimen of mycophenolic…
  • 2019 American Transplant Congress

    Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction

    J. Kang, L. Belyayev, K. Loh, P. Cha, S. Moturi, K. Khan, J. Hawksworth, C. Matsumoto, M. Zasloff, T. Fishbein, A. Kroemer

    Georgetown University, Washington, DC

    *Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…
  • 2019 American Transplant Congress

    First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant

    J. Weiner1, S. Moturi1, C. Ashokkumar2, K. Khan1, S. Kaufman1, R. Sindhi2, C. Matsumoto1, T. Fishbein1, A. Kroemer1

    1MedStar Georgetown Transplant Institute, Washington, DC, 2University of Pittsburgh, Pittsburgh, PA

    *Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…
  • 2019 American Transplant Congress

    Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation

    J. Weiner, N. Svetlicky, J. Schmidt, S. Moturi, O. Aguirre, J. Kang, M. Sadat, K. Khan, J. Hawksworth, C. Matsumoto, T. Fishbein, A. Kroemer

    MedStar Georgetown Transplant Institute, Washington, DC

    *Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…
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