2019 American Transplant Congress
Effects of Thalidomide and Dexamethasone Co-Treatment on CD8+ T Cells
*Purpose: Thalidomide (TM) is known to have anti-cancer and anti-inflammatory effects and dexamethasone (DX) has been reported that it also reduces inflammation and inhibits inflammatory…2019 American Transplant Congress
Examination of a Novel Immunoregulatory Marker in Kidney and Lung Transplant Recipients
*Purpose: The T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domain (TIGIT) is a co-inhibitory receptor mainly expressed on T cells and NK cells. TIGIT has…2019 American Transplant Congress
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Lymphocyte Biology and Transplant Immunity
*Purpose: Spleen-derived lymphocytes and myeloid cell populations are critical to the development of organ transplant ischemia-reperfusion injury (IRI) and allograft rejection. In this study, we…2019 American Transplant Congress
One Study: A Consortium Model of Clinical Trials Optimized for Comparing New Immune Therapies via Centralized Immune Monitoring
*Purpose: Immune regulatory cell subpopulations can potentially control immune responses to allow immunosuppression (IS) drug minimization. In the ONE Study, an EU FP7-funded research group…2019 American Transplant Congress
First Report and Mechanistic Analysis of Chronic GVHD after Solid Organ Transplantation
Georgetown University Hospital, Washington, DC
*Purpose: Chronic graft-versus-host disease (cGVHD) occurs late after bone marrow transplantation and is associated with a characteristic lichenoid rash (cutaneous sclerosis) and effects on multiple…2019 American Transplant Congress
Elevated Podocyte-specific Urinary Extracellular Vesicles In Patients With Fsgs Recurrence After Kidney Transplantation
University of California Irvine, Orange, CA
*Purpose: Kidney graft failure is a major concern in patients with kidney transplantation. Patients who suffered graft failure are at a higher risk for mortality…2019 American Transplant Congress
Differences in CMV-Specific CD4 T Cell Population in De Novo Kidney Transplant Recipients Treated with Everolimus-Based Regimen Compared to a Standard Tacrolimus-MPA Regimen: Results from ATHENA
1ATHENA, CMV Substudy Group, Germany, 2Novartis, Pharma GmbH, Germany
*Purpose: The ATHENA trial was designed to compare everolimus [EVR] in combination with tacrolimus [TAC] or cyclosporine A [CyA] vs. a standard regimen of mycophenolic…2019 American Transplant Congress
Absence of Protective Innate Lymphoid Cell Type 3 (ILC3) and Persistence of Proinflammatory Innate Lymphoid Cell Subsets Immediately Post-Transplant Plays a Appreciable Role in Early Intestinal Barrier Dysfunction
Georgetown University, Washington, DC
*Purpose: Innate lymphoid cells (ILCs) , the most recently described family of lymphoid cells, play fundamental roles in mucosal barrier immunity, tissue homeostasis, and immune…2019 American Transplant Congress
First Report and Mechanistic Analysis of Operational Tolerance after Intestinal Transplant
1MedStar Georgetown Transplant Institute, Washington, DC, 2University of Pittsburgh, Pittsburgh, PA
*Purpose: Transplantation tolerance is a highly sought and rarely achieved state in clinical medicine. Defined as long-term stable and acceptable graft tolerance without immunosuppression and…2019 American Transplant Congress
Central Role of Graft Resident Memory T Cells in Pathogenesis of GVHD after Bowel Transplantation
MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Graft-versus-host disease (GVHD) is a relatively common and highly morbid complication after intestinal transplantation. Its pathophysiology remains poorly understood. Resident memory T cells (TRM)…
- « Previous Page
- 1
- 2
- 3
- 4
- 5
- 6
- …
- 9
- Next Page »