Articles tagged "Epitopes"

2015 American Transplant Congress
HLA Broad Antigen and Eplet Mismatches in Determining the Risk of Acute Rejection After Kidney Transplantation
H. Do Nguyen,¹ W. Lim,^1,2 J. Chapman,³ J. Craig,^3,4 G. Wong.^3,4
¹School of Medicine and Pharmacology, University of Western Australia, Crawley, Western Australia, Australia; ²Renal Medicine, Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia; ³Nephrology, The Children's Hospital at Westmead, Sydney, New South Wales, Australia; ⁴School of Medicine, University of New South Wales, Sydney, New South Wales, Australia.
Aim: To determine the clinical relevance of HLA-ABDR broad antigen and eplet matching for predicting acute rejection after kidney transplantation.Background: HLAMatchmaker determines structurally HLA compatibility…
2015 American Transplant Congress
DQB1 Epitope Matching Predicts the Development of De Novo DSA and Antibody Mediated Rejection
M. Willicombe,¹ M. Blow,² P. Brookes,² E. Santos,² D. Taube.¹
¹Imperial College Kidney and Transplant Centre, Hammersmith Hospital, London, United Kingdom; ²H&I, Hammersmith Hospital, London, United Kingdom.
HLA DQ antibodies are the commonest de novo [DN] DSA specificity seen post renal transplantation. Their presence is associated with antibody mediated injury and allograft…
2015 American Transplant Congress
The Synergistic Effect of Class II HLA Epitope-Mismatch and Non-Adherence on Acute Rejection and Graft Survival
C. Wiebe,^1,2 T. Nevins,³ W. Robiner,^3,4 W. Thomas,⁵ A. Matas,⁶ P. Nickerson.^1,2,8
¹Medicine, University of Manitoba, Winnipeg, MB, Canada; ²Transplant Immunology, Diagnostic Services of Manitoba, Winnipeg, MB, Canada; ³Pediatrics, University of Minnesota, Minneapolis, MN; ⁴Medicine, University of Minnesota, Minneapolis, MN; ⁵Public Health, University of Minnesota, Minneapolis, MN; ⁶Surgery, University of Minnesota, Minneapolis, MN; ⁷Immunology, University of Manitoba, Winnipeg, MB, Canada.
Predicting long-term outcomes in renal transplant recipients is essential to optimize medical therapy and determine the frequency of post-transplant pathologic and serologic monitoring. Non-adherence and…
2015 American Transplant Congress
Structural and Functional Basis for Non-HLA Antibody Mediated AT1R Activation
D. Dragun, D. Postpieszala, N. Zhu, R. Catar, A. Philippe.
Nephrology and Intensive Care Medicine, Charité University Hospital, Berlin, Germany.
Angiotensin II type receptor (AT1R), a heptahelical protein signals stimuli upon binding of natural peptide ligand angiotensin II (Ang II) and the pathogenic non-HLA IgG…
2015 American Transplant Congress
Are DQA Antibodies Real?
J. Jones, D. Lucas, M. Leffell, A. Zachary.
Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Antibodies specific for HLA-DQ antigens appear to be increasing in frequency in the post-transplant period and are difficult to reduce effectively with desensitization protocols using…