Articles tagged "Epitopes"

2018 American Transplant Congress
Lower Incidence of De Novo Donor-Specific Antibodies against HLA-DR in ABO-Incompatible Renal Transplantation
M. Okada,¹ K. Futamura,¹ T. Hiramitsu,¹ M. Tsujita,¹ N. Goto,¹ S. Narumi,¹ Y. Watarai,¹ K. Iwasaki,² T. Kobayashi.²
¹Department of Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Department of Transplant Surgery, Aichi Medical University, Nagakute, Japan.
IntroductionDe novo DSA-induced chronic antibody-mediated rejection (AMR) is one of major obstacles to long term graft survival. We have reported that anti-A/B antibody binding could…
2018 American Transplant Congress
Eplet Mismatches and De Novo Donor Surface Antibody Development in Pediatric Renal Transplant Recipients
E. Blanchette,¹ M. Bradford,¹ P. Warner,² C. Blosser,³ I. Gimferrer,² J. Smith.¹
¹Seattle Children's Hospital, Seattle; ²Bloodworks Northwest, Seattle; ³UW Medicine, Seattle.
Background: De novo donor surface antibody (dnDSA) development is arguably the first step in the natural history of allograft injury secondary to humoral alloimmunity. This…
2018 American Transplant Congress
Epitope/Eplet Mismatch in Pediatric Renal Transplantation and Development of Donor Specific Antibody
R. George,¹ H. Sullivan,² R. Garro,¹ P. Winterberg,¹ B. Warshaw,¹ H. Gebel,² R. Bray.²
¹Pediatric Nephrology, Emory University & Children's Healthcare of Atlanta, Atlanta, GA; ²Dept. of Pathology, Emory Transplant Center, Emory University, Atlanta, GA.
Background: De-novo donor specific antibody (DSA) is one of the strongest independent predictors of graft loss with HLA mismatching being a major risk factor for…
2017 American Transplant Congress
Kidney Transplant Rejection Associated with DQ Eplet Mismatches.
S. Chakola,¹ P. Warner,² N. Andeen,³ B. Najafian,³ N. Leca,¹ C. Blosser.¹
¹Medicine, University of Washington, Seattle, WA; ²Bloodworks Northwest, Seattle, WA; ³Pathology, University of Washington, Seattle, WA
The presence of anti-HLA antibodies is associated with acute rejection, allograft dysfunction and earlier graft loss. HLA antibodies are recognized as being specific to these…
2017 American Transplant Congress
Precise Antibody Characterization Using Multiple Solid Phase Assay Platforms Is Critical for Accurate Virtual Crossmatching.
D. Li,¹ O. Timofeeva,¹ M. Awwad,¹ C. Cody,² S. Najjar,² S. Rosen-Bronson.¹
¹Histocompatibility Laboratory, MedStar Georgetown University Hospital, Washington, DC; ²MedStar Heart Institute, Washington Hospital Center, Washington, DC
Purpose: Virtual crossmatch (VXM) has been utilized in heart transplant (txp) for more than a decade. Many labs base the VXM solely on single antigen…
2017 American Transplant Congress
Shared Epitopes Contribute to Accumulation of Highly Sensitized Patients in Kidney Paired Donation Program.
S. Stepkowski, B. Mierzejewska, C. Baum, D. Bekbolsynov, R. Brunner, J. Kopke, S. Rees, M. Rees.
University of Toledo, Toledo, OH
Introduction: Kidney Paired Donation (KPD) programs suffer from the accumulation of highly sensitized patients. We evaluated the sensitization patterns in our KPD program-by comparison of…
2017 American Transplant Congress
HLA Eplet Mismatches Predict DSA Formation, Graft Survival, and Re-Transplantation Rate in Pediatric Renal Transplantation.
M. Sypek,^1,2 S. Hiho,³ L. Cantwell,³ P. Hughes,² A. Le Page,⁴ J. Kausman.¹
¹Royal Children's Hospital, Melbourne, Australia; ²Royal Melbourne Hospital, Melbourne, Australia; ³Victorian Transplant and Immunogenetics Service, Melbourne, Australia; ⁴Monash Children's Hospital, Melbourne, Australia
The potential benefits of HLA epitope based matching are greatest for pediatric recipients, however, there is little published data on the association of epitope mismatches…
2017 American Transplant Congress
Donor Recipient Matching Based on HLA Epitopes Improves Outcome in Kidney Transplant Recipients.
O. Staeck,¹ M. Niemann,³ F. Halleck,¹ D. Khadzhynov,¹ C. Schönemann,² P. Reinke,¹ E. Spierings,⁴ K. Budde,¹ N. Lachmann.²
¹Nephrology, Charité Universitaetsmedizin, Berlin, Germany; ²HLA Laboratory, Charité Universitaetsmedizin, Berlin, Germany; ³PIRCHE, Berlin, Germany; ⁴Laboratory of Translational Immunology, UMC Utrecht, Utrecht, Netherlands
Background: HLA mismatches of the donor and recipient causing de novo donor-specific HLA antibodies (dnDSA) are a risk factor for immunologic complications and poor graft…
2016 American Transplant Congress
The Distance Between Us: The Landscape of Recipient-Specific Loss-of-Function in Solid Organ Transplantation and Association with Rejection-Free Graft Survival.
B. Cole,^1,2,5 J. van Setten,^3,5 B. Keating.^1,4,5
¹Department of Surgery, The Penn Transplant Institute, Philadelphia, PA; ²Center for Clinical Epidemiology and Biostatistics, The Institute for Biomedical Informatics, Philadelphia, PA; ³Department of Medical Genetics, University Medical Center Utrecht, Utrecht, Netherlands; ⁴Department of Surgery, Division of Transplant, the Children's Hospital of Philadelphia, Philadelphia, PA; ⁵The Omics Working Group, iGeneTRAiN Consortium, Philadelphia, PA.
Purpose: This study aims to comprehensively identify genes that are inactivated in both copies in transplant recipients but not in their respective donors, uncovering a…
2016 American Transplant Congress
Should HLA DR and DQ Eplet Mismatching Replace Traditional DR and DQ Mismatching for Deceased Donor Offers in Pediatric Renal Transplantation?
C. Bryan, V. Chadha, B. Warady.
Midwest Transplant Network, Kansas City, KS; Nephrology, Childrens Mercy Hospital, Kansas City, MO; Nephrology, Childrens Mercy Hospital, Kansas City, MO.
Introduction. It is now appreciated that greater HLA DR mismatching of the first pediatric kidney transplantation is associated with higher degrees of sensitization, lower rates…