Articles tagged "Epitopes"

2020 American Transplant Congress
Ranking Eplet Mismatches as Predictors of Graft Failure
W. Zhang¹, H. Mohammadhassanzadeh¹, K. Oualkacha², H. Gebel³, W. Klement⁴, R. Sapir-Pichhadze¹
¹McGill University, Montreal, QC, Canada, ²UQAM, Montreal, QC, Canada, ³Emory University Hospital, Atlanta, GA, ⁴Canadian Blood Services, Ottawa, ON, Canada
*Purpose: Donor:recipient matching at the level of sequence defined HLA targets (eplets) is being promoted as a biologically sound strategy to prevent graft failure. Because…
2020 American Transplant Congress
Impact of Eplet Mismatches on the Risk of Graft Loss: Not All Eplets are Created Equal
H. Mohammadhassanzadeh¹, W. Klement², H. Gebel³, B. Foster⁴, P. Keown⁵, K. Oualkacha⁶, R. Sapir-Pichhadze¹
¹Medicine, McGill University, Montreal, QC, Canada, ²Organ Donation and Transplantation, Canadian Blood Services, Ottawa, ON, Canada, ³Emory University Hospital, Atlanta, GA, ⁴Montreal Children's Hospital, Montreal, QC, Canada, ⁵Medicine, University of British Columbia, Vancouver, BC, Canada, ⁶Université du Québec À Montréal, Montreal, QC, Canada
*Purpose: To mitigate risks related to HLA incompatibility, we assessed whether some unique sequence defined HLA targets (eplets) are associated with graft failure while others…
2020 American Transplant Congress
Eplet Mismatch Not Correlated with Antibody Mediated Rejection or Allograft Loss Among Kidney Transplant Recipients with De Novo Donor Specific Antibody
A. Basu¹, W. Jiqiu², A. Bentall², M. Gandhi², B. Dukek², N. Henderson², C. Schinstock²
¹Emory Healthcare, Atlanta, GA, ²Mayo Clinic, Rochester, MN
*Purpose: Eplet mismatches are associated with development of de novo DSA (dnDSA) in kidney transplant recipients. However, it remains unclear how the degree of eplet…
2020 American Transplant Congress
Epitope Analysis of Complement-Binding De Novo Donor-Specific HLA Class II Antibody
K. Yamanaka, M. Hashimoto, T. Kinoshita, Y. Fujita, S. Matsumura, T. Imanaka, A. Taniguchi, T. Yoshida, H. Kishikawa
Department of Kidney Transplantation Center, Hyogo Prefectural Nishinomiya Hospital, Nishinomiya, Hyogo, Japan
*Purpose: Patients with de novo donor specific antibody (dnDSA) after kidney transplantation have a poorer prognosis than patients without dnDSA. Meanwhile, patients with dnDSA do…
2019 American Transplant Congress
Can Imputation of HLA Allele Level Typing Be Used Clinically in a Multiethnic Population?
R. M. Engen¹, A. M. Jedraszko¹, A. Tambur²
¹Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, ²Northwestern University, Chicago, IL
*Purpose: Assignment of eplets in transplantation for the purpose of matching or risk stratification requires high-resolution HLA typing, which is not readily available. Computer algorithms…
2019 American Transplant Congress
Predicted Indirectly Recognizable H L A Epitopes Are Associated with T-cell Mediated Rejection among Kidney Transplant Recipients with Preformed and De Novo Donor-Reactive T-cells
T. Schachtner¹, M. Stein², N. M. Otto³, P. M. Reinke²
¹Nephrology, University Hospital Zurich, Zurich, Switzerland, ²Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany, ³Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berin, Germany
*Purpose: Very recently Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) have been suggested to demonstrate early and late effects on kidney allograft outcomes. The association between…
2019 American Transplant Congress
ABO Incompatibility in Kidney Transplantation Can Increase a Safety Margin of Epitope Mismatch Levels against De Novo DSA Production
T. Kobayashi¹, K. Iwasaki¹, M. Okada², K. Horimi¹, Y. Matsuoka¹, A. Takeda², N. Goto², S. Narumi², Y. Watarai²
¹Aichi Medical University School of Medicine, Nagakute, Japan, ²Nagoya Daini Red Cross Hospital, Nagoya, Japan
*Purpose: Chronic antibody-mediated rejection (cABMR) caused by de novo donor specific HLA antibodies (DSA) is one of major obstacles to long term graft outcome. ABO…
2019 American Transplant Congress
The Impact of Eplet Mismatches on Kidney Transplant Outcome: A Single-Center Cohort Study
A. Senev¹, M. Coemans¹, V. Van Sandt², B. Sprangers³, D. Kuypers³, M. Emonds², M. Naesens³
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium, ³University Hospitals Leuven, Leuven, Belgium
*Purpose: It has been shown that HLA-matching at classic antigen-level for HLA-A, -B and -DRB1 loci, provides benefits in matching and outcome after solid organ…
2019 American Transplant Congress
Epitope-Based Matching in Pediatric Kidney Transplantation
C. Boussard¹, M. Ould Rabah², O. Boyer², M. Macher¹, J. Taupin³, J. Hogan⁴
¹Department of Pediatric Nephrology, Robert Debre hospital, APHP, Paris, France, ²Department of Pediatric Nephrology, Necker Enfants-Malades, APHP, Paris, France, ³Department of Immunology, Saint-Louis Hospital, APHP, Paris, France, ⁴Transplant Research Center, Department of Surgery, Emory University, ATLANTA, GA
*Purpose: Following the allocation of a transplant by the allocation system, each pediatric transplant team reviews the proposal and decides based on various criteria whether…
2019 American Transplant Congress
Mismatched Antibody Epitopes and the Development of HLA-DQ De Novo DSA during Immunosuppression Withdrawal in Liver Transplant Recipients
V. Jucaud¹, A. Shaked², M. DesMarais³, P. Sayre⁴, S. Feng⁴, J. Levitsky⁵, M. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²University of Pennsylvania, Philadelphia, PA, ³Immune Tolerance Network, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵Northern Western University, Chicago, IL
*Purpose: We recently described, in liver transplant (LT) recipients from the ITN030ST study, the development of de novo donor-specific HLA antibodies (dnDSA) and their impact…