ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Epitopes"

  • 2020 American Transplant Congress

    Low HLA Class I Epitope Mismatch Associated with Improved Pancreas Graft Survival in Simultaneous Pancreas-Kidney Transplantation

    J. M. Ladowski, M. Romine, D. Kloda, C. Young, J. Locke, V. Hauptfeld-Dolejsek, J. Houp

    University of Alabama-Birmingham, Birmingham, AL

    *Purpose: Antibody-mediated rejection remains the principal cause of allotransplant graft failure. Human leukocyte antigen (HLA) matching between donor and recipients significantly reduces the risk of…
  • 2020 American Transplant Congress

    HLA Molecular Mismatch Analysis in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplant Tolerance Induction Protocol

    C. Garcia-Sanchez1, V. Kosmoliaptsis2, H. Copley2, J. Leventhal1, S. Ildstad3

    1NU, Chicago, IL, 2Cambridge, Cambridge, United Kingdom, 3U of Louisville, Lousville, KY

    *Purpose: To evaluate the potential role of HLA molecular mismatch (MM) analysis in predicting outcomes in a cohort of HLA-mismatched, related and unrelated recipients of…
  • 2020 American Transplant Congress

    HLA-DR/DQ Molecular Mismatch Dictates Early Risk of De Novo Donor-Specific Antibody Development and Offers a Personalized Approach to Immunosuppression Management in Kidney Transplantation

    S. Davis1, C. Wiebe2, K. Campbell1, C. Anobile3, M. Aubrey3, A. Wiseman1, E. Pomfret1, P. Nickerson2, J. Cooper1

    1University of Colorado, Aurora, CO, 2University of Manitoba, Winnipeg, MB, Canada, 3Clinimmune, Aurora, CO

    *Purpose: Clinicians have few tools to predict the risk of alloimmune injury in a patient undergoing renal transplantation, as traditional demographic or clinical variables lack…
  • 2020 American Transplant Congress

    Clinical Significance of T Cell and B Cell Epitope Prediction as a Risk Factor of De Novo DSA Production after Kidney Transplantation

    T. Kobayashi1, K. Iwasaki1, T. Tomosugi2, Y. Miwa1, M. Niemann3, E. Spierings4, K. Horimi1, Y. Matsuoka1, A. Takeda2, N. Goto2, S. Narumi2, Y. Watarai2

    1Aichi Medical University School of Medicine, Nagakute, Japan, 2Nagoya Daini Red Cross Hospital, Nagoya, Japan, 3PIRCHE AG, Berlin, Germany, 4UMC Utrecht, Utrecht, Netherlands

    *Purpose: Chronic antibody-mediated rejection caused by de novo DSA (dnDSA) is a major cause of graft failure. Risk prediction of dnDSA would be important for…
  • 2019 American Transplant Congress

    Mismatched Epitope and De Novo DSA Development: An Analysis of the Benefit and Benefit-EXT Renal Transplant Cohorts

    V. Jucaud1, V. Burnett1, H. Gebel2, R. Bray2, M. Polinsky3, M. Everly1

    1Terasaki Research Institute, Los Angeles, CA, 2Emory University, Atlanta, GA, 3Bristol-Myers Squibb, Princeton, NJ

    *Purpose: De novo donor-specific HLA antibodies (dnDSA) target epitopes rather than whole antigens, and their development is associated with the mismatched HLA antibody epitope load…
  • 2019 American Transplant Congress

    Solving Target Recognition and Activation Mediated by Non-HLA Agonistic Antibodies Targeting ETAR

    A. Philippe1, R. Catar1, P. Scheerer2, M. Szczepek2, D. Dragun1

    1Nephrology and Medical Intensive Care, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Medical Physics and Biophysics, Charité Universitätsmedizin Berlin, Berlin, Germany

    *Purpose: Endothelin-1 type A receptor (ETAR) exhibits multiligand binding abilities and may signal upon natural ligand Endothelin-1 (ET-1) and non-HLA ETAR-agonistic IgG (ETAR-IgG)-mediated stimulation similar…
  • 2019 American Transplant Congress

    Can Imputation of HLA Allele Level Typing Be Used Clinically in a Multiethnic Population?

    R. M. Engen1, A. M. Jedraszko1, A. Tambur2

    1Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, 2Northwestern University, Chicago, IL

    *Purpose: Assignment of eplets in transplantation for the purpose of matching or risk stratification requires high-resolution HLA typing, which is not readily available. Computer algorithms…
  • 2019 American Transplant Congress

    Predicted Indirectly Recognizable H L A Epitopes Are Associated with T-cell Mediated Rejection among Kidney Transplant Recipients with Preformed and De Novo Donor-Reactive T-cells

    T. Schachtner1, M. Stein2, N. M. Otto3, P. M. Reinke2

    1Nephrology, University Hospital Zurich, Zurich, Switzerland, 2Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berlin, Germany, 3Berlin-Brandenburg Center for Regenerative Therapies, Charite University Medicine Berlin, Berin, Germany

    *Purpose: Very recently Predicted Indirectly ReCognizable HLA Epitopes (PIRCHE) have been suggested to demonstrate early and late effects on kidney allograft outcomes. The association between…
  • 2019 American Transplant Congress

    ABO Incompatibility in Kidney Transplantation Can Increase a Safety Margin of Epitope Mismatch Levels against De Novo DSA Production

    T. Kobayashi1, K. Iwasaki1, M. Okada2, K. Horimi1, Y. Matsuoka1, A. Takeda2, N. Goto2, S. Narumi2, Y. Watarai2

    1Aichi Medical University School of Medicine, Nagakute, Japan, 2Nagoya Daini Red Cross Hospital, Nagoya, Japan

    *Purpose: Chronic antibody-mediated rejection (cABMR) caused by de novo donor specific HLA antibodies (DSA) is one of major obstacles to long term graft outcome. ABO…
  • 2019 American Transplant Congress

    The Impact of Eplet Mismatches on Kidney Transplant Outcome: A Single-Center Cohort Study

    A. Senev1, M. Coemans1, V. Van Sandt2, B. Sprangers3, D. Kuypers3, M. Emonds2, M. Naesens3

    1Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, 2Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium, 3University Hospitals Leuven, Leuven, Belgium

    *Purpose: It has been shown that HLA-matching at classic antigen-level for HLA-A, -B and -DRB1 loci, provides benefits in matching and outcome after solid organ…
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