ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Epithelial cells"

  • 2019 American Transplant Congress

    Bortezomib Attenuates the Progression of Epithelial to Mesenchymal Transition through Smurf1 Akt mTOR P70S6K Pathway in Rat Allograft Renal Interstitial Fibrosis Model

    R. Tan, Z. Wang, S. Fei, Z. Han, J. Tao, X. Ju, M. Gu

    No.300 Guangzhou Road of Nanjing, Nanjing, China

    *Purpose: Our study was to detect the effects of Bortezomib and Smurf1 in the EMT and allograft renal interstitial fibrosis.*Methods: Biomarkers of EMT, as well…
  • 2019 American Transplant Congress

    Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant

    S. Jain1, R. Plenter2, T. Nydam2, A. Jani1

    1Renal Division, University of Colorado, Aurora, CO, 2Transplant Microsurgery Program, University of Colorado, Aurora, CO

    *Purpose: Delayed graft function portends reduced 5-year graft survival and is associated with prolonged cold ischemia (CI). The aim of this study was to determine…
  • 2019 American Transplant Congress

    Inhibition of CXCR3 Expression through Blockade of STAT3 Alpha Signaling Down-Regulate Inflammation of Renal Ischemia-Reperfusion Injury

    J. Kim1, J. Park2, K. Yoo2, J. Moon1, J. Jeong1, C. Lee3, Y. Kim1, S. Yang4

    1Seoul National University College of Medicine, Seoul, Korea, Republic of, 2Dongguk University College of Medicine, Gyeonggi-do, Korea, Republic of, 3Cheju Halla General Hospital, Cheju, Jeju-do, Korea, Republic of, 4Kidney Research Institute, Seoul National University, Seoul, Korea, Republic of

    *Purpose: Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. Although it exists in two isoforms:…
  • 2018 American Transplant Congress

    Inhibition of Neutrophil Recruitment and Activation Protects Airway Epithelium after Transplantation

    R. Zhang,1 H. Fang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Obliterative bronchiolitis (OB) is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases.…
  • 2018 American Transplant Congress

    Regulation of NK Cell Cytotoxicity by TEC Expression of Clr Proteins in Kidney Ischemia Reperfusion Injury (IRI)

    B. Fuhrmann,1,5 D. Lian,5 Z. Yin,5 S. Ma,4,5 J. Arp,5 Z. Zhang,2,3,4,5 A. Jevnikar.1,3,4,5

    1Microbiology and Immunology, Western University, London, Canada; 2Pathology, Western University, London, Canada; 3Medicine, Western University, London, Canada; 4Multi-Organ Transplant Program, London Health Sciences Centre, London, Canada; 5Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.

    Background: Kidney tubular epithelial cells (TEC) may negatively regulate NK cell activation and cytotoxic capacity by surface expression of a novel class of C-type lectin-related…
  • 2018 American Transplant Congress

    IL-17 is Critical for Airway Epithelial Injury after Transplantation

    R. Zhang,1 H. Fang,1 Q. Chen,2 J. Ochando,3 Y. Ding,1 J. Xu.1

    1Department of Immunology, Capital Medical University, Beijing, China; 2Department of Thoracic Surgery, Chaoyang Hospital, Beijing, China; 3Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY.

    Background: Obliterative bronchiolitis is the major obstacle limiting long-term allograft survival of lung transplantation. Airway epithelium is the primary target in obliterative airway diseases. Th17…
  • 2017 American Transplant Congress

    Anti-CD40 mAb Promotes Kidney Immunoregulatory Capacity in NHP Transplants by Altering Kidney Tubular Cell (TEC) Expression of CD40 and IL-6.

    J. Arp,1 Y. Ma,1 H. Yang,2 A. El Warrak,1 A. Haig,1 W. Liu,1 K. Reimann,3 P. Luke,1 Z. Zhang,1 D. Rothstein,4 A. Jevnikar.1

    1Medicine, Pathology & Microbiology & Immunology, Western University, London, ON, Canada; 2Sichuan Provincial Hospital, Chengdu, Sichuan, China; 3University of Massachusetts, Boston, MA; 4University of Pittsburgh, Pittsburgh, PA

    Treatment of cynolmolgus monkey (NHP) renal transplant recipients with a combination of 2 rhesus-mouse chimeric α-CD45RB (r6G3R1; 6G3) and α-CD40 (r2C10R4; 2C10) mAbs increased circulating…
  • 2017 American Transplant Congress

    Signal Inhibitory Regulatory Protein-α Regulates Pathologic Reactive Oxygen Species in Acute Kidney Injury.

    N. Rogers,1,2,3 D. Meijles,3 P. Pagano,3 J. Isenberg.3

    1Centre for Transplant and Renal Research, Westmead Institute for Medical Research, Sydney, NSW, Australia; 2Starzl Transplant Institute, University of Pittsburgh, Pittsburgh, PA; 3Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA

    Background: Ischemia reperfusion injury (IRI) is mediated by a complex cascade of pro-inflammatory and oxidative processes. We have reported that signal regulatory inhibitory protein (SIRP)-α…
  • 2017 American Transplant Congress

    Transcriptomic Analysis Revealed a Fibrotic Role of Epithelial Cells Originated from the Recipient in Kidney Transplant.

    W. Zhang,1 Z. Yi,1 E. Stahl,2 M. Menon,1 K. Keung,3 K. Hao,2 P. O'Connell,3 B. Murphy.1

    1Medicine, Icahn School of Medicine at Mount Sinai, New York, NY; 2Department of Genetics and Genomic Science, Ichan School of Medicine at Mount Sinai, New York, NY; 3Renal Unit, University of Sydney at Westmead Hospital, Sydney, Australia

    Renal fibrosis is one of major causes for chronic renal dysfunction in kidney diseases and graft loss in kidney transplant. With an aim to better…
  • 2017 American Transplant Congress

    Poor Outcome of Polyomavirus -Associated Nephropathy with Glomerular Parietal Epithelial Cells Infected by Polyomavirus.

    G. Huang,1 W. Chen,2 J. Qiu,1 X. Chen,1 L. Chen,1 C. Wang.1

    1Department of Organ Transplantation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China; 2Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

    Background: Bowman's capsular epithelium infected by polyomavirus(Py) in polyomavirus -associated nephropathy (PyVAN) is infrequent and considered as the advanced stage of the disease. The aim…
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