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American Transplant Congress abstracts

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Articles tagged "Engraftment"

  • 2019 American Transplant Congress

    Parathyroid CD34+ Cells Induce Neovascularization of Donor and Recipient Leading to Chimeric Vessel Formation and Improved Engraftment of Co-Transplanted Pancreatic Islets

    Y. Kelly1, C. Ward1, Q. Duh1, W. Chang2, P. Stock1, Q. Tang1

    1UCSF, San Francisco, CA, 2San Francisco Veterans Affairs, San Francisco, CA

    *Purpose: We recently showed improved engraftment and diabetes reversal when mature islets or stem-cell-derived beta cells (SCIPC) were co-transplanted with parathyroid gland (PTG). The CD34+…
  • 2019 American Transplant Congress

    Can Cxcl8 Inhibitor (reparixin) Improve Islet Engraftment And Clinical Outcomes After Islet Allotransplantation? University Of Chicago Preliminary Results From A Phase 3 Multicenter Randomized, Double-blinded, Prospective Study.

    P. Bachul1, K. Golab1, L. Basto1, L. Wang1, M. Tibudan1, J. Golebiewska2, M. Para1, L. Perea1, F. Antic1, J. Fung1, P. Witkowski1

    1University of Chicago Medicine, Chicago, IL, 2Medical University of Gdansk, Gdansk, Poland

    *Purpose: Reparixin is a novel CxCR1/2 chemokine receptor-blocking molecule, which has been shown improving islet engraftment in animal models. A multicenter trial was organized to…
  • 2019 American Transplant Congress

    Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney

    S. Noel1, J. T. Kurzhagen1, S. Lee1, M. Sadasivam2, A. R. Hamad2, P. M. Pierorazio3, H. Rabb1

    1Medicine, Johns Hopkins University, Baltimore, MD, 2Pathology, Johns Hopkins University, Baltimore, MD, 3Urology, Johns Hopkins University, Baltimore, MD

    *Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
  • 2019 American Transplant Congress

    Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation

    J. Fair1, M. M. Shoja1, N. Liu1, I. Patrikeev2, M. Motamedi2, W. S. Fagg1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX

    *Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…
  • 2019 American Transplant Congress

    CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation

    M. Song, K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, A. D. Kirk

    Surgery, Duke University, Durham, NC

    *Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…
  • 2018 American Transplant Congress

    The Role of CD46 in Early Islet Engraftment in a Dual Transplant Model

    Q. Gao, K. Samy, R. Davis, M. Song, A. MacDonald, F. Leopardi, T. How, K. Williams, G. Devi, B. Collins, A. Kirk.

    Department of Surgery, Duke University School of Medicine, Durham, NC.

    IntroductionMembrane cofactor protein (CD46) is known to attenuate the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46…
  • 2018 American Transplant Congress

    Robust Hematopoietic Mixed Chimerism and Donor-Specific Skin Allograft Tolerance after Non-Genotoxic Anti-CD117 Immunotoxin Conditioning and Donor Bone Marrow Allotransplantation

    Z. Li,1 A. Czechowicz,2,3,4,5,6,7 A. Scheck,2,3,4,5,6 D. Rossi,3,4,5,6 P. Murphy.1

    1Lab of Molecular Immunology (LMI), NIAID, Bethesda; 2Dept Pediatrics, Div Stem Cell Transplantation and Regenerative Med, Stanford Univ, Stanford; 3Pgram Cellular & Molecular Med, Div Hematology/Oncology, Boston Children's Hosp, Boston; 4Dept Stem Cell & Regenerative Biol, Harvard Univ, Boston; 5Dept Pediatrics, Harvard Med Sch, Boston; 6Harvard Stem Cell Inst, Harvard Univ, Cambridge; 7Dept Pediatric Oncology, Dana Farber Cancer Inst, Boston.

    Establishing hematopoietic chimerism enables donor-specific allograft tolerance; however, chimerism protocols typically require either genotoxic conditioning or mega-doses of donor bone marrow cells (BMC), impeding clinical…
  • 2018 American Transplant Congress

    A Novel Approach to Preserve Pancreatic Islet Grafts in Extrahepatic Space for Reversal of Diabetes Using Parathyroid Gland Co-Transplantation

    C. Ward, G. Faleo, G. Nair, Q. Duh, M. Hebrok, W. Chang, P. Stock, Q. Tang.

    UCSF, San Francisco, CA.

    Intro: Islet transplantation can cure type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets away from their native blood…
  • 2018 American Transplant Congress

    Enhancement of Muscle Regeneration and Function via Transplantation of Human Dystrophin Expressing Chimeric Cells as a Novel Myoblast Stem-Cell Based Therapy

    M. Siemionow,1 J. Cwykiel,1 E. Marchese,1 G. Rafidi,1 K. Futoma,1 A. Heydemann,2 J. Garcia-Martinez,2 E. Szilagyi.1

    1Orthopaedics, University of Illinois at Chicago, Chicago; 2Physiology and Biophysics, University of Illinois at Chicago, Chicago.

    PURPOSE: Allogeneic myogenic stem cell transplantation aims to restore muscle tissue after traumatic loss or to treat muscular dystrophies. Limited engraftment due to allogeneic rejection…
  • 2017 American Transplant Congress

    Delayed Tolerance Induction Protocol for Vascularized Composite Allografts in Non-Human Primates: The Immunomodulatory Effect of Donor Bone Marrow Transplantation Does Not Prevent the Development of Chronic Rejection in the Absence of Durable Mixed Chimerism.

    Z. Ng, A. Lellouch, A.-R. Gama, I. Schol, I. Rosales, R. Colvin, L. Geoghegan, J. Kurtz, C. Cetrulo.

    Massachusetts General Hospital, Boston, MA

    PURPOSE: Donor bone marrow transplantation (DBMT) has been investigated in experimental and clinical vascularized composite allotransplantation (VCA). With longer-term follow-up, reports of chronic VCA rejection…
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