ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Engraftment"

  • 2019 American Transplant Congress

    CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation

    M. Song, K. Samy, Q. Gao, R. P. Davis, F. Leopard, Z. Fitch, C. Bennett, G. R. Devi, B. H. Collins, A. D. Kirk

    Surgery, Duke University, Durham, NC

    *Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…
  • 2019 American Transplant Congress

    Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies­

    W. S. Fagg1, N. Liu1, M. Shoja1, I. Patrikeev2, M. Motamedi2, J. Fair1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX

    *Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…
  • 2019 American Transplant Congress

    AMD3100 (Plerixafor) as a Single-Dose Stem Cell Mobilizing Agent in Vascularized Composite Tissue Allograft (VCA) Transplantation in a Canine DLA-Mismatch Model

    B. Swearingen1, S. Graves2, R. Storb2, D. W. Mathes1

    1University of Colorado School of Medicine, Aurora, CO, 2Fred Hutchinson Cancer Research Center, Seattle, WA

    *Purpose: Vascularized Composite Allograft (VCA) transplantation is a clinical reality but limited by toxicities of chronic immunosuppression and rejection. Current clinical tolerance protocols rely on…
  • 2019 American Transplant Congress

    Parathyroid CD34+ Cells Induce Neovascularization of Donor and Recipient Leading to Chimeric Vessel Formation and Improved Engraftment of Co-Transplanted Pancreatic Islets

    Y. Kelly1, C. Ward1, Q. Duh1, W. Chang2, P. Stock1, Q. Tang1

    1UCSF, San Francisco, CA, 2San Francisco Veterans Affairs, San Francisco, CA

    *Purpose: We recently showed improved engraftment and diabetes reversal when mature islets or stem-cell-derived beta cells (SCIPC) were co-transplanted with parathyroid gland (PTG). The CD34+…
  • 2019 American Transplant Congress

    Can Cxcl8 Inhibitor (reparixin) Improve Islet Engraftment And Clinical Outcomes After Islet Allotransplantation? University Of Chicago Preliminary Results From A Phase 3 Multicenter Randomized, Double-blinded, Prospective Study.

    P. Bachul1, K. Golab1, L. Basto1, L. Wang1, M. Tibudan1, J. Golebiewska2, M. Para1, L. Perea1, F. Antic1, J. Fung1, P. Witkowski1

    1University of Chicago Medicine, Chicago, IL, 2Medical University of Gdansk, Gdansk, Poland

    *Purpose: Reparixin is a novel CxCR1/2 chemokine receptor-blocking molecule, which has been shown improving islet engraftment in animal models. A multicenter trial was organized to…
  • 2018 American Transplant Congress

    The Role of CD46 in Early Islet Engraftment in a Dual Transplant Model

    Q. Gao, K. Samy, R. Davis, M. Song, A. MacDonald, F. Leopardi, T. How, K. Williams, G. Devi, B. Collins, A. Kirk.

    Department of Surgery, Duke University School of Medicine, Durham, NC.

    IntroductionMembrane cofactor protein (CD46) is known to attenuate the complement cascade by facilitating cleavage of C3b and C4b. In solid organ xenotransplantation, organs expressing CD46…
  • 2018 American Transplant Congress

    Robust Hematopoietic Mixed Chimerism and Donor-Specific Skin Allograft Tolerance after Non-Genotoxic Anti-CD117 Immunotoxin Conditioning and Donor Bone Marrow Allotransplantation

    Z. Li,1 A. Czechowicz,2,3,4,5,6,7 A. Scheck,2,3,4,5,6 D. Rossi,3,4,5,6 P. Murphy.1

    1Lab of Molecular Immunology (LMI), NIAID, Bethesda; 2Dept Pediatrics, Div Stem Cell Transplantation and Regenerative Med, Stanford Univ, Stanford; 3Pgram Cellular & Molecular Med, Div Hematology/Oncology, Boston Children's Hosp, Boston; 4Dept Stem Cell & Regenerative Biol, Harvard Univ, Boston; 5Dept Pediatrics, Harvard Med Sch, Boston; 6Harvard Stem Cell Inst, Harvard Univ, Cambridge; 7Dept Pediatric Oncology, Dana Farber Cancer Inst, Boston.

    Establishing hematopoietic chimerism enables donor-specific allograft tolerance; however, chimerism protocols typically require either genotoxic conditioning or mega-doses of donor bone marrow cells (BMC), impeding clinical…
  • 2018 American Transplant Congress

    A Novel Approach to Preserve Pancreatic Islet Grafts in Extrahepatic Space for Reversal of Diabetes Using Parathyroid Gland Co-Transplantation

    C. Ward, G. Faleo, G. Nair, Q. Duh, M. Hebrok, W. Chang, P. Stock, Q. Tang.

    UCSF, San Francisco, CA.

    Intro: Islet transplantation can cure type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets away from their native blood…
  • 2018 American Transplant Congress

    Enhancement of Muscle Regeneration and Function via Transplantation of Human Dystrophin Expressing Chimeric Cells as a Novel Myoblast Stem-Cell Based Therapy

    M. Siemionow,1 J. Cwykiel,1 E. Marchese,1 G. Rafidi,1 K. Futoma,1 A. Heydemann,2 J. Garcia-Martinez,2 E. Szilagyi.1

    1Orthopaedics, University of Illinois at Chicago, Chicago; 2Physiology and Biophysics, University of Illinois at Chicago, Chicago.

    PURPOSE: Allogeneic myogenic stem cell transplantation aims to restore muscle tissue after traumatic loss or to treat muscular dystrophies. Limited engraftment due to allogeneic rejection…
  • 2017 American Transplant Congress

    Assessment of Islet Damage During Isolation Utilizing miRNAs and Its Significance with Post-Transplant Outcome in TPIAT.

    P. Saravanan,1 M. Kanak,2 G. Yoshimatsu,1 M. Lawrence,1 B. Naziruddin.3

    1Baylor Scott and White Research Institute, Dallas, TX; 2Virginia Commonwealth University, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX

    Background: Pancreatic islets with high quality are essential for better endocrine function and post-transplant outcome in total pancreatectomy with islet autotransplantation (TPIAT). The islets are…
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