2022 American Transplant Congress
Pancreatic Islets Engineered with Thrombomodulin Show Enhanced Engraftment in an Intraportal Transplantation Model by Mitigating Instant Blood-Mediated Inflammatory Reactions
*Purpose: IBMIR is a major culprit of early islet loss post-transplant. Thrombomodulin (TM) is an anti-coagulant and cofactor of activated Protein C (APC) that perpetuates…2022 American Transplant Congress
Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice
1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI
*Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…2021 American Transplant Congress
Islet Allotransplantation Into Pre-vascularized Sernova Cell PouchTM – Preliminary Results from the University of Chicago
1Surgery, University of Chicago, Chicago, IL, 2Medicine, University of Chicago, Chicago, IL
*Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…2021 American Transplant Congress
Cleveland Clinic Experience with Cadaveric Uterus Transplant
1Cleveland Clinic, Cleveland, OH, 2University Hospital, Cleveland, OH
*Purpose: Uterus transplantation (UTx) is the only treatment for women with uterine factor infertility (UFI). The majority of overall experience is from living donation. Little…2021 American Transplant Congress
Inducing Transient Mixed Chimerism without Chimeric Transition Syndrome for Tolerance Induction After Kidney Transplantation
Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Immunological or operational tolerance, defined as the absence of a destructive immune response to a transplanted tissue without ongoing immunosuppression, is one strategy that…2020 American Transplant Congress
Hepatitis B Virus Prophylaxis and Treatment among Hematopoietic Stem Cell Transplant Recipients: Impact on Engraftment and Outcomes
*Purpose: Hepatitis B virus infection is a worldwide concern with a broad distribution. It can reactivate in immunocompromised populations such as solid organ and hematopoietic…2020 American Transplant Congress
Epithelial To Mesenchymal Transition Mediates Engraftment Of Endoderm And Hepatic Progenitor Cells In The Quiescent Liver
*Purpose: Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short term efficacy, but can…2020 American Transplant Congress
CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction
*Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…2019 American Transplant Congress
CD46 Transgene Modification and Thrombosis in Neonatal Porcine Islet Xenotransplantation
Surgery, Duke University, Durham, NC
*Purpose: Vascular thrombosis activation is an important cause for early xeno-islet loss. To better understand the thrombosis process in islet xenotransplantation and the effect of…2019 American Transplant Congress
Differentiation and Characterization of Human Endodermal Precursors for Liver Cell Therapies
*Purpose: Mouse pluripotent stem cell (PSC)-derived endoderm precursors (EPs) have small size, endoderm lineage gene expression signatures, and high proliferation rates, that allow engraftment in…
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