ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Engraftment"

  • 2022 American Transplant Congress

    Pancreatic Islets Engineered with Thrombomodulin Show Enhanced Engraftment in an Intraportal Transplantation Model by Mitigating Instant Blood-Mediated Inflammatory Reactions

    A. Turan1, L. Zhang2, M. Tarique2, V. Ulker2, E. Yolcu3, H. Shirwan3

    1Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO, 2Department of Child Health, University of Missouri at Columbia, Columbia, MO, 3Child Health and Molecular Microbiology and Immunology, University of Missouri at Columbia, Columbia, MO

    *Purpose: IBMIR is a major culprit of early islet loss post-transplant. Thrombomodulin (TM) is an anti-coagulant and cofactor of activated Protein C (APC) that perpetuates…
  • 2022 American Transplant Congress

    Rhesus-Primatized Mouse Model Generated Using Transgenic Immunodeficient Mice

    C. Little1, W. J. Haynes1, L. Huang1, C. Daffada1, K. B. Wolfe2, E. Perrin2, J. A. Simpson1, J. A. Kropp Schmidt2, H. M. Hinkle2, L. T. Keding2, R. T. Behrens2, D. T. Evans2, D. Kaufman1, J. A. Thomson2, T. G. Golos2, M. Brown1

    1Surgery, University of Wisconsin, Madison, WI, 2University of Wisconsin, Madison, WI

    *Purpose: To develop a translational primatized mouse model, akin to humanized mice, that allows for high-throughput in vivo experimentation to augment non-human primate pre-clinical studies.*Methods:…
  • 2021 American Transplant Congress

    Islet Allotransplantation Into Pre-vascularized Sernova Cell PouchTM – Preliminary Results from the University of Chicago

    P. J. Bachul1, P. E. Borek1, G. S. Generette1, A. Perez-Gutierrez1, K. Jayant1, K. Golab1, L. Basto1, L. Perea1, M. Tibudan1, C. Thomas2, L. Philipson2, J. Fung1, P. Witkowski1

    1Surgery, University of Chicago, Chicago, IL, 2Medicine, University of Chicago, Chicago, IL

    *Purpose: Previous first-in-human pilot study showed safety but the conditions did not allow for detectable islet function post-transplantation into the pre-vascularized Sernova Cell Pouches (SCPs)…
  • 2021 American Transplant Congress

    Cleveland Clinic Experience with Cadaveric Uterus Transplant

    L. Del Prete1, C. Quintini1, K. Hashimoto1, B. Eghtesad1, G. D'Amico1, C. Kwon1, D. Priebe1, E. Richards1, S. Ricci1, U. Perni1, C. Ferrando1, A. Chiesa-Vottero1, S. Mawhorter1, N. Yeaney1, R. Farrell1, R. Flyckt2, C. Miller1, T. Falcone1, A. Tzakis1

    1Cleveland Clinic, Cleveland, OH, 2University Hospital, Cleveland, OH

    *Purpose: Uterus transplantation (UTx) is the only treatment for women with uterine factor infertility (UFI). The majority of overall experience is from living donation. Little…
  • 2021 American Transplant Congress

    Inducing Transient Mixed Chimerism without Chimeric Transition Syndrome for Tolerance Induction After Kidney Transplantation

    K. Lee, J. Park

    Samsung Medical Center, Seoul, Korea, Republic of

    *Purpose: Immunological or operational tolerance, defined as the absence of a destructive immune response to a transplanted tissue without ongoing immunosuppression, is one strategy that…
  • 2020 American Transplant Congress

    Hepatitis B Virus Prophylaxis and Treatment among Hematopoietic Stem Cell Transplant Recipients: Impact on Engraftment and Outcomes

    B. Buzo1, J. Fernandes Ramos2, R. Marques Rossetti3, N. Salles4, A. Mendrone-Junior4, V. Rocha3, A. de Seixas Santos Nastri5

    1Division of Infectious Diseases, University of Alberta, Edmonton, AB, Canada, 2Division of Infectious Diseases and Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, 3Division of Hematology, University of Sao Paulo, Sao Paulo, Brazil, 4Fundacao Pro-Sangue, Sao Paulo, Brazil, 5Division of Infectious Diseases, University of Sao Paulo, Sao Paulo, Brazil

    *Purpose: Hepatitis B virus infection is a worldwide concern with a broad distribution. It can reactivate in immunocompromised populations such as solid organ and hematopoietic…
  • 2020 American Transplant Congress

    Epithelial To Mesenchymal Transition Mediates Engraftment Of Endoderm And Hepatic Progenitor Cells In The Quiescent Liver

    W. S. Fagg1, N. Lui2, L. Patrikeev3, O. Saldarriaga*4, H. Lerner-Stevenson5, V. Popov6, M. Motamade3, J. H. Fair1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Surgery, Naiyou Lui, Galveston, TX, 3Ophthalmology, University of Texas Medical Branch, Galveston, TX, 4Pathology, Omar Saldarriaga, Galveston, TX, 5pathology, University of Texas Medical Branch, Galveston, TX, 6Pathology, University of Texas Medical Branch, Galveston, TX

    *Purpose: Stem cell transplantation to the liver is a promising therapeutic strategy for a variety of disorders. Hepatocyte transplantation has short term efficacy, but can…
  • 2020 American Transplant Congress

    CD47 Innate Immune Checkpoint Enhances Islet Engraftment Following Intraportal Transplantation by Mitigating Instant Blood Mediated Inflammatory Reaction

    P. Shrestha, L. Batra, M. T. Malik, M. Tan, E. S. Yolcu, H. Shirwan

    Institute for Cellular Therapeutics and Department of Microbiology and Immunology, University of Louisville, Louisville, KY

    *Purpose: Transplantation of islets into hepatic portal vein is associated with significant islet mass loss immediate post-transplantation. Instant blood mediated inflammatory reaction (IBMIR), characterized by…
  • 2019 American Transplant Congress

    Immune Cells Composition of Humanized Mouse Kidney Compared to Normal Human Kidney

    S. Noel1, J. T. Kurzhagen1, S. Lee1, M. Sadasivam2, A. R. Hamad2, P. M. Pierorazio3, H. Rabb1

    1Medicine, Johns Hopkins University, Baltimore, MD, 2Pathology, Johns Hopkins University, Baltimore, MD, 3Urology, Johns Hopkins University, Baltimore, MD

    *Purpose: Most clinical studies fail in spite of promising mouse studies, in part due to fundamental differences between mice and human responses. Attempts have been…
  • 2019 American Transplant Congress

    Pluripotent Stem Cell Differentiation: Delaying Forward Differentiation Signals Maintains Definitive Endoderm Phenotype for Cellular Transplantation

    J. Fair1, M. M. Shoja1, N. Liu1, I. Patrikeev2, M. Motamedi2, W. S. Fagg1

    1Surgery, University of Texas Medical Branch, Galveston, TX, 2Opthalmology and Visual Sciences, University of Texas Medical Branch, Galveston, TX

    *Purpose: Endodermal precursors (EP), derived in vitro from mouse pluripotent stem cell (PSC) sources, are capable of clinically useful engraftment in the unmodified (quiescent) liver…
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