Articles tagged "Endothelial cells"

2020 American Transplant Congress
Single Cell Analysis Reveals Endothelial Activation of Interleukin-6 Mediated Signaling Pathway in Microvascular Inflammation with and without c4d
A. S. Naik¹, R. Menon¹, E. Farkash¹, E. Otto¹, C. C. Berthier¹, S. Norman¹, M. Samaniego², M. Kretzler¹
¹University of Michigan, Ann Arbor, MI, ²Henry Ford Hospital, Detroit, MI
*Purpose: Microvascular inflammation (MVI) is a feature of antibody mediated rejection. MVI can be seen with or without activation of other effectors of antibody injury…
2020 American Transplant Congress
Cyclophilin-D Inhibition Mitigates Cardiac Allograft Ischemia-Reperfusion Injury and Rejection
A. Qamar¹, P. McLeod², J. Jiang², X. Huang², A. M. Jevnikar², Z. Zhang²
¹Pathology & Laboratory Medicine, University of Western Ontario, London, ON, Canada, ²London Health Sciences Center, London, ON, Canada
*Purpose: The clinical relevance of ischemia-reperfusion injury (IRI) in the context of organ transplantation is well-established. IRI is associated with various forms of programmed cell…
2020 American Transplant Congress
Bone Marrow Mesenchymal Stem Cells Improve Rat Islet Angiogenesis by Upregulating of ISL1 and VEGF-A
Y. Wang¹, J. Wang², X. Ding²
¹Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China, ²Department of Renal Transplantation, Nephropathy Hospital, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China
*Purpose: Islet transplantation is an important therapy to cure diabetes, but poor angiogenesis in the early stage of islet transplantation is one of the main…
2019 American Transplant Congress
Multiplexed Droplet Single-Cell RNA-Sequencing for Cellular Profiling of Transplant Rejection
A. Schroeder, T. Sigdel, I. Damm, S. Sur, G. Hartoularos, J. Ye, M. Sarwal
Department of Surgery, UCSF, San Francisco, CA
*Purpose: Multiplexed droplet single-cell RNA-sequencing (mdscRNA-seq) has been utilized across many tissue types for fast and paralleled transcriptomic profiling. However, maintaining sample identity for differential…
2019 American Transplant Congress
Sphingosine 1-Phosphate Receptors and CCR7 Sequentially Coordinate T Cell Migration
Y. Xiong¹, W. Piao¹, C. Brinkman¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla⁴, K. Hippen⁵, B. Blazar⁵, S. Schwab⁶, J. Bromberg¹
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴Boston Children's hospital, Boston, MD, ⁵U.Minnesota, Minneapolis, MN, ⁶NYU, NY, NY
*Purpose: CCR7 plays critical roles in T cell migration to CCL21 across lymphatic endothelial cells from tissues to lymph nodes (LN). S1PR1 and S1PR4 are…
2019 American Transplant Congress
Promoting Mitochondrial Fusion Alters the Interaction between Endothelial Cells and T Cells in Models of Transplantation
D. T. Tran, C. Atkinson, S. N. Nadig
Medical University of South Carolina, Charleston, SC
*Purpose: As semi-professional antigen-presenting cells, microvascular endothelial cells (mECs) play a central role in mediating allograft rejection. Cold storage and ischemia reperfusion injury increases mEC…
2019 American Transplant Congress
Treg Lymphotoxin and Lymphatic Endothelial Cell Lymphotoxin Receptor Interactions Are Required for Treg Stability and Allograft Protection
V. Saxena, W. Piao, L. Li, C. M. Palusckievicz, Y. Xiong, T. Simon, J. S. Bromberg
U Maryland, Baltimore, MD
*Purpose: Regulatory T cells (Treg) restrain allograft rejection through suppressor functions that are dependent upon expression of the transcription factor Foxp3, their proper migration, and…
2019 American Transplant Congress
Cryopreserved Human Iliac Arteries Allografts: Different Thawing Rates Affect on Their Structural Changes and Mechanical Properties
R. Novotny¹, J. Chlupac¹, R. Matejka², T. Marada¹, P. Mericka³, L. Sterba³, L. Janousek¹, J. Fronek¹
¹Transplant Surgery Department, Institute for Clinical and Experimental Medicine, Prague, Czech Republic, ²Department of Biomedical Engineerin, Faculty of Biomedical Engineering, Czech Technical University, Prague, Czech Republic, ³Tissue Bank, Faculty Hospital Hradec Kralove, Hradec Kralove, Czech Republic
*Purpose: The rate of thawing of cryopreserved human iliac arteries allografts (CHIAA) directly affects the severeness of structural changes that occur during this process. This…
2019 American Transplant Congress
Laminin Dependent T Cell Migration Determines Allograft Survival
L. Li, M. Shirkey, W. Piao, Y. Xiong, V. Saxena, T. Zhang, B. M. Cerel, C. Paluskievicz, J. S. Bromberg
Surgery, U. Maryland, Baltimore, Baltimore, MD
*Purpose: Differential expression of lymph node (LN) stromal laminins α5β1γ1 (511) and α4β1γ1 (411) is associated with tolerance and immunity, respectively. We investigated the hypothesis…
2019 American Transplant Congress
Protection of the Donor Kidney Vascular Endothelium by Ex-Vivo Perfusion with a Pan-Caspase Inhibitor
R. Plenter¹, S. Jain², T. Nydam¹, A. jani²
¹Transplant Microsurgery Program, University of Colorado, Aurora, CO, ²Renal Division, University of Colorado, Aurora, CO
*Purpose: Orthotopic kidney transplantation is a life-saving therapeutic option for patients with end stage organ failure. Pulsatile perfusion (PP) of deceased donor kidneys is increasingly…

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