2020 American Transplant Congress
Crosstalk between TLR4 and HLA Class I Mediates P-Selectin Expression and Monocyte Capture to Endothelial Cells
Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific HLA antibodies (DSA) are at risk for acute and chronic antibody-mediated rejection (AMR). DSA contribute to the process of…2020 American Transplant Congress
Characterization of Laminin Alpha 4 Conditional Knockout Mice: Model for Immune Stimulation
*Purpose: Lymph node (LN) stromal laminin α4 (Lama4) and α5 (Lama5) are associated with tolerance and immunity, respectively. We created a Lama4 conditional knockout (KO)…2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…2019 American Transplant Congress
Preservation of Pancreatic Islets with Stem Cell Derived CD34+ Vascular Endothelial Progenitor Cells
1Surgery, UCSF, San Francisco, CA, 2Diabetes Center, UCSF, San Francisco, CA
*Purpose: Islet transplantation can cure Type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets when removed from their native…2019 American Transplant Congress
Cellular Sources of Cytokine Production during Cold Ischemia Induced AKI after Kidney Transplant
*Purpose: Delayed graft function portends reduced 5-year graft survival and is associated with prolonged cold ischemia (CI). The aim of this study was to determine…2019 American Transplant Congress
Lymphotoxin Beta Receptor in Lymphatic Endothelial Cells Regulates Treg Migration and Allograft Protection
*Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…2019 American Transplant Congress
Endothelial Cells Do Not Regulate Expression of CD46, CD55 and CD59 in the Presence of Anti-HLA Class I and 11 Antibodies
*Purpose: Anti-HLA antibodies, both pre-formed and de novo are associated with worse graft survival. Complement activation is an important mechanism of antibody mediated immunological injury.…2019 American Transplant Congress
Platelets Augment Granzyme K Production By Macrophages In Antibody-mediated Rejection
Cleveland Clinic Main Campus, Lerner Research Institute, Cleveland, OH
*Purpose: When antibodies bind to MHC antigens on endothelial cells a cascade of responses is initiated including exocytosis of adhesion molecules followed by attachment and…2019 American Transplant Congress
Lymphotoxin Beta Receptor Determines Lymph Node Structure for Treg Migration and Suppression of Graft Rejection
*Purpose: Lymphotoxin beta receptor (LTβR) mediated signaling in lymphatic endothelium cells (LEC) is important for migration of regulatory T cells (Treg) to afferent lymphatic vessels…2019 American Transplant Congress
Intact Lymphatics Are Essential for Costimulation Blockade-Induced Lung Allograft Survival
*Purpose: Blocking lymphangiogenesis is thought to diminish immune responses to donor tissues. However, lung transplantation (Tx), which involves airway and vascular but not lymphatic anastomoses,…
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