Articles tagged "Endothelial cells"

2020 American Transplant Congress
Lymphotoxin Beta Receptor Regulates Draining Lymph Node Structure and Treg Migration
V. Saxena¹, W. Piao¹, L. Li¹, Y. Xiong¹, C. C. Palusckievicz¹, T. Simon¹, M. W. Shirkey¹, R. Abdi², J. S. Bromberg¹
¹University of Maryland, Baltimore, Baltimore, MD, ²Harvard U, Boston, MA
*Purpose: To induce tolerance, regulatory T cells (Treg) are required to migrate from tissues via afferent lymphatic vessels (LV) to the draining lymph node (dLN).…
2020 American Transplant Congress
Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft
J. S. Uzarski¹, E. E. Russell¹, E. C. Beck¹, M. Holzner², V. Wadhera², D. Adamson², T. Gilbert¹, S. Florman², D. S. Davidow¹, R. Shapiro², J. Ross¹
¹Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, ²Recanati/Miller Institute, Mount Sinai, New York, NY
*Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
2020 American Transplant Congress
Treg Use PD-1 for Lymphatic Migration
W. Piao¹, L. Li¹, K. Hippen², Y. Zhang³, Y. Xiong¹, V. Saxena¹, C. Paluskievicz¹, M. WillsonShirkey¹, B. Blazar⁴, L. Riella⁵, J. Bromberg⁶
¹Surgery, U of Maryland, Baltimore, MD, ²U of Minnesota, Minneapolis, MN, ³U of Maryland, Minneapolis, MD, ⁴U of Minnesota, Minneapolis, MA, ⁵Harvard U, Boston, MA, ⁶Surgery and Microbiology and Immunology, U of Maryland, Baltimore, MD
*Purpose: Regulatory T cell (Treg) lymphatic migration is important for immune tolerance. Treg express both programmed death-1 (PD-1) and its ligand PD-L1, which are important…
2019 American Transplant Congress
Apoptotic Exosome-Like Vesicles Induce Endothelial Cell Plasticity and Accelerate Allograft Vascular Remodeling
F. Migneault¹, M. Dieudé¹, J. Turgeon¹, A. Karakeussian Rimbaud¹, D. Beillevaire¹, M. Hardy², A. Brodeur¹, N. Thibodeau¹, C. Perreault², M. Hébert¹
¹CRCHUM, Montreal, QC, Canada, ²IRIC, Montreal, QC, Canada
*Purpose: Acute vascular rejection of allografts is associated with endothelial apoptosis which in turn contributes to the development of transplant vasculopathy. We previously showed that…
2019 American Transplant Congress
Predominant Role of Microvascular over Tubular Injury as Driver of Progressive Renal Damage and Fibrosis Post Ischemia Reperfusion Injury
S. Lan¹, B. Yang¹, M. Dieudé¹, J. Sabo-Vatasescu², A. Karakeussian-Rimbaud², J. Turgeon², S. Qi³, N. Patey⁴, M. Hébert¹
¹Medicine Faculty, CRCHUM, University of Montreal, Montreal, QC, Canada, ²CRCHUM, Montreal, QC, Canada, ³Department of Surgery, CRCHUM, University of Montreal, Montreal, QC, Canada, ⁴Department of Pathology and Cell Biology, CHU Saint-Justine, University of Montreal, Montreal, QC, Canada
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for allograft dysfunction and chronic renal failure. Although tubular epithelial cells (TEC) are considered the main…
2019 American Transplant Congress
Cytomegalovirus (CMV) Infection Induces an Angiogenic Response through Hepatic Stellate Cells (HSCs) and Leads to Early Post-Transplant Liver Fibrosis (LF) and Poor Graft Survival
B. H. Ozdemir¹, G. Ozgun¹, E. H. Ayvazoglu Soy², N. Haberal¹, G. Moray², M. Haberal²
¹Pathology, Baskent University, Ankara, Turkey, ²Transplantation, Baskent University, Ankara, Turkey
*Purpose: The ability of the CMV to infect the endothelial cells (ECs) is critical. CMV can increase EC adhesion, permeability, and create a pro-inflammatory environment…
2019 American Transplant Congress
Normothermic Ex Situ Liver Perfusion with Different Clinical Perfusates and Their Effect on Pig Liver Transplant Outcomes in a Donation after Circulatory Death Model
I. Linares-Cervantes, D. Kollmann, T. Goto, J. Echeverri, M. Kaths, M. Hamar, P. Urbanellis, L. Mazilescu, R. Rosales, C. Bruguera, F. Oquendo, S. Ganesh, O. Adeyi, P. Yip, N. Selzner, M. Selzner
Toronto General Hospital, Toronto, ON, Canada
*Purpose: Human-albumin/Dextran (HA-D), Bovine-gelatin (BG) and packed red blood cells plus plasma have been used in European and North-American clinical trials of normothermic ex-situ liver…
2019 American Transplant Congress
Sphingosine 1-Phosphate Receptor 2 Regulates Migration through Endothelial Cell VCAM and Adherens Junctions
Y. Xiong¹, W. Piao¹, C. Brinkman¹, L. Li¹, J. Kulinski², A. Olivera², A. Cartier³, T. Hla³, K. Hippen⁴, B. Blazar⁴, S. Schwab⁵
¹Surgery, UMB, Baltimore, MD, ²NIH, Bethesda, MD, ³Boston Children's hospital, Boston, MA, ⁴U.Minnesota, Minneapolis, MN, ⁵NYU, NY, NY
*Purpose: Lymphatic endothelial cells (LEC) highly expres S1PR1 and S1PR2. The ligand S1P is produced by LEC and regulates T cell migration. The mechanisms of…
2019 American Transplant Congress
Use Of Perirenal Adipose Tissue As A Source Of Donor Cells Allowing Evaluation Of Endothelial Inflammation And Quality Of Expanded Criteria Kidneys
R. Boissier¹, L. Lyonnet², P. Francois³, M. Meunier⁴, B. Gondran-Tellier⁵, T. Legris⁶, J. Magalon⁵, C. Picard⁷, F. Dignat George⁵, E. Lechevallier⁸, G. Karsenty⁸, F. Sabatier⁹, P. Paul¹
¹INSERM 1263, Centre de recherche en cardiovasculaire et nutrition, INSERM, Aix Marseille Univ, Assistance Publique Hopitaux Marseille, Marseille, France, ²Vascular Biology and Hematology department, Assistance publique Hopitaux Marseille (AP-HM), Marseille, France, ³INSERM 1263, Centre de recherche en cardiovasculaire et nutrition, INSERM, Aix Marseille Univ., Marseille, France, ⁴Nephrology Dialysis and Renal Transplantation Center, AP-HM, Marseille, France, ⁵INSERM 1263, C2VN, INSERM, Aix Marseille Univ., Marseille, France, ⁶Nephrology Dialysis and Renal Transplantation Center, AP-HM, Marseille, France, ⁷Etablissement Français du Sang, Alpes Méditerranée, Marseille, France, ⁸Urology and Transplantation Unit , AP-HM, Marseille, France, ⁹INSERM 1263, Centre de recherche en cardiovasculaire et nutrition, INSERM, Aix Marseille Univ, Marseille, France
*Purpose: Use of expanded-criteria donor (ECD) kidneys is a perspective to overcome organ shortage. Age and donor-related co-morbidy factors are known to affect graft function…
2019 American Transplant Congress
Inhibition of mTORC2 Causes Hyper Phosphorylation of ERK Induced by Co-Ligation of HLA-I and II Antibody
Y. Jin¹, J. Sinnet-Smith², E. Rozengurt², E. F. Reed¹
¹Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, ²Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific antibodies (DSA) are at risk for antibody-mediated rejection (AMR). It has been reported that as many as 30% of…

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