Articles tagged "Endothelial cells"

2015 American Transplant Congress
Interactions Between Platelets and Liver Sinusoidal Endothelial Cells Initiate Liver Regeneration
J. Meyer,^1,2 E. Lejmi,² P. Fontana,^2,3 P. Morel,^1,2 C. Gonelle-Gispert,² L. Bühler.^1,2
¹Division of Digestive and Transplantation Surgery, University Hospitals of Geneva, Geneva, Switzerland; ²Geneva Medical School, Geneva, Switzerland; ³Division of Angiology and Haemostasis, University Hospitals of Geneva, Geneva, Switzerland.
ObjectivesPlatelets and liver sinusoidal endothelial cells (LSEC) were shown to be important contributors to liver regeneration. Several recent studies suggested that their interactions might be…
2015 American Transplant Congress
The 20S Proteasome Is Active in Apoptotic Nanovesicles and Controls Anti-LG3 Antibody Production
M. Dieudé,^1,4 C. Bell,^2,4 J. Turgeon,^1,4 D. Beillevaire,^1,4 K. Hamelin,^1,4 S. Qi,^1,4 N. Pallet,^1,4 C. Rondeau,³ D. Gingras,³ M. Desjardins,³ P. Thibault,^2,4 M.-J. Hébert.^1,4
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Institute for Research in Immunology and Cancer (IRIC), Montreal, QC, Canada; ³Université de Montréal, Montreal, QC, Canada; ⁴Canadian National Transplant Research Program (CNTRP), Montreal, Canada.
Humoral autoreactivity to apoptotic cells and perlecan/LG3, a proteoglycan fragment released by apoptotic cells, predicts poor allograft outcomes in renal transplant patients. How apoptotic cells…
2015 American Transplant Congress
Anti-LG3 Antibodies Aggravate Ischemia-Reperfusion Injury
B. Yang,¹ K. Hamelin,¹ L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ N. Patey,² M.-J. Hébert.¹
¹Centre de Recherche du Centre Hospitalier de l'Université de Montréal (CRCHUM) and Université de Montréal, Montréal, Canada; ²Department of Pathology, CHU Ste-Justine Université de Montréal, Montréal, Canada.
Ischemia-Reperfusion Injury (IRI) is a significant cause of renal allograft dysfunction and a risk factor for poor long-term graft outcomes. Microvascular injury is an important…
2015 American Transplant Congress
mTOR Inhibitors Reduce the Endothelial Transmigration of Leukocytes After Ischemia
I. Werner, A. Hernandez-Sierra, F. Guo, A. Moritz, A. Beiras-Fernandez.
Department of Thoracic and Cardiovascular Surgery, University Hospital Frankfurt, Frankfurt am Main, Germany.
ObjectivemTOR inhibitors Everolimus and Sirolimus are currently used as maintenance immunosuppressive agents to prevent rejection of solid transplanted organs. Episodes of transplant rejection and graft…
2015 American Transplant Congress
Pancreas Transplant Sera Improves the Function and Proliferation of Endothelial Cells
J. Pollett, L. Margetich, N. Thai.
Transplant Services, Allegheny General Hospital, Pittsburgh, PA.
Pancreas transplantation (Tx) allows for the study of diabetes by examining the reversal of the disease. Previously, we observed that after pancreas Tx many patients'…
2015 American Transplant Congress
Increased Vascular Stiffness in Pediatric Renal Transplant Recipients Despite Normal Kidney Function, Blood Pressure, and Body Mass Index
M. Seifert,^1,2 N. Kulsum-Mecci,² L. de las Fuentes,² V. Davila-Roman,² K. Hruska.²
¹Southern Illinois University, Springfield, IL; ²Washington University, St. Louis, MO.
Background: Chronic kidney disease (CKD) imparts enormous cardiovascular (CV) risk that is only partially improved by renal transplantation. We sought to understand the determinants of…
2015 American Transplant Congress
Lymphatic Endothelium Uniquely Enhances T Cell Migration to S1P
C. Brinkman, Y. Xiong, J. Bromberg.
University of Maryland, Baltimore, MD.
Introduction: Sphingosine-1-phosphate (S1P) is a signaling sphingolipid that regulates cell egress from lymphoid and non-lymphoid tissues. While S1P has been described as a chemoattractant, its…